T cell epitope immunotherapy induces a CD4+ T cell population with regulatory activity

PLoS Medicine

Volumn 2, Issue , 2005, Pages 0253-0261

  Verhoef, Adrienne ^a   Alexander, Clare ^a   Kay, A Barry ^a   Larché, Mark ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANYLVALYLGLUTAMINYLASPARAGINYLTHREONYLVALYLGLUTAMYLASPARTYLLEUCYLLYSYLLEUCYLASPARAGINYLTHREONYLLEUCYLGLYCYLARGININE; ALLERGEN; ARGINYLISOLEUCYLLEUCYLLYSYLASPARAGINYLCYSTEINYLVALYLASPARTYLALANYLLYSYLMETHIONYLTHREONYLGLUTAMYLGLUTAMYLASPARTYLLYSYLGLUTAMIC ACID; CD4 ANTIGEN; CD5 ANTIGEN; CD8 ANTIGEN; CYTOKINE; EPITOPE; GLUTAMYLGLUTAMINYLVALYLALANYLGLUTAMINYLTYROSYLLYSYLALANYLLEUCYLPROLYLVALYLVALYLLEUCYLGLUTAMYLASPARAGINYLALANINE; GLUTAMYLISOLEUCYLCYSTEINYLPROLYLALANYLVALYLLYSYLARGINYLASPARTYLVALYLASPARTYLLEUCYLPHENYLALANYLLEUCYLTHREONYLGLYCYLTHREONINE; INTERLEUKIN 10; INTERLEUKIN 5; ISOLEUCYLSERYLSERYLSERYLLYSYLASPARTYLCYSTEINYLMETHIONYLGLYCYLGLUTAMYLALANYLVALYLGLUTAMINYLASPARAGINYLTHREONYLVALINE; LEUCYLPHENYLALANYLLEUCYLTHREONYLGLYCYLTHREONYLPROLYLASPARTYLGLUTAMYLTYROSYLVALYLGLUTAMYLGLUTAMINYLVALYLALANYLGLUTAMINYLTYROSINE; LEUCYLTHREONYLLYSYLVALYLASPARAGINYLALANYLTHREONYLGLUTAMYLPROLYLGLUTAMYLARGINYLTHREONYLALANYLMETHIONYLLYSYLLYSINE; LYSYLALANYLLEUCYLPROLYLVALYLVALYLLEUCYLGLUTAMYLASPARAGINYLALANYLARGINYLISOLEUCYLLEUCYLLYSYLASPARAGINYLCYSTEINYLVALINE; LYSYLGLUTAMYLASPARAGINYLALANYLLEUCYLSERYLLEUCYLLEUCYLASPARTYLLYSYLISOLEUCYLTYROSYLTHREONYLSERYLPROLYLLEUCINE; LYSYLMETHIONYLTHREONYLGLUTAMYLGLUTAMYLASPARTYLLYSYLGLUTAMYLASPARAGINYLALANYLLEUCYLSERYLLEUCYLLEUCYLASPARTYLLYSINE; SERYLARGINYLVALYLLEUCYLASPARTYLGLYCYLLEUCYLVALYLMETHIONYLTHREONYLTHREONYLISOLEUCYLSERYLSERYLSERYLLYSINE; UNCLASSIFIED DRUG; IMMUNOGLOBULIN E;

ALLERGIC ASTHMA; ANTIGEN EXPRESSION; ARTICLE; CELL ACTIVITY; CELL CULTURE; CELL DIVISION; CELL PROLIFERATION; CELL SURFACE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG MECHANISM; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOTHERAPY; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PROTEIN DETERMINATION; SURFACE PROPERTY; T LYMPHOCYTE SUBPOPULATION; UPREGULATION; AMINO ACID SEQUENCE; ANIMAL; ASTHMA; BIOSYNTHESIS; CAT; CD4+ T LYMPHOCYTE; CLINICAL TRIAL; DOWN REGULATION; HYPERSENSITIVITY; IMMUNOLOGY; INFLAMMATION; MAST CELL; METHODOLOGY; MOLECULAR GENETICS;

ALLERGENS; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD5; ASTHMA; CATS; CD4-POSITIVE T-LYMPHOCYTES; DOWN-REGULATION; EPITOPES, T-LYMPHOCYTE; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; IMMUNOTHERAPY; INFLAMMATION; MAST CELLS; MOLECULAR SEQUENCE DATA; PHENOTYPE;

EID: 18244391173     PISSN: 15491277     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pmed.0020078     Document Type: Article

References (54)

