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Volumn 170, Issue 4, 2016, Pages 211-233

On peptides and altered peptide ligands: From origin, mode of action and design to clinical application (Immunotherapy)

Author keywords

Altered peptide ligand; Immunotherapy; Peptides; T cell activation; T cell epitopes; T cell responses; T cells

Indexed keywords

ALLERGEN; ALTERED PEPTIDE LIGAND; ANTIALLERGIC AGENT; BEE VENOM; COLLAGEN TYPE 4; CYTOCHROME C; GAG PROTEIN; GAG PROTEIN[33-41]; GAMMA INTERFERON; HEPATITIS B CORE ANTIGEN; HEPATITIS B CORE ANTIGEN[18-27]; IMMUNOMODULATING AGENT; INFLUENZA VIRUS HEMAGGLUTININ; INFLUENZA VIRUS HEMAGGLUTININ[307-319]; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; LIGAND; MOTH CYTOCHROME C[88-103]; OVALBUMIN; OVALBUMIN[257-264]; PEPTIDE; PIGEON CYTOCHROME C[88-104]; POLLEN ANTIGEN; RECOMBINANT PROTEIN; T LYMPHOCYTE RECEPTOR; TETANUS TOXOID; TETANUS TOXOID[830-843]; TOLL LIKE RECEPTOR AFFECTING AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG; EPITOPE; HISTOCOMPATIBILITY ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN BINDING;

EID: 84988646234     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000448756     Document Type: Review
Times cited : (30)

References (210)
  • 1
    • 0026434554 scopus 로고
    • Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand
    • Evavold BD, Allen PM: Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 1991; 252: 1308-1310
    • (1991) Science , vol.252 , pp. 1308-1310
    • Evavold, B.D.1    Allen, P.M.2
  • 2
    • 0026586413 scopus 로고
    • Complete dissection of the Hb(64-76) determinant using T helper 1, T helper 2 clones, and T cell hybridomas
    • Evavold BD, Williams SG, Hsu BL, Buus S, Allen PM: Complete dissection of the Hb(64-76) determinant using T helper 1, T helper 2 clones, and T cell hybridomas. J Immunol 1992; 148: 347-353
    • (1992) J Immunol , Issue.148 , pp. 347-353
    • Evavold, B.D.1    Williams, S.G.2    Hsu, B.L.3    Buus, S.4    Allen, P.M.5
  • 4
    • 0027205194 scopus 로고
    • Clonespecific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells
    • Jameson SC, Carbone FR, Bevan MJ: Clonespecific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells. J Exp Med 1993; 177: 1541-1550
    • (1993) J Exp Med , vol.177 , pp. 1541-1550
    • Jameson, S.C.1    Carbone, F.R.2    Bevan, M.J.3
  • 5
    • 0027238112 scopus 로고
    • T cell receptor antagonism mediated by interaction between T cell receptor junctional residues and peptide antigen analogues
    • Ostrov D, Krieger J, Sidney J, Sette A, Concannon P: T cell receptor antagonism mediated by interaction between T cell receptor junctional residues and peptide antigen analogues. J Immunol 1993; 150: 4277-4283
    • (1993) J Immunol , vol.150 , pp. 4277-4283
    • Ostrov, D.1    Krieger, J.2    Sidney, J.3    Sette, A.4    Concannon, P.5
  • 7
    • 0026759622 scopus 로고
    • Disease inhibition by major histocompatibility complex binding peptide analogues of disease-associated epitopes: More than blocking alone
    • Wauben MH, Boog CJ, van der Zee R, Joosten I, Schlief A, van Eden W: Disease inhibition by major histocompatibility complex binding peptide analogues of disease-associated epitopes: more than blocking alone. J Exp Med 1992; 176: 667-677
    • (1992) J Exp Med , vol.176 , pp. 667-677
    • Wauben, M.H.1    Boog, C.J.2    Van Der Zee, R.3    Joosten, I.4    Schlief, A.5    Van Eden, W.6
  • 8
    • 0028148199 scopus 로고
    • Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon γ and tumor necrosis factor α production
    • Karin N, Mitchell DJ, Brocke S, Ling N, Steinman L: Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon γ and tumor necrosis factor α production. J Exp Med 1994; 180: 2227-2237
    • (1994) J Exp Med , vol.180 , pp. 2227-2237
    • Karin, N.1    Mitchell, D.J.2    Brocke, S.3    Ling, N.4    Steinman, L.5
  • 9
    • 0027333348 scopus 로고
    • Tickling the TCR: Selective T-cell functions stimulated by altered peptide ligands
    • Evavold BD, Sloan-Lancaster J, Allen PM: Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands. Immunol Today 1993; 14: 602-609
    • (1993) Immunol Today , vol.14 , pp. 602-609
    • Evavold, B.D.1    Sloan-Lancaster, J.2    Allen, P.M.3
  • 10
    • 0027298445 scopus 로고
    • Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells
    • Sloan-Lancaster J, Evavold BD, Allen PM: Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature 1993; 363: 156-159
    • (1993) Nature , vol.363 , pp. 156-159
    • Sloan-Lancaster, J.1    Evavold, B.D.2    Allen, P.M.3
  • 11
  • 12
    • 0027409792 scopus 로고
    • Peptide-major histocompatibility complex class II complexes with mixed agonist/ antagonist properties provide evidence for ligand-related differences in T cell receptordependent intracellular signaling
    • Racioppi L, Ronchese F, Matis LA, Germain RN: Peptide-major histocompatibility complex class II complexes with mixed agonist/ antagonist properties provide evidence for ligand-related differences in T cell receptordependent intracellular signaling. J Exp Med 1993; 177: 1047-1060
    • (1993) J Exp Med , vol.177 , pp. 1047-1060
    • Racioppi, L.1    Ronchese, F.2    Matis, L.A.3    Germain, R.N.4
  • 14
    • 0033566824 scopus 로고    scopus 로고
    • Cutting edge: Dueling TCRs: Peptide antagonism of CD4+ T cells with dual antigen specificities
    • Robertson JM, Evavold BD: Cutting edge: dueling TCRs: peptide antagonism of CD4+ T cells with dual antigen specificities. J Immunol 1999; 163: 1750-1754
    • (1999) J Immunol , vol.163 , pp. 1750-1754
    • Robertson, J.M.1    Evavold, B.D.2
  • 15
    • 0033199986 scopus 로고    scopus 로고
    • Cross-antagonism of a T cell clone expressing two distinct T cell receptors
    • Dittel BN, Stefanova I, Germain RN, Janeway CA Jr: Cross-antagonism of a T cell clone expressing two distinct T cell receptors. Immunity 1999; 11: 289-298
    • (1999) Immunity , vol.11 , pp. 289-298
    • Dittel, B.N.1    Stefanova, I.2    Germain, R.N.3    Janeway, C.A.4
  • 16
    • 0037406912 scopus 로고    scopus 로고
    • Study of the mechanism of TCR antagonism using dual-TCR-expressing T cells
    • Yang W, Grey HM: Study of the mechanism of TCR antagonism using dual-TCR-expressing T cells. J Immunol 2003; 170: 4532-4538
    • (2003) J Immunol , vol.170 , pp. 4532-4538
    • Yang, W.1    Grey, H.M.2
  • 18
    • 0037338890 scopus 로고    scopus 로고
    • TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
    • Stefanova I, Hemmer B, Vergelli M, Martin R, Biddison WE, Germain RN: TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nat Immunol 2003; 4: 248-254
    • (2003) Nat Immunol , vol.4 , pp. 248-254
    • Stefanova, I.1    Hemmer, B.2    Vergelli, M.3    Martin, R.4    Biddison, W.E.5    Germain, R.N.6
  • 19
    • 34248399201 scopus 로고    scopus 로고
    • Sensitivity of T cells to antigen and antagonism emerges from differential regulation of the same molecular signaling module
    • Wylie DC, Das J, Chakraborty AK: Sensitivity of T cells to antigen and antagonism emerges from differential regulation of the same molecular signaling module. Proc Natl Acad Sci USA 2007; 104: 5533-5538
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 5533-5538
    • Wylie, D.C.1    Das, J.2    Chakraborty, A.K.3
  • 21
    • 0028956709 scopus 로고
    • Significance of T-cell stimulation by altered peptide ligands in T cell biology
    • Sloan-Lancaster J, Allen PM: Significance of T-cell stimulation by altered peptide ligands in T cell biology. Curr Opin Immunol 1995; 7: 103-109
    • (1995) Curr Opin Immunol , vol.7 , pp. 103-109
    • Sloan-Lancaster, J.1    Allen, P.M.2
  • 22
    • 0027967385 scopus 로고
    • Partial T cell signaling: Altered phospho- and lack of zap70 recruitment in APL-induced T cell anergy
    • Sloan-Lancaster J, Shaw AS, Rothbard JB, Allen PM: Partial T cell signaling: altered phospho- and lack of zap70 recruitment in APL-induced T cell anergy. Cell 1994; 79: 913-922
    • (1994) Cell , vol.79 , pp. 913-922
    • Sloan-Lancaster, J.1    Shaw, A.S.2    Rothbard, J.B.3    Allen, P.M.4
  • 25
    • 0031573513 scopus 로고    scopus 로고
    • Distinct biochemical signals characterize agonist- and altered peptide ligand-induced differentiation of naive CD4+ T cells into Th1 and Th2 subsets
    • Boutin Y, Leitenberg D, Tao X, Bottomly K: Distinct biochemical signals characterize agonist- and altered peptide ligand-induced differentiation of naive CD4+ T cells into Th1 and Th2 subsets. J Immunol 1997; 159: 5802-5809
    • (1997) J Immunol , vol.159 , pp. 5802-5809
    • Boutin, Y.1    Leitenberg, D.2    Tao, X.3    Bottomly, K.4
