A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix

Cell Cycle

Volumn 8, Issue 6, 2009, Pages 931-939

  Kaminker, Patrick G ^a,b,d   Kim, Sahn Ho ^b,e   Desprez, Pierre Yves ^a,c   Campisi, Judith ^a,b  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^c CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^d GLAXOSMITHKLINE   (United States)

^e HENRY FORD HEALTH SYSTEM   (United States)

Author keywords

Alternative splicing; Human fibroblasts; Human mammary epithelial cells; Tankyrase; Telomerase; TRF1; TRF2

Indexed keywords

AMINO ACID; DETERGENT; ISOPROTEIN; PROTEIN TIN2L; PROTEIN TIN2S; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BREAST EPITHELIUM; CELL CYCLE; CELL NUCLEUS MATRIX; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EXTRACTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PROTEIN LOCALIZATION; TELOMERE;

EID: 65349150505     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.6.7941     Document Type: Article

References (49)

1. McClintock B. The stability of broken ends of chromosomes in Zea Mays. Genetics 1941; 26:234-82.
2. Reaper PM, di Fagagna F, Jackson SP. Activation of the DNA damage response by telomere attrition: a passage to cellular senescence. Cell Cycle 2004; 3:543-6.
3. Campisi J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol 2001; 11:27-31.
4. Hornsby PJ. Senescence as an anticancer mechanism. J Clin Oncol 2007; 25:1852-7.
5. Campisi J. Senescent cells, tumor suppression and organismal aging: good citizens, bad neighbors. Cell 2005; 120:513-22.
6. Yildiz O. Vascular smooth muscle and endothelial functions in aging. Ann N Y Acad Sci 2007; 1100:353-60.
7. Effros RB. T cell replicative senescence: pleiotropic effects on human aging. Ann N Y Acad Sci 2004; 1019:123-6.
8. Krtolica A, Parrinello S, Lockett S, Desprez PY, Campisi J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci USA 2001; 98:12072-7.
9. Martin GM. Modalities of gene action predicted by the classical evolutionary biological theory of aging. Ann NY Acad Sci 2007; 1100:14-20.
10. Griffith JD, Comeau L, Rosenfield S, Stansel RM, Bianchi A, Moss H, et al. Mammalian telomeres end in a large duplex loop. Cell 1999; 97:503-14.
11. Molenaar C, Wiesmeijer K, Verwoerd NP, Khazen S, Eils R, Tanke HJ, et al. Visualizing telom- ere dynamics in living mammalian cells using PNA probes. EMBO J 2003; 22:6631-41.
12. Weierich C, Brero A, Stein S, von Hase J, Cremer C, Cremer T, et al. Three-dimensional arrangements of centromeres and telomeres in nuclei of human and murine lymphocytes. Chromosome Res 2003; 11:485-502.
13. Vermolen BJ, Garini Y, Mai S, Mougey V, Fest T, Chuang TC, et al. Characterizing the three-dimensional organization of telomeres. Cytometry A 2005; 67:144-50.
14. de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev 2005; 19:2100-10.
15. Liu D, O'Connor MS, Qin J, Songyang Z. Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. J Biol Chem 2004; 279:51338-42.
16. Broccoli D, Smogorzewska A, Chong L, de Lange T Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet 1997; 17:231-5.
17. Baumann P, Cech TR. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 2001; 292:1171-5.
18. Li B, Oestreich S, de Lange T Identification of human Rap1: implications for telomere evolution. Cell 2000; 101:471-83.
19. Kim SH, Beausejour C, Davalos AR, Kaminker P, Heo SJ, Campisi J. TIN2 mediates functions of TRF2 at human telomeres. J Biol Chem 2004; 279:43799-804.
20. Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, et al. PTOP interacts with POT1 and regulates its localization to telomeres. Nat Cell Biol 2004; 6:673-80.
21. Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, et al. POT1- interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes Dev 2004; 18:1649-54.
22. Hediger F, Neumann FR, Van Houwe G, Dubrana K, Gasser SM. Live imaging of telomeres: yKu and Sir proteins define redundant telomere-anchoring pathways in yeast. Curr Biol 2002; 12:2076-89.
