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Volumn 37, Issue 5, 2014, Pages 256-263

Telomere shortening in neurological disorders: An abundance of unanswered questions

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ALZHEIMER DISEASE; BRAIN CELL; CHRONIC STRESS; EXHAUSTION; GLIA CELL; HUMAN; LEUKOCYTE; MEMORY T LYMPHOCYTE; NERVE DEGENERATION; NEUROLOGIC DISEASE; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW; TELOMERE SHORTENING; ANIMAL; GENETICS;

EID: 84899960174     PISSN: 01662236     EISSN: 1878108X     Source Type: Journal    
DOI: 10.1016/j.tins.2014.02.010     Document Type: Review
Times cited : (127)

References (102)
  • 1
    • 84855490226 scopus 로고    scopus 로고
    • Maintaining the end: roles of telomere proteins in end-protection, telomere replication and length regulation
    • Stewart J.A., et al. Maintaining the end: roles of telomere proteins in end-protection, telomere replication and length regulation. Mutat. Res. 2012, 730:12-19.
    • (2012) Mutat. Res. , vol.730 , pp. 12-19
    • Stewart, J.A.1
  • 2
    • 0026460896 scopus 로고
    • Telomere length predicts replicative capacity of human fibroblasts
    • Allsopp R.C., et al. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 1992, 89:10114-10118.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 10114-10118
    • Allsopp, R.C.1
  • 3
    • 84873262839 scopus 로고    scopus 로고
    • A systematic review of leukocyte telomere length and age in adults
    • Muezzinler A., et al. A systematic review of leukocyte telomere length and age in adults. Ageing Res. Rev. 2013, 12:509-519.
    • (2013) Ageing Res. Rev. , vol.12 , pp. 509-519
    • Muezzinler, A.1
  • 4
    • 81255209208 scopus 로고    scopus 로고
    • Normal mammalian cells negatively regulate telomere length by telomere trimming
    • Pickett H.A., et al. Normal mammalian cells negatively regulate telomere length by telomere trimming. Hum. Mol. Genet. 2011, 20:4684-4692.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 4684-4692
    • Pickett, H.A.1
  • 5
    • 0029894199 scopus 로고    scopus 로고
    • Regulated expression of telomerase activity in human T lymphocyte development and activation
    • Weng N.P., et al. Regulated expression of telomerase activity in human T lymphocyte development and activation. J. Exp. Med. 1996, 183:2471-2479.
    • (1996) J. Exp. Med. , vol.183 , pp. 2471-2479
    • Weng, N.P.1
  • 6
    • 34447543913 scopus 로고    scopus 로고
    • Cellular senescence in cancer and aging
    • Collado M., et al. Cellular senescence in cancer and aging. Cell 2007, 130:223-233.
    • (2007) Cell , vol.130 , pp. 223-233
    • Collado, M.1
  • 7
    • 38749147684 scopus 로고    scopus 로고
    • The association between physical activity in leisure time and leukocyte telomere length
    • Cherkas L.F., et al. The association between physical activity in leisure time and leukocyte telomere length. Arch. Intern. Med. 2008, 168:154-158.
    • (2008) Arch. Intern. Med. , vol.168 , pp. 154-158
    • Cherkas, L.F.1
  • 8
    • 78049441699 scopus 로고    scopus 로고
    • Lifestyle impacts on the aging-associated expression of biomarkers of DNA damage and telomere dysfunction in human blood
    • Song Z., et al. Lifestyle impacts on the aging-associated expression of biomarkers of DNA damage and telomere dysfunction in human blood. Aging Cell 2010, 9:607-615.
    • (2010) Aging Cell , vol.9 , pp. 607-615
    • Song, Z.1
  • 9
    • 84866363682 scopus 로고    scopus 로고
    • Shorter telomeres are associated with obesity and weight gain in the elderly
    • Njajou O.T., et al. Shorter telomeres are associated with obesity and weight gain in the elderly. Int. J. Obesity 2012, 36:1176-1179.
    • (2012) Int. J. Obesity , vol.36 , pp. 1176-1179
    • Njajou, O.T.1
  • 10
    • 84855161230 scopus 로고    scopus 로고
    • "Is obesity linked to aging?": adipose tissue and the role of telomeres
    • Tzanetakou I.P., et al. "Is obesity linked to aging?": adipose tissue and the role of telomeres. Ageing Res. Rev. 2012, 11:220-229.
    • (2012) Ageing Res. Rev. , vol.11 , pp. 220-229
    • Tzanetakou, I.P.1
  • 11
    • 84879985879 scopus 로고    scopus 로고
    • Telomere shortening in human diseases
    • Kong C.M., et al. Telomere shortening in human diseases. FEBS J. 2013, 280:3180-3193.
    • (2013) FEBS J. , vol.280 , pp. 3180-3193
    • Kong, C.M.1
  • 12
    • 77955269067 scopus 로고    scopus 로고
    • The telomere/telomerase system in autoimmune and systemic immune-mediated diseases
    • Georgin-Lavialle S., et al. The telomere/telomerase system in autoimmune and systemic immune-mediated diseases. Autoimmun. Rev. 2010, 9:646-651.
