메뉴 건너뛰기




Volumn 153, Issue , 2015, Pages 125-134

Telomere Dysfunction and Cell Senescence in Chronic Lung Diseases: Therapeutic Potential

Author keywords

Cellular senescence; COPD; emphysema; lung disease; pulmonary hypertension

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PROSTAGLANDIN;

EID: 84938421192     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2015.06.007     Document Type: Review
Times cited : (42)

References (117)
  • 1
    • 84881399206 scopus 로고    scopus 로고
    • A complex secretory program orchestrated by the inflammasome controls paracrine senescence
    • J.C. Acosta, A. Banito, T. Wuestefeld, A. Georgilis, P. Janich, J.P. Morton, and et al. A complex secretory program orchestrated by the inflammasome controls paracrine senescence Nat Cell Biol 15 2013 978 990
    • (2013) Nat Cell Biol , vol.15 , pp. 978-990
    • Acosta, J.C.1    Banito, A.2    Wuestefeld, T.3    Georgilis, A.4    Janich, P.5    Morton, J.P.6
  • 2
    • 44649120132 scopus 로고    scopus 로고
    • Chemokine signaling via the CXCR2 receptor reinforces senescence
    • J.C. Acosta, A. O'Loghlen, A. Banito, M.V. Guijarro, A. Augert, S. Raguz, and et al. Chemokine signaling via the CXCR2 receptor reinforces senescence Cell 133 2008 1006 1018
    • (2008) Cell , vol.133 , pp. 1006-1018
    • Acosta, J.C.1    O'Loghlen, A.2    Banito, A.3    Guijarro, M.V.4    Augert, A.5    Raguz, S.6
  • 4
    • 20444501324 scopus 로고    scopus 로고
    • Lessons learned from cancer may help in the treatment of pulmonary hypertension
    • S. Adnot Lessons learned from cancer may help in the treatment of pulmonary hypertension J Clin Investig 115 2005 1461 1463
    • (2005) J Clin Investig , vol.115 , pp. 1461-1463
    • Adnot, S.1
  • 5
    • 78851470225 scopus 로고    scopus 로고
    • Resveratrol and life extension
    • B. Agarwal, and J.A. Baur Resveratrol and life extension Ann N Y Acad Sci 1215 2011 138 143
    • (2011) Ann N Y Acad Sci , vol.1215 , pp. 138-143
    • Agarwal, B.1    Baur, J.A.2
  • 6
    • 84862100999 scopus 로고    scopus 로고
    • Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype
    • A. Agusti, L.D. Edwards, S.I. Rennard, W. MacNee, R. Tal-Singer, B.E. Miller, and et al. Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype PLoS One 7 2012 e37483
    • (2012) PLoS One , vol.7
    • Agusti, A.1    Edwards, L.D.2    Rennard, S.I.3    MacNee, W.4    Tal-Singer, R.5    Miller, B.E.6
  • 10
  • 11
    • 84874611617 scopus 로고    scopus 로고
    • Telomeres and age-related disease: how telomere biology informs clinical paradigms
    • M. Armanios Telomeres and age-related disease: how telomere biology informs clinical paradigms J Clin Investig 123 2013 996 1002
    • (2013) J Clin Investig , vol.123 , pp. 996-1002
    • Armanios, M.1
  • 14
    • 61849129365 scopus 로고    scopus 로고
    • The M-type receptor PLA2R regulates senescence through the p53 pathway
    • A. Augert, C. Payre, Y. de Launoit, J. Gil, G. Lambeau, and D. Bernard The M-type receptor PLA2R regulates senescence through the p53 pathway EMBO Rep 10 2009 271 277
    • (2009) EMBO Rep , vol.10 , pp. 271-277
    • Augert, A.1    Payre, C.2    De Launoit, Y.3    Gil, J.4    Lambeau, G.5    Bernard, D.6
  • 16
    • 66749141807 scopus 로고    scopus 로고
    • Systemic manifestations and comorbidities of COPD
    • P.J. Barnes, and B.R. Celli Systemic manifestations and comorbidities of COPD Eur Respir J 33 2009 1165 1185
    • (2009) Eur Respir J , vol.33 , pp. 1165-1185
    • Barnes, P.J.1    Celli, B.R.2
  • 21
    • 34548267728 scopus 로고    scopus 로고
    • International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study
    • A.S. Buist, M.A. McBurnie, W.M. Vollmer, S. Gillespie, P. Burney, D.M. Mannino, and et al. International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study Lancet 370 2007 741 750
    • (2007) Lancet , vol.370 , pp. 741-750
    • Buist, A.S.1    McBurnie, M.A.2    Vollmer, W.M.3    Gillespie, S.4    Burney, P.5    Mannino, D.M.6
  • 22
    • 33847172367 scopus 로고    scopus 로고
    • Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease
    • P.M. Calverley, J.A. Anderson, B. Celli, G.T. Ferguson, C. Jenkins, P.W. Jones, and et al. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease N Engl J Med 356 2007 775 789
