Structural basis for gluten intolerance in Celiac Sprue

Science

Volumn 297, Issue 5590, 2002, Pages 2275-2279

  Shan, Lu ^a   Molberg, Øyvind ^a   Parrot, Isabelle ^a   Hausch, Felix ^a   Filiz, Ferda ^a   Gray, Gary M ^a   Sollid, Ludvig M ^a   Khosla, Chaitan ^a  

^a Stanford University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; BACTERIA; BIOLOGICAL MEMBRANES; BIOLOGICAL ORGANS; CELLS; GENES; NUTRITION; PATIENT MONITORING; PROTEINS; TISSUE;

GENETICALLY SUSCEPTIBLE INDIVIDUALS;

DISEASES;

AUTOANTIGEN; GLUTEN; PEPTIDASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PROTEINASE;

DISEASE; IMMUNE RESPONSE; PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALYSIS; CELIAC DISEASE; DIGESTION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; MASS SPECTROMETRY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; CELIAC DISEASE; CELL LINE; CEREALS; ENDOPEPTIDASES; EPITOPES, T-LYMPHOCYTE; GLIADIN; GTP-BINDING PROTEINS; HLA-DQ ANTIGENS; HUMANS; IMMUNODOMINANT EPITOPES; INTESTINAL MUCOSA; INTESTINE, SMALL; LYMPHOCYTE ACTIVATION; MICROVILLI; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; RATS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SERINE ENDOPEPTIDASES; T-LYMPHOCYTES; TRANSGLUTAMINASES;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0037183929     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1074129     Document Type: Article

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42. We thank H. Arentz-Hansen for providing the α-2 gliadin gene and R. Castillo for use of his laboratory for animal procedures performed in this study. We also thank M. Davis (Stanford Univ.) and C. T. Walsh (Harvard Univ.) for their critical reading of the manuscript and for their helpful suggestions. Supported by the Alan T. Waterman Award from the National Science Foundation (to C.K.) and by grants from the Research Council of Norway and the European Commission (to L.M.S.). L.S. is a recipient of the Stanford Graduate Fellowship, and I.P. is a recipient of a post-doctoral fellowship from Fondation pour la Recherche Medicale.