-
1
-
-
0025743306
-
Importance of the nef gene for maintenance of high virus loads and for development of AIDS
-
Kestler HW, Ringler DJ, Mori K, Panicali DL, Sehgal PK, Daniel MD, Desrosiers RC. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 1991;65:651–662.
-
(1991)
Cell
, vol.65
, pp. 651-662
-
-
Kestler, H.W.1
Ringler, D.J.2
Mori, K.3
Panicali, D.L.4
Sehgal, P.K.5
Daniel, M.D.6
Desrosiers, R.C.7
-
2
-
-
0033519616
-
Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort
-
Learmont JC, Geczy AF, Mills J, Ashton LJ, Raynes-Greenow CH, Garsia RJ, Dyer WB, McIntyre L, Oelrichs RB, Rhodes DI, Deacon NJ, Sullivan JS. Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort. N Engl J Med 1999;340:1715–1722.
-
(1999)
N Engl J Med
, vol.340
, pp. 1715-1722
-
-
Learmont, J.C.1
Geczy, A.F.2
Mills, J.3
Ashton, L.J.4
Raynes-Greenow, C.H.5
Garsia, R.J.6
Dyer, W.B.7
McIntyre, L.8
Oelrichs, R.B.9
Rhodes, D.I.10
Deacon, N.J.11
Sullivan, J.S.12
-
3
-
-
36048974619
-
Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo
-
Gorry PR, McPhee DA, Verity E, Dyer WB, Wesselingh SL, Learmont J, Sullivan JS, Roche M, Zaunders JJ, Gabuzda D, Crowe SM, Mills J, Lewin SR, Brew BJ, Cunningham AL, et al. Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo. Retrovirology 2007;4:66.
-
(2007)
Retrovirology
, vol.4
, pp. 66
-
-
Gorry, P.R.1
McPhee, D.A.2
Verity, E.3
Dyer, W.B.4
Wesselingh, S.L.5
Learmont, J.6
Sullivan, J.S.7
Roche, M.8
Zaunders, J.J.9
Gabuzda, D.10
Crowe, S.M.11
Mills, J.12
Lewin, S.R.13
Brew, B.J.14
Cunningham, A.L.15
-
4
-
-
0028804160
-
Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients
-
Deacon NJ, Tsykin A, Solomon A, Smith K, Ludford-Menting M, Hooker DJ, McPhee DA, Greenway AL, Ellett A, Chatfield C, Lawson VA, Crowe S, Maerz A, Sonza S, Learmont J, et al. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science 1995;270:988–991.
-
(1995)
Science
, vol.270
, pp. 988-991
-
-
Deacon, N.J.1
Tsykin, A.2
Solomon, A.3
Smith, K.4
Ludford-Menting, M.5
Hooker, D.J.6
McPhee, D.A.7
Greenway, A.L.8
Ellett, A.9
Chatfield, C.10
Lawson, V.A.11
Crowe, S.12
Maerz, A.13
Sonza, S.14
Learmont, J.15
-
5
-
-
0032503585
-
Genomic sequence of HIV type 1 from four members of the Sydney Blood Bank Cohort of long-term nonprogressors
-
Oelrichs R, Tsykin A, Rhodes D, Solomon A, Ellett A, McPhee D, Deacon N. Genomic sequence of HIV type 1 from four members of the Sydney Blood Bank Cohort of long-term nonprogressors. AIDS Res Hum Retroviruses 1998;14:811–814.
-
(1998)
AIDS Res Hum Retroviruses
, vol.14
, pp. 811-814
-
-
Oelrichs, R.1
Tsykin, A.2
Rhodes, D.3
Solomon, A.4
Ellett, A.5
McPhee, D.6
Deacon, N.7
-
6
-
-
0030896502
-
Deletion of nef slows but does not prevent CD4-positive T-cell depletion in human immunodeficiency virus type 1-infected human-PBL-SCID mice
-
Gulizia RJ, Collman RG, Levy JA, Trono D, Mosier DE. Deletion of nef slows but does not prevent CD4-positive T-cell depletion in human immunodeficiency virus type 1-infected human-PBL-SCID mice. J Virol 1997;71:4161–4164.