1. Larche M, Robinson DS, Kay AB (2003) The role of T lymphocytes in the pathogenesis of asthma. J Allergy Clin Immunol 111: 450-463.
2. Kay AB (2001) Allergy and allergic diseases. First of two parts. N Engl J Med 344: 30-37.
3. Kay AB (2001) Allergy and allergic diseases. Second of two parts. N Engl J Med 344: 109-113.
4. Akdis M, Verhagen J, Taylor A, Karamloo F, Karagiannidis C, et al. (2004) Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 199: 1567-1575.
5. high regulatory cells in human peripheral blood. J Immunol 167: 1245-1253.
6. Piccirillo CA, Shevach EM (2001) Cutting edge: Control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J Immunol 167: 1137-1140.
7. Thornton AM, Shevach EM (1998) CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 188: 287-296.
8. Hori S, Nomura T, Sakaguchi S (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
9. Zuany-Amorim C, Sawicka E, Manlius C, Le Moine A, Brunet LR, et al. (2002) Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells. Nat Med 8: 625-629.
10. Bluestone JA, Abbas AK (2003) Natural versus adaptive regulatory T cells. Nat Rev Immunol 3: 253-257.
11. Taams LS, Smith J, Rustin MH, Salmon M, Poulter LW, et al. (2001) Human anergic/suppressive CD4(+)CD25(+) T cells: A highly differentiated and apoptosis-prone population. Eur J Immunol 31: 1122-1131.
12. Jonuleit H, Schmitt E, Kakirman H, Stassen M, Knop J, et al. (2002) Infectious tolerance: Human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells. J Exp Med 196: 255-260.
13. Dhodapkar MV, Steinman RM, Krasovsky J, Munz C, Bhardwaj N (2001) Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med 193: 233-238.
14. Dhodapkar MV, Steinman RM (2002) Antigen-bearing immature dendritic cells induce peptide-specific CD8(+) regulatory T cells in vivo in humans. Blood 100: 174-177.
15. Akbari O, DeKruyff RH, Umetsu DT (2001) Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2: 725-731.
16. Lutz MB, Schuler G (2002) Immature, semi-mature and fully mature dendritic cells: Which signals induce tolerance or immunity? Trends Immunol 23: 445-449.
17. Tarakhovsky A, Kanner SB, Hombach J, Ledbetter JA, Muller W, et al. (1995) A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science 269: 535-537.
18. Barthlott T, Kassiotis G, Stockinger B (2003) T cell regulation as a side effect of homeostasis and competition. J Exp Med 197: 451-460.
19. Hawiger D, Masilamani RF, Bettelli E, Kuchroo VK, Nussenzweig MC (2004) Immunological unresponsiveness characterized by increased expression of CD5 on peripheral T cells induced by dendritic cells in vivo. Immunity 20: 695-705.
20. Stamou P, De Jersey J, Carmignac D, Mamalaki C, Kioussis D, et al. (2003) Chronic exposure to low levels of antigen in the periphery causes reversible functional impairment correlating with changes in CD5 levels in monoclonal CD8 T cells. J Immunol 171: 1278-1284.
21. Apostolou I, Von Boehmer H (2004) In vivo instruction of suppressor commitment in naive T cells. J Exp Med 199: 1401-1408.
22. Sundstedt A, O'Neill EJ, Nicolson KS, Wraith DC (2003) Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo. J Immunol 170: 1240-1248.
23. Chai JG, James E, Dewchand H, Simpson E, Scott D (2004) Transplantation tolerance induced by intranasal administration of HY peptides. Blood 103: 3951-3959.
24. Chen TC, Waldmann H, Fairchild PJ (2004) Induction of dominant transplantation tolerance by an altered peptide ligand of the male antigen Dby. J Clin Invest 113: 1754-1762.
25. Oldfield WL, Kay AB, Larche M (2001) Allergen-derived T cell peptide-induced late asthmatic reactions precede the induction of antigen-specific hyporesponsiveness in atopic allergic asthmatic subjects. J Immunol 167: 1734-1739.
26. Oldfield WL, Larche M, Kay AB (2002) Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: A randomised controlled trial. Lancet 360: 47-53.
27. Alexander C, Ying S, Kay B, Larche M (2005) Fel d 1-derived T cell peptide therapy induces recruitment of CD4CD25; CD4 interferon-gamma T helper type 1 cells to sites of allergen-induced late-phase skin reactions in cat-allergic subjects. Clin Exp Allergy 35: 52-58.
28. Alexander C, Tarzi M, Larche M, Kay AB (2005) The effect of Fel d 1-derived T cell peptides on upper and lower airway outcome measurements in cat-allergic subjects. Allergy. In press.
29. Haselden BM, Kay AB, Larche M (1999) Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions. J Exp Med 189: 1885-1894.