    • (2010) Autoimmun. Rev. , vol.9 , pp. 646-651
    • Georgin-Lavialle, S.1
  • 13
    • 84890123153 scopus 로고    scopus 로고
    • Telomere length and Parkinson's disease in men: a nested case-control study
    • Schurks M., et al. Telomere length and Parkinson's disease in men: a nested case-control study. Eur. J. Neurol. 2014, 21:93-99.
    • (2014) Eur. J. Neurol. , vol.21 , pp. 93-99
    • Schurks, M.1
  • 14
    • 84884594493 scopus 로고    scopus 로고
    • Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect
    • Broer L., et al. Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect. Eur. J. Hum. Genet. 2013, 21:1163-1168.
    • (2013) Eur. J. Hum. Genet. , vol.21 , pp. 1163-1168
    • Broer, L.1
  • 15
    • 77952671005 scopus 로고    scopus 로고
    • Regulation of telomerase activity by apparently opposing elements
    • Liu J.P., et al. Regulation of telomerase activity by apparently opposing elements. Ageing Res. Rev. 2010, 9:245-256.
    • (2010) Ageing Res. Rev. , vol.9 , pp. 245-256
    • Liu, J.P.1
  • 16
    • 84859080364 scopus 로고    scopus 로고
    • Association between ApoE phenotypes and telomere erosion in Alzheimer's disease
    • Takata Y., et al. Association between ApoE phenotypes and telomere erosion in Alzheimer's disease. J. Gerontol. A: Biol. Sci. Med. Sci. 2012, 67:330-335.
    • (2012) J. Gerontol. A: Biol. Sci. Med. Sci. , vol.67 , pp. 330-335
    • Takata, Y.1
  • 17
    • 0037108213 scopus 로고    scopus 로고
    • Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue
    • Shea T.B., et al. Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue. Free Radic. Biol. Med. 2002, 33:1115-1120.
    • (2002) Free Radic. Biol. Med. , vol.33 , pp. 1115-1120
    • Shea, T.B.1
  • 18
    • 0036629255 scopus 로고    scopus 로고
    • Oxidative stress shortens telomeres
    • von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem. Sci. 2002, 27:339-344.
    • (2002) Trends Biochem. Sci. , vol.27 , pp. 339-344
    • von Zglinicki, T.1
  • 19
    • 45249121846 scopus 로고    scopus 로고
    • Nitrous oxide sedation for intra-articular injection in juvenile idiopathic arthritis
    • Uziel Y., et al. Nitrous oxide sedation for intra-articular injection in juvenile idiopathic arthritis. Pediatr. Rheumatol. Online J. 2008, 6:1.
    • (2008) Pediatr. Rheumatol. Online J. , vol.6 , pp. 1
    • Uziel, Y.1
  • 20
    • 33947683316 scopus 로고    scopus 로고
    • Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients
    • Pedersen-Lane J.H., et al. Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients. J. Leukoc. Biol. 2007, 81:934-941.
    • (2007) J. Leukoc. Biol. , vol.81 , pp. 934-941
    • Pedersen-Lane, J.H.1
  • 21
    • 33646353210 scopus 로고    scopus 로고
    • Monocyte telomere shortening and oxidative DNA damage in type 2 diabetes
    • Sampson M.J., et al. Monocyte telomere shortening and oxidative DNA damage in type 2 diabetes. Diabetes Care 2006, 29:283-289.
    • (2006) Diabetes Care , vol.29 , pp. 283-289
    • Sampson, M.J.1
  • 22
    • 84859372986 scopus 로고    scopus 로고
    • Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation
    • Fumagalli M., et al. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat. Cell Biol. 2012, 14:355-365.
    • (2012) Nat. Cell Biol. , vol.14 , pp. 355-365
    • Fumagalli, M.1
  • 23
    • 0036141861 scopus 로고    scopus 로고
    • Elevated levels of oxidative DNA damage in lymphocytes from patients with Alzheimer's disease
    • Morocz M., et al. Elevated levels of oxidative DNA damage in lymphocytes from patients with Alzheimer's disease. Neurobiol. Aging 2002, 23:47-53.
    • (2002) Neurobiol. Aging , vol.23 , pp. 47-53
    • Morocz, M.1
  • 24
    • 84878243748 scopus 로고    scopus 로고
    • Analysis of calcium homeostasis in fresh lymphocytes from patients with sporadic Alzheimer's disease or mild cognitive impairment
    • Jaworska A., et al. Analysis of calcium homeostasis in fresh lymphocytes from patients with sporadic Alzheimer's disease or mild cognitive impairment. Biochim. Biophys. Acta 2013, 1833:1692-1699.
    • (2013) Biochim. Biophys. Acta , vol.1833 , pp. 1692-1699
    • Jaworska, A.1
  • 25
    • 57049143140 scopus 로고    scopus 로고
    • Mitochondria in neuroplasticity and neurological disorders
    • Mattson M.P., et al. Mitochondria in neuroplasticity and neurological disorders. Neuron 2008, 60:748-766.