-
(1997)
J Virol
, vol.71
, pp. 4161-4164
-
-
Gulizia, R.J.1
Collman, R.G.2
Levy, J.A.3
Trono, D.4
Mosier, D.E.5
-
8
-
-
0030852135
-
Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization
-
Fackler OT, Kienzle N, Kremmer E, Boese A, Schramm B, Klimkait T, Kücherer C, Mueller-Lantzsch N. Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization. Eur J Biochem 1997;247:843–851.
-
(1997)
Eur J Biochem
, vol.247
, pp. 843-851
-
-
Fackler, O.T.1
Kienzle, N.2
Kremmer, E.3
Boese, A.4
Schramm, B.5
Klimkait, T.6
Kücherer, C.7
Mueller-Lantzsch, N.8
-
9
-
-
0031572847
-
The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling
-
Arold S, Franken P, Strub MP, Hoh F, Benichou S, Benarous R, Dumas C. The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling. Structure 1997;5:1361–1372.
-
(1997)
Structure
, vol.5
, pp. 1361-1372
-
-
Arold, S.1
Franken, P.2
Strub, M.P.3
Hoh, F.4
Benichou, S.5
Benarous, R.6
Dumas, C.7
-
10
-
-
0343494918
-
Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain
-
Lee CH, Saksela K, Mirza UA, Chait BT, Kuriyan J. Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain. Cell 1996;85:931–942.
-
(1996)
Cell
, vol.85
, pp. 931-942
-
-
Lee, C.H.1
Saksela, K.2
Mirza, U.A.3
Chait, B.T.4
Kuriyan, J.5
-
11
-
-
0030980288
-
Refined solution structure and backbone dynamics of HIV-1 Nef
-
Grzesiek S, Bax A, Hu JS, Kaufman J, Palmer I, Stahl SJ, Tjandra N, Wingfield PT. Refined solution structure and backbone dynamics of HIV-1 Nef. Protein Sci 1997;6:1248–1263.
-
(1997)
Protein Sci
, vol.6
, pp. 1248-1263
-
-
Grzesiek, S.1
Bax, A.2
Hu, J.S.3
Kaufman, J.4
Palmer, I.5
Stahl, S.J.6
Tjandra, N.7
Wingfield, P.T.8
-
12
-
-
0029795040
-
The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR
-
Grzesiek S, Stahl SJ, Wingfield PT, Bax A. The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR. Biochemistry 1996;35:10256–10261.
-
(1996)
Biochemistry
, vol.35
, pp. 10256-10261
-
-
Grzesiek, S.1
Stahl, S.J.2
Wingfield, P.T.3
Bax, A.4
-
13
-
-
0035844009
-
Domain assembly, surface accessibility and sequence conservation in full length HIV-1 Nef
-
Geyer M, Peterlin BM. Domain assembly, surface accessibility and sequence conservation in full length HIV-1 Nef. FEBS Lett 2001;496:91–95.
-
(2001)
FEBS Lett
, vol.496
, pp. 91-95
-
-
Geyer, M.1
Peterlin, B.M.2
-
14
-
-
84855998457
-
Global landscape of HIV-human protein complexes
-
Jäger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, et al. Global landscape of HIV-human protein complexes. Nature 2012;481:365–370.
-
(2012)
Nature
, vol.481
, pp. 365-370
-
-
Jäger, S.1
Cimermancic, P.2
Gulbahce, N.3
Johnson, J.R.4
McGovern, K.E.5
Clarke, S.C.6
Shales, M.7
Mercenne, G.8
Pache, L.9
Li, K.10
Hernandez, H.11
Jang, G.M.12
Roth, S.L.13
Akiva, E.14
Marlett, J.15
-
15
-
-
84863674566
-
Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef
-
Jia X, Singh R, Homann S, Yang H, Guatelli J, Xiong Y. Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef. Nat Struct Mol Biol 2012;19:701–706.
-
(2012)
Nat Struct Mol Biol
, vol.19
, pp. 701-706
-
-
Jia, X.1
Singh, R.2
Homann, S.3
Yang, H.4
Guatelli, J.5
Xiong, Y.6
-
16
-
-
84898733948
-
How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4
-
Ren X, Park SY, Bonifacino JS, Hurley JH. How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4. Elife 2014;3:e01754.
