메뉴 건너뛰기




Volumn 11, Issue 4S, 2005, Pages S69-

Peptide-based therapeutic vaccines for allergic and autoimmune diseases

Author keywords

[No Author keywords available]

Indexed keywords

API M 1 ANTIGEN; FEL D 1 ANTIGEN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 60; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; MYELIN BASIC PROTEIN; PEPTIDE; PHOSPHOLIPASE A2; PROTEIN DNAJ; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VACCINE;

EID: 17644401678     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1226     Document Type: Article
Times cited : (293)

References (128)
  • 1
    • 0036951192 scopus 로고    scopus 로고
    • Genetics and genomics of asthma and allergic diseases
    • Cookson, W. Genetics and genomics of asthma and allergic diseases. Immunol. Rev. 190, 195-206 (2002).
    • (2002) Immunol. Rev , vol.190 , pp. 195-206
    • Cookson, W.1
  • 3
    • 15844368830 scopus 로고    scopus 로고
    • A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p2l and i/q22
    • Sawcer, S. et al. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p2l and i/q22. Nat. Genet. 13, 464-468 (1996).
    • (1996) Nat. Genet , vol.13 , pp. 464-468
    • Sawcer, S.1
  • 4
    • 0033188479 scopus 로고    scopus 로고
    • Genetic analysis of multiplex rheumatoid arthritis families
    • Bali, D. et al. Genetic analysis of multiplex rheumatoid arthritis families. Genes Immun. 1, 28-36 (1999).
    • (1999) Genes Immun , vol.1 , pp. 28-36
    • Bali, D.1
  • 5
    • 0024417450 scopus 로고
    • Hay fever, hygiene, and household size
    • Strachan, D.P. Hay fever, hygiene, and household size. Br. Med. J. 299, 1259-1260 (1989).
    • (1989) Br. Med. J , vol.299 , pp. 1259-1260
    • Strachan, D.P.1
  • 6
    • 0035988197 scopus 로고    scopus 로고
    • A missing link in the hygiene hypothesis?
    • Gale, E.A. A missing link in the hygiene hypothesis? Diabetologia 45, 588-594 (2002).
    • (2002) Diabetologia , vol.45 , pp. 588-594
    • Gale, E.A.1
  • 7
    • 19944427405 scopus 로고    scopus 로고
    • An immunoepidemiological approach to asthma: Identification of in vitro T-cell response patterns associated with different wheezing phenotypes in children
    • Heaton, T. et al. An immunoepidemiological approach to asthma: Identification of in vitro T-cell response patterns associated with different wheezing phenotypes in children. Lancet 365, 142-149 (2005).
    • (2005) Lancet , vol.365 , pp. 142-149
    • Heaton, T.1
  • 8
    • 0032945548 scopus 로고    scopus 로고
    • Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation
    • Hansen, G., Berry, G., DeKruyff, R.H. & Umetsu, D. T. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J. Clin. Invest. 103, 175-183 (1999).
    • (1999) J. Clin. Invest , vol.103 , pp. 175-183
    • Hansen, G.1    Berry, G.2    Dekruyff, R.H.3    Umetsu, D.T.4
  • 9
    • 0030739650 scopus 로고    scopus 로고
    • Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease
    • Lafaille, J.J. et al. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J. Exp. Med. 186, 307-312 (1997).
    • (1997) J. Exp. Med , vol.186 , pp. 307-312
    • Lafaille, J.J.1
  • 10
    • 0037450727 scopus 로고    scopus 로고
    • Cell regulation as a side effect of homeostasis and competition
    • Barthlott, T., Kassiotis, G. & Stockinger, B. T cell regulation as a side effect of homeostasis and competition. J. Exp. Med. 197, 451-460 (2003).
    • (2003) J. Exp. Med , vol.197 , pp. 451-460
    • Barthlott, T.1    Kassiotis, G.2    Stockinger, B.T.3
  • 11
    • 0037136537 scopus 로고    scopus 로고
    • The effect of infections on susceptibility to autoimmune and allergic diseases
    • Bach, J.F. The effect of infections on susceptibility to autoimmune and allergic diseases. N. Engl. J. Med. 347, 911-920 (2002).
    • (2002) N. Engl. J. Med , vol.347 , pp. 911-920
    • Bach, J.F.1
  • 12
    • 7044224867 scopus 로고    scopus 로고
    • Regulatory CD4(+) T cells and the control of autoimmune disease
    • Wraith, D.C., Nicolson, K.S. & Whitley, N.T. Regulatory CD4(+) T cells and the control of autoimmune disease. Curr. Opin. Immunol. 16, 695-701 (2004).
    • (2004) Curr. Opin. Immunol , vol.16 , pp. 695-701
    • Wraith, D.C.1    Nicolson, K.S.2    Whitley, N.T.3
  • 13
    • 1342308180 scopus 로고    scopus 로고
    • Relation of CD4+CD25+ regulatory T-cell suppression of allergen- driven T-cell activation to atopic status and expression of allergic disease
    • Ling, E.M. et al. Relation of CD4+CD25+ regulatory T-cell suppression of allergen- driven T-cell activation to atopic status and expression of allergic disease. Lancet 363, 608-615 (2004).
    • (2004) Lancet , vol.363 , pp. 608-615
    • Ling, E.M.1
  • 14
    • 0345016451 scopus 로고    scopus 로고
    • Human CD25+ regulatory T cells maintain immune tolerance to nickel in healthy, nonallergic individuals
    • Cavani, A. et al. Human CD25+ regulatory T cells maintain immune tolerance to nickel in healthy, nonallergic individuals. J. Immunol. 171, 5760-5768 (2003).
    • (2003) J. Immunol , vol.171 , pp. 5760-5768
    • Cavani, A.1
  • 15
    • 3042594506 scopus 로고    scopus 로고
    • Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow’s milk allergy
    • Karlsson, M.R., Rugtveit, J. & Brandtzaeg, P. Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow’s milk allergy. J. Exp. Med. 199, 1679-1688 (2004).
    • (2004) J. Exp. Med , vol.199 , pp. 1679-1688
    • Karlsson, M.R.1    Rugtveit, J.2    Brandtzaeg, P.3
  • 16
    • 1942531991 scopus 로고    scopus 로고
    • T regulatory cells in atopic dermatitis and subversion of their activity by superantigens
    • Ou, L.S., Goleva, E., Hall, C. & Leung, D.Y. T regulatory cells in atopic dermatitis and subversion of their activity by superantigens. J. Allergy Clin. Immunol. 113, 756-763 (2004).
    • (2004) J. Allergy Clin. Immunol , vol.113 , pp. 756-763
    • Ou, L.S.1    Goleva, E.2    Hall, C.3    Leung, D.Y.4
  • 17
    • 11244291391 scopus 로고    scopus 로고
    • Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis
    • Balandina, A., Lecart, S., Dartevelle, P., Saoudi, A. & Berrih-Aknin, S. Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis. Blood 105, 735-741 (2005).
