Telomerase structure

Current Opinion in Structural Biology

Volumn 25, Issue , 2014, Pages 104-110

  Sandin, Sara ^a   Rhodes, Daniela ^b  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; RNA;

AMINO TERMINAL SEQUENCE; CHEMICAL COMPOSITION; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME LOCALIZATION; ENZYME MECHANISM; HUMAN; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; STRUCTURE ANALYSIS; ANIMAL; CHEMISTRY; METABOLISM; PROTEIN TERTIARY STRUCTURE;

ANIMALS; HUMANS; PROTEIN STRUCTURE, TERTIARY; RNA; TELOMERASE;

EID: 84897379649     PISSN: 0959440X     EISSN: 1879033X     Source Type: Journal    
DOI: 10.1016/j.sbi.2014.02.003     Document Type: Review

References (47)

1. Blackburn E.H., Collins K. Telomerase: an RNP enzyme synthesizes DNA. Cold Spring Harb Perspect Biol 2011, 3.
2. Pfeiffer V., Lingner J. Replication of telomeres and the regulation of telomerase. Cold Spring Harb Perspect Biol 2013, 5:a010405.
3. de Lange T. How telomeres solve the end-protection problem. Science 2009, 326:948-952.
4. Gunes C., Rudolph K.L. The role of telomeres in stem cells and cancer. Cell 2013, 152:390-393.
5. Greider C.W., Blackburn E.H. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 1985, 43:405-413.
6. Greider C.W., Blackburn E.H. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 1989, 337:331-337.
7. Yu G.L., Bradley J.D., Attardi L.D., Blackburn E.H. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature 1990, 344:126-132.
8. Lingner J., Cech T.R. Purification of telomerase from Euplotes aediculatus: requirement of a primer 3' overhang. Proc Natl Acad Sci U S A 1996, 93:10712-10717.
9. Lundblad V., Szostak J.W. A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 1989, 57:633-643.
10. Lingner J., Hughes T.R., Shevchenko A., Mann M., Lundblad V., Cech T.R. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 1997, 276:561-567.
11. Bodnar A.G., Ouellette M., Frolkis M., Holt S.E., Chiu C.P., Morin G.B., Harley C.B., Shay J.W., Lichtsteiner S., Wright W.E. Extension of life-span by introduction of telomerase into normal human cells. Science 1998, 279:349-352.
12. Weinrich S.L., Pruzan R., Ma L., Ouellette M., Tesmer V.M., Holt S.E., Bodnar A.G., Lichtsteiner S., Kim N.W., Trager J.B., et al. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet 1997, 17:498-502.
13. Bryan T.M., Goodrich K.J., Cech T.R. Tetrahymena telomerase is active as a monomer. Mol Biol Cell 2003, 14:4794-4804.
14. Witkin K.L., Collins K. Holoenzyme proteins required for the physiological assembly and activity of telomerase. Genes Dev 2004, 18:1107-1118.
15. Sauerwald A., Sandin S., Cristofari G., Scheres S.H., Lingner J., Rhodes D. Structure of active dimeric human telomerase. Nat Struct Mol Biol 2013, 20:454-460.
16. Jiang J., Miracco E.J., Hong K., Eckert B., Chan H., Cash D.D., Min B., Zhou Z.H., Collins K., Feigon J. The architecture of Tetrahymena telomerase holoenzyme. Nature 2013, 496:187-192.
17. Smogorzewska A., de Lange T. Regulation of telomerase by telomeric proteins. Annu Rev Biochem 2004, 73:177-208.
18. Cohen P., Blackburn E.H. Two types of telomeric chromatin in Tetrahymena thermophila. J Mol Biol 1998, 280:327-344.
19. Fairall L., Chapman L., Moss H., de Lange T., Rhodes D. Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2. Mol Cell 2001, 8:351-361.
20. Court R., Chapman L., Fairall L., Rhodes D. How the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: a view from high-resolution crystal structures. EMBO Rep 2005, 6:39-45.
21. Lei M., Podell E.R., Baumann P., Cech T.R. DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA. Nature 2003, 426:198-203.
22. Rhodes D., Fairall L., Simonsson T., Court R., Chapman L. Telomere architecture. EMBO Rep 2002, 3:1139-1145.
23. Lewis K.A., Wuttke D.S. Telomerase and telomere-associated proteins: structural insights into mechanism and evolution. Structure 2012, 20:28-39.