  • 26
    • 0032438551 scopus 로고    scopus 로고
    • High- and low-potency ligands with similar affinities for the TCR: The importance of kinetics in TCR signaling
    • Kersh GJ, Kersh EN, Fremont DH, Allen PM: High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling. Immunity 1998; 9: 817-826
    • (1998) Immunity , vol.9 , pp. 817-826
    • Kersh, G.J.1    Kersh, E.N.2    Fremont, D.H.3    Allen, P.M.4
  • 27
    • 0029933309 scopus 로고    scopus 로고
    • Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
    • Sloan-Lancaster J, Allen PM: Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu Rev Immunol 1996; 14: 1-27
    • (1996) Annu Rev Immunol , vol.14 , pp. 1-27
    • Sloan-Lancaster, J.1    Allen, P.M.2
  • 28
    • 0028025705 scopus 로고
    • Th2 cell clonal anergy as a consequence of partial activation
    • Sloan-Lancaster J, Evavold BD, Allen PM: Th2 cell clonal anergy as a consequence of partial activation. J Exp Med 1994; 180: 1195-1205
    • (1994) J Exp Med , vol.180 , pp. 1195-1205
    • Sloan-Lancaster, J.1    Evavold, B.D.2    Allen, P.M.3
  • 29
    • 0029952074 scopus 로고    scopus 로고
    • Selective activation of the calcium signaling pathway by altered peptide ligands
    • Sloan-Lancaster J, Steinberg TH, Allen PM: Selective activation of the calcium signaling pathway by altered peptide ligands. J Exp Med 1996; 184: 1525-1530
    • (1996) J Exp Med , vol.184 , pp. 1525-1530
    • Sloan-Lancaster, J.1    Steinberg, T.H.2    Allen, P.M.3
  • 30
    • 0032534567 scopus 로고    scopus 로고
    • Differential effects of CD28 engagement and IL-12 on T cell activation by altered peptide ligands
    • Ding L, Shevach EM: Differential effects of CD28 engagement and IL-12 on T cell activation by altered peptide ligands. J Immunol 1998; 161: 6614-6621
    • (1998) J Immunol , vol.161 , pp. 6614-6621
    • Ding, L.1    Shevach, E.M.2
  • 31
    • 0031665410 scopus 로고    scopus 로고
    • Altered peptide ligands and wild-type peptide induce indistinguishable responses of a human Th0 clone
    • van Bergen J, Koning F: Altered peptide ligands and wild-type peptide induce indistinguishable responses of a human Th0 clone. Eur J Immunol 1998; 28: 2801-2808
    • (1998) Eur J Immunol , vol.28 , pp. 2801-2808
    • Van Bergen, J.1    Koning, F.2
  • 32
    • 0034533497 scopus 로고    scopus 로고
    • Cytokine profile and T cell adhesiveness to endothelial selectins: In vivo induction by a myasthenogenic T cell epitope and immunomodulation by a dual altered peptide ligand
    • Faber-Elmann A, Grabovsky V, Dayan M, Sela M, Alon R, Mozes E: Cytokine profile and T cell adhesiveness to endothelial selectins: in vivo induction by a myasthenogenic T cell epitope and immunomodulation by a dual altered peptide ligand. Int Immunol 2000; 12: 1651-1658
    • (2000) Int Immunol , vol.12 , pp. 1651-1658
    • Faber-Elmann, A.1    Grabovsky, V.2    Dayan, M.3    Sela, M.4    Alon, R.5    Mozes, E.6
  • 33
    • 0029042507 scopus 로고
    • Differential activation of proliferation and cytotoxicity in human Tcell lymphotropic virus type i Tax-specific CD8 T cells by an altered peptide ligand
    • Hollsberg P, Weber WE, Dangond F, Batra V, Sette A, Hafler DA: Differential activation of proliferation and cytotoxicity in human Tcell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand. Proc Natl Acad Sci USA 1995; 92: 4036-4040
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4036-4040
    • Hollsberg, P.1    Weber, W.E.2    Dangond, F.3    Batra, V.4    Sette, A.5    Hafler, D.A.6
  • 34
    • 0031137616 scopus 로고    scopus 로고
    • Induction of IL-4-producing CD4+ T cells by antigenic peptides altered for TCR binding
    • Tao X, Grant C, Constant S, Bottomly K: Induction of IL-4-producing CD4+ T cells by antigenic peptides altered for TCR binding. J Immunol 1997; 158: 4237-4244
    • (1997) J Immunol , vol.158 , pp. 4237-4244
    • Tao, X.1    Grant, C.2    Constant, S.3    Bottomly, K.4
  • 35
    • 0028866978 scopus 로고
    • An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis
    • Nicholson LB, Greer JM, Sobel RA, Lees MB, Kuchroo VK: An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 1995; 3: 397-405
    • (1995) Immunity , vol.3 , pp. 397-405
    • Nicholson, L.B.1    Greer, J.M.2    Sobel, R.A.3    Lees, M.B.4    Kuchroo, V.K.5
  • 36
    • 0029961893 scopus 로고    scopus 로고
    • Structural basis for T cell recognition of altered peptide ligands: A single T cell receptor can productively recognize a large
    • continuum of related ligands
    • Kersh GJ, Allen PM: Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands. J Exp Med 1996; 184: 1259-1268
    • (1996) J Exp Med , vol.184 , pp. 1259-1268
    • Kersh, G.J.1    Allen, P.M.2
  • 37
    • 0027174663 scopus 로고
    • Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides
    • Evavold BD, Sloan-Lancaster J, Hsu BL, Allen PM: Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides. J Immunol 1993; 150: 3131-3140
    • (1993) J Immunol , vol.150 , pp. 3131-3140
    • Evavold, B.D.1    Sloan-Lancaster, J.2    Hsu, B.L.3    Allen, P.M.4
  • 39
    • 0028949199 scopus 로고
    • In vivo CTL induction with point-substituted ovalbumin peptides: Immunogenicity correlates with peptide-induced MHC class i stability
    • Lipford GB, Bauer S, Wagner H, Heeg K: In vivo CTL induction with point-substituted ovalbumin peptides: immunogenicity correlates with peptide-induced MHC class I stability. Vaccine 1995; 13: 313-320
    • (1995) Vaccine , vol.13 , pp. 313-320
    • Lipford, G.B.1    Bauer, S.2    Wagner, H.3    Heeg, K.4
  • 40
    • 0027983589 scopus 로고
    • Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues
    • Chen W, Khilko S, Fecondo J, Margulies DH, McCluskey J: Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues. J Exp Med 1994; 180: 1471-1483
    • (1994) J Exp Med , vol.180 , pp. 1471-1483
    • Chen, W.1    Khilko, S.2    Fecondo, J.3    Margulies, D.H.4    McCluskey, J.5
  • 42
    • 0030587077 scopus 로고    scopus 로고
    • Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A∗0201- binding residues
    • Parkhurst MR, Salgaller ML, Southwood S, Robbins PF, Sette A, Rosenberg SA, Kawakami Y: Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A∗0201- binding residues. J Immunol 1996; 157: 2539-2548
    • (1996) J Immunol , vol.157 , pp. 2539-2548
    • Parkhurst, M.R.1    Salgaller, M.L.2    Southwood, S.3    Robbins, P.F.4    Sette, A.5    Rosenberg, S.A.6    Kawakami, Y.7
  • 43
    • 17044415359 scopus 로고    scopus 로고
    • Increased immunogenicity of an anchor-modified tumor-associated antigen is due to the enhanced stability of the peptide/ MHC complex: Implications for vaccine design
    • Borbulevych OY, Baxter TK, Yu ZY, Restifo NP, Baker BM: Increased immunogenicity of an anchor-modified tumor-associated antigen is due to the enhanced stability of the peptide/ MHC complex: implications for vaccine design. J Immunol 2005; 174: 4812-4820
    • (2005) J Immunol , vol.174 , pp. 4812-4820
    • Borbulevych, O.Y.1    Baxter, T.K.2    Yu, Z.Y.3    Restifo, N.P.4    Baker, B.M.5
  • 44
    • 0037108364 scopus 로고    scopus 로고
    • Modification of a tumor-derived peptide at an HLAA2 anchor residue can alter the conformation of the MHC-peptide complex: Probing with TCR-like recombinant antibodies
    • Denkberg G, Klechevsky E, Reiter Y: Modification of a tumor-derived peptide at an HLAA2 anchor residue can alter the conformation of the MHC-peptide complex: probing with TCR-like recombinant antibodies. J Immunol 2002; 169: 4399-4407
    • (2002) J Immunol , vol.169 , pp. 4399-4407
    • Denkberg, G.1    Klechevsky, E.2    Reiter, Y.3
  • 46
    • 70350244535 scopus 로고    scopus 로고
    • Design of agonistic altered peptides for the robust induction of CTL directed towards H-2Db in complex with the melanoma-associated epitope gp100
    • van Stipdonk MJ, Badia-Martinez D, Sluijter M, Offringa R, van Hall T, Achour A: Design of agonistic altered peptides for the robust induction of CTL directed towards H-2Db in complex with the melanoma-associated epitope gp100. Cancer Res 2009; 69: 7784-7792
    • (2009) Cancer Res , vol.69 , pp. 7784-7792
    • Van Stipdonk, M.J.1    Badia-Martinez, D.2    Sluijter, M.3    Offringa, R.4    Van Hall, T.5    Achour, A.6
  • 48
    • 0028238668 scopus 로고
    • Specificity and flexibility in thymic selection
    • Jameson SC, Hogquist KA, Bevan MJ: Specificity and flexibility in thymic selection. Nature 1994; 369: 750-752
    • (1994) Nature , vol.369 , pp. 750-752
    • Jameson, S.C.1    Hogquist, K.A.2    Bevan, M.J.3
  • 50
    • 0028911484 scopus 로고
