Study of the mechanism of TCR antagonism using dual-TCR-expressing T cells

Journal of Immunology

Volumn 170, Issue 9, 2003, Pages 4532-4538

  Yang, Wen ^a   Grey, Howard M ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; COMPARATIVE STUDY; COMPETITIVE INHIBITION; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; HOMOZYGOSITY; LYMPHOCYTE PROLIFERATION; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0037406912     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.9.4532     Document Type: Article

References (39)

1. Hogquist, K. A., S. C. Jameson, W. R. Heath, J. L. Howard, M. J. Bevan, and F. R. Carbone, 1994. T cell receptor antagonist peptides induce positive selection, Cell 76:17.
2. Ashton-Rickardt, P. G., A. Bandeira, J. R. Delaney, L. Van Kaer, H. P. Pitcher, R. M. Zinkernagel, and S. Tonegawa. 1994. Evidence for a differential avidity model of T cell selection in the thymus. Cell 76:651.
3. + thymocytes by T-cell receptor peptide antagonists. Proc. Natl. Acad. Sci. USA 91:4057.
4. Sebzda, E., S. Mariathasan, T. Ohteki, R. Jones, M. F. Bachmann, and P. S. Ohashi. 1999. Selection of the T cell repertoire. Annu. Rev. Immunol. 17:829.
5. Alam, S. M., P. J. Ravers, J. L. Wung, W. Nasholds, S. Redpath, S. C. Jameson, and N. R. Ascoigne. 1996. T-cell-receptor affinity and thymocyte positive selection. Nature 381:616.
6. Pfeiffer, C., J. Stein, S. Southwood, H. Ketelaar, A. Sette, and K. Bottomly. 1995. Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J. Exp. Med. 181:1569.
7. Nicholson, L. B., J. M. Greer, R. A. Sobel, M. B. Lees, and V. K. Kuchroo. 1995. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 3:397.
8. Singh, R. A., Y. C. Zang, A. Shrivastava, J. Hong, G. T. Wang, S. Li, M. V. Tejada-Simon, M. Kozovska, V. M. Rivera, and J. Z. Zhang. 1999. Th1 and Th2 deviation of myelin-autoreactive T cells by altered peptide ligands is associated with reciprocal regulation of Lck, Fyn, and ZAP-70. J. Immunol. 163:6393.
9. Sloan-Lancaster, J., B. D. Evavold, and P. M. Allen. 1993. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature 363:156.
10. Zugel, U., R. Wang, G. Shih, A. Sette, J. Alexander, and H. M. Grey. 1998. Termination of peripheral tolerance to a T cell epitope by heteroclitic antigen analogues. J. Immunol. 161:1705.
11. Wang, R., Y. Wang-Zhu, C. R. Gabaglia, K. Kimachi, and H. M. Grey. 1999. The stimulation of low-affinity, nontolerized clones by heteroclitic antigen analogues causes the breaking of tolerance established to an immunodominant T cell epitope. J. Exp. Med. 190:983.
12. Evavold, B. D., and P. M. Allen. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252:1308.
13. De Magistris, M. T., J. Alexander, M. Coggeshall, A. Altman, F. C. A. Gaeta, H. M. Grey, and A. Sette. 1992. Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor. Cell 68:625.
14. Sette, A., J. Alexander, J. Ruppert, K. Snoke, A. Franco, G. Ishioka, and H. M. Grey. 1994. Antigen analogs/MHC complexes as specific T cell receptor antagonists. Annu. Rev. Immunol. 12:413.
15. Daniels, M. A., S. L. Schober, K. A. Hogquist, and S. C. Jameson. 1999. Cutting edge: a test of the dominant negative signal model for TCR antagonism. J. Immunol. 162:3761.
16. Stotz, S. H., L. Bolliger, F. R. Carbone. and E. Palmer. 1999. T cell receptor (TCR) antagonism without a negative signal: evidence from T cell hybridomas expressing two independent TCRs. J. Exp. Med. 189:253.
17. Torigoe, C., J. K. Inman, and H. Metzger. 1998. An unusual mechanism for ligand antagonism. Science 281:568.
18. Dittel B. N., I. Stefanova, R. N. Germain, and C. A. Janeway, Jr. 1999. Cross-antagonism of a T cell clone expressing two distinct T cell receptors. Immunity 11:289.
19. Sykulev, Y., Y. Vugmeyster, A. Brunmark, H. L. Ploegh, and H. N. Eisen. 1998. Peptide antagonism and T cell receptor interactions with peptide-MHC complexes. Immunity 9:475.