    • (2007) N Engl J Med , vol.356 , pp. 775-789
    • Calverley, P.M.1    Anderson, J.A.2    Celli, B.3    Ferguson, G.T.4    Jenkins, C.5    Jones, P.W.6
  • 23
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
    • J. Campisi Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors Cell 120 2005 513 522
    • (2005) Cell , vol.120 , pp. 513-522
    • Campisi, J.1
  • 24
    • 23244452684 scopus 로고    scopus 로고
    • Suppressing cancer: The importance of being senescent
    • J. Campisi Suppressing cancer: The importance of being senescent Science 309 2005 886 887
    • (2005) Science , vol.309 , pp. 886-887
    • Campisi, J.1
  • 25
    • 80054899332 scopus 로고    scopus 로고
    • Resveratrol inhibition of inducible nitric oxide synthase in skeletal muscle involves AMPK but not SIRT1
    • C. Centeno-Baez, P. Dallaire, and A. Marette Resveratrol inhibition of inducible nitric oxide synthase in skeletal muscle involves AMPK but not SIRT1 Am J Physiol Endocrinol Metab 301 2011 E922 E930
    • (2011) Am J Physiol Endocrinol Metab , vol.301 , pp. E922-E930
    • Centeno-Baez, C.1    Dallaire, P.2    Marette, A.3
  • 26
    • 84871937830 scopus 로고    scopus 로고
    • A three-state model of telomere control over human proliferative boundaries
    • A.J. Cesare, and J. Karlseder A three-state model of telomere control over human proliferative boundaries Curr Opin Cell Biol 24 2012 731 738
    • (2012) Curr Opin Cell Biol , vol.24 , pp. 731-738
    • Cesare, A.J.1    Karlseder, J.2
  • 27
    • 84865839933 scopus 로고    scopus 로고
    • The relationship between pulmonary emphysema and kidney function in smokers
    • D. Chandra, J.A. Stamm, P.M. Palevsky, J.K. Leader, C.R. Fuhrman, Y. Zhang, and et al. The relationship between pulmonary emphysema and kidney function in smokers Chest 142 2012 655 662
    • (2012) Chest , vol.142 , pp. 655-662
    • Chandra, D.1    Stamm, J.A.2    Palevsky, P.M.3    Leader, J.K.4    Fuhrman, C.R.5    Zhang, Y.6
  • 29
    • 0028345161 scopus 로고
    • Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells
    • Q. Chen, and B.N. Ames Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells Proc Natl Acad Sci U S A 91 1994 4130 4134
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 4130-4134
    • Chen, Q.1    Ames, B.N.2
  • 31
    • 77949881221 scopus 로고    scopus 로고
    • The senescence-associated secretory phenotype: the dark side of tumor suppression
    • J.P. Coppe, P.Y. Desprez, A. Krtolica, and J. Campisi The senescence-associated secretory phenotype: the dark side of tumor suppression Annu Rev Pathol 5 2009 99 118
    • (2009) Annu Rev Pathol , vol.5 , pp. 99-118
    • Coppe, J.P.1    Desprez, P.Y.2    Krtolica, A.3    Campisi, J.4
  • 32
    • 77949881221 scopus 로고    scopus 로고
    • The senescence-associated secretory phenotype: the dark side of tumor suppression
    • J.P. Coppe, P.Y. Desprez, A. Krtolica, and J. Campisi The senescence-associated secretory phenotype: the dark side of tumor suppression Annu Rev Pathol 5 2010 99 118
    • (2010) Annu Rev Pathol , vol.5 , pp. 99-118
    • Coppe, J.P.1    Desprez, P.Y.2    Krtolica, A.3    Campisi, J.4
  • 33
    • 84891713034 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
    • J.P. Coppe, C.K. Patil, F. Rodier, Y. Sun, D.P. Munoz, J. Goldstein, and et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor PLoS Biol 6 2008 2853 2868
    • (2008) PLoS Biol , vol.6 , pp. 2853-2868
    • Coppe, J.P.1    Patil, C.K.2    Rodier, F.3    Sun, Y.4    Munoz, D.P.5    Goldstein, J.6
  • 34
    • 84875849501 scopus 로고    scopus 로고
    • The cyclooxygenase-2-prostaglandin E2 pathway maintains senescence of chronic obstructive pulmonary disease fibroblasts
    • M. Dagouassat, J.M. Gagliolo, S. Chrusciel, M.C. Bourin, C. Duprez, P. Caramelle, and et al. The cyclooxygenase-2-prostaglandin E2 pathway maintains senescence of chronic obstructive pulmonary disease fibroblasts Am J Respir Crit Care Med 187 2013 703 714
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 703-714
    • Dagouassat, M.1    Gagliolo, J.M.2    Chrusciel, S.3    Bourin, M.C.4    Duprez, C.5    Caramelle, P.6
  • 36
    • 77952105389 scopus 로고    scopus 로고
    • Inflammatory networks during cellular senescence: causes and consequences