    • Modulation of T cell development by an endogenous altered peptide ligand
    • Hsu BL, Evavold BD, Allen PM: Modulation of T cell development by an endogenous altered peptide ligand. J Exp Med 1995; 181: 805-810
    • (1995) J Exp Med , vol.181 , pp. 805-810
    • Hsu, B.L.1    Evavold, B.D.2    Allen, P.M.3
  • 51
    • 84907222730 scopus 로고    scopus 로고
    • Cutting edge: CD8+ recent thymic emigrants exhibit increased responses to low-affinity ligands and improved access to peripheral sites of inflammation
    • Berkley AM, Fink PJ: Cutting edge: CD8+ recent thymic emigrants exhibit increased responses to low-affinity ligands and improved access to peripheral sites of inflammation. J Immunol 2014; 193: 3262-3266
    • (2014) J Immunol , vol.193 , pp. 3262-3266
    • Berkley, A.M.1    Fink, P.J.2
  • 53
    • 84942573021 scopus 로고    scopus 로고
    • APL-2, an altered peptide ligand derived from heat-shock protein 60, induces interleukin-10 in peripheral blood mononuclear cell derived from juvenile idiopathic arthritis patients and downregulates the inflammatory response in collagen-induced arthritis model
    • Lorenzo N, Cantera D, Barbera A, Alonso A, Chall E, Franco L, Ancizar J, Nunez Y, Altruda F, Silengo L, Padron G, Del Carmen Dominguez M: APL-2, an altered peptide ligand derived from heat-shock protein 60, induces interleukin-10 in peripheral blood mononuclear cell derived from juvenile idiopathic arthritis patients and downregulates the inflammatory response in collagen-induced arthritis model. Clin Exp Med 2015; 15: 31-39
    • (2015) Clin Exp Med , vol.15 , pp. 31-39
    • Lorenzo, N.1    Cantera, D.2    Barbera, A.3    Alonso, A.4    Chall, E.5    Franco, L.6    Ancizar, J.7    Nunez, Y.8    Altruda, F.9    Silengo, L.10    Padron, G.11    Del Carmen Dominguez, M.12
  • 54
    • 0035172568 scopus 로고    scopus 로고
    • An altered peptide ligand inhibits the activities of matrix metalloproteinase-and phospholipase C, and inhibits T cell interactions with VCAM-1 induced in vivo by a myasthenogenic T cell epitope
    • Faber-Elmann A, Grabovsky V, Dayan M, Sela M, Alon R, Mozes E: An altered peptide ligand inhibits the activities of matrix metalloproteinase-and phospholipase C, and inhibits T cell interactions with VCAM-1 induced in vivo by a myasthenogenic T cell epitope. FASEB J 2001; 15: 187-194
    • (2001) FASEB J , vol.15 , pp. 187-194
    • Faber-Elmann, A.1    Grabovsky, V.2    Dayan, M.3    Sela, M.4    Alon, R.5    Mozes, E.6
  • 55
    • 0035940454 scopus 로고    scopus 로고
    • The nature of the active suppression of responses associated with experimental autoimmune myasthenia gravis by a dual altered peptide ligand administered by different routes
    • Paas-Rozner M, Sela M, Mozes E: The nature of the active suppression of responses associated with experimental autoimmune myasthenia gravis by a dual altered peptide ligand administered by different routes. Proc Natl Acad Sci USA 2001; 98: 12642-12647
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12642-12647
    • Paas-Rozner, M.1    Sela, M.2    Mozes, E.3
  • 56
    • 0037974772 scopus 로고    scopus 로고
    • A dual altered peptide ligand down-regulates myasthenogenic T cell responses by up-regulating CD25- and CTLA-4-expressing CD4+ T cells
    • Paas-Rozner M, Sela M, Mozes E: A dual altered peptide ligand down-regulates myasthenogenic T cell responses by up-regulating CD25- and CTLA-4-expressing CD4+ T cells. Proc Natl Acad Sci USA 2003; 100: 6676-6681
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6676-6681
    • Paas-Rozner, M.1    Sela, M.2    Mozes, E.3
  • 57
    • 36849010574 scopus 로고    scopus 로고
    • The role of CD8+CD28 regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand
    • Ben-David H, Sharabi A, Dayan M, Sela M, Mozes E: The role of CD8+CD28 regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand. Proc Natl Acad Sci USA 2007; 104: 17459-17464
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 17459-17464
    • Ben-David, H.1    Sharabi, A.2    Dayan, M.3    Sela, M.4    Mozes, E.5
  • 58
    • 33845310844 scopus 로고    scopus 로고
    • A 50-kDa ERK-like protein is upregulated by a dual altered peptide ligand that suppresses myasthenia gravis-associated responses
    • Ben-David H, Aruna BV, Seger R, Sela M, Mozes E: A 50-kDa ERK-like protein is upregulated by a dual altered peptide ligand that suppresses myasthenia gravis-associated responses. Proc Natl Acad Sci USA 2006; 103: 18232-18237
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 18232-18237
    • Ben-David, H.1    Aruna, B.V.2    Seger, R.3    Sela, M.4    Mozes, E.5
  • 59
    • 13844321751 scopus 로고    scopus 로고
    • Down-regulation of myasthenogenic T cell responses by a dual altered peptide ligand via CD4+CD25+- regulated events leading to apoptosis
    • Ben-David H, Sela M, Mozes E: Down-regulation of myasthenogenic T cell responses by a dual altered peptide ligand via CD4+CD25+- regulated events leading to apoptosis. Proc Natl Acad Sci USA 2005; 102: 2028-2033
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 2028-2033
    • Ben-David, H.1    Sela, M.2    Mozes, E.3
  • 62
    • 0032557045 scopus 로고    scopus 로고
    • Dynamics of T-cell antagonism: Enhanced viral diversity and survival
    • Burroughs NJ, Rand DA: Dynamics of T-cell antagonism: enhanced viral diversity and survival. Proc Biol Sci 1998; 265: 529-535
    • (1998) Proc Biol Sci , vol.265 , pp. 529-535
    • Burroughs, N.J.1    Rand, D.A.2
  • 68
    • 0038107566 scopus 로고    scopus 로고
    • Cutting edge: The conversion of arginine to citrulline allows for a highaffinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1∗0401 MHC class II molecule
    • Hill JA, Southwood S, Sette A, Jevnikar AM, Bell DA, Cairns E: Cutting edge: the conversion of arginine to citrulline allows for a highaffinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1∗0401 MHC class II molecule. J Immunol 2003; 171: 538-541
    • (2003) J Immunol , vol.171 , pp. 538-541
    • Hill, J.A.1    Southwood, S.2    Sette, A.3    Jevnikar, A.M.4    Bell, D.A.5    Cairns, E.6
  • 70
    • 0142234077 scopus 로고    scopus 로고
    • Multiple sclerosis: An important role for post-translational modifications of myelin basic protein in pathogenesis
    • Kim JK, Mastronardi FG, Wood DD, Lubman DM, Zand R, Moscarello MA: Multiple sclerosis: an important role for post-translational modifications of myelin basic protein in pathogenesis. Mol Cell Proteomics 2003; 2: 453-462
    • (2003) Mol Cell Proteomics , vol.2 , pp. 453-462
    • Kim, J.K.1    Mastronardi, F.G.2    Wood, D.D.3    Lubman, D.M.4    Zand, R.5    Moscarello, M.A.6
  • 71
    • 33746214870 scopus 로고    scopus 로고
    • Cutting edge: Unique T cells that recognize citrullinated peptides are a feature of protein immunization
    • Ireland J, Herzog J, Unanue ER: Cutting edge: Unique T cells that recognize citrullinated peptides are a feature of protein immunization. J Immunol 2006; 177: 1421-1425
    • (2006) J Immunol , vol.177 , pp. 1421-1425
    • Ireland, J.1    Herzog, J.2    Unanue, E.R.3
  • 72
    • 0033600723 scopus 로고    scopus 로고
    • Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1α,25-dihydroxyvitamin D 3
    • Nakashima K, Hagiwara T, Ishigami A, Nagata S, Asaga H, Kuramoto M, Senshu T, Yamada M: Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1α,25-dihydroxyvitamin D 3 . J Biol Chem 1999; 274: 27786-27792
    • (1999) J Biol Chem , vol.274 , pp. 27786-27792
    • Nakashima, K.1    Hagiwara, T.2    Ishigami, A.3    Nagata, S.4    Asaga, H.5    Kuramoto, M.6    Senshu, T.7    Yamada, M.8
  • 73
    • 84855516226 scopus 로고    scopus 로고
    • Autophagy in antigen- presenting cells results in presentation of citrullinated peptides to CD4 T cells
    • Ireland JM, Unanue ER: Autophagy in antigen- presenting cells results in presentation of citrullinated peptides to CD4 T cells. J Exp Med 2011; 208: 2625-2632
    • (2011) J Exp Med , vol.208 , pp. 2625-2632
    • Ireland, J.M.1    Unanue, E.R.2
  • 74
    • 0026654253 scopus 로고
    • HLA class II alleles associated with celiac disease susceptibility in a southern European population
    • Tighe MR, Hall MA, Barbado M, Cardi E, Welsh KI, Ciclitira PJ: HLA class II alleles associated with celiac disease susceptibility in a southern European population. Tissue Antigens 1992; 40: 90-97
    • (1992) Tissue Antigens , vol.40 , pp. 90-97
    • Tighe, M.R.1    Hall, M.A.2    Barbado, M.3    Cardi, E.4    Welsh, K.I.5    Ciclitira, P.J.6
  • 75
    • 0024492512 scopus 로고
    • Evidence for a primary association of celiac disease to a particular HLA-DQ α/β heterodimer
