APL-1, an altered peptide ligand derived from human heat-shock protein 60, selectively induces apoptosis in activated CD4 + CD25 + T cells from peripheral blood of rheumatoid arthritis patients

International Immunopharmacology

Volumn 17, Issue 4, 2013, Pages 1075-1083

  Barberá, Ariana ^a   Lorenzo, Noraylis ^a   Garrido, Greta ^b   Mazola, Yuliet ^a   Falcón, Viviana ^a   Torres, Ana María ^c   Hernández, María Isabel ^c   Hernández, María Victoria ^c   Margry, Bram ^d   De Groot, A Marit ^d   Van Roon, Joel ^e   Van Der Zee, Ruurd ^d   Broere, Femke ^d   Van Eden, Willem ^d   Padrón, Gabriel ^a   Del Carmen Domínguez, María ^a  

^a CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Cuba)

^b CENTER OF MOLECULAR IMMUNOLOGY   (Cuba)

^c Institute of Rheumatology   (Cuba)

^d UTRECHT UNIVERSITY   (Netherlands)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Altered peptide ligands; Epitope specific immunotherapy; Heat shock protein 60; Rheumatoid arthritis

Indexed keywords

ALTERED PEPTIDE LIGAND 1; ANTIRHEUMATIC AGENT; C REACTIVE PROTEIN; CHAPERONIN 60; LIGAND; PEPTIDE DERIVATIVE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIGEN PRESENTATION; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL VIABILITY; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DAS28; DISEASE ACTIVITY SCORE; DISEASE DURATION; DNA FRAGMENTATION; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; RHEUMATOID ARTHRITIS; T LYMPHOCYTE ACTIVATION; TRANSMISSION ELECTRON MICROSCOPY;

ALTERED PEPTIDE LIGAND; ALTERED PEPTIDE LIGANDS; APL; EPITOPE-SPECIFIC IMMUNOTHERAPY; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN OF 60KDA; HSP60; RA; REGULATORY T CELLS; RHEUMATOID ARTHRITIS; T HELPER; TH; TLR; TOLL LIKE RECEPTORS; TREGS;

ADULT; AGED; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; ARTHRITIS, RHEUMATOID; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CELL SURVIVAL; CHAPERONIN 60; DNA FRAGMENTATION; FEMALE; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LEUKOCYTES, MONONUCLEAR; LIGANDS; MALE; MIDDLE AGED; MITOCHONDRIAL PROTEINS; PEPTIDE FRAGMENTS; PEPTIDES; T-LYMPHOCYTE SUBSETS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 84887079834     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2013.10.010     Document Type: Article

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