    • A. Freund, A.V. Orjalo, P.Y. Desprez, and J. Campisi Inflammatory networks during cellular senescence: causes and consequences Trends Mol Med 16 2010 238 246
    • (2010) Trends Mol Med , vol.16 , pp. 238-246
    • Freund, A.1    Orjalo, A.V.2    Desprez, P.Y.3    Campisi, J.4
  • 37
    • 80052747314 scopus 로고    scopus 로고
    • Lifetime risk of developing chronic obstructive pulmonary disease: a longitudinal population study
    • A.S. Gershon, L. Warner, P. Cascagnette, J.C. Victor, and T. To Lifetime risk of developing chronic obstructive pulmonary disease: a longitudinal population study Lancet 378 2011 991 996
    • (2011) Lancet , vol.378 , pp. 991-996
    • Gershon, A.S.1    Warner, L.2    Cascagnette, P.3    Victor, J.C.4    To, T.5
  • 40
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • D.E. Harrison, R. Strong, Z.D. Sharp, J.F. Nelson, C.M. Astle, K. Flurkey, and et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice Nature 460 2009 392 395
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1    Strong, R.2    Sharp, Z.D.3    Nelson, J.F.4    Astle, C.M.5    Flurkey, K.6
  • 41
    • 50549218525 scopus 로고
    • The Limited in Vitro Lifetime of Human Diploid Cell Strains
    • L. Hayflick The Limited in Vitro Lifetime of Human Diploid Cell Strains Exp Cell Res 37 1965 614 636
    • (1965) Exp Cell Res , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 43
    • 80053124673 scopus 로고    scopus 로고
    • Taking a "good" look at free radicals in the aging process
    • S. Hekimi, J. Lapointe, and Y. Wen Taking a "good" look at free radicals in the aging process Trends Cell Biol 21 2011 569 576
    • (2011) Trends Cell Biol , vol.21 , pp. 569-576
    • Hekimi, S.1    Lapointe, J.2    Wen, Y.3
  • 44
    • 34347375071 scopus 로고    scopus 로고
    • On why decreasing protein synthesis can increase lifespan
    • A.R. Hipkiss On why decreasing protein synthesis can increase lifespan Mech Ageing Dev 128 2007 412 414
    • (2007) Mech Ageing Dev , vol.128 , pp. 412-414
    • Hipkiss, A.R.1
  • 45
    • 84933572955 scopus 로고    scopus 로고
    • Safety of Metformin in Patients with Chronic Obstructive Pulmonary Disease and Type 2 Diabetes Mellitus
    • A.W. Hitchings, J.R. Archer, S.A. Srivastava, and E.H. Baker Safety of Metformin in Patients with Chronic Obstructive Pulmonary Disease and Type 2 Diabetes Mellitus COPD 2014
    • (2014) COPD
    • Hitchings, A.W.1    Archer, J.R.2    Srivastava, S.A.3    Baker, E.H.4
  • 46
    • 84864306922 scopus 로고    scopus 로고
    • Immune surveillance of senescent cells - Biological significance in cancer- and non-cancer pathologies
    • L. Hoenicke, and L. Zender Immune surveillance of senescent cells - biological significance in cancer- and non-cancer pathologies Carcinogenesis 33 2012 1123 1126
    • (2012) Carcinogenesis , vol.33 , pp. 1123-1126
    • Hoenicke, L.1    Zender, L.2
  • 47
    • 84879285500 scopus 로고    scopus 로고
    • Rapamycin reverses pulmonary artery smooth muscle cell proliferation in pulmonary hypertension
    • A. Houssaini, S. Abid, N. Mouraret, F. Wan, D. Rideau, M. Saker, and et al. Rapamycin reverses pulmonary artery smooth muscle cell proliferation in pulmonary hypertension Am J Respir Cell Mol Biol 48 2013 568 577
    • (2013) Am J Respir Cell Mol Biol , vol.48 , pp. 568-577
    • Houssaini, A.1    Abid, S.2    Mouraret, N.3    Wan, F.4    Rideau, D.5    Saker, M.6
  • 49
    • 0035834121 scopus 로고    scopus 로고
    • Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging
    • A. Krtolica, S. Parrinello, S. Lockett, P.Y. Desprez, and J. Campisi Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging Proc Natl Acad Sci U S A 98 2001 12072 12077
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 12072-12077
    • Krtolica, A.1    Parrinello, S.2    Lockett, S.3    Desprez, P.Y.4    Campisi, J.5
  • 50
    • 44649101304 scopus 로고    scopus 로고
    • Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
    • T. Kuilman, C. Michaloglou, L.C. Vredeveld, S. Douma, R. van Doorn, C.J. Desmet, and et al. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network Cell 133 2008 1019 1031
    • (2008) Cell , vol.133 , pp. 1019-1031
    • Kuilman, T.1    Michaloglou, C.2    Vredeveld, L.C.3    Douma, S.4    Van Doorn, R.5    Desmet, C.J.6
  • 51
    • 58849154235 scopus 로고    scopus 로고