-
(2014)
Elife
, vol.3
-
-
Ren, X.1
Park, S.Y.2
Bonifacino, J.S.3
Hurley, J.H.4
-
17
-
-
84856499935
-
One protein to rule them all: modulation of cell surface receptors and molecules by HIV Nef
-
Landi A, Iannucci V, Nuffel AV, Meuwissen P, Verhasselt B. One protein to rule them all: modulation of cell surface receptors and molecules by HIV Nef. Curr HIV Res 2011;9:496–504.
-
(2011)
Curr HIV Res
, vol.9
, pp. 496-504
-
-
Landi, A.1
Iannucci, V.2
Nuffel, A.V.3
Meuwissen, P.4
Verhasselt, B.5
-
18
-
-
0033819615
-
Human immunodeficiency virus type 1 Nef mediates sustained membrane expression of tumor necrosis factor and the related cytokine LIGHT on activated T cells
-
Lama J, Ware CF. Human immunodeficiency virus type 1 Nef mediates sustained membrane expression of tumor necrosis factor and the related cytokine LIGHT on activated T cells. J Virol 2000;74:9396–9402.
-
(2000)
J Virol
, vol.74
, pp. 9396-9402
-
-
Lama, J.1
Ware, C.F.2
-
19
-
-
0036169006
-
HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread
-
Sol-Foulon N, Moris A, Nobile C, Boccaccio C, Engering A, Abastado JP, Heard JM, van Kooyk Y, Schwartz O. HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread. Immunity 2002;16:145–155.
-
(2002)
Immunity
, vol.16
, pp. 145-155
-
-
Sol-Foulon, N.1
Moris, A.2
Nobile, C.3
Boccaccio, C.4
Engering, A.5
Abastado, J.P.6
Heard, J.M.7
van Kooyk, Y.8
Schwartz, O.9
-
20
-
-
0035834141
-
HIV-1 Nef impairs MHC class II antigen presentation and surface expression
-
Stumptner-Cuvelette P, Morchoisne S, Dugast M, Le Gall S, Raposo G, Schwartz O, Benaroch P. HIV-1 Nef impairs MHC class II antigen presentation and surface expression. Proc Natl Acad Sci USA 2001;98:12144–12149.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 12144-12149
-
-
Stumptner-Cuvelette, P.1
Morchoisne, S.2
Dugast, M.3
Le Gall, S.4
Raposo, G.5
Schwartz, O.6
Benaroch, P.7
-
21
-
-
0141521574
-
Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles
-
Schindler M, Würfl S, Benaroch P, Greenough TC, Daniels R, Easterbrook P, Brenner M, Münch J, Kirchhoff F. Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles. J Virol 2003;77:10548–10556.
-
(2003)
J Virol
, vol.77
, pp. 10548-10556
-
-
Schindler, M.1
Würfl, S.2
Benaroch, P.3
Greenough, T.C.4
Daniels, R.5
Easterbrook, P.6
Brenner, M.7
Münch, J.8
Kirchhoff, F.9
-
22
-
-
0344875506
-
Human immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of phosphatidylinositol 3-kinase
-
Stumptner-Cuvelette P, Jouve M, Helft J, Dugast M, Glouzman AS, Jooss K, Raposo G, Benaroch P. Human immunodeficiency virus-1 Nef expression induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of phosphatidylinositol 3-kinase. Mol Biol Cell 2003;14:4857–4870.
-
(2003)
Mol Biol Cell
, vol.14
, pp. 4857-4870
-
-
Stumptner-Cuvelette, P.1
Jouve, M.2
Helft, J.3
Dugast, M.4
Glouzman, A.S.5
Jooss, K.6
Raposo, G.7
Benaroch, P.8
-
23
-
-
0025733252
-
Serine phosphorylation-independent downregulation of cell-surface CD4 by nef
-
Garcia JV, Miller AD. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature 1991;350:508–511.
-
(1991)
Nature
, vol.350
, pp. 508-511
-
-
Garcia, J.V.1
Miller, A.D.2
-
24
-
-
0029875421
-
Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
-
Schwartz O, Maréchal V, Le Gall S, Lemonnier F, Heard JM. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nat Med 1996;2:338–342.
