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Volumn 159, Issue 12, 1997, Pages 5802-5809

Distinct Biochemical Signals Characterize Agonist- and Altered Peptide Ligand-Induced Differentiation of Naive CD4+ T Cells into Th1 and Th2 Subsets

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CYTOCHROME C; LIGAND; LYMPHOCYTE ANTIGEN RECEPTOR; PEPTIDE; TYROSINE;

EID: 0031573513     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (84)

References (49)
  • 1
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L. Coffmann. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
    • (1986) J. Immunol. , vol.136 , pp. 2348
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffmann, R.L.5
  • 2
    • 0023093430 scopus 로고
    • Cloned, Ia-restricted T cells that do not produce interleukin 4(IL-4)/B cell stimulatory factor 1 (BSF-1) fail to help antigen-specific B cells
    • Killar, L., G. MacDonald, J. West, A. Woods, and K. Bottomly. 1987. Cloned, Ia-restricted T cells that do not produce interleukin 4(IL-4)/B cell stimulatory factor 1 (BSF-1) fail to help antigen-specific B cells. J. Immunol. 138:1674.
    • (1987) J. Immunol. , vol.138 , pp. 1674
    • Killar, L.1    MacDonald, G.2    West, J.3    Woods, A.4    Bottomly, K.5
  • 3
    • 0024540908 scopus 로고
    • Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis: Evidence for expansion of distinct helper T cell subsets
    • Heinzel, F. P., M. D. Sadick, B. J. Holaday, R. L. Coffmann, and R. M. Locksley. 1989. Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis: evidence for expansion of distinct helper T cell subsets. J. Exp. Med. 169:59.
    • (1989) J. Exp. Med. , vol.169 , pp. 59
    • Heinzel, F.P.1    Sadick, M.D.2    Holaday, B.J.3    Coffmann, R.L.4    Locksley, R.M.5
  • 5
    • 0023269443 scopus 로고
    • Two types of murine helper T cell clone. II. Delayed type hypersensitivity is mediated by Th1 clones
    • Cher, D., and T. Mosmann. 1987. Two types of murine helper T cell clone. II. Delayed type hypersensitivity is mediated by Th1 clones. J. Immunol. 138:3688.
    • (1987) J. Immunol. , vol.138 , pp. 3688
    • Cher, D.1    Mosmann, T.2
  • 6
    • 0024567163 scopus 로고
    • Antigen-specific activation of effector macrophages by IFN-γ producing (Th1) T cell clones: Failure of IL-4-producing (Th2) T cell clones to activate effector function in macrophages
    • Stout, R. D., and K. Bottomly. 1989. Antigen-specific activation of effector macrophages by IFN-γ producing (Th1) T cell clones: failure of IL-4-producing (Th2) T cell clones to activate effector function in macrophages. J. Immunol. 142:760.
    • (1989) J. Immunol. , vol.142 , pp. 760
    • Stout, R.D.1    Bottomly, K.2
  • 10
    • 0027409793 scopus 로고
    • Natural killer cell stimulatory factor (IL-12) induces Th1 specific immune responses and inhibits the development of IL-4 producing Th cells
    • Manetti, R., P. Parronchi, M. G. Giudizi, M. P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (IL-12) induces Th1 specific immune responses and inhibits the development of IL-4 producing Th cells. J. Exp. Med. 177:1199.
    • (1993) J. Exp. Med. , vol.177 , pp. 1199
    • Manetti, R.1    Parronchi, P.2    Giudizi, M.G.3    Piccinni, M.P.4    Maggi, E.5    Trinchieri, G.6    Romagnani, S.7
  • 11
    • 0025082313 scopus 로고
    • Generation of IL4-producing cells in vivo and in vitro. IL2 and IL4 are required for in vitro generation of IL4-producing cells
    • LeGros, G., S. Z. Ben-Sasson, R. Seder, F. D. Finkelman, and W. E. Paul. 1990. Generation of IL4-producing cells in vivo and in vitro. IL2 and IL4 are required for in vitro generation of IL4-producing cells. J. Exp. Med. 172:921.
    • (1990) J. Exp. Med. , vol.172 , pp. 921
    • LeGros, G.1    Ben-Sasson, S.Z.2    Seder, R.3    Finkelman, F.D.4    Paul, W.E.5
  • 12
    • 0025819491 scopus 로고
    • Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell population
    • Gajewski, T. F., M. Pinnas, T. Wong, and F. W. Fitch. 1991. Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell population. J. Immunol. 146:1750.