    • (2008) Neuron , vol.60 , pp. 748-766
    • Mattson, M.P.1
  • 26
    • 65949121134 scopus 로고    scopus 로고
    • Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options
    • Uttara B., et al. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr. Neuropharmacol. 2009, 7:65-74.
    • (2009) Curr. Neuropharmacol. , vol.7 , pp. 65-74
    • Uttara, B.1
  • 27
    • 73949090103 scopus 로고    scopus 로고
    • Inflammation in neurodegenerative diseases
    • Amor S., et al. Inflammation in neurodegenerative diseases. Immunology 2010, 129:154-169.
    • (2010) Immunology , vol.129 , pp. 154-169
    • Amor, S.1
  • 28
    • 33746318600 scopus 로고    scopus 로고
    • Hypothalamic-pituitary-adrenal axis, glucocorticoids, and neurologic disease
    • vi
    • Herman J.P., Seroogy K. Hypothalamic-pituitary-adrenal axis, glucocorticoids, and neurologic disease. Neurol. Clin. 2006, 24:461-481. vi.
    • (2006) Neurol. Clin. , vol.24 , pp. 461-481
    • Herman, J.P.1    Seroogy, K.2
  • 29
    • 60349095684 scopus 로고    scopus 로고
    • The role of stress factors during aging of the immune system
    • Bauer M.E., et al. The role of stress factors during aging of the immune system. Ann. N. Y. Acad. Sci. 2009, 1153:139-152.
    • (2009) Ann. N. Y. Acad. Sci. , vol.1153 , pp. 139-152
    • Bauer, M.E.1
  • 30
    • 63049110712 scopus 로고    scopus 로고
    • Psychological and metabolic stress: a recipe for accelerated cellular aging?
    • Epel E.S. Psychological and metabolic stress: a recipe for accelerated cellular aging?. Hormones 2009, 8:7-22.
    • (2009) Hormones , vol.8 , pp. 7-22
    • Epel, E.S.1
  • 31
    • 84870713520 scopus 로고    scopus 로고
    • Telomeres and early-life stress: an overview
    • Price L.H., et al. Telomeres and early-life stress: an overview. Biol. Psychiatry 2013, 73:15-23.
    • (2013) Biol. Psychiatry , vol.73 , pp. 15-23
    • Price, L.H.1
  • 32
    • 76849098870 scopus 로고    scopus 로고
    • Telomerase deficiency affects normal brain functions in mice
    • Lee J., et al. Telomerase deficiency affects normal brain functions in mice. Neurochem. Res. 2010, 35:211-218.
    • (2010) Neurochem. Res. , vol.35 , pp. 211-218
    • Lee, J.1
  • 33
    • 84872808844 scopus 로고    scopus 로고
    • Association between anxiety but not depressive disorders and leukocyte telomere length after 2 years of follow-up in a population-based sample
    • Hoen P.W., et al. Association between anxiety but not depressive disorders and leukocyte telomere length after 2 years of follow-up in a population-based sample. Psychol. Med. 2013, 43:689-697.
    • (2013) Psychol. Med. , vol.43 , pp. 689-697
    • Hoen, P.W.1
  • 34
    • 84863814764 scopus 로고    scopus 로고
    • High phobic anxiety is related to lower leukocyte telomere length in women
    • Okereke O.I., et al. High phobic anxiety is related to lower leukocyte telomere length in women. PLoS ONE 2012, 7:e40516.
    • (2012) PLoS ONE , vol.7
    • Okereke, O.I.1
  • 35
    • 0345643319 scopus 로고    scopus 로고
    • Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood
    • Rufer N., et al. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J. Exp. Med. 1999, 190:157-167.
    • (1999) J. Exp. Med. , vol.190 , pp. 157-167
    • Rufer, N.1
  • 36
    • 80055020926 scopus 로고    scopus 로고
    • Telomere biology in hematopoiesis and stem cell transplantation
    • Gadalla S.M., Savage S.A. Telomere biology in hematopoiesis and stem cell transplantation. Blood Rev. 2011, 25:261-269.
    • (2011) Blood Rev. , vol.25 , pp. 261-269
    • Gadalla, S.M.1    Savage, S.A.2
  • 37
    • 0028850465 scopus 로고
    • Human naive and memory T lymphocytes differ in telomeric length and replicative potential
    • Weng N.P., et al. Human naive and memory T lymphocytes differ in telomeric length and replicative potential. Proc. Natl. Acad. Sci. U.S.A. 1995, 92:11091-11094.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 11091-11094
    • Weng, N.P.1
  • 38
    • 84865304245 scopus 로고    scopus 로고
    • Telomeres and immune competency
    • Weng N.P. Telomeres and immune competency. Curr. Opin. Immunol. 2012, 24:470-475.