    • Sollid LM, Markussen G, Ek J, Gjerde H, Vartdal F, Thorsby E: Evidence for a primary association of celiac disease to a particular HLA-DQ α/β heterodimer. J Exp Med 1989; 169: 345-350
    • (1989) J Exp Med , vol.169 , pp. 345-350
    • Sollid, L.M.1    Markussen, G.2    Ek, J.3    Gjerde, H.4    Vartdal, F.5    Thorsby, E.6
  • 76
    • 70649092298 scopus 로고    scopus 로고
    • Celiac disease: From pathogenesis to novel therapies
    • Schuppan D, Junker Y, Barisani D: Celiac disease: from pathogenesis to novel therapies. Gastroenterology 2009; 137: 1912-1933
    • (2009) Gastroenterology , vol.137 , pp. 1912-1933
    • Schuppan, D.1    Junker, Y.2    Barisani, D.3
  • 77
    • 0028556659 scopus 로고
    • T cells from the small intestinal mucosa of a DR4, DQ7/DR4, DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8
    • Lundin KE, Scott H, Fausa O, Thorsby E, Sollid LM: T cells from the small intestinal mucosa of a DR4, DQ7/DR4, DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8. Hum Immunol 1994; 41: 285-291
    • (1994) Hum Immunol , vol.41 , pp. 285-291
    • Lundin, K.E.1    Scott, H.2    Fausa, O.3    Thorsby, E.4    Sollid, L.M.5
  • 79
    • 65249178698 scopus 로고    scopus 로고
    • Transglutaminases in inflammation and fibrosis of the gastrointestinal tract and the liver
    • Elli L, Bergamini CM, Bardella MT, Schuppan D: Transglutaminases in inflammation and fibrosis of the gastrointestinal tract and the liver. Dig Liver Dis 2009; 41: 541-550
    • (2009) Dig Liver Dis , vol.41 , pp. 541-550
    • Elli, L.1    Bergamini, C.M.2    Bardella, M.T.3    Schuppan, D.4
  • 80
    • 0026338017 scopus 로고
    • Transglutaminases: Multifunctional crosslinking enzymes that stabilize tissues
    • Greenberg CS, Birckbichler PJ, Rice RH: Transglutaminases: multifunctional crosslinking enzymes that stabilize tissues. FASEB J 1991; 5: 3071-3077
    • (1991) FASEB J , vol.5 , pp. 3071-3077
    • Greenberg, C.S.1    Birckbichler, P.J.2    Rice, R.H.3
  • 81
    • 0021969767 scopus 로고
    • Human jejunal transglutaminase: Demonstration of activity, enzyme kinetics and substrate specificity with special relation to gliadin and coeliac disease
    • Bruce SE, Bjarnason I, Peters TJ: Human jejunal transglutaminase: demonstration of activity, enzyme kinetics and substrate specificity with special relation to gliadin and coeliac disease. Clin Sci (Lond) 1985; 68: 573-579
    • (1985) Clin Sci (Lond) , vol.68 , pp. 573-579
    • Bruce, S.E.1    Bjarnason, I.2    Peters, T.J.3
  • 82
    • 0030877557 scopus 로고    scopus 로고
    • Gliadin specific, HLA DQ2- restricted T cells are commonly found in small intestinal biopsies from coeliac disease patients, but not from controls
    • Molberg O, Kett K, Scott H, Thorsby E, Sollid LM, Lundin KE: Gliadin specific, HLA DQ2- restricted T cells are commonly found in small intestinal biopsies from coeliac disease patients, but not from controls. Scand J Immunol 1997; 46: 103-109
    • (1997) Scand J Immunol , vol.46 , pp. 103-109
    • Molberg, O.1    Kett, K.2    Scott, H.3    Thorsby, E.4    Sollid, L.M.5    Lundin, K.E.6
  • 83
    • 0027319208 scopus 로고
    • Gliadin-specific, HLA-DQ(α1∗0501,β1∗0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients
    • Lundin KE, Scott H, Hansen T, Paulsen G, Halstensen TS, Fausa O, Thorsby E, Sollid LM: Gliadin-specific, HLA-DQ(α1∗0501,β1∗0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med 1993; 178: 187-196
    • (1993) J Exp Med , vol.178 , pp. 187-196
    • Lundin, K.E.1    Scott, H.2    Hansen, T.3    Paulsen, G.4    Halstensen, T.S.5    Fausa, O.6    Thorsby, E.7    Sollid, L.M.8
  • 84
    • 0032528813 scopus 로고    scopus 로고
    • Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity
    • van de Wal Y, Kooy Y, van Veelen P, Pena S, Mearin L, Papadopoulos G, Koning F: Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity. J Immunol 1998; 161: 1585-1588
    • (1998) J Immunol , vol.161 , pp. 1585-1588
    • Van De Wal, Y.1    Kooy, Y.2    Van Veelen, P.3    Pena, S.4    Mearin, L.5    Papadopoulos, G.6    Koning, F.7
  • 89
    • 1642447710 scopus 로고    scopus 로고
    • Structural basis for HLA-DQ2- mediated presentation of gluten epitopes in celiac disease
    • Kim CY, Quarsten H, Bergseng E, Khosla C, Sollid LM: Structural basis for HLA-DQ2- mediated presentation of gluten epitopes in celiac disease. Proc Natl Acad Sci USA 2004; 101: 4175-4179
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4175-4179
    • Kim, C.Y.1    Quarsten, H.2    Bergseng, E.3    Khosla, C.4    Sollid, L.M.5
  • 91
    • 0037072829 scopus 로고    scopus 로고
    • Gliadin T cell epitope selection by tissue transglutaminase in celiac disease: Role of enzyme specificity and pH influence on the transamidation versus deamidation process
    • Fleckenstein B, Molberg O, Qiao SW, Schmid DG, von der Mulbe F, Elgstoen K, Jung G, Sollid LM: Gliadin T cell epitope selection by tissue transglutaminase in celiac disease: role of enzyme specificity and pH influence on the transamidation versus deamidation process. J Biol Chem 2002; 277: 34109-34116
    • (2002) J Biol Chem , vol.277 , pp. 34109-34116
    • Fleckenstein, B.1    Molberg, O.2    Qiao, S.W.3    Schmid, D.G.4    Von Der Mulbe, F.5    Elgstoen, K.6    Jung, G.7    Sollid, L.M.8
  • 92
    • 0034066695 scopus 로고    scopus 로고
    • In vivo antigen challenge in celiac disease identifies a single transglutaminase- modified peptide as the dominant A-gliadin T-cell epitope
    • Anderson RP, Degano P, Godkin AJ, Jewell DP, Hill AV: In vivo antigen challenge in celiac disease identifies a single transglutaminase- modified peptide as the dominant A-gliadin T-cell epitope. Nat Med 2000; 6: 337-342
    • (2000) Nat Med , vol.6 , pp. 337-342
    • Anderson, R.P.1    Degano, P.2    Godkin, A.J.3    Jewell, D.P.4    Hill, A.V.5
  • 94
    • 3242801934 scopus 로고    scopus 로고
    • Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion
    • Qiao SW, Bergseng E, Molberg O, Xia J, Fleckenstein B, Khosla C, Sollid LM: Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion. J Immunol 2004; 173: 1757-1762
    • (2004) J Immunol , vol.173 , pp. 1757-1762
    • Qiao, S.W.1    Bergseng, E.2    Molberg, O.3    Xia, J.4    Fleckenstein, B.5    Khosla, C.6    Sollid, L.M.7
  • 95
    • 15544376625 scopus 로고    scopus 로고
    • Equilibrium and kinetic analysis of the unusual binding behavior of a highly immunogenic gluten peptide to HLA-DQ2
    • Xia J, Sollid LM, Khosla C: Equilibrium and kinetic analysis of the unusual binding behavior of a highly immunogenic gluten peptide to HLA-DQ2. Biochemistry 2005; 44: 4442-4449
    • (2005) Biochemistry , vol.44 , pp. 4442-4449
    • Xia, J.1    Sollid, L.M.2    Khosla, C.3
  • 96
    • 33244472849 scopus 로고    scopus 로고
    • Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from α2-gliadin
    • Xia J, Siegel M, Bergseng E, Sollid LM, Khosla C: Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from α2-gliadin. J Am Chem Soc 2006; 128: 1859-1867
    • (2006) J Am Chem Soc , vol.128 , pp. 1859-1867
    • Xia, J.1    Siegel, M.2    Bergseng, E.3    Sollid, L.M.4    Khosla, C.5
  • 97
    • 0034684676 scopus 로고    scopus 로고
    • Phosphorylated peptides are naturally processed and presented by major histocompatibility complex class i molecules in vivo
    • Zarling AL, Ficarro SB, White FM, Shabanowitz J, Hunt DF, Engelhard VH: Phosphorylated peptides are naturally processed and presented by major histocompatibility complex class I molecules in vivo. J Exp Med 2000; 192: 1755-1762
    • (2000) J Exp Med , vol.192 , pp. 1755-1762
    • Zarling, A.L.1    Ficarro, S.B.2    White, F.M.3    Shabanowitz, J.4    Hunt, D.F.5    Engelhard, V.H.6
  • 98
    • 0038107581 scopus 로고    scopus 로고
    • Cutting edge: MHC class II-restricted peptides containing the inflammation- associated marker 3-nitrotyrosine evade central tolerance and elicit a robust cellmediated immune response
    • Birnboim HC, Lemay AM, Lam DK, Goldstein R, Webb JR: Cutting edge: MHC class II-restricted peptides containing the inflammation- associated marker 3-nitrotyrosine evade central tolerance and elicit a robust cellmediated immune response. J Immunol 2003; 171: 528-532
    • (2003) J Immunol , vol.171 , pp. 528-532
    • Birnboim, H.C.1    Lemay, A.M.2    Lam, D.K.3    Goldstein, R.4    Webb, J.R.5
  • 99
    • 0035451422 scopus 로고    scopus 로고
    • Monomorphic molecules function as additional recognition structures on haptenated target cells for HLA-A1-restricted, hapten-specific CTL
    • Stockl J, Majdic O, Fischer G, Maurer D, Knapp W: Monomorphic molecules function as additional recognition structures on haptenated target cells for HLA-A1-restricted, hapten-specific CTL. J Immunol 2001; 167: 2724-2733