    • (2005) Blood , vol.105 , pp. 735-741
    • Balandina, A.1    Lecart, S.2    Dartevelle, P.3    Saoudi, A.4    Berrih-Aknin, S.5
  • 18
    • 2442618129 scopus 로고    scopus 로고
    • CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis
    • de Kleer, I.M. et al. CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis. J. Immunol. 172, 6435-6443 (2004).
    • (2004) J. Immunol , vol.172 , pp. 6435-6443
    • de Kleer, I.M.1
  • 19
    • 85047690395 scopus 로고    scopus 로고
    • Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health
    • Arif, S. et al. Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J. Clin. Invest. 113, 451-463 (2004).
    • (2004) J. Clin. Invest , vol.113 , pp. 451-463
    • Arif, S.1
  • 20
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    • Viglietta, V., Baecher-Allan, C., Weiner, H.L. & Hafler, D.A. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J. Exp. Med. 199, 971-979 (2004).
    • (2004) J. Exp. Med , vol.199 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 21
    • 0033064101 scopus 로고    scopus 로고
    • Does rheumatoid arthritis remit during pregnancy and relapse postpartum? Results from a nationwide study in the United Kingdom performed prospectively from late pregnancy
    • Barrett, J.H., Brennan, P., Fiddler, M. & Silman, A.J. Does rheumatoid arthritis remit during pregnancy and relapse postpartum? Results from a nationwide study in the United Kingdom performed prospectively from late pregnancy. Arthritis Rheum. 42, 1219-1227 (1999).
    • (1999) Arthritis Rheum , vol.42 , pp. 1219-1227
    • Barrett, J.H.1    Brennan, P.2    Fiddler, M.3    Silman, A.J.4
  • 22
    • 0035835981 scopus 로고    scopus 로고
    • Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: A population-based cross-sectional study
    • Platts-Mills, T., Vaughan, J., Squillace, S., Woodfolk, J. & Sporik, R. Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: A population-based cross-sectional study. Lancet 357, 752-756 (2001).
    • (2001) Lancet , vol.357 , pp. 752-756
    • Platts-Mills, T.1    Vaughan, J.2    Squillace, S.3    Woodfolk, J.4    Sporik, R.5
  • 23
    • 0033549827 scopus 로고    scopus 로고
    • Long-term clinical efficacy of grass-pollen immunotherapy
    • Durham, S.R. et al. Long-term clinical efficacy of grass-pollen immunotherapy. N. Engl. J. Med. 341, 468-475 (1999).
    • (1999) N. Engl. J. Med , vol.341 , pp. 468-475
    • Durham, S.R.1
  • 24
    • 2442648797 scopus 로고    scopus 로고
    • Allergen immunotherapy: Therapeutic vaccines for allergic diseases. World Health Organization. American academy of Allergy, Asthma and Immunology
    • Bousquet, J. et al. Allergen immunotherapy: Therapeutic vaccines for allergic diseases. World Health Organization. American academy of Allergy, Asthma and Immunology. Ann. Allergy Asthma Immunol. 81, 401-405 (1998).
    • (1998) Ann. Allergy Asthma Immunol , vol.81 , pp. 401-405
    • Bousquet, J.1
  • 25
    • 50249230114 scopus 로고
    • Prophylactic innoculation against hay fever
    • Noon, L. Prophylactic innoculation against hay fever. Lancet i, 1572-1573 (1911).
    • (1911) Lancet I , pp. 1572-1573
    • Noon, L.1
  • 26
    • 9844266243 scopus 로고    scopus 로고
    • Immunological changes during specific immunotherapy of grass pollen allergy: Reduced lymphoproliferative responses to allergen and shift from TH2 to TH1 in T-cell clones specific for Phl p 1, a major grass pollen allergen
    • Ebner, C. et al. Immunological changes during specific immunotherapy of grass pollen allergy: Reduced lymphoproliferative responses to allergen and shift from TH2 to TH1 in T-cell clones specific for Phl p 1, a major grass pollen allergen. Clin. Exp. Allergy 27, 1007-1015 (1997).
    • (1997) Clin. Exp. Allergy , vol.27 , pp. 1007-1015
    • Ebner, C.1
  • 27
    • 0027443372 scopus 로고
    • Allergen immuno- therapy decreases interleukin 4 production in CD4+ T cells from allergic individuals
    • Secrist, H., Chelen, C.J., Wen, Y., Marshall, J.D. & Umetsu, D.T. Allergen immuno- therapy decreases interleukin 4 production in CD4+ T cells from allergic individuals. J. Exp. Med. 178, 2123-2130 (1993).
    • (1993) J. Exp. Med , vol.178 , pp. 2123-2130
    • Secrist, H.1    Chelen, C.J.2    Wen, Y.3    Marshall, J.D.4    Umetsu, D.T.5
  • 28
    • 0027222095 scopus 로고
    • Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses
    • Varney, V.A. et al. Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. J. Clin. Invest. 92, 644-651 (1993).
    • (1993) J. Clin. Invest , vol.92 , pp. 644-651
    • Varney, V.A.1
  • 29
    • 0036164580 scopus 로고    scopus 로고
    • Grass pollen immunotherapy for hayfever is associated with increases in local nasal but not peripheral Th1: Th2 cytokine ratios
    • Wachholz, P.A. et al. Grass pollen immunotherapy for hayfever is associated with increases in local nasal but not peripheral Th1: Th2 cytokine ratios. Immunology 105, 56-62 (2002).
    • (2002) Immunology , vol.105 , pp. 56-62
    • Wachholz, P.A.1
  • 30
    • 0037504093 scopus 로고    scopus 로고
    • Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy
    • Francis, J.N., Till, S.J. & Durham, S.R. Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy. J. Allergy Clin. Immunol. 111, 1255-1261 (2003).
    • (2003) J. Allergy Clin. Immunol , vol.111 , pp. 1255-1261
    • Francis, J.N.1    Till, S.J.2    Durham, S.R.3
  • 31
    • 0038363534 scopus 로고    scopus 로고
    • IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
    • Jutel, M. et al. IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur. J. Immunol. 33, 1205-1214 (2003).
    • (2003) Eur. J. Immunol , vol.33 , pp. 1205-1214
    • Jutel, M.1
  • 32
    • 10744232817 scopus 로고    scopus 로고
    • Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity
    • Nouri-Aria, K.T. et al. Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity. J. Immunol. 172, 3252-3259 (2004).
    • (2004) J. Immunol , vol.172 , pp. 3252-3259
    • Nouri-Aria, K.T.1
  • 33
    • 0035666653 scopus 로고    scopus 로고
    • Interleukin-10 levels increase in cutaneous biopsies of patients undergoing wasp venom immunotherapy
    • Nasser, S.M., Ying, S., Meng, Q., Kay, A.B. & Ewan, P.W. Interleukin-10 levels increase in cutaneous biopsies of patients undergoing wasp venom immunotherapy. Eur. J. Immunol. 31, 3704-3713 (2001).