-
(1996)
Nat Med
, vol.2
, pp. 338-342
-
-
Schwartz, O.1
Maréchal, V.2
Le Gall, S.3
Lemonnier, F.4
Heard, J.M.5
-
25
-
-
33745070227
-
Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1
-
Schindler M, Münch J, Kutsch O, Li H, Santiago ML, Bibollet-Ruche F, Müller-Trutwin MC, Novembre FJ, Peeters M, Courgnaud V, Bailes E, Roques P, Sodora DL, Silvestri G, Sharp PM, et al. Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell 2006;125:1055–1067.
-
(2006)
Cell
, vol.125
, pp. 1055-1067
-
-
Schindler, M.1
Münch, J.2
Kutsch, O.3
Li, H.4
Santiago, M.L.5
Bibollet-Ruche, F.6
Müller-Trutwin, M.C.7
Novembre, F.J.8
Peeters, M.9
Courgnaud, V.10
Bailes, E.11
Roques, P.12
Sodora, D.L.13
Silvestri, G.14
Sharp, P.M.15
-
26
-
-
0035054394
-
Down-modulation of TCR/CD3 surface complexes after HIV-1 infection is associated with differential expression of the viral regulatory genes
-
Willard-Gallo KE, Furtado M, Burny A, Wolinsky SM. Down-modulation of TCR/CD3 surface complexes after HIV-1 infection is associated with differential expression of the viral regulatory genes. Eur J Immunol 2001;31:969–979.
-
(2001)
Eur J Immunol
, vol.31
, pp. 969-979
-
-
Willard-Gallo, K.E.1
Furtado, M.2
Burny, A.3
Wolinsky, S.M.4
-
27
-
-
67651111833
-
Nef proteins from simian immunodeficiency viruses are tetherin antagonists
-
Zhang F, Wilson SJ, Landford WC, Virgen B, Gregory D, Johnson MC, Munch J, Kirchhoff F, Bieniasz PD, Hatziioannou T. Nef proteins from simian immunodeficiency viruses are tetherin antagonists. Cell Host Microbe 2009;6:54–67.
-
(2009)
Cell Host Microbe
, vol.6
, pp. 54-67
-
-
Zhang, F.1
Wilson, S.J.2
Landford, W.C.3
Virgen, B.4
Gregory, D.5
Johnson, M.C.6
Munch, J.7
Kirchhoff, F.8
Bieniasz, P.D.9
Hatziioannou, T.10
-
28
-
-
67249114758
-
Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2
-
Jia B, Serra-Moreno R, Neidermyer W, Rahmberg A, Mackey J, Fofana IB, Johnson WE, Westmoreland S, Evans DT. Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2. PLoS Pathog 2009;5:e1000429.
-
(2009)
PLoS Pathog
, vol.5
-
-
Jia, B.1
Serra-Moreno, R.2
Neidermyer, W.3
Rahmberg, A.4
Mackey, J.5
Fofana, I.B.6
Johnson, W.E.7
Westmoreland, S.8
Evans, D.T.9
-
29
-
-
23844471509
-
Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta
-
Stove V, Van de Walle I, Naessens E, Coene E, Stove C, Plum J, Verhasselt B. Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta. J Virol 2005;79:11422–11433.
-
(2005)
J Virol
, vol.79
, pp. 11422-11433
-
-
Stove, V.1
Van de Walle, I.2
Naessens, E.3
Coene, E.4
Stove, C.5
Plum, J.6
Verhasselt, B.7
-
30
-
-
0035794535
-
Mechanism for down-regulation of CD28 by Nef
-
Swigut T, Shohdy N, Skowronski J. Mechanism for down-regulation of CD28 by Nef. EMBO J 2001;20:1593–1604.
-
(2001)
EMBO J
, vol.20
, pp. 1593-1604
-
-
Swigut, T.1
Shohdy, N.2
Skowronski, J.3
-
31
-
-
23244459907
-
Nef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1
-
Hrecka K, Swigut T, Schindler M, Kirchhoff F, Skowronski J. Nef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1. J Virol 2005;79:10650–10659.
