Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease

Aging Cell

Volumn 6, Issue 5, 2007, Pages 639-647

  Bekaert, Sofie ^a   De Meyer, Tim ^a   Rietzschel, Ernst R ^b   De Buyzere, Marc L ^b   De Bacquer, Dirk ^b   Langlois, Michel ^c   Segers, Patrick ^a   Cooman, Luc ^d   Van Damme, Piet ^d   Cassiman, Peter ^d   Van Criekinge, Wim ^a   Verdonck, Pascal ^a   De Backer, Guy G ^b   Gillebert, Thierry C ^b   Van Oostveldt, Patrick ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c General Hospital St Jan   (Belgium)

^d Association of Primary Care Physicians Asklepios VOF   (Belgium)

Author keywords

Aging; Cardiovascular disease; Inflammation; Lifestyle; Oxidative stress; Telomere

Indexed keywords

ACETYLSALICYLIC ACID; ANTIHYPERTENSIVE AGENT; BIOLOGICAL MARKER; CHOLESTEROL; NONSTEROID ANTIINFLAMMATORY AGENT;

ADULT; AGING; ARTICLE; BLOOD PRESSURE; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CAUCASIAN; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; COMMUNITY LIVING; CONTROLLED STUDY; FEMALE; HUMAN; HYPERTENSION; INFLAMMATION; LEUKOCYTE; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; OXIDATIVE STRESS; PREVALENCE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; SEX DIFFERENCE; SMOKING; TELOMERE; WAIST CIRCUMFERENCE;

ADULT; AGING; BIOLOGICAL MARKERS; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; CHOLESTEROL; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INFLAMMATION MEDIATORS; LIFE STYLE; MALE; MIDDLE AGED; OXIDATIVE STRESS; RISK FACTORS; SEX CHARACTERISTICS; TELOMERE;

EID: 34548625163     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2007.00321.x     Document Type: Article

References (37)