    • (2001) Eur. J. Immunol , vol.31 , pp. 3704-3713
    • Nasser, S.M.1    Ying, S.2    Meng, Q.3    Kay, A.B.4    Ewan, P.W.5
  • 34
    • 0032821774 scopus 로고    scopus 로고
    • Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: A role for IL-10
    • Burkhart, C., Liu, G.Y., Anderton, S.M., Metzler, B. & Wraith, D.C. Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: A role for IL-10. Int. Immunol. 11, 1625-1634 (1999).
    • (1999) Int. Immunol , vol.11 , pp. 1625-1634
    • Burkhart, C.1    Liu, G.Y.2    Erton, S.M.3    Metzler, B.4    Wraith, D.C.5
  • 35
    • 0037310355 scopus 로고    scopus 로고
    • Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo
    • Sundstedt, A., O’Neill, E. J., Nicolson, K. S. & Wraith, D. C. Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo. J. Immunol. 170, 1240-1248 (2003).
    • (2003) J. Immunol , vol.170 , pp. 1240-1248
    • Sundstedt, A.1    O’neill, E.J.2    Nicolson, K.S.3    Wraith, D.C.4
  • 36
    • 0037018104 scopus 로고    scopus 로고
    • In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines
    • Barrat, F.J. et al. In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J. Exp. Med. 195, 603-616 (2002).
    • (2002) J. Exp. Med , vol.195 , pp. 603-616
    • Barrat, F.J.1
  • 37
    • 0030738659 scopus 로고    scopus 로고
    • Treatment of experimental autoimmune encephalomyelitis with genetically modified memory T cells
    • Mathisen, P.M., Yu, M., Johnson, J.M., Drazba, J.A. & Tuohy, V.K. Treatment of experimental autoimmune encephalomyelitis with genetically modified memory T cells. J. Exp. Med. 186, 159-164 (1997).
    • (1997) J. Exp. Med , vol.186 , pp. 159-164
    • Mathisen, P.M.1    Yu, M.2    Johnson, J.M.3    Drazba, J.A.4    Tuohy, V.K.5
  • 38
    • 0029820287 scopus 로고    scopus 로고
    • Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro
    • Akdis, C.A. et al. Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro. J. Clin. Invest. 98, 16761683 (1996).
    • (1996) J. Clin. Invest , vol.167 , pp. 98
    • Akdis, C.A.1
  • 40
    • 0032055598 scopus 로고    scopus 로고
    • IgE versus IgG4 production can be differentially regulated by IL-10
    • Jeannin, P., Lecoanet, S., Delneste, Y., Gauchat, J.F. & Bonnefoy, J.Y. IgE versus IgG4 production can be differentially regulated by IL-10. J. Immunol. 160, 3555-3561 (1998).
    • (1998) J. Immunol , vol.160 , pp. 3555-3561
    • Jeannin, P.1    Lecoanet, S.2    Delneste, Y.3    Gauchat, J.F.4    Bonnefoy, J.Y.5
  • 41
    • 13944249962 scopus 로고    scopus 로고
    • Mast cells in the development of adaptive immune responses
    • Galli, S.J., Nakae, S. & Tsai, M. Mast cells in the development of adaptive immune responses. Nat. Immunol. 6, 135-142 (2005).
    • (2005) Nat. Immunol , vol.6 , pp. 135-142
    • Galli, S.J.1    Nakae, S.2    Tsai, M.3
  • 42
    • 0042380071 scopus 로고    scopus 로고
    • Involvement of both ’allergic’ and ’autoimmune’ mechanisms in EAE, MS and other autoimmune diseases
    • Pedotti, R., De Voss, J.J., Steinman, L. & Galli, S.J. Involvement of both ’allergic’ and ’autoimmune’ mechanisms in EAE, MS and other autoimmune diseases. Trends Immunol. 24, 479-484 (2003).
    • (2003) Trends Immunol , vol.24 , pp. 479-484
    • Pedotti, R.1    de Voss, J.J.2    Steinman, L.3    Galli, S.J.4
  • 43
    • 0028890866 scopus 로고
    • Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases
    • Liblau, R.S., Singer, S.M. & McDevitt, H.O. Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 16, 34-38 (1995).
    • (1995) Immunol , vol.16 , pp. 34-38
    • Liblau, R.S.1    Singer, S.M.2    McDevitt, H.O.3
  • 44
    • 0034041863 scopus 로고    scopus 로고
    • Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis
    • Duda, P.W., Schmied, M.C., Cook, S.L., Krieger, J.I. & Hafler, D.A. Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis. J. Clin. Invest. 105, 967-976 (2000).
    • (2000) J. Clin. Invest , vol.105 , pp. 967-976
    • Duda, P.W.1    Schmied, M.C.2    Cook, S.L.3    Krieger, J.I.4    Hafler, D.A.5
  • 45
    • 2942703895 scopus 로고    scopus 로고
    • Therapy with glatiramer acetate for multiple sclerosis. Cochrane Database Syst
    • Munari, L., Lovati, R. & Boiko, A. Therapy with glatiramer acetate for multiple sclerosis. Cochrane Database Syst. Rev. CD004678 (2004).
    • (2004) Rev. CD004678
    • Munari, L.1    Lovati, R.2    Boiko, A.3
  • 46
    • 10744230723 scopus 로고    scopus 로고
    • Glatiramer acetate (Copaxone): Comparison of continuous versus delayed therapy in a six-year organized multiple sclerosis trial
    • Johnson, K.P. et al. Glatiramer acetate (Copaxone): Comparison of continuous versus delayed therapy in a six-year organized multiple sclerosis trial. Mult. Scler. 9, 585-591 (2003).
    • (2003) Mult. Scler , vol.9 , pp. 585-591
    • Johnson, K.P.1
  • 47
    • 12744273688 scopus 로고    scopus 로고
    • Neurologic consequence of delaying glatiramer acetate therapy for multiple sclerosis: 8-year data
    • Johnson, K.P., Ford, C.C., Lisak, R.P. & Wolinsky, J.S. Neurologic consequence of delaying glatiramer acetate therapy for multiple sclerosis: 8-year data. Acta Neurol. Scand. 111, 42-47 (2005).
    • (2005) Acta Neurol. Scand , vol.111 , pp. 42-47
    • Johnson, K.P.1    Ford, C.C.2    Lisak, R.P.3    Wolinsky, J.S.4
  • 48
    • 4143124536 scopus 로고    scopus 로고
    • Amelioration of proteolipid protein 139-151-induced encephalomy- elitis in SJL mice by modified amino acid copolymers and their mechanisms
    • Stern, J.N. et al. Amelioration of proteolipid protein 139-151-induced encephalomy- elitis in SJL mice by modified amino acid copolymers and their mechanisms. Proc. Natl. Acad. Sci. USA 101, 11743-11748 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 11743-11748
    • Stern, J.N.1
  • 49
    • 13444281915 scopus 로고    scopus 로고
    • Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomy- elitis
    • Stern, J.N. et al. Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomy- elitis. Proc. Natl. Acad. Sci. USA 102, 1620-1625 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 1620-1625
    • Stern, J.N.1
  • 50
    • 0033066588 scopus 로고    scopus 로고
    • Oral tolerance: Mechanisms and therapeutic applications
    • Faria, A.M. & Weiner, H.L. Oral tolerance: Mechanisms and therapeutic applications. Adv. Immunol. 73, 153-264 (1999).