-
(2005)
J Virol
, vol.79
, pp. 10650-10659
-
-
Hrecka, K.1
Swigut, T.2
Schindler, M.3
Kirchhoff, F.4
Skowronski, J.5
-
32
-
-
18044378256
-
The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4
-
Michel N, Allespach I, Venzke S, Fackler OT, Keppler OT. The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4. Curr Biol 2005;15:714–723.
-
(2005)
Curr Biol
, vol.15
, pp. 714-723
-
-
Michel, N.1
Allespach, I.2
Venzke, S.3
Fackler, O.T.4
Keppler, O.T.5
-
33
-
-
33746582688
-
The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling
-
Michel N, Ganter K, Venzke S, Bitzegeio J, Fackler OT, Keppler OT. The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling. Mol Biol Cell 2006;17:3578–3590.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 3578-3590
-
-
Michel, N.1
Ganter, K.2
Venzke, S.3
Bitzegeio, J.4
Fackler, O.T.5
Keppler, O.T.6
-
34
-
-
3242662807
-
Endogenously expressed HIV-1 nef down-regulates antigen-presenting molecules, not only class I MHC but also CD1a, in immature dendritic cells
-
Shinya E, Owaki A, Shimizu M, Takeuchi J, Kawashima T, Hidaka C, Satomi M, Watari E, Sugita M, Takahashi H. Endogenously expressed HIV-1 nef down-regulates antigen-presenting molecules, not only class I MHC but also CD1a, in immature dendritic cells. Virology 2004;326:79–89.
-
(2004)
Virology
, vol.326
, pp. 79-89
-
-
Shinya, E.1
Owaki, A.2
Shimizu, M.3
Takeuchi, J.4
Kawashima, T.5
Hidaka, C.6
Satomi, M.7
Watari, E.8
Sugita, M.9
Takahashi, H.10
-
35
-
-
25444510358
-
The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs
-
Chaudhry A, Das SR, Hussain A, Mayor S, George A, Bal V, Jameel S, Rath S. The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs. J Immunol 2005;175:4566–4574.
-
(2005)
J Immunol
, vol.175
, pp. 4566-4574
-
-
Chaudhry, A.1
Das, S.R.2
Hussain, A.3
Mayor, S.4
George, A.5
Bal, V.6
Jameel, S.7
Rath, S.8
-
36
-
-
84872804428
-
Down-regulation of CTLA-4 by HIV-1 Nef protein
-
El-Far M, Isabelle C, Chomont N, Bourbonnière M, Fonseca S, Ancuta P, Peretz Y, Chouikh Y, Halwani R, Schwartz O, Madrenas J, Freeman GJ, Routy JP, Haddad EK, Sékaly RP. Down-regulation of CTLA-4 by HIV-1 Nef protein. PLoS One 2013;8:e54295.
-
(2013)
PLoS One
, vol.8
-
-
El-Far, M.1
Isabelle, C.2
Chomont, N.3
Bourbonnière, M.4
Fonseca, S.5
Ancuta, P.6
Peretz, Y.7
Chouikh, Y.8
Halwani, R.9
Schwartz, O.10
Madrenas, J.11
Freeman, G.J.12
Routy, J.P.13
Haddad, E.K.14
Sékaly, R.P.15
-
37
-
-
84944110470
-
SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef
-
Usami Y, Wu Y, Gottlinger HG. SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef. Nature 2015;526:218–223.
-
(2015)
Nature
, vol.526
, pp. 218-223
-
-
Usami, Y.1
Wu, Y.2
Gottlinger, H.G.3
-
38
-
-
84944049517
-
HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation
-
Rosa A, Chande A, Ziglio S, De Sanctis V, Bertorelli R, Goh SL, McCauley SM, Nowosielska A, Antonarakis SE, Luban J, Santoni FA, Pizzato M. HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation. Nature 2015;526:212–217.
-
(2015)
Nature
, vol.526
, pp. 212-217
-
-
Rosa, A.1
Chande, A.2
Ziglio, S.3
De Sanctis, V.4
Bertorelli, R.5
Goh, S.L.6
McCauley, S.M.7
Nowosielska, A.8
Antonarakis, S.E.9
Luban, J.10
Santoni, F.A.11
Pizzato, M.12
-
39
-
-
84944269311
-
Cell surface proteomic map of HIV infection reveals antagonism of amino acid metabolism by Vpu and Nef
-
Matheson NJ, Sumner J, Wals K, Rapiteanu R, Weekes MP, Vigan R, Weinelt J, Schindler M, Antrobus R, Costa AS, Frezza C, Clish CB, Neil SJ, Lehner PJ. Cell surface proteomic map of HIV infection reveals antagonism of amino acid metabolism by Vpu and Nef. Cell Host Microbe 2015;18:409–423.