    • Senescence-messaging secretome: SMS-ing cellular stress
    • T. Kuilman, and D.S. Peeper Senescence-messaging secretome: SMS-ing cellular stress Nat Rev Cancer 9 2009 81 94
    • (2009) Nat Rev Cancer , vol.9 , pp. 81-94
    • Kuilman, T.1    Peeper, D.S.2
  • 52
    • 84864010194 scopus 로고    scopus 로고
    • Glucocorticoids suppress selected components of the senescence-associated secretory phenotype
    • R.M. Laberge, L. Zhou, M.R. Sarantos, F. Rodier, A. Freund, P.L. de Keizer, and et al. Glucocorticoids suppress selected components of the senescence-associated secretory phenotype Aging Cell 11 2012 569 578
    • (2012) Aging Cell , vol.11 , pp. 569-578
    • Laberge, R.M.1    Zhou, L.2    Sarantos, M.R.3    Rodier, F.4    Freund, A.5    De Keizer, P.L.6
  • 53
    • 78149268561 scopus 로고    scopus 로고
    • First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis
    • B. Laleu, F. Gaggini, M. Orchard, L. Fioraso-Cartier, L. Cagnon, S. Houngninou-Molango, and et al. First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis J Med Chem 53 2010 7715 7730
    • (2010) J Med Chem , vol.53 , pp. 7715-7730
    • Laleu, B.1    Gaggini, F.2    Orchard, M.3    Fioraso-Cartier, L.4    Cagnon, L.5    Houngninou-Molango, S.6
  • 54
    • 84874611570 scopus 로고    scopus 로고
    • Rapalogs and mTOR inhibitors as anti-aging therapeutics
    • D.W. Lamming, L. Ye, D.M. Sabatini, and J.A. Baur Rapalogs and mTOR inhibitors as anti-aging therapeutics J Clin Investig 123 2013 980 989
    • (2013) J Clin Investig , vol.123 , pp. 980-989
    • Lamming, D.W.1    Ye, L.2    Sabatini, D.M.3    Baur, J.A.4
  • 56
    • 84859778293 scopus 로고    scopus 로고
    • mTOR signaling in growth control and disease
    • M. Laplante, and D.M. Sabatini mTOR signaling in growth control and disease Cell 149 2012 274 293
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 58
    • 0001784193 scopus 로고
    • Pulmonary emphysema with special reference to vascular changes
    • A.A. Liebow Pulmonary emphysema with special reference to vascular changes Am Rev Respir Dis 80 1959 67 93
    • (1959) Am Rev Respir Dis , vol.80 , pp. 67-93
    • Liebow, A.A.1
  • 60
    • 84923543492 scopus 로고    scopus 로고
    • DDR-mediated crosstalk between DNA-damaged cells and their microenvironment
    • N. Malaquin, A. Carrier-Leclerc, M. Dessureault, and F. Rodier DDR-mediated crosstalk between DNA-damaged cells and their microenvironment Front Genet 6 2015 94
    • (2015) Front Genet , vol.6 , pp. 94
    • Malaquin, N.1    Carrier-Leclerc, A.2    Dessureault, M.3    Rodier, F.4
  • 61
    • 0037106368 scopus 로고    scopus 로고
    • Midthigh muscle cross-sectional area is a better predictor of mortality than body mass index in patients with chronic obstructive pulmonary disease
    • K. Marquis, R. Debigare, Y. Lacasse, P. LeBlanc, J. Jobin, G. Carrier, and et al. Midthigh muscle cross-sectional area is a better predictor of mortality than body mass index in patients with chronic obstructive pulmonary disease Am J Respir Crit Care Med 166 2002 809 813
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 809-813
    • Marquis, K.1    Debigare, R.2    Lacasse, Y.3    LeBlanc, P.4    Jobin, J.5    Carrier, G.6
  • 62
    • 0035754079 scopus 로고    scopus 로고
    • Cell senescence and cancer
    • N.F. Mathon, and A.C. Lloyd Cell senescence and cancer Nat Rev Cancer 1 2001 203 213
    • (2001) Nat Rev Cancer , vol.1 , pp. 203-213
    • Mathon, N.F.1    Lloyd, A.C.2
  • 63
    • 33747625689 scopus 로고    scopus 로고
    • Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress
    • C. Matthews, I. Gorenne, S. Scott, N. Figg, P. Kirkpatrick, A. Ritchie, and et al. Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress Circ Res 99 2006 156 164
    • (2006) Circ Res , vol.99 , pp. 156-164
    • Matthews, C.1    Gorenne, I.2    Scott, S.3    Figg, N.4    Kirkpatrick, P.5    Ritchie, A.6
  • 64
    • 37149042861 scopus 로고    scopus 로고
    • Arterial stiffness is independently associated with emphysema severity in patients with chronic obstructive pulmonary disease
    • D.A. McAllister, J.D. Maclay, N.L. Mills, G. Mair, J. Miller, D. Anderson, and et al. Arterial stiffness is independently associated with emphysema severity in patients with chronic obstructive pulmonary disease Am J Respir Crit Care Med 176 2007 1208 1214
