Use of antagonist peptides to inhibit in vitro T cell responses to Par j1, the major allergen of Parietaria judaica pollen

Journal of Immunology

Volumn 162, Issue 4, 1999, Pages 1982-1987

  De Palma, Raffaele ^a,b,c   Wu, Shenhong ^c   Sallusto, Federica ^d,g   Di Felice, Gabriella ^d   Martucci, Paola ^a,h   Geraci, Domenico ^e   Colombo, Paolo ^e   Troise, Costantino ^f   Sacerdoti, Guido ^a   Nocera, Arcangelo ^f   Gorski, Jack ^c  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b IRCCS   (Italy)

^c BLOOD RESEARCH INSTITUTE   (United States)

^d ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^e Istituto di Biologia dello Sviluppo   (Italy)

^f UNIVERSITY OF GENOA   (Italy)

^g BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^h CARDARELLI HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DR ANTIGEN; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE; POLLEN ANTIGEN; PROTEIN PAR J1; UNCLASSIFIED DRUG;

ALLERGIC REACTION; ARTICLE; CELL LINE; CONTROLLED STUDY; HLA SYSTEM; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; PEPTIDE ANALYSIS; POLLEN ALLERGY; PRIORITY JOURNAL; T LYMPHOCYTE;

ALLERGENS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIGENS; BINDING, COMPETITIVE; CELL LINE; GLYCOPROTEINS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-DR ANTIGENS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; PEPTIDES; PLANT PROTEINS; POLLEN; PROTEIN BINDING; T-LYMPHOCYTES;