-
(2015)
Cell Host Microbe
, vol.18
, pp. 409-423
-
-
Matheson, N.J.1
Sumner, J.2
Wals, K.3
Rapiteanu, R.4
Weekes, M.P.5
Vigan, R.6
Weinelt, J.7
Schindler, M.8
Antrobus, R.9
Costa, A.S.10
Frezza, C.11
Clish, C.B.12
Neil, S.J.13
Lehner, P.J.14
-
40
-
-
0027158904
-
Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection
-
Benson RE, Sanfridson A, Ottinger JS, Doyle C, Cullen BR. Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection. J Exp Med 1993;177:1561–1566.
-
(1993)
J Exp Med
, vol.177
, pp. 1561-1566
-
-
Benson, R.E.1
Sanfridson, A.2
Ottinger, J.S.3
Doyle, C.4
Cullen, B.R.5
-
41
-
-
0033578072
-
Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner
-
Lama J, Mangasarian A, Trono D. Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner. Curr Biol 1999;9:622–631.
-
(1999)
Curr Biol
, vol.9
, pp. 622-631
-
-
Lama, J.1
Mangasarian, A.2
Trono, D.3
-
42
-
-
0033578016
-
Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein
-
Ross TM, Oran AE, Cullen BR. Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein. Curr Biol 1999;9:613–621.
-
(1999)
Curr Biol
, vol.9
, pp. 613-621
-
-
Ross, T.M.1
Oran, A.E.2
Cullen, B.R.3
-
43
-
-
0141780822
-
Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication
-
Argañaraz ER, Schindler M, Kirchhoff F, Cortes MJ, Lama J. Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication. J Biol Chem 2003;278:33912–33919.
-
(2003)
J Biol Chem
, vol.278
, pp. 33912-33919
-
-
Argañaraz, E.R.1
Schindler, M.2
Kirchhoff, F.3
Cortes, M.J.4
Lama, J.5
-
44
-
-
0346601814
-
The physiological relevance of CD4 receptor down-modulation during HIV infection
-
Lama J. The physiological relevance of CD4 receptor down-modulation during HIV infection. Curr HIV Res 2003;1:167–184.
-
(2003)
Curr HIV Res
, vol.1
, pp. 167-184
-
-
Lama, J.1
-
45
-
-
0037127303
-
Cell surface CD4 interferes with the infectivity of HIV-1 particles released from T cells
-
Cortés MJ, Wong-Staal F, Lama J. Cell surface CD4 interferes with the infectivity of HIV-1 particles released from T cells. J Biol Chem 2002;277:1770–1779.
-
(2002)
J Biol Chem
, vol.277
, pp. 1770-1779
-
-
Cortés, M.J.1
Wong-Staal, F.2
Lama, J.3
-
46
-
-
84921324515
-
HIV-1 Nef: a master manipulator of the membrane trafficking machinery mediating immune evasion
-
Pawlak EN, Dikeakos JD. HIV-1 Nef: a master manipulator of the membrane trafficking machinery mediating immune evasion. Biochim Biophys Acta 2015;1850:733–741.
-
(2015)
Biochim Biophys Acta
, vol.1850
, pp. 733-741
-
-
Pawlak, E.N.1
Dikeakos, J.D.2
-
47
-
-
79960255087
-
HIV immune evasion disruption of antigen presentation by the HIV Nef protein
-
Wonderlich ER, Leonard JA, Collins KL. HIV immune evasion disruption of antigen presentation by the HIV Nef protein. Adv Virus Res 2011;80:103–127.
-
(2011)
Adv Virus Res
, vol.80
, pp. 103-127
-
-
Wonderlich, E.R.1
Leonard, J.A.2
Collins, K.L.3
-
49
-
-
84929907228
-
Intrinsic host restrictions to HIV-1 and mechanisms of viral escape
-
Simon V, Bloch N, Landau NR. Intrinsic host restrictions to HIV-1 and mechanisms of viral escape. Nat Immunol 2015;16:546–553.