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 1208-1214
    • McAllister, D.A.1    Maclay, J.D.2    Mills, N.L.3    Mair, G.4    Miller, J.5    Anderson, D.6
  • 65
    • 77953305629 scopus 로고    scopus 로고
    • Pulmonary hypertension in COPD: epidemiology, significance, and management: pulmonary vascular disease: the global perspective
    • O.A. Minai, A. Chaouat, and S. Adnot Pulmonary hypertension in COPD: epidemiology, significance, and management: pulmonary vascular disease: the global perspective Chest 137 2010 39S 51S
    • (2010) Chest , vol.137 , pp. 39S-51S
    • Minai, O.A.1    Chaouat, A.2    Adnot, S.3
  • 66
    • 0037007075 scopus 로고    scopus 로고
    • Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction
    • T. Minamino, H. Miyauchi, T. Yoshida, Y. Ishida, H. Yoshida, and I. Komuro Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction Circulation 105 2002 1541 1544
    • (2002) Circulation , vol.105 , pp. 1541-1544
    • Minamino, T.1    Miyauchi, H.2    Yoshida, T.3    Ishida, Y.4    Yoshida, H.5    Komuro, I.6
  • 67
    • 33745363911 scopus 로고    scopus 로고
    • DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation
    • O. Moiseeva, F.A. Mallette, U.K. Mukhopadhyay, A. Moores, and G. Ferbeyre DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation Mol Biol Cell 17 2006 1583 1592
    • (2006) Mol Biol Cell , vol.17 , pp. 1583-1592
    • Moiseeva, O.1    Mallette, F.A.2    Mukhopadhyay, U.K.3    Moores, A.4    Ferbeyre, G.5
  • 69
    • 84876577725 scopus 로고    scopus 로고
    • Activation of lung p53 by Nutlin-3a prevents and reverses experimental pulmonary hypertension
    • N. Mouraret, E. Marcos, S. Abid, G. Gary-Bobo, M. Saker, A. Houssaini, and et al. Activation of lung p53 by Nutlin-3a prevents and reverses experimental pulmonary hypertension Circulation 127 2013 1664 1676
    • (2013) Circulation , vol.127 , pp. 1664-1676
    • Mouraret, N.1    Marcos, E.2    Abid, S.3    Gary-Bobo, G.4    Saker, M.5    Houssaini, A.6
  • 70
    • 84904702784 scopus 로고    scopus 로고
    • Cellular senescence: from physiology to pathology
    • D. Munoz-Espin, and M. Serrano Cellular senescence: from physiology to pathology Nat Rev Mol Cell Biol 15 2014 482 496
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 482-496
    • Munoz-Espin, D.1    Serrano, M.2
  • 72
    • 84891390764 scopus 로고    scopus 로고
    • Clinical factors associated with the humoral immune response to influenza vaccination in chronic obstructive pulmonary disease
    • K.D. Nath, J.G. Burel, V. Shankar, A.L. Pritchard, M. Towers, D. Looke, and et al. Clinical factors associated with the humoral immune response to influenza vaccination in chronic obstructive pulmonary disease Int J Chron Obstruct Pulmon Dis 9 2014 51 56
    • (2014) Int J Chron Obstruct Pulmon Dis , vol.9 , pp. 51-56
    • Nath, K.D.1    Burel, J.G.2    Shankar, V.3    Pritchard, A.L.4    Towers, M.5    Looke, D.6
  • 73
    • 84871302192 scopus 로고    scopus 로고
    • Senescent cells: a novel therapeutic target for aging and age-related diseases
    • R.M. Naylor, D.J. Baker, and J.M. van Deursen Senescent cells: a novel therapeutic target for aging and age-related diseases Clin Pharmacol Ther 93 2013 105 116
    • (2013) Clin Pharmacol Ther , vol.93 , pp. 105-116
    • Naylor, R.M.1    Baker, D.J.2    Van Deursen, J.M.3
  • 74
    • 84874599388 scopus 로고    scopus 로고
    • Coming of age: molecular drivers of aging and therapeutic opportunities
    • C.B. Newgard, and N.E. Sharpless Coming of age: molecular drivers of aging and therapeutic opportunities J Clin Investig 123 2013 946 950
    • (2013) J Clin Investig , vol.123 , pp. 946-950
    • Newgard, C.B.1    Sharpless, N.E.2
  • 75
    • 56849118516 scopus 로고    scopus 로고
    • Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis
    • V. Nogueira, Y. Park, C.C. Chen, P.Z. Xu, M.L. Chen, I. Tonic, and et al. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis Cancer Cell 14 2008 458 470
    • (2008) Cancer Cell , vol.14 , pp. 458-470
    • Nogueira, V.1    Park, Y.2    Chen, C.C.3    Xu, P.Z.4    Chen, M.L.5    Tonic, I.6
  • 76
    • 80052178805 scopus 로고    scopus 로고
