Small organic compounds enhance antigen loading of class II major histocompatibility complex proteins by targeting the polymorphic P1 pocket

Journal of Biological Chemistry

Volumn 281, Issue 50, 2006, Pages 38535-38542

  Höpner, Sabine ^a   Dickhaut, Katharina ^a,e   Hofstätter, Maria ^a   Krämer, Heiko ^a   Rückerl, Dominik ^a   Söderhäll, J Arvid ^b   Gupta, Shashank ^a   Marin Esteban, Viviana ^a   Kühne, Ronald ^b   Freund, Christian ^b,c   Jung, Günther ^d   Falk, Kirsten ^a   Rötzschke, Olaf ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BIOCOMPATIBILITY; CATALYSIS; GENETIC ENGINEERING; HISTOLOGY; NEUROLOGY;

HISTOCOMPATIBILITY; IMMUNE RESPONSE; RECEPTORS; T CELLS;

PROTEINS;

ADAMANTANE DERIVATIVE; ADENOSINE RECEPTOR; GLYCINE; HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; ORGANIC COMPOUND;

ANIMAL CELL; ANTIBODY COMBINING SITE; ANTIGEN PRESENTING CELL; ARTICLE; BINDING SITE; CATALYST; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ADAMANTANE; ALLELES; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; DNA PRIMERS; HISTOCOMPATIBILITY ANTIGENS CLASS II; INSECTS; MOLECULAR SEQUENCE DATA; ORGANIC CHEMICALS; POLYMORPHISM, GENETIC;

EID: 33846018428     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M606437200     Document Type: Article

References (34)

1. Boes, M., and Ploegh, H. L. (2004) Nature 430, 264-271
2. Sloan, V. S., Cameron, P., Porter, G., Gammon, M., Amaya, M., Mellins, E., and Zaller, D. M. (1995) Nature 375, 802-806
3. Weber, D. A., Evavold, B. D., and Jensen, P. E. (1996) Science 274, 618-620
4. Watts, C. (2001) Curr. Opin. Immunol. 13, 26-31
5. Cella, M., Engering, A., Pinet, V., Pieters, J., and Lanzavecchia, A. (1997) Nature 388, 782-787
6. Santambrogio, L., Sato, A. K., Carven, G. J., Belyanskaya, S. L., Strominger, J. L., and Stern, L. J. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 15056-15061
7. Santambrogio, L., Sato, A. K., Fischer, F. R., Dorf, M. E., and Stern, L. J. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 15050-15055
8. Rabinowitz, J. D., Vrljic, M., Kasson, P. M., Liang, M. N., Busch, R., Boniface, J. J., Davis, M. M., and McConnell, H. M. (1998) Immunity 9, 699-709
9. Falk, K., Lau, J. M., Santambrogio, L., Marin-Esteban, V., Puentes, F., Rotzschke, O., and Strominger, J. L. (2002) J. Biol. Chem. 277, 2709-2715
10. Marin-Esteban, V., Falk, K., and Rotzschke, O. (2004) J. Biol. Chem. 279, 50684-50690
11. Riberdy, J. M., Newcomb, J. R., Surman, M. J., Barbosa, J. A., and Cresswell, P. (1992) Nature 360, 474-477
12. Lamb, J. R., Eckels, D. D., Lake, P., Woody, J. N., and Green, N. (1982) Nature 300, 66-69
13. Zamvil, S. S., Mitchell, D. J., Moore, A. C., Kitamura, K., Steinman, L., and Rothbard, J. B. (1986) Nature 324, 258-260
14. Rosloniec, E. F., Brand, D. D., Myers, L. K., Whittington, K. B., Gumanovskaya, M., Zaller, D. M., Woods, A., Altmann, D. M., Stuart, J. M., and Kang, A. H. (1997) J. Exp. Med. 185, 1113-1122
15. Marin-Esteban, V., Falk, K., and Rotzschke, O. (2003) J. Autoimmun. 20, 63-69
16. Ong, B., Willcox, N., Wordsworth, P., Beeson, D., Vincent, A., Altmann, D., Lanchbury, J. S., Harcourt, G. C., Bell, J. I., and Newsom-Davis, J. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 7343-7347
17. Rammensee, H.-G., Bachmann, J., and Stevanovic, S. (1997) MHC Ligands and Peptide Motifs, pp. 55-60, Landes Bioscience, Austin, TX
18. Stern, L. J., Brown, J. H., Jardetzky, T. S., Gorga, J. C., Urban, R. G., Strominger, J. L., and Wiley, D. C. (1994) Nature 368, 215-221
19. Falk, K., Rotzschke, O., Stevanovic, S., Jung, G., and Rammensee, H. G. (1991) Nature 351, 290-296
20. Hammer, J., Takacs, B., and Sinigaglia, F. (1992) J. Exp. Med. 176, 1007-1013
21. Falk, K., Rotzschke, O., Stevanovic, S., Jung, G., and Rammensee, H. G. (1994) Immunogenetics 39, 230-242
22. Smith, K. J., Pyrdol, J., Gauthier, L., Wiley, D. C., and Wucherpfennig, K. W. (1998) J. Exp. Med. 188, 1511-1520
23. Chou, C. L., and Sadegh-Nasseri, S. (2000) J. Exp. Med. 192, 1697-1706
24. De Wall, S. L., Painter, C., Stone, J. D., Bandaranayake, R., Wiley, D. C., Mitchison, T. J., Stern, L. J., and Dedecker, B. S. (2006) Nat. Chem. Biol. 2, 197-201
25. Nicholson, M. J., Moradi, B., Seth, N. P., Xing, X., Cuny, G. D., Stein, R. L., and Wucherpfennig, K. W. (2006) J. Immunol. 176, 4208-4220
26. Altman, J. D., Moss, P. A., Goulder, P. J., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., and Davis, M. M. (1996) Science 274, 94-96
27. Jones, E. Y., Fugger, L., Strominger, J. L., and Siebold, C. (2006) Nat. Rev. Immunol. 6, 271-282
28. Todd, J. A., Bell, J. I., and McDevitt, H. O. (1987) Nature 329, 599-604
29. Hammer, J., Gallazzi, F., Bono, E., Karr, R. W., Guenot, J., Valsasnini, P., Nagy, Z. A., and Sinigaglia, F. (1995) J. Exp. Med. 181, 1847-1855
30. Gibert, M., Balandraud, N., Touinssi, M., Mercier, P., Roudier, J., and Reviron, D. (2003) Hum. Immunol. 64, 930-935
31. Teutsch, S. M., Bennetts, B. H., Buhler, M. M., Heard, R. N., and Stewart, G. J. (1999) Hum. Immunol. 60, 715-722
32. D'Cruz, D. (2000) Toxicol. Lett. 112-113, 421-432
33. Joshi, R. V., Zarutskie, J. A., and Stern, L. J. (2000) Biochemistry 39, 3751-3762
34. Sadegh-Nasseri, S., Stern, L. J., Wiley, D. C., and Germain, R. N. (1994) Nature 370, 647-650