    • (2001) J Immunol , vol.167 , pp. 2724-2733
    • Stockl, J.1    Majdic, O.2    Fischer, G.3    Maurer, D.4    Knapp, W.5
  • 100
    • 20344391931 scopus 로고    scopus 로고
    • Activated antigen-presenting cells select and present chemically modified peptides recognized by unique CD4 T cells
    • Herzog J, Maekawa Y, Cirrito TP, Illian BS, Unanue ER: Activated antigen-presenting cells select and present chemically modified peptides recognized by unique CD4 T cells. Proc Natl Acad Sci USA 2005; 102: 7928-7933
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 7928-7933
    • Herzog, J.1    Maekawa, Y.2    Cirrito, T.P.3    Illian, B.S.4    Unanue, E.R.5
  • 101
    • 3042663180 scopus 로고    scopus 로고
    • T lymphocyte-mediated immune responses to chemical haptens and metal ions: Implications for allergic and autoimmune disease
    • Martin SF: T lymphocyte-mediated immune responses to chemical haptens and metal ions: implications for allergic and autoimmune disease. Int Arch Allergy Immunol 2004; 134: 186-198
    • (2004) Int Arch Allergy Immunol , vol.134 , pp. 186-198
    • Martin, S.F.1
  • 103
    • 84946751276 scopus 로고    scopus 로고
    • Drug hypersensitivity: How drugs stimulate T cells via pharmacological interaction with immune receptors
    • Pichler WJ, Adam J, Watkins S, Wuillemin N, Yun J, Yerly D: Drug hypersensitivity: how drugs stimulate T cells via pharmacological interaction with immune receptors. Int Arch Allergy Immunol 2015; 168: 13-24
    • (2015) Int Arch Allergy Immunol , vol.168 , pp. 13-24
    • Pichler, W.J.1    Adam, J.2    Watkins, S.3    Wuillemin, N.4    Yun, J.5    Yerly, D.6
  • 104
    • 0035122749 scopus 로고    scopus 로고
    • Clonal anergy induced in a CD8+ hapten-specific cytotoxic T-cell clone by an altered hapten-peptide ligand
    • Preckel T, Hellwig S, Pflugfelder U, Lappin MB, Weltzien HU: Clonal anergy induced in a CD8+ hapten-specific cytotoxic T-cell clone by an altered hapten-peptide ligand. Immunology 2001; 102: 8-14
    • (2001) Immunology , vol.102 , pp. 8-14
    • Preckel, T.1    Hellwig, S.2    Pflugfelder, U.3    Lappin, M.B.4    Weltzien, H.U.5
  • 105
    • 0031739790 scopus 로고    scopus 로고
    • Partial agonism and independent modulation of T cell receptor and CD8 in hapten-specific cytotoxic T cells
    • Preckel T, Breloer M, Kohler H, von Bonin A, Weltzien HU: Partial agonism and independent modulation of T cell receptor and CD8 in hapten-specific cytotoxic T cells. Eur J Immunol 1998; 28: 3706-3718
    • (1998) Eur J Immunol , vol.28 , pp. 3706-3718
    • Preckel, T.1    Breloer, M.2    Kohler, H.3    Von Bonin, A.4    Weltzien, H.U.5
  • 106
    • 0029937756 scopus 로고    scopus 로고
    • Complexes generated by the binding of free peptides to class II MHC molecules are antigenically diverse compared with those generated by intracellular processing
    • Viner NJ, Nelson CA, Deck B, Unanue ER: Complexes generated by the binding of free peptides to class II MHC molecules are antigenically diverse compared with those generated by intracellular processing. J Immunol 1996; 156: 2365-2368
    • (1996) J Immunol , vol.156 , pp. 2365-2368
    • Viner, N.J.1    Nelson, C.A.2    Deck, B.3    Unanue, E.R.4
  • 107
    • 0028986855 scopus 로고
    • Identification of a major I-Ek-restricted determinant of hen egg lysozyme: Limitations of lymph node proliferation studies in defining immunodominance and crypticity
    • Viner NJ, Nelson CA, Unanue ER: Identification of a major I-Ek-restricted determinant of hen egg lysozyme: limitations of lymph node proliferation studies in defining immunodominance and crypticity. Proc Natl Acad Sci USA 1995; 92: 2214-2218
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2214-2218
    • Viner, N.J.1    Nelson, C.A.2    Unanue, E.R.3
  • 108
    • 0035873184 scopus 로고    scopus 로고
    • Cutting edge: A single MHC anchor residue alters the conformation of a peptide-MHC complex inducing T cells that survive negative selection
    • Peterson DA, DiPaolo RJ, Kanagawa O, Unanue ER: Cutting edge: a single MHC anchor residue alters the conformation of a peptide-MHC complex inducing T cells that survive negative selection. J Immunol 2001; 166: 5874-5877
    • (2001) J Immunol , vol.166 , pp. 5874-5877
    • Peterson, D.A.1    DiPaolo, R.J.2    Kanagawa, O.3    Unanue, E.R.4
  • 109
    • 0033213226 scopus 로고    scopus 로고
    • Quantitative analysis of the T cell repertoire that escapes negative selection
    • Peterson DA, DiPaolo RJ, Kanagawa O, Unanue ER: Quantitative analysis of the T cell repertoire that escapes negative selection. Immunity 1999; 11: 453-462
    • (1999) Immunity , vol.11 , pp. 453-462
    • Peterson, D.A.1    DiPaolo, R.J.2    Kanagawa, O.3    Unanue, E.R.4
  • 110
    • 30044446973 scopus 로고    scopus 로고
    • The wide diversity and complexity of peptides bound to class II MHC molecules
    • Suri A, Lovitch SB, Unanue ER: The wide diversity and complexity of peptides bound to class II MHC molecules. Curr Opin Immunol 2006; 18: 70-77
    • (2006) Curr Opin Immunol , vol.18 , pp. 70-77
    • Suri, A.1    Lovitch, S.B.2    Unanue, E.R.3
  • 111
    • 0025826118 scopus 로고
    • MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding
    • Germain RN, Hendrix LR: MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding. Nature 1991; 353: 134-139
    • (1991) Nature , vol.353 , pp. 134-139
    • Germain, R.N.1    Hendrix, L.R.2
  • 112
    • 0026583941 scopus 로고
    • Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes
    • Neefjes JJ, Ploegh HL: Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes. EMBO J 1992; 11: 411-416
    • (1992) EMBO J , vol.11 , pp. 411-416
    • Neefjes, J.J.1    Ploegh, H.L.2
  • 113
    • 0030451002 scopus 로고    scopus 로고
    • Distinct antigen MHC class II complexes generated by separate processing pathways
    • Lindner R, Unanue ER: Distinct antigen MHC class II complexes generated by separate processing pathways. EMBO J 1996; 15: 6910-6920
    • (1996) EMBO J , vol.15 , pp. 6910-6920
    • Lindner, R.1    Unanue, E.R.2
  • 114
    • 0035886947 scopus 로고    scopus 로고
    • Deamidation of asparagine in a major histocompatibility complex-bound peptide affects T cell recognition but does not explain type B reactivity
    • Cirrito TP, Pu Z, Deck MB, Unanue ER: Deamidation of asparagine in a major histocompatibility complex-bound peptide affects T cell recognition but does not explain type B reactivity. J Exp Med 2001; 194: 1165-1170
    • (2001) J Exp Med , vol.194 , pp. 1165-1170
    • Cirrito, T.P.1    Pu, Z.2    Deck, M.B.3    Unanue, E.R.4
  • 116
    • 0026034448 scopus 로고
    • Segregation of MHC class II molecules from MHC class i molecules in the Golgi complex for transport to lysosomal compartments
    • Peters PJ, Neefjes JJ, Oorschot V, Ploegh HL, Geuze HJ: Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments. Nature 1991; 349: 669-676
    • (1991) Nature , vol.349 , pp. 669-676
    • Peters, P.J.1    Neefjes, J.J.2    Oorschot, V.3    Ploegh, H.L.4    Geuze, H.J.5
  • 117
    • 0029449012 scopus 로고
    • Intracellular organelles involved in antigen processing and the binding of peptides to class II MHC molecules
    • Harding CV: Intracellular organelles involved in antigen processing and the binding of peptides to class II MHC molecules. Semin Immunol 1995; 7: 355-360
    • (1995) Semin Immunol , vol.7 , pp. 355-360
    • Harding, C.V.1
  • 118
    • 0037169536 scopus 로고    scopus 로고
    • Ligand exchange of major histocompatibility complex class II proteins is triggered by H-bond donor groups of small molecules
    • Falk K, Lau JM, Santambrogio L, Esteban VM, Puentes F, Rotzschke O, Strominger JL: Ligand exchange of major histocompatibility complex class II proteins is triggered by H-bond donor groups of small molecules. J Biol Chem 2002; 277: 2709-2715
    • (2002) J Biol Chem , vol.277 , pp. 2709-2715
    • Falk, K.1    Lau, J.M.2    Santambrogio, L.3    Esteban, V.M.4    Puentes, F.5    Rotzschke, O.6    Strominger, J.L.7
  • 123
    • 9644262504 scopus 로고    scopus 로고
    • Neuraminidase inhibitor-rimantadine combinations exert additive and synergistic anti-influenza virus effects in MDCK cells
    • Govorkova EA, Fang HB, Tan M, Webster RG: Neuraminidase inhibitor-rimantadine combinations exert additive and synergistic anti-influenza virus effects in MDCK cells. Antimicrob Agents Chemother 2004; 48: 4855-4863
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 4855-4863
    • Govorkova, E.A.1    Fang, H.B.2    Tan, M.3    Webster, R.G.4