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 470-475
    • Weng, N.P.1
  • 39
    • 0026569408 scopus 로고
    • Age-related changes in human blood lymphocyte subpopulations
    • Erkeller-Yuksel F.M., et al. Age-related changes in human blood lymphocyte subpopulations. J. Pediatr. 1992, 120:216-222.
    • (1992) J. Pediatr. , vol.120 , pp. 216-222
    • Erkeller-Yuksel, F.M.1
  • 40
    • 84879552161 scopus 로고    scopus 로고
    • Peripheral markers of Alzheimer's disease: surveillance of white blood cells
    • Shad K.F., et al. Peripheral markers of Alzheimer's disease: surveillance of white blood cells. Synapse 2013, 67:541-543.
    • (2013) Synapse , vol.67 , pp. 541-543
    • Shad, K.F.1
  • 41
    • 70349153086 scopus 로고    scopus 로고
    • Weight loss in obese men is associated with increased telomere length and decreased abasic sites in rectal mucosa
    • O'Callaghan N.J., et al. Weight loss in obese men is associated with increased telomere length and decreased abasic sites in rectal mucosa. Rejuvenation Res. 2009, 12:169-176.
    • (2009) Rejuvenation Res. , vol.12 , pp. 169-176
    • O'Callaghan, N.J.1
  • 42
    • 79959699254 scopus 로고    scopus 로고
    • Telomere shortening reduces Alzheimer's disease amyloid pathology in mice
    • Rolyan H., et al. Telomere shortening reduces Alzheimer's disease amyloid pathology in mice. Brain 2011, 134:2044-2056.
    • (2011) Brain , vol.134 , pp. 2044-2056
    • Rolyan, H.1
  • 43
    • 77954865635 scopus 로고    scopus 로고
    • Systemic inflammatory cells fight off neurodegenerative disease
    • Schwartz M., Shechter R. Systemic inflammatory cells fight off neurodegenerative disease. Nat. Rev. Neurol. 2010, 6:405-410.
    • (2010) Nat. Rev. Neurol. , vol.6 , pp. 405-410
    • Schwartz, M.1    Shechter, R.2
  • 44
    • 84869186918 scopus 로고    scopus 로고
    • Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response
    • Jurk D., et al. Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell 2012, 11:996-1004.
    • (2012) Aging Cell , vol.11 , pp. 996-1004
    • Jurk, D.1
  • 45
    • 0035812845 scopus 로고    scopus 로고
    • The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
    • Hemann M.T., et al. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 2001, 107:67-77.
    • (2001) Cell , vol.107 , pp. 67-77
    • Hemann, M.T.1
  • 46
    • 84868116500 scopus 로고    scopus 로고
    • The rate of increase of short telomeres predicts longevity in mammals
    • Vera E., et al. The rate of increase of short telomeres predicts longevity in mammals. Cell Rep. 2012, 2:732-737.
    • (2012) Cell Rep. , vol.2 , pp. 732-737
    • Vera, E.1
  • 47
    • 84863808563 scopus 로고    scopus 로고
    • Prion-like spread of protein aggregates in neurodegeneration
    • Polymenidou M., Cleveland D.W. Prion-like spread of protein aggregates in neurodegeneration. J. Exp. Med. 2012, 209:889-893.
    • (2012) J. Exp. Med. , vol.209 , pp. 889-893
    • Polymenidou, M.1    Cleveland, D.W.2
  • 48
    • 84867346421 scopus 로고    scopus 로고
    • Association of shorter leukocyte telomere repeat length with dementia and mortality
    • Honig L.S., et al. Association of shorter leukocyte telomere repeat length with dementia and mortality. Arch. Neurol. 2012, 69:1332-1339.
    • (2012) Arch. Neurol. , vol.69 , pp. 1332-1339
    • Honig, L.S.1
  • 49
    • 33746812586 scopus 로고    scopus 로고
    • Shorter telomeres are associated with mortality in those with APOE epsilon4 and dementia
    • Honig L.S., et al. Shorter telomeres are associated with mortality in those with APOE epsilon4 and dementia. Ann. Neurol. 2006, 60:181-187.
    • (2006) Ann. Neurol. , vol.60 , pp. 181-187
    • Honig, L.S.1
  • 50
    • 46049085018 scopus 로고    scopus 로고
    • Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the Nurses' Health Study
    • Grodstein F., et al. Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the Nurses' Health Study. PLoS ONE 2008, 3:e1590.
    • (2008) PLoS ONE , vol.3
    • Grodstein, F.1
  • 51
    • 80052617023 scopus 로고    scopus 로고
    • Telomere length and cognitive function in community-dwelling elders: findings from the Health ABC Study
    • Yaffe K., et al. Telomere length and cognitive function in community-dwelling elders: findings from the Health ABC Study. Neurobiol. Aging 2011, 32:2055-2060.
    • (2011) Neurobiol. Aging , vol.32 , pp. 2055-2060
    • Yaffe, K.1
  • 52
    • 77951978549 scopus 로고    scopus 로고
    • Leukocyte telomere length is associated with cognitive performance in healthy women
    • Valdes A.M., et al. Leukocyte telomere length is associated with cognitive performance in healthy women. Neurobiol. Aging 2010, 31:986-992.