    • (1999) Adv , vol.73 , pp. 153-264
    • Faria, A.M.1    Weiner, H.L.2
  • 51
    • 0002428852 scopus 로고
    • Remarks on a cutaneous affection produced by certain poisonous vegetables
    • Dakin, R. Remarks on a cutaneous affection produced by certain poisonous vegetables. Am. J. Med. Sci. 4, 98-100 (1829).
    • (1829) Am. J. Med. Sci , vol.4 , pp. 98-100
    • Dakin, R.1
  • 52
    • 0030847054 scopus 로고    scopus 로고
    • Oral tolerance: Immune mechanisms and treatment of autoimmune diseases
    • Weiner, H.L. Oral tolerance: Immune mechanisms and treatment of autoimmune diseases. Immunol. Today 18, 335-343 (1997).
    • (1997) Immunol. Today , vol.18 , pp. 335-343
    • Weiner, H.L.1
  • 53
    • 0030946927 scopus 로고    scopus 로고
    • Treatment of uveitis by oral administration of retinal antigens: Results of a phase I/II randomized masked trial
    • Nussenblatt, R.B. et al. Treatment of uveitis by oral administration of retinal antigens: Results of a phase I/II randomized masked trial. Am. J. Ophthalmol. 123, 583-592 (1997).
    • (1997) Am. J. Ophthalmol , vol.123 , pp. 583-592
    • Nussenblatt, R.B.1
  • 54
    • 0029900868 scopus 로고    scopus 로고
    • Treatment of experimental autoimmune encephalomyelitis by feeding myelin basic protein conjugated to cholera toxin B subunit
    • Sun, J.B., Rask, C., Olsson, T., Holmgren, J. & Czerkinsky, C. Treatment of experimental autoimmune encephalomyelitis by feeding myelin basic protein conjugated to cholera toxin B subunit. Proc. Natl. Acad. Sci. USA 93, 7196-7201 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 7196-7201
    • Sun, J.B.1    Rask, C.2    Olsson, T.3    Holmgren, J.4    Czerkinsky, C.5
  • 55
    • 0033083188 scopus 로고    scopus 로고
    • Immune modulation by the cholera-like enterotoxins: From adjuvant to therapeutic
    • Williams, N.A., Hirst, T.R., & Nashar, T.O. Immune modulation by the cholera-like enterotoxins: From adjuvant to therapeutic. Immunol. Today20, 95-101 (1999).
    • (1999) Immunol. Today20 , pp. 95-101
    • Williams, N.A.1    Hirst, T.R.2    Nashar, T.O.3
  • 56
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • Chen, Y., Kuchroo, V.K., Inobe, J., Hafler, D.A., & Weiner, H.L. Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis. Science 265, 1237-1240 (1994).
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3    Hafler, D.A.4    Weiner, H.L.5
  • 57
    • 0033055884 scopus 로고    scopus 로고
    • Regulatory Th2-type T cell lines against insulin and GAD peptides derived from orally- and nasally-treated NOD mice suppress diabetes
    • Maron, R., Melican, N.S., & Weiner, H.L. Regulatory Th2-type T cell lines against insulin and GAD peptides derived from orally- and nasally-treated NOD mice suppress diabetes. J. Autoimmun. 12, 251-258 (1999).
    • (1999) J. Autoimmun , vol.12 , pp. 251-258
    • Maron, R.1    Melican, N.S.2    Weiner, H.L.3
  • 58
    • 0030578412 scopus 로고    scopus 로고
    • Antigen- driven peripheral immune tolerance: Suppression of experimental autoimmmune encephalomyelitis and collagen-induced arthritis by aerosol administration of myelin basic protein or type II collagen
    • al Sabbagh, A., Nelson, P.A., Akselband, Y., Sobel, R.A., & Weiner, H.L. Antigen- driven peripheral immune tolerance: Suppression of experimental autoimmmune encephalomyelitis and collagen-induced arthritis by aerosol administration of myelin basic protein or type II collagen. Cell. Immunol. 171, 111-119 (1996).
    • (1996) Cell. Immunol , vol.171 , pp. 111-119
    • Al Sabbagh, A.1    Nelson, P.A.2    Akselband, Y.3    Sobel, R.A.4    Weiner, H.L.5
  • 59
    • 0031615666 scopus 로고    scopus 로고
    • Antigen-specific tolerance induction and the immunotherapy of experimental autoimmune disease
    • Anderton, S.M., Burkhart, C., Liu, G.Y., Metzler, B. & Wraith, D. C. Antigen-specific tolerance induction and the immunotherapy of experimental autoimmune disease. Novartis Found. Symp. 215, 120-131 (1998).
    • (1998) Novartis Found. Symp , vol.215 , pp. 120-131
    • Anderton, S.M.1    Burkhart, C.2    Liu, G.Y.3    Metzler, B.4    Wraith, D.C.5
  • 60
    • 2942655175 scopus 로고    scopus 로고
    • ‘Educated’ dendritic cells act as messengers from memory to naive T helper cells
    • Alpan, O., Bachelder, E., Isil, E., Arnheiter, H. & Matzinger, P. ’Educated’ dendritic cells act as messengers from memory to naive T helper cells. Nat. Immunol 5, 615-622 (2004).
    • (2004) Nat. Immunol , vol.5 , pp. 615-622
    • Alpan, O.1    Bachelder, E.2    Isil, E.3    Arnheiter, H.4    Matzinger, P.5
  • 61
    • 0026664422 scopus 로고
    • Spreading of T-cell autoim- munity to cryptic determinants of an autoantigen
    • Lehmann, P.V., Forsthuber, T., Miller, A. & Sercarz, E.E. Spreading of T-cell autoim- munity to cryptic determinants of an autoantigen. Nature 358, 155-157 (1992).
    • (1992) Nature , vol.358 , pp. 155-157
    • Lehmann, P.V.1    Forsthuber, T.2    Miller, A.3    Sercarz, E.E.4
  • 62
    • 0030452309 scopus 로고    scopus 로고
    • Late complications of immune deviation therapy in a nonhuman primate
    • Genain, C. P. et al. Late complications of immune deviation therapy in a nonhuman primate. Science 274, 2054-2057 (1996).
    • (1996) Science , vol.274 , pp. 2054-2057
    • Genain, C.P.1
  • 63
    • 0029807595 scopus 로고    scopus 로고
    • Induction of autoimmune diabetes by oral administration of autoantigen
    • Blanas, E., Carbone, F.R., Allison, J., Miller, J.F. & Heath, W.R. Induction of autoimmune diabetes by oral administration of autoantigen. Science 274, 1707-1709 (1996).
