Structural basis for T cell recognition of altered peptide ligands: A single T cell receptor can productively recognize a large continuum of related ligands

Journal of Experimental Medicine

Volumn 184, Issue 4, 1996, Pages 1259-1268

  Kersh, Gilbert J ^a   Allen, Paul M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIGEN ANTIBODY COMPLEX; ANTIGEN RECOGNITION; ARTICLE; CELLULAR IMMUNITY; HUMAN; HUMAN CELL; LIGAND BINDING; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROTEIN STRUCTURE;

ANIMALS; APOPTOSIS; CLONE CELLS; EPITOPES; HEMOGLOBINS; HISTOCOMPATIBILITY ANTIGENS; HYBRIDOMAS; LIGANDS; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

EID: 0029961893     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.4.1259     Document Type: Article

References (39)

1. Babbitt, B.P., P.M. Allen, G. Matsueda, E. Haber, and E.R. Unanue. 1985. Binding of immunogenic peptides to Ia histocompatibility molecules. Nature (Lond.). 317:359-361.
2. Townsend, A.R.M., J. Rothbard, F.M. Gotch, G. Bahadur, D. Wraith, and A.J. McMichael. 1986. The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell. 44:959-968.
3. Kersh, G.J., and P.M. Allen. 1996. Essential flexibility in the T-cell recognition of antigen. Nature (Lond.). 222:495-498.
4. Evavold, B.D., and P.M. Allen. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science (Wash. DC). 252:1308-1310.
5. Sloan-Lancaster, J., and P.M. Allen. 1996. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14:1-27.
6. Pfeiffer, C., J. Stein, S. Southwood, H. Ketelaar, A. Sette, and K. Bottomly. 1995. Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J. Exp. Med. 181: 1569-1574.
7. Sloan-Lancaster, J., B.D. Evavold, and P.M. Allen. 1993. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature (Lond.). 363:156-159.
8. De Magistris, M.T., J. Alexander, M. Coggeshall, A. Altman, F.C.A. Gaeta, H.M. Grey, and A. Sette. 1992. Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor. Cell. 68:625-634.
9. Allen, P.M. 1994. Peptides in positive and negative selection: a delicate balance. Cell. 76:593-596.
10. Hogquist, K.A., S.C. Jameson, W.R. Heath, J.L. Howard, M.J. Bevan, and F.R. Carbone. 1994. T cell receptor antagonist peptides induce positive selection. Cell. 76:17-27.
11. Ashton-Rickardt, P.G., A. Bandeira, J.R. Delaney, L. Van Kaer, H.-P. Pircher, R.M. Zinkernagel, and S. Tonegawa. 1994. Evidence for a differential avidity model of T cell selection in the thymus. Cell. 76:651-663.
12. Sebzda, E., V.A. Wallace, J. Mayer, R.S.M. Yeung, T.W. Mak, and P.S. Ohashi. 1994. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science (Wash. DC). 263:1615-1618.
13. + thymocytes by T-cell receptor peptide antagonists. Proc. Natl. Acad. Sci. USA. 91:4057-4061.
14. Vidal, K., B.L. Hsu, C.B. Williams, and P.M. Allen. 1996. Endogenous altered peptide ligands can effect peripheral T cell responses. J. Exp. Med. 183:1311-1321.
15. Klenerman, P., S. Rowland-Jones, S. McAdam, J. Edwards, S. Daenke, D. Lalloo, B. Köppe, W. Rosenberg, D. Boyd, A. Edwards et al. 1994. Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants. Nature (Lond.). 369:403-407.
16. Bertoletti, A., A. Sette, F.V. Chisari, A. Penna, M. Levrero, M. De Carli, F. Fiaccadori, and C. Ferrari. 1994. Natural variants of cytotoxic epitopes are T cell receptor antagonists for anti-viral cytotoxic T cells. Nature (Lond.). 369:407-410.
17. Nicholson, L.B., J.M. Greer, R.A. Sobel, M.B. Lees, and V.K. Kuchroo. 1995. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity. 3:397-405.