    • (1991) J. Immunol. , vol.146 , pp. 1750
    • Gajewski, T.F.1    Pinnas, M.2    Wong, T.3    Fitch, F.W.4
  • 13
    • 0028931038 scopus 로고
    • + T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type
    • + T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type. J. Exp. Med. 181:1081.
    • (1995) J. Exp. Med. , vol.181 , pp. 1081
    • Secrist, H.1    Dekruyff, R.H.2    Umetsu, D.T.3
  • 14
    • 0029073050 scopus 로고
    • B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4
    • Freeman, G. J., V. A. Boussiotis, A. Anumanthan, G. M. Bernstein, X.-Y. Ke, P. D. Rennert, G. S. Gray, J. G. Gribben, and L. M. Nadler. 1995. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity 2:523.
    • (1995) Immunity , vol.2 , pp. 523
    • Freeman, G.J.1    Boussiotis, V.A.2    Anumanthan, A.3    Bernstein, G.M.4    Ke, X.-Y.5    Rennert, P.D.6    Gray, G.S.7    Gribben, J.G.8    Nadler, L.M.9
  • 15
    • 0028949152 scopus 로고
    • B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
    • Kuchroo, V. K., M. P. Das, J. A. Brown, A. M. Ranger, S. S. Zamvil, R. A. Sobel, H. L. Weiner, N. Nabavi, and L. H. Glimcher. 1995. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80:707.
    • (1995) Cell , vol.80 , pp. 707
    • Kuchroo, V.K.1    Das, M.P.2    Brown, J.A.3    Ranger, A.M.4    Zamvil, S.S.5    Sobel, R.A.6    Weiner, H.L.7    Nabavi, N.8    Glimcher, L.H.9
  • 18
    • 0030062937 scopus 로고    scopus 로고
    • Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and β2-microglobulin-deficient BALB/c mice
    • Guery, J.-C., F. Galbiati, S. Smiroldo, and L. Adorini. 1996. Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and β2-microglobulin-deficient BALB/c mice. J. Exp. Med. 183:485.
    • (1996) J. Exp. Med. , vol.183 , pp. 485
    • Guery, J.-C.1    Galbiati, F.2    Smiroldo, S.3    Adorini, L.4
  • 19
    • 0028919877 scopus 로고
    • Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo
    • Pfeiffer, C., K. Stein, S. Southwood, K. H. A. Sette, and K. Bottomly. 1995. Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J. Exp. Med. 181:1569.
    • (1995) J. Exp. Med. , vol.181 , pp. 1569
    • Pfeiffer, C.1    Stein, K.2    Southwood, S.3    Sette, K.H.A.4    Bottomly, K.5
  • 20
    • 0028956146 scopus 로고
    • Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand
    • Windhagen, A., C. Scholz, P. Höllsberg, H. Fukaura, A. Sette, and D. A. Hafler. 1995. Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand. Immunity 2:373.
    • (1995) Immunity , vol.2 , pp. 373
    • Windhagen, A.1    Scholz, C.2    Höllsberg, P.3    Fukaura, H.4    Sette, A.5    Hafler, D.A.6
  • 21
    • 0028849807 scopus 로고
    • Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon γ by T cells
    • Kumar, V., V. Bhardwaj, L. Soares, J. Alexander, A. Sette, and E. Sercarz. 1995. Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon γ by T cells. Proc. Natl. Acad. Sci. USA 92:9510.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9510
    • Kumar, V.1    Bhardwaj, V.2    Soares, L.3    Alexander, J.4    Sette, A.5    Sercarz, E.6
  • 22
    • 0029932144 scopus 로고    scopus 로고
    • Peptide analogs with different affinities for MHC alter the cytokine profile of T helper cells
    • Chaturvedi, P., Q. Yu, S. Southwood, A. Sette, and B. Singh. 1996. Peptide analogs with different affinities for MHC alter the cytokine profile of T helper cells. Int. Immunol. 8:745.
    • (1996) Int. Immunol. , vol.8 , pp. 745
    • Chaturvedi, P.1    Yu, Q.2    Southwood, S.3    Sette, A.4    Singh, B.5
  • 23
    • 0027298445 scopus 로고
    • Induction of T-cell anergy by altered T cell-receptor ligand on live antigen-presenting cells
    • Sloan-Lancaster, J., B. D. Evavold, and P. M. Allen. 1993. Induction of T-cell anergy by altered T cell-receptor ligand on live antigen-presenting cells. Nature 363:156.