    • (1996) Science , vol.274 , pp. 1707-1709
    • Blanas, E.1    Carbone, F.R.2    Allison, J.3    Miller, J.F.4    Heath, W.R.5
  • 64
    • 0035085647 scopus 로고    scopus 로고
    • Mucosal antigen primes diabetogenic cytotoxic T-lymphocytes regardless of dose or delivery route
    • Hanninen, A., Braakhuis, A., Heath, W. R., & Harrison, L. C. Mucosal antigen primes diabetogenic cytotoxic T-lymphocytes regardless of dose or delivery route. Diabetes 50, 771-775 (2001).
    • (2001) Diabetes , vol.50 , pp. 771-775
    • Hanninen, A.1    Braakhuis, A.2    Heath, W.R.3    Harrison, L.C.4
  • 65
    • 0019865909 scopus 로고
    • Studies on allergoids from naturally occurring allergens. IV. Efficacy and safety of long-term allergoid treatment of ragweed hay fever
    • Norman, P.S., Lichtenstein, L.M., & Marsh, D.G. Studies on allergoids from naturally occurring allergens. IV. Efficacy and safety of long-term allergoid treatment of ragweed hay fever. J. Allergy Clin. Immunol. 68, 460-470 (1981).
    • (1981) J. Allergy Clin. Immunol , vol.68 , pp. 460-470
    • Norman, P.S.1    Lichtenstein, L.M.2    Marsh, D.G.3
  • 66
    • 5144222703 scopus 로고    scopus 로고
    • Vaccination with genetically engineered allergens prevents progression of allergic disease
    • Niederberger, V. et al. Vaccination with genetically engineered allergens prevents progression of allergic disease. Proc. Natl. Acad. Sci. USA 101 Suppl 2, 14677-14682 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 14677-14682
    • Niederberger, V.1
  • 67
    • 0032826306 scopus 로고    scopus 로고
    • Genetically engineered and synthetic allergen derivatives: Candidates for vaccination against type I allergy
    • Valenta, R. et al. Genetically engineered and synthetic allergen derivatives: Candidates for vaccination against type I allergy. Biol. Chem. 380, 815-824 (1999).
    • (1999) Biol. Chem , vol.380 , pp. 815-824
    • Valenta, R.1
  • 68
    • 0027451437 scopus 로고
    • Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice
    • Hoyne, G.F., O’Hehir, R.E., Wraith, D.C., Thomas, W.R., & Lamb, J.R. Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice. J. Exp. Med. 178, 1783-1788 (1993).
    • (1993) J. Exp. Med , vol.178 , pp. 1783-1788
    • Hoyne, G.F.1    O’hehir, R.E.2    Wraith, D.C.3    Thomas, W.R.4    Lamb, J.R.5
  • 69
    • 0027323846 scopus 로고
    • Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d I
    • Briner, T. J., Kuo, M. C., Keating, K. M., Rogers, B. L. & Greenstein, J. L. Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d I. Proc. Natl. Acad. Sci. USA 90, 7608-7612 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 7608-7612
    • Briner, T.J.1    Kuo, M.C.2    Keating, K.M.3    Rogers, B.L.4    Greenstein, J.L.5
  • 70
    • 8044227212 scopus 로고    scopus 로고
    • Treatment of cat allergy with T-cell reactive peptides
    • Norman, P.S. et al. Treatment of cat allergy with T-cell reactive peptides. Am. J. Respir. Crit. Care Med. 154, 1623-1628 (1996).
    • (1996) Am. J. Respir. Crit. Care Med , vol.154 , pp. 1623-1628
    • Norman, P.S.1
  • 72
    • 0030444839 scopus 로고    scopus 로고
    • Fel d 1 peptides: Effect on skin tests and cytokine synthesis in cat-allergic human subjects
    • Simons, F.E., Imada, M., Li, Y., Watson, W.T., & HayGlass, K.T. Fel d 1 peptides: Effect on skin tests and cytokine synthesis in cat-allergic human subjects. Int. Immunol. 8, 1937-1945 (1996).
    • (1996) Int. Immunol , vol.8 , pp. 1937-1945
    • Simons, F.E.1    Imada, M.2    Li, Y.3    Watson, W.T.4    Hayglass, K.T.5
  • 73
    • 0031793244 scopus 로고    scopus 로고
    • Immunotherapy with Fel d 1 peptides decreases IL-4 release by peripheral blood T cells of patients allergic to cats
    • Pene, J. et al. Immunotherapy with Fel d 1 peptides decreases IL-4 release by peripheral blood T cells of patients allergic to cats. J. Allergy Clin. Immunol. 102, 571-578 (1998).
    • (1998) J. Allergy Clin. Immunol , vol.102 , pp. 571-578
    • Pene, J.1
  • 74
    • 0031866059 scopus 로고    scopus 로고
    • Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom
    • Muller, U. et al. Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom. J. Allergy Clin. Immunol. 101, 747-754 (1998).
    • (1998) J. Allergy Clin. Immunol , vol.101 , pp. 747-754
    • Muller, U.1
  • 75
    • 0037395291 scopus 로고    scopus 로고
    • Allergen-specific T-cell tolerance induction with allergen-derived long synthetic peptides: Results of a phase I trial
    • Fellrath, J.M. et al. Allergen-specific T-cell tolerance induction with allergen-derived long synthetic peptides: Results of a phase I trial. J. Allergy Clin. Immunol. 111, 854-861 (2003).
    • (2003) J. Allergy Clin. Immunol , vol.111 , pp. 854-861
    • Fellrath, J.M.1
  • 76
    • 0035423535 scopus 로고    scopus 로고
    • Allergen-derived T cell peptide-induced late asthmatic reactions precede the induction of antigen-specific hyporesponsiveness in atopic allergic asthmatic subjects
    • Oldfield, W.L., Kay, A.B. & Larche, M. Allergen-derived T cell peptide-induced late asthmatic reactions precede the induction of antigen-specific hyporesponsiveness in atopic allergic asthmatic subjects. J. Immunol. 167, 1734-1739 (2001).
    • (2001) J. Immunol , vol.167 , pp. 1734-1739
    • Oldfield, W.L.1    Kay, A.B.2    Larche, M.3
  • 77
    • 0037031090 scopus 로고    scopus 로고
    • Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: A randomised controlled trial
    • Oldfield, W.L., Larche, M. & Kay, A.B. Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: A randomised controlled trial. Lancet 360, 47-53 (2002).
    • (2002) Lancet , vol.360 , pp. 47-53
    • Oldfield, W.L.1    Larche, M.2    Kay, A.B.3
  • 78
    • 17644370107 scopus 로고    scopus 로고
    • The effect of Fel d 1-derived T cell peptides on upper and lower airway outcome measurements in cat-allergic subjects
    • Alexander, C., Tarzi, M., Larche, M. & Kay, A. B. The effect of Fel d 1-derived T cell peptides on upper and lower airway outcome measurements in cat-allergic subjects. Allergy, in the press.