    • (2010) Neurobiol. Aging , vol.31 , pp. 986-992
    • Valdes, A.M.1
  • 53
    • 84860875209 scopus 로고    scopus 로고
    • Telomere length, comorbidity, functional, nutritional and cognitive status as predictors of 5 years post hospital discharge survival in the oldest old
    • Zekry D., et al. Telomere length, comorbidity, functional, nutritional and cognitive status as predictors of 5 years post hospital discharge survival in the oldest old. J. Nutr. Health Aging 2012, 16:225-230.
    • (2012) J. Nutr. Health Aging , vol.16 , pp. 225-230
    • Zekry, D.1
  • 54
    • 77049118511 scopus 로고    scopus 로고
    • Telomere length is not predictive of dementia or MCI conversion in the oldest old
    • Zekry D., et al. Telomere length is not predictive of dementia or MCI conversion in the oldest old. Neurobiol. Aging 2010, 31:719-720.
    • (2010) Neurobiol. Aging , vol.31 , pp. 719-720
    • Zekry, D.1
  • 55
    • 51649093878 scopus 로고    scopus 로고
    • Relative telomere length in patients with late-onset Alzheimer's dementia or vascular dementia
    • Lof-Ohlin Z.M., et al. Relative telomere length in patients with late-onset Alzheimer's dementia or vascular dementia. Neuroreport 2008, 19:1199-1202.
    • (2008) Neuroreport , vol.19 , pp. 1199-1202
    • Lof-Ohlin, Z.M.1
  • 57
    • 84863229585 scopus 로고    scopus 로고
    • A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage
    • Wang J., et al. A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage. Cell 2012, 148:1001-1014.
    • (2012) Cell , vol.148 , pp. 1001-1014
    • Wang, J.1
  • 58
    • 0034669642 scopus 로고    scopus 로고
    • Telomere length in different tissues of elderly patients
    • Friedrich U., et al. Telomere length in different tissues of elderly patients. Mech. Ageing Dev. 2000, 119:89-99.
    • (2000) Mech. Ageing Dev. , vol.119 , pp. 89-99
    • Friedrich, U.1
  • 59
    • 84875824032 scopus 로고    scopus 로고
    • Telomeres shorten at equivalent rates in somatic tissues of adults
    • Daniali L., et al. Telomeres shorten at equivalent rates in somatic tissues of adults. Nat. Commun. 2013, 4:1597.
    • (2013) Nat. Commun. , vol.4 , pp. 1597
    • Daniali, L.1
  • 60
    • 0029040101 scopus 로고
    • Developmental and tissue-specific regulation of mouse telomerase and telomere length
    • Prowse K.R., Greider C.W. Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc. Natl. Acad. Sci. U.S.A. 1995, 92:4818-4822.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 4818-4822
    • Prowse, K.R.1    Greider, C.W.2
  • 61
    • 79952733859 scopus 로고    scopus 로고
    • Telomere length in blood, buccal cells, and fibroblasts from patients with inherited bone marrow failure syndromes
    • Gadalla S.M., et al. Telomere length in blood, buccal cells, and fibroblasts from patients with inherited bone marrow failure syndromes. Aging (Albany, NY) 2010, 2:867-874.
    • (2010) Aging (Albany, NY) , vol.2 , pp. 867-874
    • Gadalla, S.M.1
  • 62
    • 0029156035 scopus 로고
    • Telomere shortening is associated with cell division in vitro and in vivo
    • Allsopp R.C., et al. Telomere shortening is associated with cell division in vitro and in vivo. Exp. Cell Res. 1995, 220:194-200.
    • (1995) Exp. Cell Res. , vol.220 , pp. 194-200
    • Allsopp, R.C.1
  • 63
    • 0347285467 scopus 로고    scopus 로고
    • Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes
    • Flanary B.E., Streit W.J. Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes. Glia 2004, 45:75-88.
    • (2004) Glia , vol.45 , pp. 75-88
    • Flanary, B.E.1    Streit, W.J.2
  • 64
    • 39749173730 scopus 로고    scopus 로고
    • Telomere length in white blood cells, buccal cells and brain tissue and its variation with ageing and Alzheimer's disease
    • Thomas P., et al. Telomere length in white blood cells, buccal cells and brain tissue and its variation with ageing and Alzheimer's disease. Mech. Ageing Dev. 2008, 129:183-190.
    • (2008) Mech. Ageing Dev. , vol.129 , pp. 183-190
    • Thomas, P.1
  • 65
    • 33744931650 scopus 로고    scopus 로고
    • Telomeres and telomerase in Alzheimer's disease: epiphenomena or a new focus for therapeutic strategy?
    • Franco S., et al. Telomeres and telomerase in Alzheimer's disease: epiphenomena or a new focus for therapeutic strategy?. Alzheimers Dement. 2006, 2:164-168.