-
(2015)
Nat Immunol
, vol.16
, pp. 546-553
-
-
Simon, V.1
Bloch, N.2
Landau, N.R.3
-
50
-
-
0032488027
-
A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor
-
Bresnahan PA, Yonemoto W, Ferrell S, Williams-Herman D, Geleziunas R, Greene WC. A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor. Curr Biol 1998;8:1235–1238.
-
(1998)
Curr Biol
, vol.8
, pp. 1235-1238
-
-
Bresnahan, P.A.1
Yonemoto, W.2
Ferrell, S.3
Williams-Herman, D.4
Geleziunas, R.5
Greene, W.C.6
-
51
-
-
0346102461
-
Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1g-s1 and AP-3 d-s3 hemicomplexes
-
Janvier K, Kato Y, Boehm M, Rose JR, Martina JA, Kim BY, Venkatesan S, Bonifacino JS. Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1g-s1 and AP-3 d-s3 hemicomplexes. J Cell Biol 2003;163:1281–1290.
-
(2003)
J Cell Biol
, vol.163
, pp. 1281-1290
-
-
Janvier, K.1
Kato, Y.2
Boehm, M.3
Rose, J.R.4
Martina, J.A.5
Kim, B.Y.6
Venkatesan, S.7
Bonifacino, J.S.8
-
52
-
-
78751505790
-
Conservation and diversification of dileucine signal recognition by adaptor protein (AP) complex variants
-
Mattera R, Boehm M, Chaudhuri R, Prabhu Y, Bonifacino JS. Conservation and diversification of dileucine signal recognition by adaptor protein (AP) complex variants. J Biol Chem 2011;286:2022–2030.
-
(2011)
J Biol Chem
, vol.286
, pp. 2022-2030
-
-
Mattera, R.1
Boehm, M.2
Chaudhuri, R.3
Prabhu, Y.4
Bonifacino, J.S.5
-
53
-
-
34248198351
-
The gamma/sigma1 and alpha/sigma2 hemicomplexes of clathrin adaptors AP-1 and AP-2 harbor the dileucine recognition site
-
Doray B, Lee I, Knisely J, Bu G, Kornfeld S. The gamma/sigma1 and alpha/sigma2 hemicomplexes of clathrin adaptors AP-1 and AP-2 harbor the dileucine recognition site. Mol Biol Cell 2007;18:1887–1896.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 1887-1896
-
-
Doray, B.1
Lee, I.2
Knisely, J.3
Bu, G.4
Kornfeld, S.5
-
54
-
-
0032055774
-
Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules
-
Le Gall S, Erdtmann L, Benichou S, Berlioz-Torrent C, Liu L, Benarous R, Heard JM, Schwartz O. Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules. Immunity 1998;8:483–495.
-
(1998)
Immunity
, vol.8
, pp. 483-495
-
-
Le Gall, S.1
Erdtmann, L.2
Benichou, S.3
Berlioz-Torrent, C.4
Liu, L.5
Benarous, R.6
Heard, J.M.7
Schwartz, O.8
-
55
-
-
0032079665
-
Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes
-
Piguet V, Chen YL, Mangasarian A, Foti M, Carpentier JL, Trono D. Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes. EMBO J 1998;17:2472–2481.
-
(1998)
EMBO J
, vol.17
, pp. 2472-2481
-
-
Piguet, V.1
Chen, Y.L.2
Mangasarian, A.3
Foti, M.4
Carpentier, J.L.5
Trono, D.6
-
56
-
-
38349127341
-
Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunit
-
Noviello CM, Benichou S, Guatelli JC. Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunit. J Virol 2008;82:1249–1258.
-
(2008)
J Virol
, vol.82
, pp. 1249-1258
-
-
Noviello, C.M.1
Benichou, S.2
Guatelli, J.C.3
-
57
-
-
41249090191
-
The tyrosine binding pocket in the adaptor protein 1 (AP-1) mu1 subunit is necessary for Nef to recruit AP-1 to the major histocompatibility complex class I cytoplasmic tail
-
Wonderlich ER, Williams M, Collins KL. The tyrosine binding pocket in the adaptor protein 1 (AP-1) mu1 subunit is necessary for Nef to recruit AP-1 to the major histocompatibility complex class I cytoplasmic tail. J Biol Chem 2008;283:3011–3022.