24. Zhong F.L., Batista L.F., Freund A., Pech M.F., Venteicher A.S., Artandi S.E. TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends. Cell 2012, 150:481-494.
25. Nandakumar J., Bell C.F., Weidenfeld I., Zaug A.J., Leinwand L.A., Cech T.R. The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature 2012, 492:285-289.
26. Nandakumar J., Cech T.R. Finding the end: recruitment of telomerase to telomeres. Nat Rev Mol Cell Biol 2013, 14:69-82.
27. Singh M., Wang Z., Koo B.K., Patel A., Cascio D., Collins K., Feigon J. Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65. Mol Cell 2012, 47:16-26.
28. Paeschke K., Juranek S., Simonsson T., Hempel A., Rhodes D., Lipps H.J. Telomerase recruitment by the telomere end binding protein-beta facilitates G-quadruplex DNA unfolding in ciliates. Nat Struct Mol Biol 2008, 15:598-604.
29. Mitchell J.R., Collins K. Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase. Mol Cell 2000, 6:361-371.
30. Leeper T., Leulliot N., Varani G. The solution structure of an essential stem-loop of human telomerase RNA. Nucleic Acids Res 2003, 31:2614-2621.
31. Theimer C.A., Blois C.A., Feigon J. Structure of the human telomerase RNA pseudoknot reveals conserved tertiary interactions essential for function. Mol Cell 2005, 17:671-682.
32. Wyatt H.D., West S.C., Beattie T.L. InTERTpreting telomerase structure and function. Nucleic Acids Res 2010, 38:5609-5622.
33. Gillis A.J., Schuller A.P., Skordalakes E. Structure of the Tribolium castaneum telomerase catalytic subunit TERT. Nature 2008, 455:633-637.
34. Mitchell M., Gillis A., Futahashi M., Fujiwara H., Skordalakes E. Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA. Nat Struct Mol Biol 2010, 17:513-518.
35. Mason M., Schuller A., Skordalakes E. Telomerase structure function. Curr Opin Struct Biol 2011, 21:92-100.
36. Jacobs S.A., Podell E.R., Cech T.R. Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase. Nat Struct Mol Biol 2006, 13:218-225.
37. Rouda S., Skordalakes E. Structure of the RNA-binding domain of telomerase: implications for RNA recognition and binding. Structure 2007, 15:1403-1412.
38. Cristofari G., Lingner J. Telomere length homeostasis requires that telomerase levels are limiting. EMBO J 2006, 25:565-574.
39. Cohen S.B., Graham M.E., Lovrecz G.O., Bache N., Robinson P.J., Reddel R.R. Protein composition of catalytically active human telomerase from immortal cells. Science 2007, 315:1850-1853.
40. Mitchell J.R., Wood E., Collins K. A telomerase component is defective in the human disease dyskeratosis congenita. Nature 1999, 402:551-555.
41. Gardano L., Holland L., Oulton R., Le Bihan T., Harrington L. Native gel electrophoresis of human telomerase distinguishes active complexes with or without dyskerin. Nucleic Acids Res 2012, 40:e36.
42. Wenz C., Enenkel B., Amacker M., Kelleher C., Damm K., Lingner J. Human telomerase contains two cooperating telomerase RNA molecules. EMBO J 2001, 20:3526-3534.
43. Hahn W.C., Stewart S.A., Brooks M.W., York S.G., Eaton E., Kurachi A., Beijersbergen R.L., Knoll J.H., Meyerson M., Weinberg R.A. Inhibition of telomerase limits the growth of human cancer cells. Nat Med 1999, 5:1164-1170.
44. Bley C.J., Qi X., Rand D.P., Borges C.R., Nelson R.W., Chen J.J. RNA-protein binding interface in the telomerase ribonucleoprotein. Proc Natl Acad Sci U S A 2011, 108:20333-20338.
45. Wang H., Blackburn E.H. De novo telomere addition by Tetrahymena telomerase in vitro. EMBO J 1997, 16:866-879.
46. Min B., Collins K. An RPA-related sequence-specific DNA-binding subunit of telomerase holoenzyme is required for elongation processivity and telomere maintenance. Mol Cell 2009, 36:609-619.
47. Witkin K.L., Prathapam R., Collins K. Positive and negative regulation of Tetrahymena telomerase holoenzyme. Mol Cell Biol 2007, 27:2074-2083.