    • (2006) Alzheimers Dement. , vol.2 , pp. 164-168
    • Franco, S.1
  • 66
    • 71549154065 scopus 로고    scopus 로고
    • Comparisons of telomere lengths in peripheral blood and cerebellum in Alzheimer's disease
    • Lukens J.N., et al. Comparisons of telomere lengths in peripheral blood and cerebellum in Alzheimer's disease. Alzheimers Dement. 2009, 5:463-469.
    • (2009) Alzheimers Dement. , vol.5 , pp. 463-469
    • Lukens, J.N.1
  • 67
    • 34548667671 scopus 로고    scopus 로고
    • Telomeric DNA length in cerebral gray and white matter is associated with longevity in individuals aged 70 years or older
    • Nakamura K., et al. Telomeric DNA length in cerebral gray and white matter is associated with longevity in individuals aged 70 years or older. Exp. Gerontol. 2007, 42:944-950.
    • (2007) Exp. Gerontol. , vol.42 , pp. 944-950
    • Nakamura, K.1
  • 68
    • 77949263574 scopus 로고    scopus 로고
    • Cerebellar telomere length and psychiatric disorders
    • Zhang D., et al. Cerebellar telomere length and psychiatric disorders. Behav. Genet. 2010, 40:250-254.
    • (2010) Behav. Genet. , vol.40 , pp. 250-254
    • Zhang, D.1
  • 69
    • 0037308404 scopus 로고    scopus 로고
    • Association between telomere length in blood and mortality in people aged 60 years or older
    • Cawthon R.M., et al. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003, 361:393-395.
    • (2003) Lancet , vol.361 , pp. 393-395
    • Cawthon, R.M.1
  • 70
    • 80052611951 scopus 로고    scopus 로고
    • No evidence of substantia nigra telomere shortening in Parkinson's disease
    • 2107.e3-e5
    • Hudson G., et al. No evidence of substantia nigra telomere shortening in Parkinson's disease. Neurobiol. Aging 2011, 32. 2107.e3-e5.
    • (2011) Neurobiol. Aging , vol.32
    • Hudson, G.1
  • 71
    • 34147107459 scopus 로고    scopus 로고
    • Telomere protection mechanisms change during neurogenesis and neuronal maturation: newly generated neurons are hypersensitive to telomere and DNA damage
    • Cheng A., et al. Telomere protection mechanisms change during neurogenesis and neuronal maturation: newly generated neurons are hypersensitive to telomere and DNA damage. J. Neurosci. 2007, 27:3722-3733.
    • (2007) J. Neurosci. , vol.27 , pp. 3722-3733
    • Cheng, A.1
  • 72
    • 84859383206 scopus 로고    scopus 로고
    • Novel telomerase-increasing compound in mouse brain delays the onset of amyotrophic lateral sclerosis
    • Eitan E., et al. Novel telomerase-increasing compound in mouse brain delays the onset of amyotrophic lateral sclerosis. EMBO Mol. Med. 2012, 4:313-329.
    • (2012) EMBO Mol. Med. , vol.4 , pp. 313-329
    • Eitan, E.1
  • 73
    • 0034086553 scopus 로고    scopus 로고
    • The catalytic subunit of telomerase protects neurons against amyloid β-peptide-induced apoptosis
    • Zhu H., et al. The catalytic subunit of telomerase protects neurons against amyloid β-peptide-induced apoptosis. J. Neurochem. 2000, 75:117-124.
    • (2000) J. Neurochem. , vol.75 , pp. 117-124
    • Zhu, H.1
  • 74
    • 38149016212 scopus 로고    scopus 로고
    • Telomere length assessment: biomarker of chronic oxidative stress?
    • Houben J.M., et al. Telomere length assessment: biomarker of chronic oxidative stress?. Free Radic. Biol. Med. 2008, 44:235-246.
    • (2008) Free Radic. Biol. Med. , vol.44 , pp. 235-246
    • Houben, J.M.1
  • 75
    • 2342452013 scopus 로고    scopus 로고
    • Telomeres shorten with age in rat cerebellum and cortex in vivo
    • Flanary B.E., Streit W.J. Telomeres shorten with age in rat cerebellum and cortex in vivo. J. Anti Aging Med. 2003, 6:299-308.
    • (2003) J. Anti Aging Med. , vol.6 , pp. 299-308
    • Flanary, B.E.1    Streit, W.J.2
  • 76
    • 70949100121 scopus 로고    scopus 로고
    • Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis
    • Ferron S.R., et al. Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis. J. Neurosci. 2009, 29:14394-14407.
    • (2009) J. Neurosci. , vol.29 , pp. 14394-14407
    • Ferron, S.R.1
  • 77
    • 78650990326 scopus 로고    scopus 로고
    • Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
    • Jaskelioff M., et al. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 2011, 469:102-106.
    • (2011) Nature , vol.469 , pp. 102-106
    • Jaskelioff, M.1
  • 78
    • 33751120668 scopus 로고    scopus 로고
    • Defects of immune regulation in the presenilin-1 mutant knockin mouse
    • Morgan G.A., et al. Defects of immune regulation in the presenilin-1 mutant knockin mouse. Neuromol. Med. 2007, 9:35-45.
