Fine specificity of the myelin-reactive T cell repertoire: Implications for TCR antagonism in autoimmunity

Journal of Immunology

Volumn 161, Issue 7, 1998, Pages 3357-3364

  Anderton, Stephen M ^a,c   Manickasingham, Shivanthi P ^a   Burkhart, Christoph ^a   Luckcuck, Tracy A ^b   Holland, Sam J ^b   Lamont, Alan G ^b   Wraith, David C ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b Peptide Therapeutics   (United Kingdom)

^c SCHOOL OF MEDICAL SCIENCES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MYELIN; MYELIN BASIC PROTEIN; PEPTIDE; RECEPTOR BLOCKING AGENT; T LYMPHOCYTE RECEPTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNITY; CELL CLONE; CELLULAR IMMUNITY; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CLONE CELLS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EPITOPES, T-LYMPHOCYTE; LIGANDS; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MYELIN BASIC PROTEINS; PEPTIDE FRAGMENTS; PHENOTYPE; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS; TRANSGENES;

EID: 0032193195     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. Sloan-Lancaster, J., and P. M. Allen. 1996. Altered peptide ligand-induced partial activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14:1.
2. Evavold, B. D., and P. M. Allen. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252:1308.
3. Evavold, B. D., J. Sloan-Lancaster, B. L. Hsu, and P. M. Allen. 1993. Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides. J. Immunol. 150:3131.
4. Evavold, B. D., J. Sloan-Lancaster, and P. M. Allen. 1993. Tickling the TCR: selective T cell functions stimulated by altered peptide ligands. Immunol. Today 14:602.