    • Pulmonary artery smooth muscle cell senescence is a pathogenic mechanism for pulmonary hypertension in chronic lung disease
    • H. Noureddine, G. Gary-Bobo, M. Alifano, E. Marcos, M. Saker, N. Vienney, and et al. Pulmonary artery smooth muscle cell senescence is a pathogenic mechanism for pulmonary hypertension in chronic lung disease Circ Res 109 2011 543 553
    • (2011) Circ Res , vol.109 , pp. 543-553
    • Noureddine, H.1    Gary-Bobo, G.2    Alifano, M.3    Marcos, E.4    Saker, M.5    Vienney, N.6
  • 77
    • 84896499887 scopus 로고    scopus 로고
    • Is telomeropathy the explanation for combined pulmonary fibrosis and emphysema syndrome?: report of a family with TERT mutation
    • H. Nunes, I. Monnet, C. Kannengiesser, Y. Uzunhan, D. Valeyre, M. Kambouchner, and et al. Is telomeropathy the explanation for combined pulmonary fibrosis and emphysema syndrome?: report of a family with TERT mutation Am J Respir Crit Care Med 189 2014 753 754
    • (2014) Am J Respir Crit Care Med , vol.189 , pp. 753-754
    • Nunes, H.1    Monnet, I.2    Kannengiesser, C.3    Uzunhan, Y.4    Valeyre, D.5    Kambouchner, M.6
  • 79
    • 84890451565 scopus 로고    scopus 로고
    • Dysfunction of endothelial progenitor cells from smokers and chronic obstructive pulmonary disease patients due to increased DNA damage and senescence
    • K.E. Paschalaki, R.D. Starke, Y. Hu, N. Mercado, A. Margariti, V.G. Gorgoulis, and et al. Dysfunction of endothelial progenitor cells from smokers and chronic obstructive pulmonary disease patients due to increased DNA damage and senescence Stem Cells 31 2013 2813 2826
    • (2013) Stem Cells , vol.31 , pp. 2813-2826
    • Paschalaki, K.E.1    Starke, R.D.2    Hu, Y.3    Mercado, N.4    Margariti, A.5    Gorgoulis, V.G.6
  • 82
    • 42649146208 scopus 로고    scopus 로고
    • SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease
    • S. Rajendrasozhan, S.R. Yang, V.L. Kinnula, and I. Rahman SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease Am J Respir Crit Care Med 177 2008 861 870
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 861-870
    • Rajendrasozhan, S.1    Yang, S.R.2    Kinnula, V.L.3    Rahman, I.4
  • 83
    • 68249096784 scopus 로고    scopus 로고
    • Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
    • F. Rodier, J.P. Coppe, C.K. Patil, W.A. Hoeijmakers, D.P. Munoz, S.R. Raza, and et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion Nat Cell Biol 11 2009 973 979
    • (2009) Nat Cell Biol , vol.11 , pp. 973-979
    • Rodier, F.1    Coppe, J.P.2    Patil, C.K.3    Hoeijmakers, W.A.4    Munoz, D.P.5    Raza, S.R.6
  • 84
    • 78651104478 scopus 로고    scopus 로고
    • DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion
    • F. Rodier, D.P. Munoz, R. Teachenor, V. Chu, O. Le, D. Bhaumik, and et al. DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion J Cell Sci 124 2011 68 81
    • (2011) J Cell Sci , vol.124 , pp. 68-81
    • Rodier, F.1    Munoz, D.P.2    Teachenor, R.3    Chu, V.4    Le, O.5    Bhaumik, D.6
  • 86
    • 84899745472 scopus 로고    scopus 로고
    • Longer telomere length in COPD patients with alpha1-antitrypsin deficiency independent of lung function
    • A. Saferali, J. Lee, D.D. Sin, F.N. Rouhani, M.L. Brantly, and A.J. Sandford Longer telomere length in COPD patients with alpha1-antitrypsin deficiency independent of lung function PLoS One 9 2014 e95600
    • (2014) PLoS One , vol.9
    • Saferali, A.1    Lee, J.2    Sin, D.D.3    Rouhani, F.N.4    Brantly, M.L.5    Sandford, A.J.6
  • 87
    • 0036212004 scopus 로고    scopus 로고
    • Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD
    • S. Santos, V.I. Peinado, J. Ramirez, T. Melgosa, J. Roca, R. Rodriguez-Roisin, and et al. Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD Eur Respir J 19 2002 632 638
    • (2002) Eur Respir J , vol.19 , pp. 632-638
    • Santos, S.1    Peinado, V.I.2    Ramirez, J.3    Melgosa, T.4    Roca, J.5    Rodriguez-Roisin, R.6
  • 88
    • 65249172518 scopus 로고    scopus 로고
    • Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease
    • L. Savale, A. Chaouat, S. Bastuji-Garin, E. Marcos, L. Boyer, B. Maitre, and et al. Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease Am J Respir Crit Care Med 179 2009 566 571
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 566-571