23. de Lange T Human telomeres are attached to the nuclear matrix. EMBO J 1992; 11:717-24.
24. Luderus ME, van Steensel B, Chong L, Sibon OC, Cremers FF, de Lange T. Structure, sub-nuclear distribution and nuclear matrix association of the mammalian telomeric complex. J Cell Biol 1996; 135:867-81.
25. Kim SH, Kaminker P, Campisi J. TIN2, a new regulator of telomere length in human cells. Nat Genet 1999; 23:405-12.
26. Ye JZ, Donigian JR, van Overbeek M, Loayza D, Luo Y, Krutchinsky AN, et al. TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem 2004; 279:47264-71.
27. Chiang YJ, Kim SH, Tessarollo L, Campisi J, Hodes RJ. Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway. Mol Cell Biol 2004; 24:6631-4.
28. Kim SH, Han S, You YH, Chen DJ, Campisi J. The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro. EMBO Rep 2003; 4:685-91.
29. Dynek JN, Smith S. Resolution of sister telomere association is required for progression through mitosis. Science 2004; 304:97-100.
30. Ye JZ, de Lange T. TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex. Nat Genet 2004; 36:618-23.
31. Okabe J, Eguchi A, Wadhwa R, Rakwal R, Tsukinoki R, Hayakawa T, et al. Limited capacity of the nuclear matrix to bind telomere repeat binding factor TRF1 may restrict the proliferation of mortal human fibroblasts. Hum Mol Genet 2004; 13:285-93.
32. Kim SH, Parrinello S, Kim J, Campisi J. Mus musculus and Mus spretus homologues of the human telomere-associated protein TIN2. Genomics 2003; 81:422-32.
33. Kaminker P, Plachot C, Kim SH, Chung P, Crippen D, Petersen OW, et al. Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2. J Cell Sci 2005; 118:1321-30.
34. He DC, Nickerson JA, Penman S. Core filaments of the nuclear matrix. J Cell Biol 1990; 110:569-80.
35. Wan KM, Nickerson JA, Krockmalnic G, Penman S. The nuclear matrix prepared by amine modification. Proc Natl Acad Sci USA 1999; 96:933-8.
36. Kim SH, Davalos AR, Heo SJ, Rodier F, Zou Y, Beausejour C, et al. Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes. J Cell Biol 2008; 181:447-60.
37. Stampfer MR, Pan CH, Hosoda J, Bartholomew J, Mendelsohn J, Yaswen P, et al. Blockage of EGF receptor signal transduction causes reversible arrest of normal and immortal human mammary epithelial cells with synchronous reentry into the cell cycle. Exp Cell Res 1993; 208:175-88.
38. van Steensel B, de Lange T. Control of telomere length by the human telomeric protein TRF1. Nature 1997; 385:740-3.
39. Smogorzewska A, van Steensel B, Bianchi A, Oelmann S, Schaefer MR, Schnapp G, et al. Control of human telomere length by TRF1 and TRF2. Mol Cell Biol 2000; 20:1659-68.
40. Benetti R, Garcia-Cao M, Blasco MA. Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres. Nat Genet 2007; 39:243-50.
41. Stampfer MR, Garbe J, Levine G, Lichtsteiner S, Vasserot AP, Yaswen P. Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells. Proc Natl Acad Sci USA 2001; 98:4498-503.
42. O'Connor MS, Safari A, Xin H, Liu D, Songyang Z. A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. Proc Natl Acad Sci USA 2006; 103:11874-9.
43. Canudas S, Houghtaling BR, Kim JY, Dynek JN, Chang WG, Smith S. Protein requirements for sister telomere association in human cells. EMBO J 2007; 26:4867-78.
44. Chen LY, Liu D, Songyang Z. Telomere maintenance through spatial control of telomeric proteins. Mol Cell Biol 2007; 27:5898-909.
45. Garcia-Cao M, O'Sullivan R, Peters AH, Jenuwein T, Blasco MA. Epigenetic regulation of telomere length in mammalian cells by the Suv39 h1 and Suv39 h2 histone methyltrans-ferases. Nat Genet 2004; 36:94-9.
46. Misteli T Beyond the sequence: cellular organization of genome function. Cell 2007; 128:787-800.
47. Kaminker PG, Kim SH, Taylor RD, Zebarjadian Y, Funk WD, Morin GB, et al. TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. J Biol Chem 2001; 276:35891-9.
48. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995; 92:9363-7.
49. Stampfer MR, Yaswen P. Human epithelial cell immortalization as a step in carcinogenesis. Cancer Lett 2003; 194:199-208.