  • 124
    • 49449093199 scopus 로고    scopus 로고
    • Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel
    • Jing X, Ma C, Ohigashi Y, Oliveira FA, Jardetzky TS, Pinto LH, Lamb RA: Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel. Proc Natl Acad Sci USA 2008; 105: 10967-10972
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 10967-10972
    • Jing, X.1    Ma, C.2    Ohigashi, Y.3    Oliveira, F.A.4    Jardetzky, T.S.5    Pinto, L.H.6    Lamb, R.A.7
  • 126
    • 0037777695 scopus 로고    scopus 로고
    • 1-[[(3-hydroxy- 1-adamantyl)amino]acetyl]-2-cyano-(S)- pyrrolidine: A potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties
    • Villhauer EB, Brinkman JA, Naderi GB, Burkey BF, Dunning BE, Prasad K, Mangold BL, Russell ME, Hughes TE: 1-[[(3-hydroxy- 1-adamantyl)amino]acetyl]-2-cyano-(S)- pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. J Med Chem 2003; 46: 2774-2789
    • (2003) J Med Chem , vol.46 , pp. 2774-2789
    • Villhauer, E.B.1    Brinkman, J.A.2    Naderi, G.B.3    Burkey, B.F.4    Dunning, B.E.5    Prasad, K.6    Mangold, B.L.7    Russell, M.E.8    Hughes, T.E.9
  • 128
    • 0142039133 scopus 로고    scopus 로고
    • Degradation of endomorphin-2 at the supraspinal level in mice is initiated by dipeptidyl peptidase IV: An in vitro and in vivo study
    • Sakurada C, Sakurada S, Hayashi T, Katsuyama S, Tan-No K, Sakurada T: Degradation of endomorphin-2 at the supraspinal level in mice is initiated by dipeptidyl peptidase IV: an in vitro and in vivo study. Biochem Pharmacol 2003; 66: 653-661
    • (2003) Biochem Pharmacol , vol.66 , pp. 653-661
    • Sakurada, C.1    Sakurada, S.2    Hayashi, T.3    Katsuyama, S.4    Tan-No, K.5    Sakurada, T.6
  • 131
    • 84902174395 scopus 로고    scopus 로고
    • Class II MHC/peptide interaction in Leishmania donovani infection: Implications in vaccine design
    • Roy K, Naskar K, Ghosh M, Roy S: Class II MHC/peptide interaction in Leishmania donovani infection: implications in vaccine design. J Immunol 2014; 192: 5873-5880
    • (2014) J Immunol , vol.192 , pp. 5873-5880
    • Roy, K.1    Naskar, K.2    Ghosh, M.3    Roy, S.4
  • 132
    • 21344438163 scopus 로고    scopus 로고
    • Bet v 1142-156 is the dominant T-cell epitope of the major birch pollen allergen and important for cross-reactivity with Bet v 1-related food allergens
    • Jahn-Schmid B, Radakovics A, Luttkopf D, Scheurer S, Vieths S, Ebner C, Bohle B: Bet v 1142-156 is the dominant T-cell epitope of the major birch pollen allergen and important for cross-reactivity with Bet v 1-related food allergens. J Allergy Clin Immunol 2005; 116: 213-219
    • (2005) J Allergy Clin Immunol , Issue.116 , pp. 213-219
    • Jahn-Schmid, B.1    Radakovics, A.2    Luttkopf, D.3    Scheurer, S.4    Vieths, S.5    Ebner, C.6    Bohle, B.7
  • 135
    • 84958156022 scopus 로고    scopus 로고
    • Classification of food allergens and cross-reactivity
    • Kazatsky AM, Wood RA: Classification of food allergens and cross-reactivity. Curr Allergy Asthma Rep 2016; 16: 22
    • (2016) Curr Allergy Asthma Rep , vol.16 , pp. 22
    • Kazatsky, A.M.1    Wood, R.A.2
  • 138
    • 84964316508 scopus 로고    scopus 로고
    • Cross-reactivity between major IgE core epitopes on Cry j 2 allergen of Japanese cedar pollen and relevant sequences on Cha o 2 allergen of Japanese cypress pollen
    • Miyaji K, Okamoto N, Saito A, Yasueda H, Takase Y, Shimakura H, Saito S, Sakaguchi M: Cross-reactivity between major IgE core epitopes on Cry j 2 allergen of Japanese cedar pollen and relevant sequences on Cha o 2 allergen of Japanese cypress pollen. Allergol Int 2016; 65: 286-292
    • (2016) Allergol Int , vol.65 , pp. 286-292
    • Miyaji, K.1    Okamoto, N.2    Saito, A.3    Yasueda, H.4    Takase, Y.5    Shimakura, H.6    Saito, S.7    Sakaguchi, M.8
  • 140
    • 0025104087 scopus 로고
    • Birch pollen allergy in relation with hypersensitivity for various kinds of fruit
    • Wuthrich B: Birch pollen allergy in relation with hypersensitivity for various kinds of fruit. Hautarzt 1990; 41: 583-584
    • (1990) Hautarzt , vol.41 , pp. 583-584
    • Wuthrich, B.1
  • 141
    • 0025123722 scopus 로고
    • Celery allergy associated with birch and mugwort pollinosis
    • Wuthrich B, Stager J, Johansson SG: Celery allergy associated with birch and mugwort pollinosis. Allergy 1990; 45: 566-571
    • (1990) Allergy , vol.45 , pp. 566-571
    • Wuthrich, B.1    Stager, J.2    Johansson, S.G.3
  • 142
    • 0036858612 scopus 로고    scopus 로고
    • Severe oral allergy syndrome and anaphylactic reactions caused by a Bet v 1- related PR-10 protein in soybean, SAM22
    • Kleine-Tebbe J, Vogel L, Crowell DN, Haustein UF, Vieths S: Severe oral allergy syndrome and anaphylactic reactions caused by a Bet v 1- related PR-10 protein in soybean, SAM22. J Allergy Clin Immunol 2002; 110: 797-804
    • (2002) J Allergy Clin Immunol , vol.110 , pp. 797-804
    • Kleine-Tebbe, J.1    Vogel, L.2    Crowell, D.N.3    Haustein, U.F.4    Vieths, S.5
  • 143
    • 0029028998 scopus 로고
    • Identification of allergens in fruits and vegetables: IgE cross-reactivities with the important birch pollen allergens Bet v 1 and Bet v 2 (birch profilin)
    • Ebner C, Hirschwehr R, Bauer L, Breiteneder H, Valenta R, Ebner H, Kraft D, Scheiner O: Identification of allergens in fruits and vegetables: IgE cross-reactivities with the important birch pollen allergens Bet v 1 and Bet v 2 (birch profilin). J Allergy Clin Immunol 1995; 95: 962-969
    • (1995) J Allergy Clin Immunol , vol.95 , pp. 962-969
    • Ebner, C.1    Hirschwehr, R.2    Bauer, L.3    Breiteneder, H.4    Valenta, R.5    Ebner, H.6    Kraft, D.7    Scheiner, O.8
  • 145
    • 0346121482 scopus 로고    scopus 로고
    • Bet v 1, the major birch pollen allergen, initiates sensitization to Api g 1, the major allergen in celery: Evidence at the T cell level
    • Bohle B, Radakovics A, Jahn-Schmid B, Hoffmann-Sommergruber K, Fischer GF, Ebner C: Bet v 1, the major birch pollen allergen, initiates sensitization to Api g 1, the major allergen in celery: evidence at the T cell level. Eur J Immunol 2003; 33: 3303-3310
    • (2003) Eur J Immunol , vol.33 , pp. 3303-3310
    • Bohle, B.1    Radakovics, A.2    Jahn-Schmid, B.3    Hoffmann-Sommergruber, K.4    Fischer, G.F.5    Ebner, C.6
  • 146
    • 28444434882 scopus 로고    scopus 로고
    • Characterization of the T cell response to the major hazelnut allergen, Cor a 1.04: Evidence for a relevant T cell epitope not cross-reactive with homologous pollen allergens
    • Bohle B, Radakovics A, Luttkopf D, Jahn- Schmid B, Vieths S, Ebner C: Characterization of the T cell response to the major hazelnut allergen, Cor a 1.04: evidence for a relevant T cell epitope not cross-reactive with homologous pollen allergens. Clin Exp Allergy 2005; 35: 1392-1399
    • (2005) Clin Exp Allergy , vol.35 , pp. 1392-1399
    • Bohle, B.1    Radakovics, A.2    Luttkopf, D.3    Jahn-Schmid, B.4    Vieths, S.5    Ebner, C.6
  • 147
    • 28444461434 scopus 로고    scopus 로고
    • Gastrointestinal digestion of Bet v 1-homologous food allergens destroys their mediator- releasing, but not T cell-activating, capacity
    • Schimek EM, Zwolfer B, Briza P, Jahn- Schmid B, Vogel L, Vieths S, Ebner C, Bohle B: Gastrointestinal digestion of Bet v 1-homologous food allergens destroys their mediator- releasing, but not T cell-activating, capacity. J Allergy Clin Immunol 2005; 116: 1327-1333
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 1327-1333
    • Schimek, E.M.1    Zwolfer, B.2    Briza, P.3    Jahn-Schmid, B.4    Vogel, L.5    Vieths, S.6    Ebner, C.7    Bohle, B.8
  • 148
    • 0030023918 scopus 로고    scopus 로고
    • Single amino acid substitutions on a Japanese cedar pollen allergen (Cry j 1)-derived peptide induced alterations in human T cell responses and T cell receptor antagonism
    • Ikagawa S, Matsushita S, Chen YZ, Ishikawa T, Nishimura Y: Single amino acid substitutions on a Japanese cedar pollen allergen (Cry j 1)-derived peptide induced alterations in human T cell responses and T cell receptor antagonism. J Allergy Clin Immunol 1996; 97: 53-64
    • (1996) J Allergy Clin Immunol , vol.97 , pp. 53-64
    • Ikagawa, S.1    Matsushita, S.2    Chen, Y.Z.3    Ishikawa, T.4    Nishimura, Y.5
  • 149
    • 0031978320 scopus 로고    scopus 로고
    • Antagonistic peptides specifically inhibit proliferation, cytokine production, CD40L expression, and help for IgE synthesis by der p 1-specific human T-cell clones
    • Fasler S, Aversa G, de Vries JE, Yssel H: Antagonistic peptides specifically inhibit proliferation, cytokine production, CD40L expression, and help for IgE synthesis by Der p 1-specific human T-cell clones. J Allergy Clin Immunol 1998; 101: 521-530