    • Allergy, in the Press
    • Alexander, C.1    Tarzi, M.2    Larche, M.3    Kay, A.B.4
  • 79
    • 13244291456 scopus 로고    scopus 로고
    • Fel d 1-derived T cell peptide therapy induces recruitment of CD4CD25; CD4 interferon-gamma T helper type 1 cells to sites of allergen-induced late-phase skin reactions in cat-allergic subjects
    • Alexander, C., Ying, S., Kay, B. & Larche, M. Fel d 1-derived T cell peptide therapy induces recruitment of CD4CD25; CD4 interferon-gamma T helper type 1 cells to sites of allergen-induced late-phase skin reactions in cat-allergic subjects. Clin. Exp. Allergy 35, 52-58 (2005).
    • (2005) Clin. Exp. Allergy , vol.35 , pp. 52-58
    • Alexander, C.1    Ying, S.2    Kay, B.3    Larche, M.4
  • 80
    • 0027380361 scopus 로고
    • Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: Influence of MHC binding affinity
    • Metzler, B. & Wraith, D.C. Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: Influence of MHC binding affinity. Int. Immunol 5, 1159-1165 (1993).
    • (1993) Int. Immunol , vol.5 , pp. 1159-1165
    • Metzler, B.1    Wraith, D.C.2
  • 81
    • 0031966915 scopus 로고    scopus 로고
    • Hierarchy in the ability of T cell epitopes to induce peripheral tolerance to antigens from myelin
    • Anderton, S.M. & Wraith, D.C. Hierarchy in the ability of T cell epitopes to induce peripheral tolerance to antigens from myelin. Eur. J. Immunol 28, 1251-1261 (1998).
    • (1998) Eur. J. Immunol , vol.28 , pp. 1251-1261
    • Anderton, S.M.1    Wraith, D.C.2
  • 82
    • 0031927667 scopus 로고    scopus 로고
    • Inhibition of experimental autoimmune encephalomyelitis in Lewis rats by nasal administration of encephalitogenic MBP peptides: Synergistic effects of MBP 68-86 and 87-99
    • Liu, J.Q. et al. Inhibition of experimental autoimmune encephalomyelitis in Lewis rats by nasal administration of encephalitogenic MBP peptides: Synergistic effects of MBP 68-86 and 87-99. Int. Immunol. 10, 1139-1148 (1998).
    • (1998) Int. Immunol , vol.10 , pp. 1139-1148
    • Liu, J.Q.1
  • 83
    • 0029962104 scopus 로고    scopus 로고
    • Mucosal tolerance and suppression of collagen-induced arthritis (CIA) induced by nasal inhalation of synthetic peptide 184-198 of bovine type II collagen (CII) expressing a dominant T cell epitope
    • Staines, N.A. et al. Mucosal tolerance and suppression of collagen-induced arthritis (CIA) induced by nasal inhalation of synthetic peptide 184-198 of bovine type II collagen (CII) expressing a dominant T cell epitope. Clin. Exp. Immunol. 103, 368-375 (1996).
    • (1996) Clin. Exp. Immunol , vol.103 , pp. 368-375
    • Staines, N.A.1
  • 84
    • 0033080994 scopus 로고    scopus 로고
    • Differential activities of immunogenic collagen type II pep- tides in the induction of nasal tolerance to collagen-induced arthritis
    • Chu, C.Q. & Londei, M. Differential activities of immunogenic collagen type II pep- tides in the induction of nasal tolerance to collagen-induced arthritis. J. Autoimmun. 12, 35-42 (1999).
    • (1999) J. Autoimmun , vol.12 , pp. 35-42
    • Chu, C.Q.1    Londei, M.2
  • 85
    • 0030953059 scopus 로고    scopus 로고
    • Peptide-induced nasal tolerance for a mycobacterial heat shock protein 60 T cell epitope in rats suppresses both adjuvant arthritis and nonmicrobi- ally induced experimental arthritis
    • Prakken, B.J. et al. Peptide-induced nasal tolerance for a mycobacterial heat shock protein 60 T cell epitope in rats suppresses both adjuvant arthritis and nonmicrobi- ally induced experimental arthritis. Proc. Natl. Acad. Sci. USA 94, 3284-3289 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 3284-3289
    • Prakken, B.J.1
  • 86
    • 0029923430 scopus 로고    scopus 로고
    • Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes
    • Tian, J. et al. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J. Exp. Med. 183, 1561-1567 (1996).
    • (1996) J. Exp. Med , vol.183 , pp. 1561-1567
    • Tian, J.1
  • 87
    • 0030069688 scopus 로고    scopus 로고
    • Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)
    • Daniel, D. & Wegmann, D. R. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc. Natl. Acad. Sci. USA 93, 956-960 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 956-960
    • Daniel, D.1    Wegmann, D.R.2
  • 88
    • 0030960632 scopus 로고    scopus 로고
    • Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various beta-cell antigens
    • Elias, D. et al. Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various beta-cell antigens. Diabetes 46, 758-764 (1997).
    • (1997) Diabetes , vol.46 , pp. 758-764
    • Elias, D.1
  • 89
    • 0025905547 scopus 로고
    • Induction of oral tolerance to S-antigen induced experimental autoimmune uveitis by a uveitogenic 20mer peptide
    • Thurau, S.R., Chan, C.C., Suh, E. & Nussenblatt, RB. Induction of oral tolerance to S-antigen induced experimental autoimmune uveitis by a uveitogenic 20mer peptide. J. Autoimmun. 4, 507-516 (1991).
    • (1991) J. Autoimmun , vol.4 , pp. 507-516
    • Thurau, S.R.1    Chan, C.C.2    Suh, E.3    Nussenblatt, R.B.4
  • 90
    • 0031452406 scopus 로고    scopus 로고
    • Prevention of experimental myasthenia gravis by nasal administration of synthetic acetylcholine receptor T epitope sequences
    • Karachunski, P.I., Ostlie, N.S., Okita, D.K. & Conti-Fine, B.M. Prevention of experimental myasthenia gravis by nasal administration of synthetic acetylcholine receptor T epitope sequences. J. Clin. Invest 100, 3027-3035 (1997).
    • (1997) J. Clin. Invest , vol.100 , pp. 3027-3035
    • Karachunski, P.I.1    Ostlie, N.S.2    Okita, D.K.3    Conti-Fine, B.M.4
  • 91
    • 0034053126 scopus 로고    scopus 로고
    • Oral administration of a dual analog of two myasthenogenic T cell epitopes down-regulates experimental autoimmune myasthenia gravis in mice
    • Paas-Rozner, M. et al. Oral administration of a dual analog of two myasthenogenic T cell epitopes down-regulates experimental autoimmune myasthenia gravis in mice. Proc. Natl. Acad. Sci. USA 97, 2168-2173 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 2168-2173
    • Paas-Rozner, M.1
  • 92
    • 0033081134 scopus 로고    scopus 로고
    • Antigen-specific immunosuppression: Nasal tolerance to P0 protein peptides for the prevention and treatment of experimental autoimmune neuritis in Lewis rats
    • Zou, L.P. et al. Antigen-specific immunosuppression: Nasal tolerance to P0 protein peptides for the prevention and treatment of experimental autoimmune neuritis in Lewis rats. J. Neuroimmunol. 94, 109-121 (1999).