    • (1993) Nature , vol.363 , pp. 156
    • Sloan-Lancaster, J.1    Evavold, B.D.2    Allen, P.M.3
  • 24
    • 0026434554 scopus 로고
    • Separation of IL4 production from Th cell proliferation by an altered T cell receptor ligand
    • Evavold, B. D., and P. Allen. 1991. Separation of IL4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252:1308.
    • (1991) Science , vol.252 , pp. 1308
    • Evavold, B.D.1    Allen, P.2
  • 25
    • 0029862940 scopus 로고    scopus 로고
    • Endogenous altered peptide ligands can affect peripheral T cell responses
    • Vidal, K., B. L. Hsu, C. B. Williams, and P. M. Allen. 1996. Endogenous altered peptide ligands can affect peripheral T cell responses. J. Exp. Med. 183:1311.
    • (1996) J. Exp. Med. , vol.183 , pp. 1311
    • Vidal, K.1    Hsu, B.L.2    Williams, C.B.3    Allen, P.M.4
  • 27
    • 0027967385 scopus 로고
    • Partial T cell signaling: Altered phospho-ζ and lack of Zap70 recruitment in APL-induced T cell anergy
    • Sloan-Lancaster, J., A. S. Shaw, J. B. Rothbard, and P. A. Allen. 1994. Partial T cell signaling: altered phospho-ζ and lack of Zap70 recruitment in APL-induced T cell anergy. Cell 79:913.
    • (1994) Cell , vol.79 , pp. 913
    • Sloan-Lancaster, J.1    Shaw, A.S.2    Rothbard, J.B.3    Allen, P.A.4
  • 28
    • 0028902752 scopus 로고
    • ζ phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists
    • Madrenas, J., R. L. Wange, J. L. Wang, N. Isakov, L. E. Samelson, and R. N. Germain. 1995. ζ phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 267:515.
    • (1995) Science , vol.267 , pp. 515
    • Madrenas, J.1    Wange, R.L.2    Wang, J.L.3    Isakov, N.4    Samelson, L.E.5    Germain, R.N.6
  • 29
    • 0029952074 scopus 로고    scopus 로고
    • Selective activation of the calcium signaling pathway by altered peptide ligand
    • Sloan-Lancaster, J., T. H. Steinberg, and P. M. Allen. 1996. Selective activation of the calcium signaling pathway by altered peptide ligand. J. Exp. Med. 184: 1525.
    • (1996) J. Exp. Med. , vol.184 , pp. 1525
    • Sloan-Lancaster, J.1    Steinberg, T.H.2    Allen, P.M.3
  • 33
    • 0028912220 scopus 로고
    • Control of memory CD4 T cell activation: MHC class II molecules on APCs and CD4 ligation inhibit memory but not naive CD4 T cells
    • Farber, D., M. Luqman, O. Acuto, and K. Bottomly. 1995. Control of memory CD4 T cell activation: MHC class II molecules on APCs and CD4 ligation inhibit memory but not naive CD4 T cells. Immunity 2:249.
    • (1995) Immunity , vol.2 , pp. 249
    • Farber, D.1    Luqman, M.2    Acuto, O.3    Bottomly, K.4
  • 37
    • 0003104975 scopus 로고    scopus 로고
    • A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists
    • Lyons, D. S., S. A. Lieberman, J. Hampl, J. J. Boniface, Y. Chien, L. J. Berg, and M. M. Davis. 1996. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity 5:53.
    • (1996) Immunity , vol.5 , pp. 53
    • Lyons, D.S.1    Lieberman, S.A.2    Hampl, J.3    Boniface, J.J.4    Chien, Y.5    Berg, L.J.6    Davis, M.M.7
  • 39
    • 0029587597 scopus 로고
    • Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase Cg1, Grb2, and phosphatidylinositol 3-kinase
    • Huang, X., Y. Li, K. Tanaka, K. G. Moore, and J. L. Hayashi. 1995. Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase Cg1, Grb2, and phosphatidylinositol 3-kinase. Proc. Natl. Acad. SCI. USA 92:11618.