1. Aviv A, Valdes A, Gardner JP, Swaminathan R, Kimura M, Spector TD (2006) Menopause modifies the association of leukocyte telomere length with insulin resistance and inflammation. J. Clin. Endocrinol. Metab. 91, 635-640.
2. Bekaert S, De Meyer T, Van Oostveldt P (2005a) Telomere attrition as ageing biomarker. Anticancer Res. 25, 3011-3021.
3. Bekaert S, Van Pottelbergh I, De Meyer T, Zmierczak H, Kaufman JM, Van Oostveldt P, Goemaere S (2005b) Telomere length versus hormonal and bone mineral status in healthy elderly men. Mech. Ageing Dev. 126, 1115-1122.
4. Benetos A, Gardner JP, Zureik M, Labat C, Xiaobin L, Adamopoulos C, Temmar M, Bean KE, Thomas F, Aviv A (2004) Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects. Hypertension 43, 182-185.
5. Benetos A, Okuda K, Lajemi M, Kimura M, Thomas F, Skurnick J, Labat C, Bean K, Aviv A (2001) Telomere length as an indicator of biological aging: The gender effect and relation with pulse pressure and pulse wave velocity. Hypertension 37, 381-385.
6. Bischoff C, Graakjaer J, Petersen HC, Jeune B, Bohr VA, Koelvraa S, Christensen K (2005) Telomere length among the elderly and oldest-old. Twin Res. Hum. Genet. 8, 425-432.
7. Blackburn EH (2000) Telomere states and cell fates. Nature 408, 53-56.
8. Brouilette SW, Moore JS, McMahon AD, Thompson JR, Ford I, Shepherd J, Packard CJ, Samani NJ (2007) Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: A nested case-control study. Lancet 369, 107-114.
9. Brouilette S, Singh RK, Thompson JR, Goodall AH, Samani NJ (2003) White cell telomere length and risk of premature myocardial infarction. Arterioscler. Thromb. Vasc. Biol. 23, 842-846.
10. Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA (2003) Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 361, 393-395.
11. Collerton J, Martin-Ruiz C, Kenny A, Barrass K, von Zglinicki T, Kirkwood T, Keavney B (2007) Telomere length is associated with left ventricular function in the oldest old: The Newcastle 85+ study. Eur. Heart J. 28, 172-176.
12. Demissie S, Levy D, Benjamin EJ, Cupples LA, Gardner JP, Herbert A, Kimura M, Larson MG, Meigs JB, Keaney JF, Aviv A (2006) Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell 5, 325-330.
13. Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM (2004) Accelerated telomere shortening in response to life stress. Proc. Natl Acad. Sci. USA 101, 17312-17315.
14. Epel ES, Lin J, Wilhelm FH, Wolkowitz OM, Cawthon R, Adler NE, Dolbier C, Mendes WB, Blackburn EH (2006) Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology 31, 277-287.
15. Fitzpatrick AL, Kronmal RA, Gardner JP, Psaty BM, Jenny NS, Tracy RP, Walston J, Kimura M, Aviv A (2007) Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. Am. J. Epidemiol. 165, 14-21.
16. Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18, 499-502.
17. Frohlich M, Doring A, Imhof A, Hutchinson WL, Pepys MB, Koenig W (1999) Oral contraceptive use is associated with a systemic acute phase response. Fibrinolysis Proteolysis 13, 239-244.
18. Gardner JP, Li S, Srinivasan SR, Chen W, Kimura M, Lu X, Berenson GS, Aviv A (2005) Rise in insulin resistance is associated with escalated telomere attrition. Circulation 111, 2171-2177.
19. Graakjaer J, Der-Sarkissian H, Schmitz A, Bayer J, Thomas G, Kolvraa S, Londono-Vallejo JA (2006) Allele-specific relative telomere lengths are inherited. Hum. Genet. 119, 344-350.
20. Harris SE, Deary IJ, MacIntyre A, Lamb KJ, Radhakrishnan K, Starr JM, Whalley LJ, Shiels PG (2006) The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people. Neurosci. Lett. 406, 260-264.
21. Jeanclos E, Krolewski A, Skurnick J, Kimura M, Aviv H, Warram JH, Aviv A (1998) Shortened telomere length in white blood cells of patients with IDDM. Diabetes 47, 482-486.
22. Jeanclos E, Schork NJ, Kyvik KO, Kimura M, Skurnick JH, Aviv A (2000) Telomere length inversely correlates with pulse pressure and is highly familial. Hypertension 36, 195-200.
23. Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J, Watanabe S, Tuttle KR, Rodriguez-Iturbe B, Herrera-Acosta J, Mazzali M (2003) Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension 41, 1183-1190.
24. Kurz DJ, Kloeckener-Gruissem B, Akhmedov A, Eberli FR, Buhler I, Berger W, Bertel O, Luscher TF (2006) Degenerative aortic valve stenosis, but not coronary disease, is associated with shorter telomere length in the elderly. Arterioscler. Thromb. Vasc. Biol. 26, e114-e117.
25. Lindsey J, McGill NI, Lindsey LA, Green DK, Cooke HJ (1991) In vivo loss of telomeric repeats with age in humans. Mutat. Res. 256, 45-48.
26. Lobbes MB, Lutgens E, Heeneman S, Cleutjens KB, Kooi ME, van Engelshoven JM, Daemen MJ, Nelemans PJ (2006) Is there more than C-reactive protein and fibrinogen? The prognostic value of soluble CD40 ligand, interleukin-6 and oxidized low-density lipoprotein with respect to coronary and cerebral vascular disease. Atherosclerosis 187, 18-25.
27. Mayer S, Bruderlein S, Perner S, Waibel I, Holdenried A, Ciloglu N, Hasel C, Mattfeldt T, Nielsen KV, Moller P (2006) Sex-specific telomere length profiles and age-dependent erosion dynamics of individual chromosome arms in humans. Cytogenet. Genome Res. 112, 194-201.
28. Nawrot TS, Staessen JA, Gardner JP, Aviv A (2004) Telomere length and possible link to X chromosome. Lancet 363, 507-510.
29. Nordfjall K, Larefalk A, Lindgren P, Holmberg D, Roos G (2005) Telomere length and heredity: Indications of paternal inheritance. Proc. Natl Acad. Sci. USA 102, 16374-16378.
30. Okuda K, Bardeguez A, Gardner JP, Rodriguez P, Ganesh V, Kimura M, Skurnick J, Awad G, Aviv A (2002) Telomere length in the newborn. Pediatr. Res. 52, 377-381.
31. Palatini P, Julius S (1997) Heart rate and the cardiovascular risk. J. Hypertens. 15, 3-17.
32. Rietzschel ER, De Buyzere ML, Bekaert S, Segers P, De Bacquer D, Cooman L, Van Damme P, Cassiman P, Langlois M, Van Oostveldt P, Verdonck P, De Backer G, Gillebert TC (2007) Rationale, design, methods and baseline characteristics of the Asklepios Study. Eur. J. Cardiovasc. Prev. Rehabil. 14, 179-191.
33. Unryn BM, Cook LS, Riabowol KT (2005) Paternal age is positively linked to telomere length of children. Aging Cell 4, 97-101.
34. Valdes AM, Andrew T, Gardner JP, Kimura M, Oelsner E, Cherkas LF, Aviv A, Spector TD (2005) Obesity, cigarette smoking, and telomere length in women. Lancet 366, 662-664.
35. Weiss N (2005) Mechanisms of increased vascular oxidant stress in hyperhomocysteinemia and its impact on endothelial function. Curr. Drug Metab. 6, 27-36.
36. Xu D, Neville R, Finkel T (2000) Homocysteine accelerates endothelial cell senescence. FEBS Lett. 470, 20-24.
37. von Zglinicki T, Saretzki G, Docke W, Lotze C (1995) Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence? Exp. Cell Res. 220, 186-193.