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Volumn 164, Issue 2, 2000, Pages 580-588

Modulation of Th2 responses by peptide analogues in a murine model of allergic asthma: Amelioration or deterioration of the disease process depends on the Th1 or Th2 skewing characteristics of the therapeutic peptide

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; LIPOSOME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OVALBUMIN; SYNTHETIC PEPTIDE;

EID: 0034650788     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.2.580     Document Type: Article
Times cited : (65)

References (48)
  • 1
    • 0025222698 scopus 로고
    • IL-4 directs the development of Th2-like helper effectors
    • Swain, S. L., A. D. Weinberg, M. English, and G. Huston. 1990. IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145:3796.
    • (1990) J. Immunol. , vol.145 , pp. 3796
    • Swain, S.L.1    Weinberg, A.D.2    English, M.3    Huston, G.4
  • 3
    • 0028176655 scopus 로고
    • Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells
    • Zurawski, G., and J. E. de Vries. 1994. Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells, Immunol. Today 15:19.
    • (1994) Immunol. Today , vol.15 , pp. 19
    • Zurawski, G.1    De Vries, J.E.2
  • 5
    • 0028878377 scopus 로고
    • Inhibition of programmed eosinophil death: A key pathogenic event for eosinophilia?
    • Simon, H. U., and K. Blaser. 1995. Inhibition of programmed eosinophil death: a key pathogenic event for eosinophilia? Immunol. Today 16:53.
    • (1995) Immunol. Today , vol.16 , pp. 53
    • Simon, H.U.1    Blaser, K.2
  • 8
    • 9844266243 scopus 로고    scopus 로고
    • Immunological changes during specific immunotherapy of grass pollen allergy: Reduced lymphoproliferative response to allergen and shift from Th2 to Th1 in T cell clones specific for Ph1 p I, a major grass pollen allergen
    • Ebner, C., U. Siemann, and B. Bohle. 1997. Immunological changes during specific immunotherapy of grass pollen allergy: reduced lymphoproliferative response to allergen and shift from Th2 to Th1 in T cell clones specific for Ph1 p I, a major grass pollen allergen. Clin. Exp. Allergy 27:1007.
    • (1997) Clin. Exp. Allergy , vol.27 , pp. 1007
    • Ebner, C.1    Siemann, U.2    Bohle, B.3
  • 10
    • 0029820287 scopus 로고    scopus 로고
    • Epitope specific tolerance to Phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro
    • Akdis, C. A., M. Akdis, T. Blesken, D. Wymann, S. S. Alkan, U. Müller, and K. Blaser. 1996. Epitope specific tolerance to Phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro. J. Clin. Invest. 98:1676.
    • (1996) J. Clin. Invest. , vol.98 , pp. 1676
    • Akdis, C.A.1    Akdis, M.2    Blesken, T.3    Wymann, D.4    Alkan, S.S.5    Müller, U.6    Blaser, K.7
  • 11
    • 0028308963 scopus 로고
    • Specific immunotherapy in asthma: Is it effective?
    • Bousquet, J., and F. B. Michel. 1994. Specific immunotherapy in asthma: is it effective? J. Allergy Clin. Immunol. 94:1.
    • (1994) J. Allergy Clin. Immunol. , vol.94 , pp. 1
    • Bousquet, J.1    Michel, F.B.2
  • 12
    • 0030458273 scopus 로고    scopus 로고
    • Risk management in allergen immunotherapy
    • Greidener, D. K. 1996. Risk management in allergen immunotherapy. J. Allergy Clin. Immunol. 98:S330-334.
    • (1996) J. Allergy Clin. Immunol. , vol.98
    • Greidener, D.K.1
  • 13
    • 0024582708 scopus 로고
    • Immunotherapy with a standardized Dermotophagoides pteronyssinus extract: Systemic reactions during the rush protocol in patients suffering from asthma
    • Bousquet, J., A. Hejjaoui, H. Dhivert, A. M. Clauzel, and F. B. Michel. 1989. Immunotherapy with a standardized Dermotophagoides pteronyssinus extract: systemic reactions during the rush protocol in patients suffering from asthma. J. Allergy Clin. Immunol. 83:797.
    • (1989) J. Allergy Clin. Immunol. , vol.83 , pp. 797
    • Bousquet, J.1    Hejjaoui, A.2    Dhivert, H.3    Clauzel, A.M.4    Michel, F.B.5
  • 15
    • 0031866059 scopus 로고    scopus 로고
    • Successful immunotherapy with T-cell epitope peptides of bee venom Phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom
    • Müller, U., C. A. Akdis, M. Fricker, M. Akdis, T. Blesken, F. Bettens, and K. Blaser. 1998. Successful immunotherapy with T-cell epitope peptides of bee venom Phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom. J. Allergy Clin. Immunol. 101:747.