    • (1995) Proc. Natl. Acad. SCI. USA , vol.92 , pp. 11618
    • Huang, X.1    Li, Y.2    Tanaka, K.3    Moore, K.G.4    Hayashi, J.L.5
  • 40
    • 0028180585 scopus 로고
    • Grb2 and phospholipase C-γ1 associate with a 36- To 38-kDa phosphotyrosine protein after T-cell receptor stimulation
    • Sieh, M., A. Bayzer, J. Schlessinger, and A. Weiss. 1994. Grb2 and phospholipase C-γ1 associate with a 36-to 38-kDa phosphotyrosine protein after T-cell receptor stimulation. MOl. Cell. Biol. 14:4435.
    • (1994) MOl. Cell. Biol. , vol.14 , pp. 4435
    • Sieh, M.1    Bayzer, A.2    Schlessinger, J.3    Weiss, A.4
  • 41
    • 0028245832 scopus 로고
    • A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in Ras activation in T cells
    • Buday, L., S. E. Egan, P. Rodriguez Viciana, D. A. Cantrell, and J. Downward. 1994. A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in Ras activation in T cells. J. Biol. Chem. 269:9019.
    • (1994) J. Biol. Chem. , vol.269 , pp. 9019
    • Buday, L.1    Egan, S.E.2    Rodriguez Viciana, P.3    Cantrell, D.A.4    Downward, J.5
  • 42
    • 0029117434 scopus 로고
    • Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR
    • NeL, A. E., S. Gupta, L. Lee, J. A. Ledbetter, and S. B. Kanner. 1995. Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR. J. Biol. Chem. 270:18428.
    • (1995) J. Biol. Chem. , vol.270 , pp. 18428
    • Nel, A.E.1    Gupta, S.2    Lee, L.3    Ledbetter, J.A.4    Kanner, S.B.5
  • 43
    • 0027958565 scopus 로고
    • Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways
    • Gajewski, T. F., D. Qian, P. Fields, and F. W. Fitch. 1994. Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways. Proc. Natl. Acad. Sci. USA 91:38.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 38
    • Gajewski, T.F.1    Qian, D.2    Fields, P.3    Fitch, F.W.4
  • 44
    • 0028167459 scopus 로고
    • Anergy of Th0 helper T lymphocytes induces downregulation of Th1 characteristics and a transition to a Th2-like phenotype
    • Gajewski, T. F., D. W. Lancki, R. Stack, and F. W. Fitch. 1994. Anergy of Th0 helper T lymphocytes induces downregulation of Th1 characteristics and a transition to a Th2-like phenotype. J. Exp. Med. 179:481.
    • (1994) J. Exp. Med. , vol.179 , pp. 481
    • Gajewski, T.F.1    Lancki, D.W.2    Stack, R.3    Fitch, F.W.4
  • 45
    • 0031205443 scopus 로고    scopus 로고
    • Selective loss of the calcium ion signaling pathway in T cells maturing toward a T helper 2 phenotype
    • Sloan-Lancaster, J., T. H. Steinberg, and P. M. Allen. 1997. Selective loss of the calcium ion signaling pathway in T cells maturing toward a T helper 2 phenotype. J. Immunol. 159:1160.
    • (1997) J. Immunol. , vol.159 , pp. 1160
    • Sloan-Lancaster, J.1    Steinberg, T.H.2    Allen, P.M.3
  • 47
    • 0023908650 scopus 로고
    • Early signal transduction by the antigen receptor without commitment to T cell activation
    • Goldsmith, M. A., and A. Weiss. 1988. Early signal transduction by the antigen receptor without commitment to T cell activation. Science 240:1029.
    • (1988) Science , vol.240 , pp. 1029
    • Goldsmith, M.A.1    Weiss, A.2
  • 48
    • 0023788987 scopus 로고
    • Regulation of receptor-mediated calcium influx across the plasma membrane in a human leukemic T-cell line: Evidence of its dependence on an initial calcium mobilization from intracellular stores
    • Ng, J., J. Gustavsson, M. Jondal, and T. Andersonn. 1988. Regulation of receptor-mediated calcium influx across the plasma membrane in a human leukemic T-cell line: evidence of its dependence on an initial calcium mobilization from intracellular stores. Biochim. Biophys. Acta 971:207.
    • (1988) Biochim. Biophys. Acta , vol.971 , pp. 207
    • Ng, J.1    Gustavsson, J.2    Jondal, M.3    Andersonn, T.4


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