    • (1999) J. Neuroimmunol , vol.94 , pp. 109-121
    • Zou, L.P.1
  • 93
    • 0035944844 scopus 로고    scopus 로고
    • Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial
    • Raz, I. et al. Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial. Lancet 358, 1749-1753 (2001).
    • (2001) Lancet , vol.358 , pp. 1749-1753
    • Raz, I.1
  • 94
    • 12144289938 scopus 로고    scopus 로고
    • Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis
    • Prakken, B.J. et al. Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 101, 4228-4233 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 4228-4233
    • Prakken, B.J.1
  • 95
    • 0029933309 scopus 로고    scopus 로고
    • Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
    • Sloan-Lancaster, J. & Allen, P. M. Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology. Annu.Rev.Immunol 14, 1-27 (1996).
    • (1996) Annu.Rev.Immunol , vol.14 , pp. 1-27
    • Sloan-Lancaster, J.1    Allen, P.M.2
  • 96
    • 0028326522 scopus 로고
    • T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis
    • Franco, A. et al. T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis. Eur. J. Immunol. 24, 940-946 (1994).
    • (1994) Eur. J. Immunol , vol.24 , pp. 940-946
    • Franco, A.1
  • 97
    • 0028148199 scopus 로고
    • Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production
    • Karin, N., Mitchell, D.J., Brocke, S., Ling, N. & Steinman, L. Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production. J. Exp. Med. 180, 2227-2237 (1994).
    • (1994) J. Exp. Med , vol.180 , pp. 2227-2237
    • Karin, N.1    Mitchell, D.J.2    Brocke, S.3    Ling, N.4    Steinman, L.5
  • 98
    • 0027964523 scopus 로고
    • A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire
    • Kuchroo, V.K. et al. A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire. J. Immunol. 153, 3326-3336 (1994).
    • (1994) J. Immunol , vol.153 , pp. 3326-3336
    • Kuchroo, V.K.1
  • 99
    • 0030797568 scopus 로고    scopus 로고
    • A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens
    • Nicholson, L.B., Murtaza, A., Hafler, B.P., Sette, A. & Kuchroo, V.K. A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens. Proc. Natl. Acad. Sci. USA 94, 9279-9284 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9279-9284
    • Nicholson, L.B.1    Murtaza, A.2    Hafler, B.P.3    Sette, A.4    Kuchroo, V.K.5
  • 100
    • 0033791462 scopus 로고    scopus 로고
    • Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The Altered Peptide Ligand in relapsing MS Study Group
    • Kappos, L. et al. Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The Altered Peptide Ligand in relapsing MS Study Group. Nat. Med. 6, 1176-1182 (2000).
    • (2000) Nat. Med , vol.6 , pp. 1176-1182
    • Kappos, L.1
  • 101
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (Amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
    • Bielekova, B. et al. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand. Nat. Med. 6, 1167-1175 (2000).
    • (2000) Nat. Med , vol.6 , pp. 1167-1175
    • Bielekova, B.1
  • 102
    • 0030980396 scopus 로고    scopus 로고
    • Fine specificity of myelin basic protein reactive T-cells: Implications for T-cell receptor antagonism
    • Anderton, S.M., Manickasingham, S.P. & Wraith, D.C. Fine specificity of myelin basic protein reactive T-cells: Implications for T-cell receptor antagonism. Biochem. Soc. Trans. 25, 659-661 (1997).
    • (1997) Biochem. Soc. Trans , vol.25 , pp. 659-661
    • Anderton, S.M.1    Manickasingham, S.P.2    Wraith, D.C.3
  • 103
    • 2342652841 scopus 로고    scopus 로고
    • Transplantation tolerance induced by intranasal administration of HY peptides
    • Chai, J.G., James, E., Dewchand, H., Simpson, E. & Scott, D. Transplantation tolerance induced by intranasal administration of HY peptides. Blood 103, 3951-3959 (2004).
    • (2004) Blood , vol.103 , pp. 3951-3959
    • Chai, J.G.1    James, E.2    Dewchand, H.3    Simpson, E.4    Scott, D.5
  • 104
    • 0028466130 scopus 로고
    • Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo
    • Kearney, E.R., Pape, K.A., Loh, D.Y. & Jenkins, M.K. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity 1, 327-339 (1994).
    • (1994) Immunity , vol.1 , pp. 327-339
    • Kearney, E.R.1    Pape, K.A.2    Loh, D.Y.3    Jenkins, M.K.4
  • 105
    • 0028215537 scopus 로고
    • T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis
    • Critchfield, J. M. et al. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science 263, 1139-1143 (1994).
    • (1994) Science , vol.263 , pp. 1139-1143
    • Critchfield, J.M.1
  • 106
    • 0035940454 scopus 로고    scopus 로고
    • The nature of the active suppression of responses associated with experimental autoimmune myasthenia gravis by a dual altered peptide ligand administered by different routes
    • Paas-Rozner, M., Sela, M., & Mozes, E. The nature of the active suppression of responses associated with experimental autoimmune myasthenia gravis by a dual altered peptide ligand administered by different routes. Proc. Natl. Acad. Sci. USA 98, 12642-12647 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12642-12647
    • Paas-Rozner, M.1    Sela, M.2    Mozes, E.3
  • 107
    • 2542420993 scopus 로고    scopus 로고
    • In vivo instruction of suppressor commitment in naive T cells
    • Apostolou, I. & Von Boehmer, H. In vivo instruction of suppressor commitment in naive T cells. J. Exp. Med. 199, 1401-1408 (2004).
    • (2004) J. Exp. Med , vol.199 , pp. 1401-1408
    • Apostolou, I.1    Von Boehmer, H.2
  • 108
    • 84984933414 scopus 로고    scopus 로고
    • T Cell epitope immunotherapy induces a CD4+ T cell population with regulatory activity
    • Verhoef, A., Alexander, C., Kay, A.B. & Larche, M. T Cell epitope immunotherapy induces a CD4+ T cell population with regulatory activity. PLoS Med., in the press.
    • Plos Med., in the Press
    • Verhoef, A.1    Alexander, C.2    Kay, A.B.3    Larche, M.4
  • 109
    • 0033591638 scopus 로고    scopus 로고
    • Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions
    • Haselden, B.M., Kay, A.B., & Larche, M. Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions. J. Exp. Med. 189, 1885-1894 (1999).