    • (1998) J Allergy Clin Immunol , vol.101 , pp. 521-530
    • Fasler, S.1    Aversa, G.2    De Vries, J.E.3    Yssel, H.4
  • 154
    • 0033083289 scopus 로고    scopus 로고
    • An altered peptide ligand specifically inhibits Th2 cytokine synthesis by abrogating TCR signaling
    • Faith A, Akdis CA, Akdis M, Joss A, Wymann D, Blaser K: An altered peptide ligand specifically inhibits Th2 cytokine synthesis by abrogating TCR signaling. J Immunol 1999; 162: 1836-1842
    • (1999) J Immunol , vol.162 , pp. 1836-1842
    • Faith, A.1    Akdis, C.A.2    Akdis, M.3    Joss, A.4    Wymann, D.5    Blaser, K.6
  • 156
    • 0025791940 scopus 로고
    • Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation
    • DeSilva DR, Urdahl KB, Jenkins MK: Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation. J Immunol 1991; 147: 3261-3267
    • (1991) J Immunol , vol.147 , pp. 3261-3267
    • DeSilva, D.R.1    Urdahl, K.B.2    Jenkins, M.K.3
  • 159
    • 0034650788 scopus 로고    scopus 로고
    • Modulation of Th2 responses by peptide analogues in a murine model of allergic asthma: Amelioration or deterioration of the disease process depends on the Th1 or Th2 skewing characteristics of the therapeutic peptide
    • Janssen EM, van Oosterhout AJ, van Rensen AJ, van Eden W, Nijkamp FP, Wauben MH: Modulation of Th2 responses by peptide analogues in a murine model of allergic asthma: amelioration or deterioration of the disease process depends on the Th1 or Th2 skewing characteristics of the therapeutic peptide. J Immunol 2000; 164: 580-588
    • (2000) J Immunol , vol.164 , pp. 580-588
    • Janssen, E.M.1    Van Oosterhout, A.J.2    Van Rensen, A.J.3    Van Eden, W.4    Nijkamp, F.P.5    Wauben, M.H.6
  • 160
    • 79955478697 scopus 로고    scopus 로고
    • Immunotherapy with peptides
    • Moldaver D, Larche M: Immunotherapy with peptides. Allergy 2011; 66: 784-791
    • (2011) Allergy , vol.66 , pp. 784-791
    • Moldaver, D.1    Larche, M.2
  • 162
    • 84895162089 scopus 로고    scopus 로고
    • Amelioration of ovalbumin-induced allergic airway disease following der p 1 peptide immunotherapy is not associated with induction of IL-35
    • Moldaver DM, Bharhani MS, Wattie JN, Ellis R, Neighbour H, Lloyd CM, Inman MD, Larche M: Amelioration of ovalbumin-induced allergic airway disease following Der p 1 peptide immunotherapy is not associated with induction of IL-35. Mucosal Immunol 2014; 7: 379-390
    • (2014) Mucosal Immunol , vol.7 , pp. 379-390
    • Moldaver, D.M.1    Bharhani, M.S.2    Wattie, J.N.3    Ellis, R.4    Neighbour, H.5    Lloyd, C.M.6    Inman, M.D.7    Larche, M.8
  • 163
    • 0027323846 scopus 로고
    • Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d i
    • Briner TJ, Kuo MC, Keating KM, Rogers BL, Greenstein JL: Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d I. Proc Natl Acad Sci USA 1993; 90: 7608-7612
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7608-7612
    • Briner, T.J.1    Kuo, M.C.2    Keating, K.M.3    Rogers, B.L.4    Greenstein, J.L.5
  • 165
    • 0028900679 scopus 로고
    • Parameters controlling the programmed death of mature mouse T lymphocytes in high-dose suppression
    • Critchfield JM, Zuniga-Pflucker JC, Lenardo MJ: Parameters controlling the programmed death of mature mouse T lymphocytes in high-dose suppression. Cell Immunol 1995; 160: 71-78
    • (1995) Cell Immunol , vol.160 , pp. 71-78
    • Critchfield, J.M.1    Zuniga-Pflucker, J.C.2    Lenardo, M.J.3
  • 166
    • 1042266493 scopus 로고    scopus 로고
    • High dose allergen stimulation of T cells from house dust mite-allergic subjects induces expansion of IFN-γ+ T cells, apoptosis of CD4+IL-4+ T cells and T cell anergy
    • Gardner LM, O'Hehir RE, Rolland JM: High dose allergen stimulation of T cells from house dust mite-allergic subjects induces expansion of IFN-γ+ T cells, apoptosis of CD4+IL-4+ T cells and T cell anergy. Int Arch Allergy Immunol 2004; 133: 1-13
    • (2004) Int Arch Allergy Immunol , vol.133 , pp. 1-13
    • Gardner, L.M.1    O'Hehir, R.E.2    Rolland, J.M.3
  • 169
    • 17644401678 scopus 로고    scopus 로고
    • Peptide-based therapeutic vaccines for allergic and autoimmune diseases
    • Larche M, Wraith DC: Peptide-based therapeutic vaccines for allergic and autoimmune diseases. Nat Med 2005; 11:S69-S76
    • (2005) Nat Med , vol.11 , pp. S69-S76
    • Larche, M.1    Wraith, D.C.2
  • 170
    • 0031054483 scopus 로고    scopus 로고
    • Modulation of the allergic immune response in BALB/c mice by subcutaneous injection of high doses of the dominant T cell epitope from the major birch pollen allergen Bet v 1
    • Bauer L, Bohle B, Jahn-Schmid B, Wiedermann U, Daser A, Renz H, Kraft D, Ebner C: Modulation of the allergic immune response in BALB/c mice by subcutaneous injection of high doses of the dominant T cell epitope from the major birch pollen allergen Bet v 1. Clin Exp Immunol 1997; 107: 536-541
    • (1997) Clin Exp Immunol , Issue.107 , pp. 536-541
    • Bauer, L.1    Bohle, B.2    Jahn-Schmid, B.3    Wiedermann, U.4    Daser, A.5    Renz, H.6    Kraft, D.7    Ebner, C.8
  • 171
    • 0027451437 scopus 로고
    • Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice
    • Hoyne GF, O'Hehir RE, Wraith DC, Thomas WR, Lamb JR: Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice. J Exp Med 1993; 178: 1783-1788
    • (1993) J Exp Med , vol.178 , pp. 1783-1788
    • Hoyne, G.F.1    O'Hehir, R.E.2    Wraith, D.C.3    Thomas, W.R.4    Lamb, J.R.5
  • 175
    • 84927775059 scopus 로고    scopus 로고
    • Fel d 1-derived synthetic peptide immuno-regulatory epitopes show a long-term treatment effect in cat allergic subjects
    • Couroux P, Patel D, Armstrong K, Larche M, Hafner RP: Fel d 1-derived synthetic peptide immuno-regulatory epitopes show a long-term treatment effect in cat allergic subjects. Clin Exp Allergy 2015; 45: 974-981
    • (2015) Clin Exp Allergy , vol.45 , pp. 974-981
    • Couroux, P.1    Patel, D.2    Armstrong, K.3    Larche, M.4    Hafner, R.P.5
  • 176
    • 84871713429 scopus 로고    scopus 로고
    • Fel d 1-derived peptide antigen desensitization shows a persistent treatment effect 1 year after the start of dosing: A randomized, placebo- controlled study
    • Patel D, Couroux P, Hickey P, Salapatek AM, Laidler P, Larche M, Hafner RP: Fel d 1-derived peptide antigen desensitization shows a persistent treatment effect 1 year after the start of dosing: a randomized, placebo- controlled study. J Allergy Clin Immunol 2013; 131: 103-109.e7
    • (2013) J Allergy Clin Immunol , vol.131 , pp. 103-103e7
    • Patel, D.1    Couroux, P.2    Hickey, P.3    Salapatek, A.M.4    Laidler, P.5    Larche, M.6    Hafner, R.P.7
  • 177
    • 18244391173 scopus 로고    scopus 로고
    • T cell epitope immunotherapy induces a CD4+ T cell population with regulatory activity
    • Verhoef A, Alexander C, Kay AB, Larche M: T cell epitope immunotherapy induces a CD4+ T cell population with regulatory activity. PLoS Med 2005; 2:e78
    • (2005) PLoS Med , vol.2 , pp. e78
    • Verhoef, A.1    Alexander, C.2    Kay, A.B.3    Larche, M.4
  • 178
    • 85019466275 scopus 로고    scopus 로고
    • Peptide dose and/or structure in vaccines as a determinant of T cell responses
    • Leggatt GR: Peptide dose and/or structure in vaccines as a determinant of T cell responses. Vaccines (Basel) 2014; 2: 537-548
    • (2014) Vaccines (Basel) , vol.2 , pp. 537-548
    • Leggatt, G.R.1
  • 180
    • 84862297459 scopus 로고    scopus 로고
    • Immune modulating peptides for the treatment and suppression of multiple sclerosis
    • Badawi AH, Siahaan TJ: Immune modulating peptides for the treatment and suppression of multiple sclerosis. Clin Immunol 2012; 144: 127-138
    • (2012) Clin Immunol , vol.144 , pp. 127-138
    • Badawi, A.H.1    Siahaan, T.J.2
  • 182
    • 77954827460 scopus 로고    scopus 로고
    • The path to personalized medicine
    • Hamburg MA, Collins FS: The path to personalized medicine. N Engl J Med 2010; 363: 301-304
    • (2010) N Engl J Med , vol.363 , pp. 301-304
    • Hamburg, M.A.1    Collins, F.S.2
  • 183
    • 0020540969 scopus 로고
    • The association between rheumatoid arthritis and the HLA antigen DR4
    • Gran JT, Husby G, Thorsby E: The association between rheumatoid arthritis and the HLA antigen DR4. Ann Rheum Dis 1983; 42: 292-296
    • (1983) Ann Rheum Dis , vol.42 , pp. 292-296
    • Gran, J.T.1    Husby, G.2    Thorsby, E.3
  • 184
  • 188
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