30. Till S, Li B, Durham S, Humbert M, Assoufi B, et al. (1995) Secretion of the eosinophil-active cytokines interleukin-5, granulocyte/macrophage colony-stimulating factor and interleukin-3 by bronchoalveolar lavage CD4+ and CD8+ T cell lines in atopic asthmatics, and atopic and non-atopic controls. Eur J Immunol 25: 2727-2731.
31. Ying S, Humbert M, Barkans J, Corrigan CJ, Pfister R, et al. (1997) Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics. J Immunol 158: 3539-3544.
32. Seneviratne SL, Jones L, King AS, Black A, Powell S, et al. (2002) Allergen-specific CD8(+) T cells and atopic disease. J Clin Invest 110: 1283-1291.
33. Akdis CA, Blesken T, Akdis M, Wuthrich B, Blaser K (1998) Role of interleukin 10 in specific immunotherapy. J Clin Invest 102: 98-106.
34. Celedon JC, Litonjua AA, Ryan L, Platts-Mills T, Weiss ST, et al. (2002) Exposure to cat allergen, maternal history of asthma, and wheezing in first 5 years of life. Lancet 360: 781-782.
35. Custovic A, Hallam CL, Simpson BM, Craven M, Simpson A, et al. (2001) Decreased prevalence of sensitization to cats with high exposure to cat allergen. J Allergy Clin Immunol 108: 537-539.
36. Reefer AJ, Carneiro RM, Custis NJ, Platts-Mills TA, Sung SS, et al. (2004) A role for IL-10-mediated HLA-DR7-restricted T cell-dependent events in development of the modified Th2 response to cat allergen. J Immunol 172: 2763-2772.
37. Wachholz PA, Nouri-Aria KT, Wilson DR, Walker SM, Verhoef A, et al. (2002) Grass pollen immunotherapy for hayfever is associated with increases in local nasal but not peripheral Th1:Th2 cytokine ratios. Immunology 105: 56-62.
38. Massey EJ, Sundstedt A, Day MJ, Corfield G, Anderton S, et al. (2002) Intranasal peptide-induced peripheral tolerance: The role of IL-10 in regulatory T cell function within the context of experimental autoimmune encephalomyelitis. Vet Immunol Immunopathol 87: 357-372.
39. Ciubotariu R, Colovai AI, Pennesi G, Liu Z, Smith D, et al. (1998) Specific suppression of human CD4+ Th cell responses to pig MHC antigens by CD8+. J Immunol 161: 5193-5202.
40. Francis JN, Till SJ, Durham SR (2003) Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy. J Allergy Clin Immunol 111: 1255-1261.
41. Jutel M, Akdis M, Budak F, Aebischer-Casaulta C, Wrzyszcz M, et al. (2003) IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol 33: 1205-1214.
42. Smith TR, Alexander C, Kay AB, Larche M, Robinson DS (2004) Cat allergen peptide immunotherapy reduces CD4 T cell responses to cat allergen but does not alter suppression by CD4 CD25 T cells: A double-blind placebo-controlled study. Allergy 59: 1097-1101.
43. Lamb JR, Skidmore BJ, Green N, Chiller JM, Feldmann M (1983) Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin. J Exp Med 157: 1434-1447.
44. Verhoef A, Lamb JR (2000) Threshold signaling of human Th0 cells in activation and anergy: Modulation of effector function by altered TCR ligand. J Immunol 164: 6034-6040.
45. Prakken BJ, Samodal R, Le TD, Giannoni F, Yung GP, et al. (2004) Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis. Proc Natl Acad Sci U S A 101: 4228-4233.
46. Pena-Rossi C, Zuckerman LA, Strong J, Kwan J, Ferris W, et al. (1999) Negative regulation of CD4 lineage development and responses by CD5. J Immunol 163: 6494-6501.
47. Brossard C, Semichon M, Trautmann A, Bismuth G (2003) CD5 inhibits signaling at the immunological synapse without impairing its formation. J Immunol 170: 4623-4629.
48. Bierer BE, Nishimura Y, Burakoff SJ, Smith BR (1988) Phenotypic and functional characterization of human cytolytic T cells lacking expression of CD5. J Clin Invest 81: 1390-1397.
49. Stievano L, Tosello V, Marcato N, Rosato A, Sebelin A, et al. (2003) CD8+ alpha beta+ T cells that lack surface CD5 antigen expression are a major lymphotactin (XCL1) source in peripheral blood lymphocytes. J Immunol 171: 4528-4538.
50. Indraccolo S, Mion M, Zamarchi R, Coppola V, Calderazzo F, et al. (1995) A CD3+CD8+ T cell population lacking CD5 antigen expression is expanded in peripheral blood of human immunodeficiency virus-infected patients. Clin Immunol Immunopathol 77: 253-261.
51. Bierer BE, Burakoff SJ, Smith BR (1989) A large proportion of T lymphocytes lack CD5 expression after bone marrow transplantation. Blood 73: 1359-1366.
52. Parish CR (1999) Fluorescent dyes for lymphocyte migration and proliferation studies. Immunol Cell Biol 77: 499-508.
53. Turcanu V, Maleki SJ, Lack G (2003) Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts. J Clin Invest 111: 1065-1072.
54. Givan AL, Fisher JL, Waugh M, Ernstoff MS, Wallace PK (1999) A flow cytometric method to estimate the precursor frequencies of cells proliferating in response to specific antigens. J Immunol Methods 230: 99-112.