18. Bjorkman, P.J., M.A. Saper, B. Samraoui, W.S. Bennett, J.L. Strominger, and D.C. Wiley. 1987. Structure of the human class I histocompatibility antigen, HLA-A2. Nature (Lond.). 329:506-512.
19. Brown, J.H., T.S. Jardetzky, J.C. Gorga, L.J. Stern, R.G. Urban, J.L. Strominger, and D.C. Wiley. 1993. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature (Lond.). 364:33-39.
20. b. Science (Wash. DC). 257:919-927.
21. Fremont, D.H., W.A. Hendrickson, P. Marrack, and J. Kappler. 1996. Structures of an MHC class II molecule with covalently bound single peptides. Science (Wash. DC). In press.
22. Alexander, J., K. Snoke, J. Ruppert, J. Sidney, M. Wall, S. Southwood, C. Oseroff, T. Arrhenius, F.C.A. Gaeta, S.M. Colón et al. 1993. Functional consequences of engagement of the T cell receptor by low affinity ligands. J. Immunol. 150:1-7.
23. Jameson, S.C., F.R. Carbone, and M.J. Bevan. 1993. Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells. J. Exp. Med. 177:1541-1550.
24. Evavold, B.D., S.G. Williams, B.L. Hsu, S. Buus, and P.M. Allen. 1992. Complete dissection of the Hb(64-76) determinant using Th1, Th2 clones, and T cell hybridomas. J. Immunol. 148:347-353.
25. Evavold, B.D., J. Sloan-Lancaster, B.L. Hsu, and P.M. Allen. 1993. Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides. J. Immunol. 150:3131-3140.
26. Evavold, B.D., J. Sloan-Lancaster, K.J. Wilson, J.B. Rothbard, and P.M. Allen. 1995. Specific T cell recognition of minimally homologous peptides: evidence for multiple endogenous ligands. Immunity. 2:655-663.
27. Evavold, B.D., J. Sloan-Lancaster, and P.M. Allen. 1993. Antagonism of superantigen-stimulated helper T-cell clones and hybridomas by altered peptide ligand. Proc. Natl. Acad. Sci. USA. 91:2300-2304.
28. Alam, S.M., P.J. Travers, J.L. Wung, W. Nasholds, S. Redpath, S.C. Jameson, and N.R.J. Gascoigne. 1996. T-cell-receptor affinity and thymocyte positive selection. Nature (Lond.). 381:616-620.
29. Gershon, H., J.S. Meek, and K. Dittmer. 1949. Propargylglycine: an acetylenic amino acid antagonist. J. Am. Chem. Soc. 71:3573-3574.
30. Scannell, J.P., D.L. Pruess, T.C. Demny, F. Weiss, T. Williams, and A. Stempel. 1971. Antimetabolites produced by microorganisms. II. L-2-amino-4-pentynoic acid. J. Antibiot. (Tokyo). 24:239-244.
31. Teale, J.M., and N.R. Klinman. 1980. Tolerance as an active process. Nature (Lond). 288:385-387.
32. Rao, A., W. Weng-Ping Ko, S.J. Faas, and H. Cantor. 1984. Binding of antigen in the absence of histocompatibility proteins by arsonace-reactive T-cell clones. Cell. 36:879-888.
33. Rao, A., S.J. Faas, and H. Cantor. 1984. Analogs that compete for antigen binding to an arsonate-reactive T-cell clone inhibit the functional response to arsonate. Cell. 36:889-895.
34. McKeithan, T.W. 1995. Kinetic proofreading in T-cell receptor signal transduction. Proc. Natl. Acad. Sci. USA. 92: 5042-5046.
35. Rabinowitz, J.D., C. Beeson, D.S. Lyons, M.M. Davis, and H.M. McConnell. 1996. Kinetic discrimination in T-cell activation. Proc. Natl. Acad. Sci. USA. 93:1401-1405.
36. Janeway, C.A., Jr. 1995. Ligands for the T-cell receptor: hard times for avidity models. Immunol. Today. 16:223-225.
37. Matsui, K., J.J. Boniface, P.A. Reay, H. Schild, B. Fazekas de St.Groth, and M.M. Davis. 1991. Low affinity interaction of peptide-MHC complexes with T cell receptors. Science (Wash. DC). 254:1788-1791.
38. k complexes: correlation of the dissociation rate with T-cell responsiveness. Proc. Natl. Acad. Sci. USA. 91:12862-12866.
39. Lyons, D.S., S.A. Lieberman, J. Hampl, J.J. Boniface, Y. Chien, L.J. Berg, and M.M. Davis. 1996. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity. 5:53-61.