    • (2007) Neuromol. Med. , vol.9 , pp. 35-45
    • Morgan, G.A.1
  • 79
    • 0034669532 scopus 로고    scopus 로고
    • Wild-derived inbred mouse strains have short telomeres
    • Hemann M.T., Greider C.W. Wild-derived inbred mouse strains have short telomeres. Nucleic Acids Res. 2000, 28:4474-4478.
    • (2000) Nucleic Acids Res. , vol.28 , pp. 4474-4478
    • Hemann, M.T.1    Greider, C.W.2
  • 80
    • 0037213048 scopus 로고    scopus 로고
    • Telomere shortening in T cells correlates with Alzheimer's disease status
    • Panossian L.A., et al. Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiol. Aging 2003, 24:77-84.
    • (2003) Neurobiol. Aging , vol.24 , pp. 77-84
    • Panossian, L.A.1
  • 81
    • 84877353185 scopus 로고    scopus 로고
    • The subtelomere of short telomeres is hypermethylated in Alzheimer's disease
    • Guan J.Z., et al. The subtelomere of short telomeres is hypermethylated in Alzheimer's disease. Aging Dis. 2012, 3:164-170.
    • (2012) Aging Dis. , vol.3 , pp. 164-170
    • Guan, J.Z.1
  • 82
    • 84856211181 scopus 로고    scopus 로고
    • Telomere length is age-dependent and reduced in monocytes of Alzheimer patients
    • Hochstrasser T., et al. Telomere length is age-dependent and reduced in monocytes of Alzheimer patients. Exp. Gerontol. 2012, 47:160-163.
    • (2012) Exp. Gerontol. , vol.47 , pp. 160-163
    • Hochstrasser, T.1
  • 83
    • 84155167262 scopus 로고    scopus 로고
    • Effect of vitamin E administration on the elevated oxygen stress and the telomeric and subtelomeric status in Alzheimer's disease
    • Guan J.Z., et al. Effect of vitamin E administration on the elevated oxygen stress and the telomeric and subtelomeric status in Alzheimer's disease. Gerontology 2012, 58:62-69.
    • (2012) Gerontology , vol.58 , pp. 62-69
    • Guan, J.Z.1
  • 84
    • 84856218257 scopus 로고    scopus 로고
    • Leukocyte telomere length (LTL) is reduced in stable mild cognitive impairment but low LTL is not associated with conversion to Alzheimer's disease: a pilot study
    • Moverare-Skrtic S., et al. Leukocyte telomere length (LTL) is reduced in stable mild cognitive impairment but low LTL is not associated with conversion to Alzheimer's disease: a pilot study. Exp. Gerontol. 2012, 47:179-182.
    • (2012) Exp. Gerontol. , vol.47 , pp. 179-182
    • Moverare-Skrtic, S.1
  • 85
    • 0033747604 scopus 로고    scopus 로고
    • Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor?
    • von Zglinicki T., et al. Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor?. Lab. Invest. 2000, 80:1739-1747.
    • (2000) Lab. Invest. , vol.80 , pp. 1739-1747
    • von Zglinicki, T.1
  • 86
    • 84887086539 scopus 로고    scopus 로고
    • Analysis of telomere length and subtelomeric methylation of circulating leukocytes in women with Alzheimer's disease
    • Guan J.Z., et al. Analysis of telomere length and subtelomeric methylation of circulating leukocytes in women with Alzheimer's disease. Aging Clin. Exp. Res. 2013, 25:17-23.
    • (2013) Aging Clin. Exp. Res. , vol.25 , pp. 17-23
    • Guan, J.Z.1
  • 87
    • 79954420408 scopus 로고    scopus 로고
    • Study of telomere length and different markers of oxidative stress in patients with Parkinson's disease
    • Watfa G., et al. Study of telomere length and different markers of oxidative stress in patients with Parkinson's disease. J. Nutr. Health Aging 2011, 15:277-281.
    • (2011) J. Nutr. Health Aging , vol.15 , pp. 277-281
    • Watfa, G.1
  • 88
    • 84863876804 scopus 로고    scopus 로고
    • Aging-associated alteration of telomere length and subtelomeric status in female patients with Parkinson's disease
    • Maeda T., et al. Aging-associated alteration of telomere length and subtelomeric status in female patients with Parkinson's disease. J. Neurogenet. 2012, 26:245-251.
    • (2012) J. Neurogenet. , vol.26 , pp. 245-251
    • Maeda, T.1
  • 89
    • 47049087917 scopus 로고    scopus 로고
    • A percentage analysis of the telomere length in Parkinson's disease patients
    • Guan J.Z., et al. A percentage analysis of the telomere length in Parkinson's disease patients. J. Gerontol. A: Biol. Sci. Med. Sci. 2008, 63:467-473.