    • (1999) J. Exp. Med , vol.189 , pp. 1885-1894
    • Haselden, B.M.1    Kay, A.B.2    Larche, M.3
  • 110
    • 0028229166 scopus 로고
    • Specific T-cell tolerance may be preceded by a primary response
    • Vidard, L., Colarusso, L.J., & Benacerraf, B. Specific T-cell tolerance may be preceded by a primary response. Proc. Natl. Acad. Sci. USA 91, 5627-5631 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5627-5631
    • Vidard, L.1    Colarusso, L.J.2    Benacerraf, B.3
  • 111
    • 0025602793 scopus 로고
    • Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity
    • Webb, S., Morris, C. & Sprent, J. Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity. Cell 63, 1249-1256 (1990).
    • (1990) Cell , vol.63 , pp. 1249-1256
    • Webb, S.1    Morris, C.2    Sprent, J.3
  • 112
    • 0030068998 scopus 로고    scopus 로고
    • Regulation of house dust mite responses by intranasally administered peptide: Transient activation of CD4+ T cells precedes the development of tolerance in vivo
    • Hoyne, G.F., Askonas, B.A., Hetzel, C., Thomas, W.R., & Lamb, J.R. Regulation of house dust mite responses by intranasally administered peptide: Transient activation of CD4+ T cells precedes the development of tolerance in vivo. Int. Immunol. 8, 335-342 (1996).
    • (1996) Int. Immunol , vol.8 , pp. 335-342
    • Hoyne, G.F.1    Askonas, B.A.2    Hetzel, C.3    Thomas, W.R.4    Lamb, J.R.5
  • 113
  • 114
    • 0033998667 scopus 로고    scopus 로고
    • Kinetics of peptide uptake and tissue distribution following a single intranasal dose of peptide
    • Metzler, B., Anderton, S.M., Manickasingham, S.P., & Wraith, D.C. Kinetics of peptide uptake and tissue distribution following a single intranasal dose of peptide. Immunol. Invest. 29, 61-70 (2000).
    • (2000) Immunol. Invest , vol.29 , pp. 61-70
    • Metzler, B.1    Erton, S.M.2    Manickasingham, S.P.3    Wraith, D.C.4
  • 115
    • 0034695893 scopus 로고    scopus 로고
    • The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase
    • Arentz-Hansen, H. et al. The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase. J. Exp. Med. 191, 603-612 (2000).
    • (2000) J. Exp. Med , vol.191 , pp. 603-612
    • Arentz-Hansen, H.1
  • 117
    • 0032055915 scopus 로고    scopus 로고
    • Several common HLA-DR types share largely overlapping peptide binding repertoires
    • Southwood, S. et al. Several common HLA-DR types share largely overlapping peptide binding repertoires. J. Immunol. 160, 3363-3373 (1998).
    • (1998) J. Immunol , vol.160 , pp. 3363-3373
    • Southwood, S.1
  • 118
    • 0034654312 scopus 로고    scopus 로고
    • HLA-DR restricted peptide candidates for bee venom immunotherapy
    • Texier, C. et al. HLA-DR restricted peptide candidates for bee venom immunotherapy. J. Immunol. 164, 3177-3184 (2000).
    • (2000) J. Immunol , vol.164 , pp. 3177-3184
    • Texier, C.1
  • 119
    • 0036172037 scopus 로고    scopus 로고
    • Influence of a dominant cryptic epitope on autoimmune T cell tolerance
    • Anderton, S.M., Viner, N.J., Matharu, P., Lowrey, P.A. & Wraith, D.C. Influence of a dominant cryptic epitope on autoimmune T cell tolerance. Nat. Immunol 3, 175-181 (2002).
    • (2002) Nat. Immunol , vol.3 , pp. 175-181
    • Anderton, S.M.1    Viner, N.J.2    Matharu, P.3    Lowrey, P.A.4    Wraith, D.C.5
  • 120
    • 0242662208 scopus 로고    scopus 로고
    • Peptides containing a dominant T-cell epitope from red cell band 3 have in vivo immunomodulatory properties in NZB mice with autoimmune hemolytic anemia
    • Shen, C.R. et al. Peptides containing a dominant T-cell epitope from red cell band 3 have in vivo immunomodulatory properties in NZB mice with autoimmune hemolytic anemia. Blood 102, 3800-3806 (2003).
    • (2003) Blood , vol.102 , pp. 3800-3806
    • Shen, C.R.1
  • 122
    • 0034613767 scopus 로고    scopus 로고
    • Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
    • Jonuleit, H., Schmitt, E., Schuler, G., Knop, J. & Enk, A. H. Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med. 192, 1213-1222 (2000).
    • (2000) J. Exp. Med , vol.192 , pp. 1213-1222
    • Jonuleit, H.1    Schmitt, E.2    Schuler, G.3    Knop, J.4    Enk, A.H.5
  • 123
    • 0037987977 scopus 로고    scopus 로고
    • Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo
    • Wakkach, A. et al. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 18, 605-617 (2003).
    • (2003) Immunity , vol.18 , pp. 605-617
    • Wakkach, A.1
  • 124
    • 0035862333 scopus 로고    scopus 로고
    • Antigen- specific inhibition of effector T cell function in humans after injection of immature dendritic cells
    • Dhodapkar, M.V., Steinman, R.M., Krasovsky, J., Munz, C. & Bhardwaj, N. Antigen- specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J. Exp. Med. 193, 233-238 (2001).
    • (2001) J. Exp. Med , vol.193 , pp. 233-238
    • Dhodapkar, M.V.1    Steinman, R.M.2    Krasovsky, J.3    Munz, C.4    Bhardwaj, N.5
  • 125
    • 0037033427 scopus 로고    scopus 로고
    • Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity
    • Menges, M. et al. Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity. J. Exp. Med. 195, 15-21 (2002).
    • (2002) J. Exp. Med , vol.195 , pp. 15-21
    • Menges, M.1
  • 126
    • 0022974996 scopus 로고
    • T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis
    • Zamvil, S.S. et al. T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature 324, 258-260 (1986).
    • (1986) Nature , vol.324 , pp. 258-260
    • Zamvil, S.S.1
  • 127
    • 0029151763 scopus 로고
    • Affinity for class II MHC determines the extent to which soluble peptides tolerize autoreactive T cells in naive and primed adult mice-implications for autoimmunity
    • Liu, G.Y. & Wraith, D.C. Affinity for class II MHC determines the extent to which soluble peptides tolerize autoreactive T cells in naive and primed adult mice-implications for autoimmunity. Int. Immunol. 7, 1255-1263 (1995).
    • (1995) Int. Immunol , vol.7 , pp. 1255-1263
    • Liu, G.Y.1    Wraith, D.C.2
  • 128
    • 0032988416 scopus 로고    scopus 로고
    • Inhibition of T-cell responsiveness by nasal peptide administration: Influence of the thymus and differential recovery of T-cell-dependent functions
    • Metzler, B. & Wraith, D.C. Inhibition of T-cell responsiveness by nasal peptide administration: Influence of the thymus and differential recovery of T-cell-dependent functions. Immunology 97, 257-263 (1999).
    • (1999) Immunology , vol.97 , pp. 257-263
    • Metzler, B.1    Wraith, D.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.