20. + T cells with dual antigen specificities. J. Immunol. 163:1750.
21. Fink, P. J., L. A. Matis, D. L. McElligott, M. Bookman, and S. M. Hedrick. 1986. Correlations between T-cell specificity and the structure of the antigen receptor. Nature 321:219.
22. Shimonkevitz, R., S. Colon, J. W. Kappler, P. Marrack, and H. M. Grey. 1984. Antigen recognition by H-2-restricted T cells. II. A tryptic ovalbumin peptide that substitutes for processed antigen. J. Immunol. 133:2067.
23. Pircher, H., K. Burki, R. Lang, H. Hengartner, and R. M. Zinkernagel. 1989. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342:559.
24. Klavinskis, L. S., J. L. Whitton, E. Joly, and M. B. A. Oldstone. 1990. Vaccination and protection from a lethal viral infection: identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitope. Virology 178:393.
25. Kelly, J. M., S. J. Sterry, S. Cose, S. J. Turner, J. Fecondo, S. Rodda, P. J. Fink, and F. R. Carbone. 1993. Identification of conserved T cell receptor CDR3 residues contacting known exposed peptide side chains from a major histocompatibility complex class I-bound determinant. Eur. J. Immunol. 23:3318.
26. + B cell hybridomas to H-2-restricted T cell hybridomas. Proc. Natl. Acad. Sci. USA 79:3604.
27. La Face, D. M., C. Couture, K. Anderson, G. Shih, J. Alexander, A. Sette, T. Mustelin, A. Altman, and H. M. Grey. 1997. Differential T cell signaling induced by antagonist peptide-MHC complexes and the associated phenotypic responses. J. Immunol. 158:2057.
28. Lyons, D. S., S. A. Lieberman, J. Hampl, J. J. Boniface, Y-h. Chien, L. J. Berg, and M. M. Davis. 1996. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity 5:53.
29. Bachmann, M. F., D. E. Speiser, A. Zakarian, and P. S. Ohashi. 1998. Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests the mechanism for TCR antagonism. Eur. J. Immunol. 28:3110.
30. Jameson, S. C., F. R. Carbone, and M. J. Bevan. 1993. Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells. J. Exp. Med. 177:1541.
31. Janeway, C. A., Jr. 1995. Ligands for the T-cell receptor: hard times for avidity models. Immunol. Today 16:223.
32. Monks, C. R., B. A. Frieberg, H. Kupfer, N. Sciaky, and A. Kupfer. 1998. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395:82.
33. Cochran, J. R., T. O. Cameron, and L. J. Stern. 2000. The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers. Immunity 12:241.
34. Hamad, A. R., S. M. O'Herrin, M. S. Lebowitz. A. Srikrishnan, J. Bieter, J. Schneck, and D. Pardoll. 1998. Potent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: the role of CD4 coreceptor. J. Exp. Med. 188:1633.
35. Boniface, J. J., J. D. Rabinowitz, C. Wulfing, J. Hampl, Z. Reich, J. D. Altman, R. M. Kantor, C. Beeson, H. M. McConnell, and M. M. Davis. 1998. Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands. Immunity 9:459.
36. Casares, S., C. S. Zong, D. L. Radu, A. Miller, C. A. Bona, and T. D. Brumeanu. 1999. Antigen-specific signaling by a soluble, dimeric peptide/major histocompatibility complex class II/Fc chimera leading to T helper cell type 2 differentiation. J. Exp. Med. 190:543.
37. Abastado, J. P., Y. C. Lone, A. Casrouge, G. Boulot, and P. Kourilsky. 1995. Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness. J. Exp. Med. 182:439.
38. Alexander, A., K. Snoke, J. Ruppert, J. Sidney, M. Wall., S. Southwood, C. Oseroff, T. Arrhenius, F. C. A. Gaeta, S. M. Colon, H. M. Grey, and A. Sette. 1993. Functional consequences of engagement of the T cell receptor by low affinity ligands. J. Immunol. 150:1.
39. Ruppert, J., J. Alexander, K. Snoke, M. Coggeshall, E. Herbert, D. McKenzie, H. M. Grey, and A. Sette. 1993. Effect of T-cell receptor antagonism on interaction between T cells and antigen-presenting cells and on T-cell signaling events. Proc. Natl. Acad. Sci. USA 90:2671.