    • Bielekova B, Goodwin B, Richert N, Cortese I, Kondo T, Afshar G, Gran B, Eaton J, Antel J, Frank JA, McFarland HF, Martin R: Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat Med 2000; 6: 1167-1175
    • (2000) Nat Med , vol.6 , pp. 1167-1175
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3    Cortese, I.4    Kondo, T.5    Afshar, G.6    Gran, B.7    Eaton, J.8    Antel, J.9    Frank, J.A.10    McFarland, H.F.11    Martin, R.12
  • 189
    • 0035675871 scopus 로고    scopus 로고
    • Peptide-based immunotherapy of autoimmunity: A path of puzzles, paradoxes and possibilities
    • Anderton SM: Peptide-based immunotherapy of autoimmunity: a path of puzzles, paradoxes and possibilities. Immunology 2001; 104: 367-376
    • (2001) Immunology , vol.104 , pp. 367-376
    • Anderton, S.M.1
  • 190
    • 0033791462 scopus 로고    scopus 로고
    • Induction of a nonencephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial
    • The Altered Peptide Ligand in Relapsing MS Study Group
    • Kappos L, Comi G, Panitch H, Oger J, Antel J, Conlon P, Steinman L: Induction of a nonencephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The Altered Peptide Ligand in Relapsing MS Study Group. Nat Med 2000; 6: 1176-1182
    • (2000) Nat Med , vol.6 , pp. 1176-1182
    • Kappos, L.1    Comi, G.2    Panitch, H.3    Oger, J.4    Antel, J.5    Conlon, P.6    Steinman, L.7
  • 191
    • 68649116551 scopus 로고    scopus 로고
    • Interleukin-production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
    • Saraiva M, Christensen JR, Veldhoen M, Murphy TL, Murphy KM, O'Garra A: Interleukin-production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity 2009; 31: 209-219
    • (2009) Immunity , vol.31 , pp. 209-219
    • Saraiva, M.1    Christensen, J.R.2    Veldhoen, M.3    Murphy, T.L.4    Murphy, K.M.5    O'Garra, A.6
  • 192
    • 0032532650 scopus 로고    scopus 로고
    • High antigen density and IL-2 are required for generation of CD4 effectors secreting Th1 rather than Th0 cytokines
    • Rogers PR, Huston G, Swain SL: High antigen density and IL-2 are required for generation of CD4 effectors secreting Th1 rather than Th0 cytokines. J Immunol 1998; 161: 3844-3852
    • (1998) J Immunol , vol.161 , pp. 3844-3852
    • Rogers, P.R.1    Huston, G.2    Swain, S.L.3
  • 193
    • 0025918161 scopus 로고
    • Selective activation of Th1- and Th2-like cells in vivo - Response to human collagen IV
    • Pfeiffer C, Murray J, Madri J, Bottomly K: Selective activation of Th1- and Th2-like cells in vivo - response to human collagen IV. Immunol Rev 1991; 123: 65-84
    • (1991) Immunol Rev , vol.123 , pp. 65-84
    • Pfeiffer, C.1    Murray, J.2    Madri, J.3    Bottomly, K.4
  • 194
    • 84924205969 scopus 로고    scopus 로고
    • Effects of vaccination with altered peptide ligand on chronic pain in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis
    • Tian DH, Perera CJ, Apostolopoulos V, Moalem-Taylor G: Effects of vaccination with altered peptide ligand on chronic pain in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Front Neurol 2013; 4: 168
    • (2013) Front Neurol , vol.4 , pp. 168
    • Tian, D.H.1    Perera, C.J.2    Apostolopoulos, V.3    Moalem-Taylor, G.4
  • 195
    • 84924157762 scopus 로고    scopus 로고
    • Active immunization with myelin-derived altered peptide ligand reduces mechanical pain hypersensitivity following peripheral nerve injury
    • Perera CJ, Duffy SS, Lees JG, Kim CF, Cameron B, Apostolopoulos V, Moalem-Taylor G: Active immunization with myelin-derived altered peptide ligand reduces mechanical pain hypersensitivity following peripheral nerve injury. J Neuroinflamm 2015; 12: 28
    • (2015) J Neuroinflamm , vol.12 , pp. 28
    • Perera, C.J.1    Duffy, S.S.2    Lees, J.G.3    Kim, C.F.4    Cameron, B.5    Apostolopoulos, V.6    Moalem-Taylor, G.7
  • 196
    • 48649107859 scopus 로고    scopus 로고
    • Inhibitory peptide analogs derived from a major uveitogenic epitope protect from antiretinal autoimmunity by inducing type 2 and regulatory T cells
    • Cortes LM, Avichezer D, Silver PB, Luger D, Mattapallil MJ, Chan CC, Caspi RR: Inhibitory peptide analogs derived from a major uveitogenic epitope protect from antiretinal autoimmunity by inducing type 2 and regulatory T cells. J Leukoc Biol 2008; 84: 577-585
    • (2008) J Leukoc Biol , vol.84 , pp. 577-585
    • Cortes, L.M.1    Avichezer, D.2    Silver, P.B.3    Luger, D.4    Mattapallil, M.J.5    Chan, C.C.6    Caspi, R.R.7
  • 198
    • 0030939933 scopus 로고    scopus 로고
    • Clinical and immunologic effects of component peptides in Allervax cat
    • Norman PS, Nicodemus CF, Creticos PS, et al: Clinical and immunologic effects of component peptides in Allervax cat. Int Arch Allergy Immunol 1997; 113: 1-3
    • (1997) Int Arch Allergy Immunol , vol.113 , pp. 1-3
    • Norman, P.S.1    Nicodemus, C.F.2    Creticos, P.S.3
  • 199
    • 0033591638 scopus 로고    scopus 로고
    • Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions
    • Haselden BM, Kay AB, Larche M: Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions. J Exp Med 1999; 189: 1885-1894
    • (1999) J Exp Med , vol.189 , pp. 1885-1894
    • Haselden, B.M.1    Kay, A.B.2    Larche, M.3
  • 200
    • 0035423535 scopus 로고    scopus 로고
    • Allergenderived T cell peptide-induced late asthmatic reactions precede the induction of antigen- specific hyporesponsiveness in atopic allergic asthmatic subjects
    • Oldfield WL, Kay AB, Larche M: Allergenderived T cell peptide-induced late asthmatic reactions precede the induction of antigen- specific hyporesponsiveness in atopic allergic asthmatic subjects. J Immunol 2001; 167: 1734-1739
    • (2001) J Immunol , vol.167 , pp. 1734-1739
    • Oldfield, W.L.1    Kay, A.B.2    Larche, M.3
  • 201
    • 0037031090 scopus 로고    scopus 로고
    • Effect of Tcell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: A randomised controlled trial
    • Oldfield WL, Larche M, Kay AB: Effect of Tcell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: a randomised controlled trial. Lancet 2002; 360: 47-53
    • (2002) Lancet , vol.360 , pp. 47-53
    • Oldfield, W.L.1    Larche, M.2    Kay, A.B.3
  • 202
    • 13244291456 scopus 로고    scopus 로고
    • Fel d 1-derived T cell peptide therapy induces recruitment of CD4 + CD25 + CD4+ interferon- γ + T helper type 1 cells to sites of allergen- induced late-phase skin reactions in catallergic subjects
    • Alexander C, Ying S, A BK, Larche M: Fel d 1-derived T cell peptide therapy induces recruitment of CD4 + CD25 + ; CD4+ interferon- γ + T helper type 1 cells to sites of allergen- induced late-phase skin reactions in catallergic subjects. Clin Exp Allergy 2005; 35: 52-58
    • (2005) Clin Exp Allergy , vol.35 , pp. 52-58
    • Alexander, C.1    Ying, S.2    Bk, A.3    Larche, M.4
  • 203
    • 24744438448 scopus 로고    scopus 로고
    • The effect of Fel d 1-derived T-cell peptides on upper and lower airway outcome measurements in cat-allergic subjects
    • Alexander C, Tarzi M, Larche M, Kay AB: The effect of Fel d 1-derived T-cell peptides on upper and lower airway outcome measurements in cat-allergic subjects. Allergy 2005; 60: 1269-1274
    • (2005) Allergy , vol.60 , pp. 1269-1274
    • Alexander, C.1    Tarzi, M.2    Larche, M.3    Kay, A.B.4
  • 204
    • 0000433201 scopus 로고    scopus 로고
    • The Allervax Ragweed Study Group: Efficacy of Allervax ragweed in the treatment of ragweed-induced allergy
    • Creticos PS, Hebert J, Philip G; The Allervax Ragweed Study Group: Efficacy of Allervax ragweed in the treatment of ragweed-induced allergy. J Allergy Clin Immunol 1997; 99:S401
    • (1997) J Allergy Clin Immunol , vol.99 , pp. S401
    • Creticos, P.S.1    Hebert, J.2    Philip, G.3
  • 205
    • 0031866059 scopus 로고    scopus 로고
    • Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom
    • Muller U, Akdis CA, Fricker M, Akdis M, Blesken T, Bettens F, Blaser K: Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom. J Allergy Clin Immunol 1998; 101: 747-754
    • (1998) J Allergy Clin Immunol , vol.101 , pp. 747-754
    • Muller, U.1    Akdis, C.A.2    Fricker, M.3    Akdis, M.4    Blesken, T.5    Bettens, F.6    Blaser, K.7
  • 209
    • 0033762708 scopus 로고    scopus 로고
    • NBI- 5788, an altered MBP83-99 peptide, induces a T-helper 2-like immune response in multiple sclerosis patients
    • Crowe PD, Qin Y, Conlon PJ, Antel JP: NBI- 5788, an altered MBP83-99 peptide, induces a T-helper 2-like immune response in multiple sclerosis patients. Ann Neurol 2000; 48: 758-765
    • (2000) Ann Neurol , vol.48 , pp. 758-765
    • Crowe, P.D.1    Qin, Y.2    Conlon, P.J.3    Antel, J.P.4


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