    • (1998) J. Allergy Clin. Immunol. , vol.101 , pp. 747
    • Müller, U.1    Akdis, C.A.2    Fricker, M.3    Akdis, M.4    Blesken, T.5    Bettens, F.6    Blaser, K.7
  • 18
    • 0033161386 scopus 로고    scopus 로고
    • Opposite effects of immunotherapy with ovalbumin and the immunodominant T cell epitope on airway eosinophilia and hyperresponsiveness in a murine model of allergic asthma
    • Janssen, E. M., M. H. M. Wauben, E. H. Jonker, G. Hofman, W. van Eden, F. P. Nijkamp, and A. J. M. van Oosterhout. 1999. Opposite effects of immunotherapy with ovalbumin and the immunodominant T cell epitope on airway eosinophilia and hyperresponsiveness in a murine model of allergic asthma. Am. J. Respir. Cell Mol. Biol. 21:21.
    • (1999) Am. J. Respir. Cell Mol. Biol. , vol.21 , pp. 21
    • Janssen, E.M.1    Wauben, M.H.M.2    Jonker, E.H.3    Hofman, G.4    Van Eden, W.5    Nijkamp, F.P.6    Van Oosterhout, A.J.M.7
  • 19
    • 0026434554 scopus 로고
    • Separation of IL-4 production from T cell proliferation by an altered T cell receptor ligand
    • Evavold, B. D., and P. M. Allen. 1991. Separation of IL-4 production from T cell proliferation by an altered T cell receptor ligand. Science 252:1308.
    • (1991) Science , vol.252 , pp. 1308
    • Evavold, B.D.1    Allen, P.M.2
  • 21
    • 0028025705 scopus 로고
    • Th2 cell clonal anergy as a consequence of partial activation
    • Sloan-Lancaster, J., B. D. Evavold, and P. M. Allen. 1994. Th2 cell clonal anergy as a consequence of partial activation. J. Exp. Med. 180:1195.
    • (1994) J. Exp. Med. , vol.180 , pp. 1195
    • Sloan-Lancaster, J.1    Evavold, B.D.2    Allen, P.M.3
  • 24
    • 0032213360 scopus 로고    scopus 로고
    • Prevention of Th2-like cell responses by coadministration of IL-12 and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness, eosinophilia, and serum IgE levels
    • Hofstra, C. L., I. van Ark, G. Hofman, M. Kool, F. P. Nijkamp, and A. J. M. van Oosterhout. 1998. Prevention of Th2-like cell responses by coadministration of IL-12 and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness, eosinophilia, and serum IgE levels. J. Immunol. 161:5054.
    • (1998) J. Immunol. , vol.161 , pp. 5054
    • Hofstra, C.L.1    Van Ark, I.2    Hofman, G.3    Kool, M.4    Nijkamp, F.P.5    Van Oosterhout, A.J.M.6
  • 28
    • 0019458092 scopus 로고
    • Amigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas: Lack of independent antigen and H-2 recognition
    • Kappler, J. W., B. Skidmore, J. White, and P. Marrack. 1981. Amigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas: lack of independent antigen and H-2 recognition. J. Exp. Med. 153:1198.
    • (1981) J. Exp. Med. , vol.153 , pp. 1198
    • Kappler, J.W.1    Skidmore, B.2    White, J.3    Marrack, P.4
  • 29
    • 0020593691 scopus 로고
    • Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development
    • Coffman, R. L. 1982. Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development. Immunol. Rev. 69:5.
    • (1982) Immunol. Rev. , vol.69 , pp. 5
    • Coffman, R.L.1
  • 30
    • 0018291288 scopus 로고
    • Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors
    • Unkeless, J. C. 1979. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J. Exp. Med. 150:580.
    • (1979) J. Exp. Med. , vol.150 , pp. 580
    • Unkeless, J.C.1
  • 31
    • 0020623652 scopus 로고
    • The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody
    • Haskins, K., R. Kubo, J. White, M. Pigeon, J. Kappler, and P. Marrack. 1983. The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody. J. Exp. Med. 175:1149.
    • (1983) J. Exp. Med. , vol.175 , pp. 1149
    • Haskins, K.1    Kubo, R.2    White, J.3    Pigeon, M.4    Kappler, J.5    Marrack, P.6
  • 32
    • 0017402665 scopus 로고
    • Long term culture of tumour-specific cytotoxic T cells
    • Villee, D. B., and M. L. Powers. 1977. Long term culture of tumour-specific cytotoxic T cells. Nature 268:154.
    • (1977) Nature , vol.268 , pp. 154
    • Villee, D.B.1    Powers, M.L.2
  • 35
    • 0028849807 scopus 로고
    • Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon γ by T cells
    • Kumar, V., V, Bhardwaj, L. Soares, J. Alexander, A. Sette, and E. Sercarz. 1995. Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon γ by T cells. Proc. Natl. Acad. Sci. USA 92:9510.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9510