EID: 0033558041     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Kenakin T. P. 1987. Agonists, partial agonists, antagonists, inverse agonists and agonist/antagonists? Trends Pharmacol. Sci. 8:423.
2. Krieger, J.I., R. W. Karr, H. M. Grey, W. Y. Yu, D. O'Sullivan, L. Batovsky, Z. L. Zheng, S. M. Colon, F. C. Gaeta, J. Sidney, H. M. Grey, and A. Sette. 1991. Single amino acid changes in DR and antigen define residues critical for peptide-MHC binding and T cell recognition. J. Immunol. 146:2331.
3. Snoke, K., J. Alexander, A. Franco, L. Smith, J. V. Brawley, P. Concannon, H. M. Grey, A. Sette, and P. Wentworth. 1993. The inhibition of different T cell lines specific for the same antigen with TCR antagonist peptides. J. Immunol. 153:1.
4. Bertoletti, A., A. Sette, F. V. Chisari, A. Penna, M. Levrero, M. De Carli, F. Fiaccadori, and C. Ferrari. 1994. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature 369:407.
5. De Magistris, M. T., J. Alexander, M. Cogesshall, A. Altman, F. C. A. Gaeta, H. M. Grey, and A. Sette. 1992. Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor. Cell 68:625.
6. Jameson, S. C., and M. J. Bevan. 1995. T cell receptor antagonists and partial agonists. Immunity 2:1.
7. Valitutti, S., S. Muller, M. Cella, E. Padovan, and A. Lanzavecchia. 1995. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375:148.
8. Sloan-Lancaster, J., and P. M. Allen 1996. Altered peptide ligand-induced partial T cell activation. Annu. Rev. Immunol. 14:1.
9. Rabinowitz, J. D., C. Beeson, D. S. Lyons, M. M. Davis, and H. M. McConnell. 1996. Kinetic discrimination in T-cell activation. Proc. Natl. Acad. Sci. USA 93:1401.
10. Rabinowitz, J. D., C. Beeson, C. Wulfing, K. Tate, P. M. Allen, M. M. Davis, and H. M. McConnell. 1996. Altered T cell receptor ligands trigger a subset of early T cell signals. Immunity 5:125.
11. Sette, A., J. Alexander, J. Ruppert, K. Snoke, A. Franco, G. Ishioka, and H. M. Grey. 1994. Antigen analogs/MHC complexes as specific T cell receptor antagonists. Annu. Rev. Immunol. 12:413.
12. Plaut, M., and E. M. Zimmerman. 1993. Allergy and mechanisms of hypersensitivity. In Fundamental Immunology, 3rd Ed. W. Paul. ed., Raven Press, New York, p. 1399.
13. Romagnani, S. 1990. Regulation and deregulation of human IgE synthesis. Immunol. Today 11:316.
14. Romagnani, S. 1994. Lymphokine production by human T cells in disease states. Annu. Rev. Immunol 12:227.
15. Bousquet, J., and P. Burney. 1993. Evidence for an increase in atopic disease and possible causes. Clin. Exp. Allergy 21:484.
16. D'Amato, G., A. Ruffilli, G. Sacerdoti, and S. Bonini. 1992. Parietaria pollinosis: a review. Allergy 47:443.
17. Holgate, S. J., L. Jackson, H. K. Watson, and M. Canderton. 1988. Sensitivity to Parietaria pollen in the Southampton area as determined by skin-prick and RAST tests. Clin. Allergy 18:549.
18. Bass, D., and B. A. Baldo. 1984. Parietaria as a cause of asthma. Meth. J. Aust. 14:511.
19. Jelks, M. L. 1990. Florida pollen review. Allergy Proc: 11:273.
20. Kauffmann, H. S. 1990. Parietaria: an unrecognized cause of respiratory allergy in the United States. Ann. Allergy 64:293.
21. Sallusto, F., S. Corinti, C. Pini, G. Biocca, and G. Di Felice. 1995. Parietaria judaica-speciftc T cell clones from atopic patients: heterogeneity in restriction. Vβ usage, and cytokine profiles. J. Allergy Clin. Immunol. 97:627.
22. Summers, M. D., and G. E. Smith. 1988. Texas Agricultural Experiment Station: A Manual of Methods for Baculovirus Vectors and Insect Cell Culture Procedures. Bulletin No 1555, College Station, TX.
23. Costa, M. A., P. Colombo, V. Izzo, H. Kennedy, S. Venturella, R. Cocchiara, G. Mistrello, P. Falagiani, and D. Geraci. 1994. cDNA cloning, expression and primary structure of Par j1, a major allergen of Parietaria judaica pollen. FEBS Letters 341:182.
24. Stern, L. J., and D. C. Wiley. 1992. The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide. Cell 68:465.
25. Wu, S., and J. Gorski. 1996. The MHC class II-associated invariant chain-derived peptide CLIP binds to the peptide binding groove of the class II molecules. Mol. Immunol. 33:371.
26. Wu, S., J. Gorski, D. D. Eckels, and D. Newton-Nash. 1996. T cell recognition of MHC class II-associated peptide is independent of peptide affinity for MHC and sodium dodecyl sulfate stability of the peptide/MHC complex. J. Immunol. 156:3815.
27. Weaver, C. T., and E. R. Unanue. 1990. The costimulatory function of antigen-presenting cells. Immunol. Today 11:49.
28. Lanzavecchia, A. 1990. Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytes. Annu. Rev. Immunol. 8:773.
29. Adorini, L., E. Appella, G. Doria, F. Cardinaux, and Z. A. Nagy. 1989. Competition for antigen presentation in living cells involves exchange of peptides bound by class II MHC molecules. Nature 342:800.
30. Harding, C. V., F. Leyva-Cobian, and E. R. Unanue 1989. Turnover of Ia peptide complexes is facilitated in viable antigen-presenting cells: biosynthetic turnover of Ia vs peptide exchange. Proc. Natl. Acad. Sci. USA 86:4230.
31. Guery, J. C., and L. Adorini. 1993. Selective immunosuppression of class II-restricted T cells by MHC-binding peptides. Crit. Rev. Immunol. 13:195.
32. + α/β T Cells. J. Exp. Med. 186:899.
33. Colombo, P., D. Kennedy, T. Ramsdale, M. A. Costa, G. Duro, V. Izzo, S. Salvadori, R. Guerrini, R. Cocchiara, M. M. Mirisola, S. Wood, and D. Geraci. 1998. Identification of an immunodominant IgE epitope of the Parietaria judaica major allergen. J. Immunol 160:2780.
34. O'Hehir, R. E., G. F. Hoyne, W. R. Thomas, and J. R. Lamb. 1993. House dust mite allergy: from T cell epitopes to immunotherapy. Eur. J. Clin. Invest. 23:763.
35. Nicodemus, C., G. Philip, N. Jones, S. Hirani, and P. Norman. 1997. Integrated clinical experience with tolerogenic peptides. Int. Arch. Allergy Immunol. 113: 326.