T-cell epitope conservation across allergen species is a major determinant of immunogenicity

Journal of Allergy and Clinical Immunology

Volumn 138, Issue 2, 2016, Pages 571-578.e7

  Westernberg, Luise ^a   Schulten, Véronique ^a   Greenbaum, Jason A ^a   Natali, Sara ^c   Tripple, Victoria ^a   McKinney, Denise M ^a   Frazier, April ^a   Hofer, Heidi ^b   Wallner, Michael ^b   Sallusto, Federica ^c   Sette, Alessandro ^a   Peters, Bjoern ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b UNIVERSITY OF SALZBURG   (Austria)

^c INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

Author keywords

cross reactivity; epitope; pollen allergy; RNA sequencing; sequence conservation; T cell; timothy grass allergy; transcriptome

Indexed keywords

EPITOPE; POLLEN ANTIGEN; TRANSCRIPTOME; ALLERGEN; IMMUNOGLOBULIN E; PLANT ANTIGEN;

ADULT; ALLERGIC REACTION; ARTICLE; CELL EXPANSION; CELL FUNCTION; CROSS REACTION; CYNODON DACTYLON; DRUG ANTIGENICITY; DRUG SENSITIZATION; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; GRASS POLLEN; HUMAN; HUMAN CELL; IMMUNOGENICITY; IMMUNOMODULATION; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; PHLEUM PRATENSE; POA PRATENSIS; POLLEN ALLERGY; PRIORITY JOURNAL; RNA SEQUENCE; SPECIES DIFFERENCE; T LYMPHOCYTE; BLOOD; CONSERVED SEQUENCE; DNA SEQUENCE; GENE EXPRESSION PROFILING; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MOLECULAR EVOLUTION; POACEAE; POLLEN; YOUNG ADULT;

ADULT; ALLERGENS; ANTIGENS, PLANT; CONSERVED SEQUENCE; CROSS REACTIONS; EPITOPES, T-LYMPHOCYTE; EVOLUTION, MOLECULAR; FEMALE; GENE EXPRESSION PROFILING; HUMANS; IMMUNOGLOBULIN E; MALE; MIDDLE AGED; POACEAE; POLLEN; RHINITIS, ALLERGIC, SEASONAL; SEQUENCE ANALYSIS, DNA; T-LYMPHOCYTES; TRANSCRIPTOME; YOUNG ADULT;

EID: 84957664760     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.11.034     Document Type: Article

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