    • Kumar, V.1    Bhardwaj, V.2    Soares, L.3    Alexander, J.4    Sette, A.5    Sercarz, E.6
  • 37
    • 0003104975 scopus 로고    scopus 로고
    • A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists
    • Lyons, D. S., S. A. Lieberman, J. Hampl, J. J. Boniface, Y. Chien, L. J. Berg, and M. M. Davis. 1996. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity 5:53.
    • (1996) Immunity , vol.5 , pp. 53
    • Lyons, D.S.1    Lieberman, S.A.2    Hampl, J.3    Boniface, J.J.4    Chien, Y.5    Berg, L.J.6    Davis, M.M.7
  • 38
    • 0032438551 scopus 로고    scopus 로고
    • High- and low-potency ligands with similar affinities for the TCR: The importance of kinetics in TCR signaling
    • Kersh, G. J., E. N. Kersh, D. H. Fremont, and P. M. Allen. 1998. High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling. Immunity 9:817.
    • (1998) Immunity , vol.9 , pp. 817
    • Kersh, G.J.1    Kersh, E.N.2    Fremont, D.H.3    Allen, P.M.4
  • 40
    • 0023257028 scopus 로고
    • Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells
    • Sette, A., S. Buus, S. Colon, J. A. Smith, C. Miles, and H. M. Grey. 1987. Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells. Nature 328:395.
    • (1987) Nature , vol.328 , pp. 395
    • Sette, A.1    Buus, S.2    Colon, S.3    Smith, J.A.4    Miles, C.5    Grey, H.M.6
  • 41
    • 0032033678 scopus 로고    scopus 로고
    • Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues
    • Scott, C. A., P. A. Peterson, L. Teyton, and I. A. Wilson. 1998. Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues. Immunity 8:319.
    • (1998) Immunity , vol.8 , pp. 319
    • Scott, C.A.1    Peterson, P.A.2    Teyton, L.3    Wilson, I.A.4
  • 42
    • 0030995954 scopus 로고    scopus 로고
    • Allergic eosinophil-rich inflammation develops in lungs and airways of B cell deficient mice
    • Korsgren, M., J. S. Erjefält, O. Korsgren, F. Sundler, and C. G. A. Persson. 1997. Allergic eosinophil-rich inflammation develops in lungs and airways of B cell deficient mice. J. Exp. Med. 185:885.
    • (1997) J. Exp. Med. , vol.185 , pp. 885
    • Korsgren, M.1    Erjefält, J.S.2    Korsgren, O.3    Sundler, F.4    Persson, C.G.A.5
  • 43
    • 2642613459 scopus 로고    scopus 로고
    • Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma
    • Mehlhop, P. D., M. Rijn, A. B. Goldberg, J. P. Brewer, V. P. Kurup, T. R. Mertin, and H. C. Oettgen. 1997. Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma. Proc. Natl. Acad. Sci. USA 94:1344.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 1344
    • Mehlhop, P.D.1    Rijn, M.2    Goldberg, A.B.3    Brewer, J.P.4    Kurup, V.P.5    Mertin, T.R.6    Oettgen, H.C.7
  • 44
    • 0032209767 scopus 로고    scopus 로고
    • Differential effects of andogenous and exogenous interferon-γ on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma
    • Hofstra, C. L., I. van Ark, G. Hofman, F. P. Nijkamp, P. M. Jardieu, and A. J. M. van Oosterhout. 1998. Differential effects of andogenous and exogenous interferon-γ on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma. Am. J. Respir. Cell Mol. Biol. 19:826.
    • (1998) Am. J. Respir. Cell Mol. Biol. , vol.19 , pp. 826
    • Hofstra, C.L.1    Van Ark, I.2    Hofman, G.3    Nijkamp, F.P.4    Jardieu, P.M.5    Van Oosterhout, A.J.M.6
  • 45
    • 0028178309 scopus 로고
    • Nebulized but not parenteral IFN-γ decreases IgE production and normalizes airway function in a murine model of allergen sensitization
    • Lack, G., H. Renz, J. Saloga, K. L. Bradley, J. Loader, D. Y. Leung, G. Larsen, and E. W. Gelfand. 1994. Nebulized but not parenteral IFN-γ decreases IgE production and normalizes airway function in a murine model of allergen sensitization. J. Immunol. 152:2546.
    • (1994) J. Immunol. , vol.152 , pp. 2546
    • Lack, G.1    Renz, H.2    Saloga, J.3    Bradley, K.L.4    Loader, J.5    Leung, D.Y.6    Larsen, G.7    Gelfand, E.W.8
  • 46
    • 0031884839 scopus 로고    scopus 로고
    • The duration of antigenic stimulation determines the fate of naive and effector T cells
    • Iezzi, G., K. Karjalainen, and A. Lanzavecchia. 1998. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 8:89.
    • (1998) Immunity , vol.8 , pp. 89
    • Iezzi, G.1    Karjalainen, K.2    Lanzavecchia, A.3


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