Degradation of endomorphin-2 at the supraspinal level in mice is initiated by dipeptidyl peptidase IV: An in vitro and in vivo study

Biochemical Pharmacology

Volumn 66, Issue 4, 2003, Pages 653-661

  Sakurada, Chikai ^a   Sakurada, Shinobu ^b   Hayashi, Takafumi ^b   Katsuyama, Sou ^b   Tan No, Koichi ^b   Sakurada, Tsukasa ^a  

^a DAIICHI UNIVERSITY OF PHARMACY   (Japan)

^b TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Antinociception; Dipeptidyl peptidase IV; Endomorphin 2; Metabolic pathway; Mouse brain; Synaptic membranes

Indexed keywords

AMINOPEPTIDASE; BESTATIN; DIPEPTIDYL PEPTIDASE IV; DIPROTIN A; DIPROTIN B; ENDOMORPHIN 2; ENZYME INHIBITOR; PHENYLALANINE; PROLINE; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BRAIN; CHEMICAL BOND; CONTROLLED STUDY; DRUG EFFECT; DRUG METABOLISM; ENZYME ACTIVITY; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; INJECTION; LEG; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SPINE; SYNAPTIC MEMBRANE;

EID: 0142039133     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00391-5     Document Type: Article

References (28)

1. Zadina J.E., Hackler L., Ge L.J., Kastin A.J. A potent and selective endogenous agonist for the μ-opiate receptor. Nature. 386:1997;499-502.
2. Hackler L., Zadina J.E., Ge L.J., Kastin A.J. Isolation of relatively large amounts of endomorphin-1 and endomorphin-2 from human brain cortex. Peptides. 18:1997;1635-1639.
3. Martin-Schild S., Gerall A.A., Kastin A.J., Zadina J.E. Differential distribution of endomorphin 1- and endomorphin 2-like immunoreactivities in the CNS of the rodent. J. Comp. Neurol. 405:1999;450-471.
4. Schreff M., Schulz S., Wilborny D., Hollt V. Immunofluorescent identification of endomorphin-2-containing nerve fibers and terminals in the rat brain and spinal cord. NeuroReport. 9:1998;1031-1034.
5. Pierce T.L., Wessendorf M.W. Immunocytochemical mapping of endomorphin-2-immunoreactivity in rat brain. J. Chem. Neuroanat. 18:2000;181-207.
6. Mansour A., Fox C.A., Burke S., Akil H., Watson S.J. Immunohistochemical localization of the cloned μ opioid receptor in the rat CNS. J. Chem. Neuroanat. 8:1995;283-305.
7. Goldberg I.E., Rossi G.C., Letchworth S.R., Mathis J.P., Ryan-Moro J., Leventhal L., Su W., Emmel D., Bolan E.A., Pasternak G.W. Pharmacological characterization of endomorohin-1 and endomorphin-2 in mouse brain. J. Pharmacol. Exp. Ther. 286:1998;1007-1013.
8. Sakurada S., Zadina J.E., Kastin A.J., Katsuyama S., Fujimura T., Murayama K., Yuki M., Ueda H., Sakurada T. Differential involvement of μ-opioid receptor subtypes in endomorphin-1- and -2-induced antinociception. Eur. J. Pharmacol. 372:1999;25-30.
9. Stone L.S., Fairbanks C.A., Laughlin T.M., Nguyen H.O., Bushy T.M., Wessendorf M.W., Wilcox G. Spinal analgesic actions of the new endogenous opioid peptides endomorphin-1 and -2. NeuroReport. 8:1997;3131-3135.
10. Sakurada S., Hayashi T., Yuhki M., Fujimura T., Murayama K., Yonezawa A., Sakurada C., Takeshita M., Sato T., Zadina J.E., Kastin A.J., Sakurada T. Differential antagonism of endomorphin-1 and endomorphin-2 supraspinal antinociception by naloxonazine and 3-methylnaltrexone. Peptides. 23:2002;895-901.
11. Mizoguchi H., Narita M., Oji D.E., Suganuma C., Nagase H., Sora I., Uhl G.R., Cheng E.Y., Tseng L.F. The μ-opioid receptor gene-dose dependent reductions in G-protein activation in the pons/medulla and antinociception induced by endomorphins in μ-opioid receptor knockout mice. Neuroscience. 94:1999;203-207.
12. Roques B.P., Noble F., Dauge V., Fournie-Zaluski M.C., Beaumont A. Neutral endopeptidase-24.11: structure, inhibition, and experimental and clinical pharmacology. Pharmacol. Rev. 45:1993;87-146.
13. Peter A., Toth G., Tomboly G., Laus G., Tourwe D. Liquid chromatographic study of the enzymatic degradation of endomorphins, with identification by electrospray ionization mass spectrometry. J. Chromatogr. 846:1999;39-48.
14. Shane R., Wilk S., Bodnar R.J. Modulation of endomorphin-2-induced analgesia by dipeptidyl peptidase IV. Brain Res. 815:1999;278-286.
15. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 16:1983;109-110.
16. Jones D.H., Matus A.I. Isolation of synaptic plasma membrane from brain by combined flotation-sedimentation density gradient centrifugation. Biochem. Biophys. Acta. 356:1974;276-287.
17. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
18. Kenny A.J., Booth A.G., George S.G., Ingram J., Kershaw D., Wood E.J., Young A.R. Dipeptidyl peptidase IV, a kidney brush-border serine peptidase. Biochem. J. 157:1976;169-182.
19. Bidlingmeyer B.A., Cohen S.A., Tarvin T.L. Rapid analysis of amino acids using pre-column derivatization. J. Chromatogr. 336:1984;93-104.
20. Haley T.J., McComick W.G. Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. Br. J. Pharmacol. 12:1957;12-15.
21. Litchfield J.T., Wilcoxon F. A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 96:1949;99-113.
22. Tanaka Y., Yoshinaga K., Kizaki K., Furuich H., Nakata N., Izumi J., Miura N., Matsumura T., Washizumi M., Kuwabara Y., Ikeda Y. Improving effects of Z-321, a new prolyl endopeptidase inhibitor, on the impaired cerebral function. Jpn. J. Pharmacol. 71(Suppl.):1996;279P.
23. Mentlein R. Dipeptidyl peptidase IV (CD26)-role in the inactivation of regulatory peptides. Regul. Pept. 85:1999;9-24.
24. Mentlein M., Dahms P., Grandt D., Kruger R. Proteolytic processing of neuropeptide Y and peptide YY by dipeptidyl peptidase IV. Regul. Pept. 49:1993;133-144.
25. Nausch I., Mentlein R., Heymann B. The degradation of bioactive peptides and proteins by dipeptidyl peptidase IV from human placenta. Biol. Chem. Hoppe-Seyler. 371:1990;1113-1118.
26. Horn A.S., Rodgers J.R. The enkephalins and opiates: structure-activity relations. J. Pharm. Pharmacol. 29:1977;257-265.
27. Schwartz J.C., Malfroy B., De La Baume S. Biological inactivation of enkephalins and the role of enkephalin-dipeptidyl-carboxypeptidase (enkephalinase) as neuropeptidase. Life Sci. 29:1981;1715-1740.
28. Ronai A.Z., Timar J., Mako E., Erdo F., Gyarmati Z., Toth G., Orosz G., Furst S., Szekely J.I. Diprotin A, an inhibitor of dipeptidyl aminopeptidase IV (EC 3.4.14.5) produces naloxone-reversible analgesia in rats. Life Sci. 64:1999;145-152.