    • Savale, L.1    Chaouat, A.2    Bastuji-Garin, S.3    Marcos, E.4    Boyer, L.5    Maitre, B.6
  • 90
    • 80054696408 scopus 로고    scopus 로고
    • Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice
    • M. Seimetz, N. Parajuli, A. Pichl, F. Veit, G. Kwapiszewska, F.C. Weisel, and et al. Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice Cell 147 2011 293 305
    • (2011) Cell , vol.147 , pp. 293-305
    • Seimetz, M.1    Parajuli, N.2    Pichl, A.3    Veit, F.4    Kwapiszewska, G.5    Weisel, F.C.6
  • 91
    • 84897074033 scopus 로고    scopus 로고
    • Respiratory effects of insulin sensitisation with metformin: a prospective observational study
    • P. Sexton, P. Metcalf, and J. Kolbe Respiratory effects of insulin sensitisation with metformin: a prospective observational study COPD 11 2014 133 142
    • (2014) COPD , vol.11 , pp. 133-142
    • Sexton, P.1    Metcalf, P.2    Kolbe, J.3
  • 92
    • 84900801448 scopus 로고    scopus 로고
    • Effect of high/low dose N-acetylcysteine on chronic obstructive pulmonary disease: a systematic review and meta-analysis
    • Y. Shen, W. Cai, S. Lei, and Z. Zhang Effect of high/low dose N-acetylcysteine on chronic obstructive pulmonary disease: a systematic review and meta-analysis COPD 11 2013 351 358
    • (2013) COPD , vol.11 , pp. 351-358
    • Shen, Y.1    Cai, W.2    Lei, S.3    Zhang, Z.4
  • 93
    • 0037465734 scopus 로고    scopus 로고
    • Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease
    • D.D. Sin, and S.F. Man Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease Circulation 107 2003 1514 1519
    • (2003) Circulation , vol.107 , pp. 1514-1519
    • Sin, D.D.1    Man, S.F.2
  • 94
    • 17644407378 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease as a risk factor for cardiovascular morbidity and mortality
    • D.D. Sin, and S.F. Man Chronic obstructive pulmonary disease as a risk factor for cardiovascular morbidity and mortality Proc Am Thorac Soc 2 2005 8 11
    • (2005) Proc Am Thorac Soc , vol.2 , pp. 8-11
    • Sin, D.D.1    Man, S.F.2
  • 96
    • 49549086620 scopus 로고    scopus 로고
    • Subgroup analyses to determine cardiovascular risk associated with nonsteroidal antiinflammatory drugs and coxibs in specific patient groups
    • D.H. Solomon, R.J. Glynn, K.J. Rothman, S. Schneeweiss, S. Setoguchi, H. Mogun, and et al. Subgroup analyses to determine cardiovascular risk associated with nonsteroidal antiinflammatory drugs and coxibs in specific patient groups Arthritis Rheum 59 2008 1097 1104
    • (2008) Arthritis Rheum , vol.59 , pp. 1097-1104
    • Solomon, D.H.1    Glynn, R.J.2    Rothman, K.J.3    Schneeweiss, S.4    Setoguchi, S.5    Mogun, H.6
  • 99
    • 84874603171 scopus 로고    scopus 로고
    • Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
    • T. Tchkonia, Y. Zhu, J. van Deursen, J. Campisi, and J.L. Kirkland Cellular senescence and the senescent secretory phenotype: therapeutic opportunities J Clin Investig 123 2013 966 972
    • (2013) J Clin Investig , vol.123 , pp. 966-972
    • Tchkonia, T.1    Zhu, Y.2    Van Deursen, J.3    Campisi, J.4    Kirkland, J.L.5
  • 100
    • 9744272376 scopus 로고    scopus 로고
    • Cigarette smoke induces senescence in alveolar epithelial cells
    • T. Tsuji, K. Aoshiba, and A. Nagai Cigarette smoke induces senescence in alveolar epithelial cells Am J Respir Cell Mol Biol 31 2004 643 649
    • (2004) Am J Respir Cell Mol Biol , vol.31 , pp. 643-649
    • Tsuji, T.1    Aoshiba, K.2    Nagai, A.3
  • 101
    • 33749841717 scopus 로고    scopus 로고
    • Alveolar cell senescence in patients with pulmonary emphysema
    • T. Tsuji, K. Aoshiba, and A. Nagai Alveolar cell senescence in patients with pulmonary emphysema Am J Respir Crit Care Med 174 2006 886 893
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 886-893
    • Tsuji, T.1    Aoshiba, K.2    Nagai, A.3
  • 102
    • 84901288438 scopus 로고    scopus 로고
    • The role of senescent cells in ageing
    • J.M. van Deursen The role of senescent cells in ageing Nature 509 2014 439 446
    • (2014) Nature , vol.509 , pp. 439-446
    • Van Deursen, J.M.1
  • 103
    • 84875847989 scopus 로고    scopus 로고
    • Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease
    • L.E. Vanfleteren, M.A. Spruit, M. Groenen, S. Gaffron, V.P. van Empel, P.L. Bruijnzeel, and et al. Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease Am J Respir Crit Care Med 187 2013 728 735
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 728-735
    • Vanfleteren, L.E.1    Spruit, M.A.2    Groenen, M.3    Gaffron, S.4    Van Empel, V.P.5    Bruijnzeel, P.L.6
  • 105
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • I. Vivanco, and C.L. Sawyers The phosphatidylinositol 3-Kinase AKT pathway in human cancer Nat Rev Cancer 2 2002 489 501
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 106
    • 38849168162 scopus 로고    scopus 로고
    • Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7
    • N. Wajapeyee, R.W. Serra, X. Zhu, M. Mahalingam, and M.R. Green Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7 Cell 132 2008 363 374
    • (2008) Cell , vol.132 , pp. 363-374
    • Wajapeyee, N.1    Serra, R.W.2    Zhu, X.3    Mahalingam, M.4    Green, M.R.5
  • 109
    • 84857790798 scopus 로고    scopus 로고
    • ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence
    • U. Weyemi, O. Lagente-Chevallier, M. Boufraqech, F. Prenois, F. Courtin, B. Caillou, and et al. ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence Oncogene 31 2012 1117 1129
    • (2012) Oncogene , vol.31 , pp. 1117-1129
    • Weyemi, U.1    Lagente-Chevallier, O.2    Boufraqech, M.3    Prenois, F.4    Courtin, F.5    Caillou, B.6
  • 110
    • 78650771315 scopus 로고    scopus 로고
    • Statin reverses smoke-induced pulmonary hypertension and prevents emphysema but not airway remodeling
    • J.L. Wright, S. Zhou, O. Preobrazhenska, C. Marshall, D.D. Sin, I. Laher, and et al. Statin reverses smoke-induced pulmonary hypertension and prevents emphysema but not airway remodeling Am J Respir Crit Care Med 183 2011 50 58
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 50-58
    • Wright, J.L.1    Zhou, S.2    Preobrazhenska, O.3    Marshall, C.4    Sin, D.D.5    Laher, I.6
  • 111
    • 33846937033 scopus 로고    scopus 로고
    • Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    • W. Xue, L. Zender, C. Miething, R.A. Dickins, E. Hernando, V. Krizhanovsky, and et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas Nature 445 2007 656 660
    • (2007) Nature , vol.445 , pp. 656-660
    • Xue, W.1    Zender, L.2    Miething, C.3    Dickins, R.A.4    Hernando, E.5    Krizhanovsky, V.6
  • 112
    • 84861831957 scopus 로고    scopus 로고
    • SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
    • H. Yao, S. Chung, J.W. Hwang, S. Rajendrasozhan, I.K. Sundar, D.A. Dean, and et al. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice J Clin Investig 122 2012 2032 2045
    • (2012) J Clin Investig , vol.122 , pp. 2032-2045
    • Yao, H.1    Chung, S.2    Hwang, J.W.3    Rajendrasozhan, S.4    Sundar, I.K.5    Dean, D.A.6
  • 113
    • 84874594650 scopus 로고    scopus 로고
    • Immune surveillance of pre-cancerous senescent hepatocytes limits hepatocellular carcinoma development
    • T. Yevsa, T.W. Kang, and L. Zender Immune surveillance of pre-cancerous senescent hepatocytes limits hepatocellular carcinoma development Oncoimmunology 1 2012 398 399
    • (2012) Oncoimmunology , vol.1 , pp. 398-399
    • Yevsa, T.1    Kang, T.W.2    Zender, L.3
  • 114
    • 77954470662 scopus 로고    scopus 로고
    • Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema
    • T. Yoshida, I. Mett, A.K. Bhunia, J. Bowman, M. Perez, L. Zhang, and et al. Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema Nat Med 16 2010 767 773
    • (2010) Nat Med , vol.16 , pp. 767-773
    • Yoshida, T.1    Mett, I.2    Bhunia, A.K.3    Bowman, J.4    Perez, M.5    Zhang, L.6
  • 115
    • 34447556991 scopus 로고    scopus 로고
    • Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease
    • T. Yoshida, and R.M. Tuder Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease Physiol Rev 87 2007 1047 1082
    • (2007) Physiol Rev , vol.87 , pp. 1047-1082
    • Yoshida, T.1    Tuder, R.M.2
  • 116
    • 67649332814 scopus 로고    scopus 로고
    • Keeping your senescent cells under control
    • L. Zender, and K.L. Rudolph Keeping your senescent cells under control Aging (Albany NY) 1 2009 438 441
    • (2009) Aging (Albany NY) , vol.1 , pp. 438-441
    • Zender, L.1    Rudolph, K.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.