Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 31, 2008, Pages 10967-10972

  Jing, Xianghong ^a   Ma, Chunlong ^a   Ohigashi, Yuki ^a   Oliveira, Fernando A ^a   Jardetzky, Theodore S ^b   Pinto, Lawrence H ^a   Lamb, Robert A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Amantadine inhibition of influenza virus; Amantadine resistance; Drug binding site; Influenza reverse genetics

Indexed keywords

ALANINE; AMANTADINE; ION CHANNEL; PROTEIN M2; RIMANTADINE;

ANIMAL CELL; ARTICLE; CHIMERA; CONTROLLED STUDY; DRUG BINDING; ELECTROPHYSIOLOGY; GENE MUTATION; INFLUENZA; INFLUENZA VIRUS A; NONHUMAN; OOCYTE; PRIORITY JOURNAL; VIRUS GENOME; XENOPUS LAEVIS;

AMANTADINE; ANIMALS; ANTIVIRAL AGENTS; BINDING SITES; CELL LINE; DOGS; HUMANS; MODELS, MOLECULAR; MUTAGENESIS; PATCH-CLAMP TECHNIQUES; VIRAL MATRIX PROTEINS; XENOPUS LAEVIS;

CERCOPITHECINE HERPESVIRUS 1; INFLUENZA A VIRUS; MAMMALIA; ORTHOMYXOVIRIDAE; XENOPUS LAEVIS;

EID: 49449093199     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0804958105     Document Type: Article

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