    • (2008) J. Gerontol. A: Biol. Sci. Med. Sci. , vol.63 , pp. 467-473
    • Guan, J.Z.1
  • 90
    • 77958066363 scopus 로고    scopus 로고
    • No evidence for shorter leukocyte telomere length in Parkinson's disease patients
    • Eerola J., et al. No evidence for shorter leukocyte telomere length in Parkinson's disease patients. J. Gerontol. A: Biol. Sci. Med. Sci. 2010, 65:1181-1184.
    • (2010) J. Gerontol. A: Biol. Sci. Med. Sci. , vol.65 , pp. 1181-1184
    • Eerola, J.1
  • 91
    • 39749146983 scopus 로고    scopus 로고
    • Telomere length and risk of Parkinson's disease
    • Wang H., et al. Telomere length and risk of Parkinson's disease. Mov. Disord. 2008, 23:302-305.
    • (2008) Mov. Disord. , vol.23 , pp. 302-305
    • Wang, H.1
  • 92
    • 84860920284 scopus 로고    scopus 로고
    • Telomere length shortening in patients with dementia with Lewy bodies
    • Kume K., et al. Telomere length shortening in patients with dementia with Lewy bodies. Eur. J. Neurol. 2012, 19:905-910.
    • (2012) Eur. J. Neurol. , vol.19 , pp. 905-910
    • Kume, K.1
  • 93
    • 33746828140 scopus 로고    scopus 로고
    • Telomere length predicts poststroke mortality, dementia, and cognitive decline
    • Martin-Ruiz C., et al. Telomere length predicts poststroke mortality, dementia, and cognitive decline. Ann. Neurol. 2006, 60:174-180.
    • (2006) Ann. Neurol. , vol.60 , pp. 174-180
    • Martin-Ruiz, C.1
  • 94
    • 33646510788 scopus 로고    scopus 로고
    • Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia
    • Jenkins E.C., et al. Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia. Neurobiol. Aging 2006, 27:941-945.
    • (2006) Neurobiol. Aging , vol.27 , pp. 941-945
    • Jenkins, E.C.1
  • 95
    • 84861939416 scopus 로고    scopus 로고
    • Mild cognitive impairment identified in older individuals with Down syndrome by reduced telomere signal numbers and shorter telomeres measured in microns
    • Jenkins E.C., et al. Mild cognitive impairment identified in older individuals with Down syndrome by reduced telomere signal numbers and shorter telomeres measured in microns. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2012, 159B:598-604.
    • (2012) Am. J. Med. Genet. B: Neuropsychiatr. Genet. , vol.159 B , pp. 598-604
    • Jenkins, E.C.1
  • 96
    • 77950535729 scopus 로고    scopus 로고
    • Shorter telomeres may indicate dementia status in older individuals with Down syndrome
    • Jenkins E.C., et al. Shorter telomeres may indicate dementia status in older individuals with Down syndrome. Neurobiol. Aging 2010, 31:765-771.
    • (2010) Neurobiol. Aging , vol.31 , pp. 765-771
    • Jenkins, E.C.1
  • 97
    • 0031879115 scopus 로고    scopus 로고
    • Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry
    • Rufer N., et al. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat. Biotechnol. 1998, 16:743-747.
    • (1998) Nat. Biotechnol. , vol.16 , pp. 743-747
    • Rufer, N.1
  • 98
    • 71749089585 scopus 로고    scopus 로고
    • Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance
    • Lin J., et al. Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance. J. Immunol. Methods 2010, 352:71-80.
    • (2010) J. Immunol. Methods , vol.352 , pp. 71-80
    • Lin, J.1
  • 99
    • 0012950854 scopus 로고    scopus 로고
    • Lineage-specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age
    • Son N.H., et al. Lineage-specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age. J. Immunol. 2000, 165:1191-1196.
    • (2000) J. Immunol. , vol.165 , pp. 1191-1196
    • Son, N.H.1
  • 100
    • 0142205623 scopus 로고    scopus 로고
    • Telomere length measurements in leukocyte subsets by automated multicolor flow-FISH
    • Baerlocher G.M., Lansdorp P.M. Telomere length measurements in leukocyte subsets by automated multicolor flow-FISH. Cytometry A 2003, 55:1-6.
    • (2003) Cytometry A , vol.55 , pp. 1-6
    • Baerlocher, G.M.1    Lansdorp, P.M.2
  • 101
    • 34548257990 scopus 로고    scopus 로고
    • Telomere length in human natural killer cell subsets
    • Ouyang Q., et al. Telomere length in human natural killer cell subsets. Ann. N. Y. Acad. Sci. 2007, 1106:240-252.
    • (2007) Ann. N. Y. Acad. Sci. , vol.1106 , pp. 240-252
    • Ouyang, Q.1
  • 102
    • 34247150402 scopus 로고    scopus 로고
    • dim NK cells upon activation
    • dim NK cells upon activation. J. Immunol. 2007, 178:4947-4955.
    • (2007) J. Immunol. , vol.178 , pp. 4947-4955
    • Romagnani, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.