Cutting edge: A single MHC anchor residue alters the conformation of a peptide-MHC complex inducing T cells that survive negative selection

Journal of Immunology

Volumn 166, Issue 10, 2001, Pages 5874-5877

  Peterson, Daniel A ^a   DiPaolo, Richard J ^a   Kanagawa, Osami ^a   Unanue, Emil R ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ASPARTIC ACID; HEL A52 PROTEIN; LYSOZYME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEIN; UNCLASSIFIED DRUG;

ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNITY; CELL SURVIVAL; GENE MUTATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; T LYMPHOCYTE; TRANSGENIC MOUSE; VACCINATION;

EID: 0035873184     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.10.5874     Document Type: Article

References (23)

1. Nelson, C. A., S. J. Petzold, and E. R. Unanue. 1994. Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell. Nature 371: 250.
2. k. J. Immunol. 157:755.
3. Carrasco-Marin, E., S. Petzold, and E. R. Unanue. 1999. Two structural states of complexes of peptide and class II major histocompatibility complex revealed by photoaffinity-labeled peptides. J. Biol. Chem. 274:31333.
4. k in complex with a dominant epitope of lysozyme. Immunity 8:305.
5. Dadaglio, G., C. A. Nelson, M. B. Deck, S. J. Petzold, and E. R. Unanue. 1997. Characterization and quantitation of peptide-MHC complexes produced from hen egg lysozyme using a monoclonal antibody. Immunity 6:727.
6. Viner, N. J., C. A. Nelson, B. Deck, and E. R. Unanue. 1996. Complexes generated by the binding of free peptides to class II MHC molecules are antigenically diverse compared with those generated by intracellular processing. J Immunol. 156:2365.
7. Peterson, D. A., R. J. DiPaolo, O. Kanagawa, and E. R. Unanue. 1999. Quantitative analysis of the T cell repertoire that escapes negative selection. Immunity 11:453.
8. + T cells. J. Exp. Med. 179:1539.
9. Nelson, C. A., I. Vidavsky, N. J. Viner, M. L. Gross, and E. R. Unanue. 1997. Amino-terminal trimming of peptides for presentation on major histocompatibilily complex class II molecules. Proc. Natl. Acad. Sci. USA 94:628.
10. Kouskoff, V., H. J. Fehling, M. Lemeur, C. Benoist, and D. Mathis. 1993. A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice. J. Immunol. Methods 166:287.
11. Kanagawa, O., S. M. Martin, B. A. Vaupel, E. Carrasco-Marin, and E. R. Unanue. 1998. Autoreactivity of T cells from nonobese diabetic mice: an I-Ag7-dependent reaction. Proc. Natl. Acad. Sci. USA 95:1721.
12. Velazquez, C., R. DiPaolo, and E. R. Unanue. 2001. Quantitation of lysozyme peptides bound to class II MHC molecules indicates very large differences in levels of presentation. J. Immunol. In press.
13. Gapin, L., J. P. Cabaniols, R. Cibotti, D. M. Ojcius, P. Kourilsky, and J. M. Kanellopoulos. 1997. Determinant selection for T-cell tolerance in HEL-transgenic mice: dissociation between immunogenicity and tolerogenicity. Cell. Immunol. 177:77.
14. Harrington, C. J., A. Paez, T. Hunkapiller, V. Mannikko, T. Brabb, M. E. Ahearn, C. Beeson, and J. Goverman. 1998. Differential tolerence is induced in T cells recognizing distinct epitopes of myelin basic protein. Immunity 8:571.
15. Accapezzato, D., R. Nisini, M. Paroli, G. Bruno, F. Bonino, M. Houghton, and V. Barnaba. 1998. Generation of an MHC class II-restricted T cell epitope by extracellular processing of hepatitis delta antigen. J. Immunol. 160:5262.
16. Wucherpfennig, K. W., and J. L. Strominger. 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80:695.
17. Zhao, Z. S., F. Granucci, L. Yeh, P. A. Schaffer, and H. Cantor. 1998. Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after viral infection. Science 279:1344.
18. Peterson, D. A., R. J. DiPaolo, O. Kanagawa, and E. R. Unanue. 1999. Cutting edge: negative selection of immature thymocytes by a few peptide-MHC complexes: differential sensitivity of immature and mature T cells. J. Immunol. 162: 3117.
19. Kersh, G. I., E. N. Kersh, D. H. Fremont, and P. M. Allen. 1998. High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling. Immunity 9:817.
20. Ahlers, J. D., T. Takeshita, C. D. Pendleton, and J. A. Berzofsky. 1997. Enhanced immunogenicity of HIV-1 vaccine construct by modification of the native peptide sequence, Proc. Natl. Acad. Sci. USA 94:10856.
21. Micheletti, F., R. Guerrini, A. Formentin, A. Canella, M. Marastoni, M. Bazzaro, R. Tomatis, S. Traniello, and R. Gavioli. 1999. Selective amino acid substitutions of a subdominant Epstein-Barr virus LMP2-derived epilope increase HLA/peptide complex stability and immunogenicity: implications for immunotherapy of Epstein-Barr virus- associated malignancies. Eur. J. Immunol. 29:2579.
22. Valmori, D., F. Levy, I. Miconnet, P. Zajac, G. C. Spagnoli, D. Rimoldi, D. Lienard, V. Cerundolo, J. C. Cerottini, and P. Romero. 2000. Induction of potent antitumor CTL responses by recombinant vaccinia encoding a melan-A peptide analogue. J. Immunol. 164:1125.
23. Wang, R., Y. Wang-Zhu, C. R. Gabaglia, K. Kimachi, and H. M. Grey. 1999. The stimulation of low-affinity, nontolerized clones by heteroclitic antigen analogues causes the breaking of tolerance established to an immunodominant T cell epitope. J. Exp. Med. 190:983.