Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues

Gastroenterology

Volumn 123, Issue 3, 2002, Pages 803-809

  ArentzHansen, Helene ^a   McAdam, Stephen N ^a   Molberg, Øyvind ^a   Fleckenstein, Burkhard ^a   Lundin, Knut E A ^a,b   Jørgensen, Thomas J D ^c   Jung, Günther ^d   Roepstorff, Peter ^c   Sollid, Ludvig M ^a  

^a Institute of Immunology   (Germany)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GLIADIN; GLUTEN; HLA DQ ANTIGEN; PROLINE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE;

ADULT; AMINO ACID COMPOSITION; ARTICLE; CELIAC DISEASE; CLINICAL ARTICLE; DEAMINATION; HUMAN; IMMUNOGENICITY; LYMPHOCYTE PROLIFERATION; MASS SPECTROMETRY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; T LYMPHOCYTE;

EID: 0036724918     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2002.35381     Document Type: Article

References (24)

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4. T cells from the small intestinal mucosa of a DR4, DQ7/DR4, DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8
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6. Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity
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