-
(2008)
J Biol Chem
, vol.283
, pp. 3011-3022
-
-
Wonderlich, E.R.1
Williams, M.2
Collins, K.L.3
-
58
-
-
77949496852
-
An MHC-I cytoplasmic domain/HIV-1 Nef fusion protein binds directly to the mu subunit of the AP-1 endosomal coat complex
-
Singh RK, Lau D, Noviello CM, Ghosh P, Guatelli JC. An MHC-I cytoplasmic domain/HIV-1 Nef fusion protein binds directly to the mu subunit of the AP-1 endosomal coat complex. PLoS One 2009;4:e8364.
-
(2009)
PLoS One
, vol.4
-
-
Singh, R.K.1
Lau, D.2
Noviello, C.M.3
Ghosh, P.4
Guatelli, J.C.5
-
59
-
-
84944755225
-
HIV-1 Nef hijacks clathrin coats by stabilizing AP-1:Arf1 polygons
-
Shen QT, Ren X, Zhang R, Lee IH, Hurley JH. HIV-1 Nef hijacks clathrin coats by stabilizing AP-1:Arf1 polygons. Science 2015;350:aac5137.
-
(2015)
Science
, vol.350
, pp. aac5137
-
-
Shen, Q.T.1
Ren, X.2
Zhang, R.3
Lee, I.H.4
Hurley, J.H.5
-
60
-
-
0032525137
-
The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes
-
Greenberg ME, Iafrate AJ, Skowronski J. The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes. EMBO J 1998;17:2777–2789.
-
(1998)
EMBO J
, vol.17
, pp. 2777-2789
-
-
Greenberg, M.E.1
Iafrate, A.J.2
Skowronski, J.3
-
61
-
-
34247129671
-
Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor
-
Chaudhuri R, Lindwasser OW, Smith WJ, Hurley JH, Bonifacino JS. Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor. J Virol 2007;81:3877–3890.
-
(2007)
J Virol
, vol.81
, pp. 3877-3890
-
-
Chaudhuri, R.1
Lindwasser, O.W.2
Smith, W.J.3
Hurley, J.H.4
Bonifacino, J.S.5
-
62
-
-
38349109364
-
A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2
-
Lindwasser OW, Smith WJ, Chaudhuri R, Yang P, Hurley JH, Bonifacino JS. A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2. J Virol 2008;82:1166–1174.
-
(2008)
J Virol
, vol.82
, pp. 1166-1174
-
-
Lindwasser, O.W.1
Smith, W.J.2
Chaudhuri, R.3
Yang, P.4
Hurley, J.H.5
Bonifacino, J.S.6
-
63
-
-
62749181801
-
A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex
-
Chaudhuri R, Mattera R, Lindwasser OW, Robinson MS, Bonifacino JS. A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex. J Virol 2009;83:2518–2530.
-
(2009)
J Virol
, vol.83
, pp. 2518-2530
-
-
Chaudhuri, R.1
Mattera, R.2
Lindwasser, O.W.3
Robinson, M.S.4
Bonifacino, J.S.5
-
64
-
-
84876220704
-
Identification of a novel binding site between HIV type 1 Nef C-terminal flexible loop and AP2 required for Nef-mediated CD4 downregulation
-
Jin YJ, Cai CY, Mezei M, Ohlmeyer M, Sanchez R, Burakoff SJ. Identification of a novel binding site between HIV type 1 Nef C-terminal flexible loop and AP2 required for Nef-mediated CD4 downregulation. AIDS Res Hum Retroviruses 2013;29:725–731.
-
(2013)
AIDS Res Hum Retroviruses
, vol.29
, pp. 725-731
-
-
Jin, Y.J.1
Cai, C.Y.2
Mezei, M.3
Ohlmeyer, M.4
Sanchez, R.5
Burakoff, S.J.6
-
65
-
-
0032530773
-
Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity
-
Craig HM, Pandori MW, Guatelli JC. Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity. Proc Natl Acad Sci USA 1998;95:11229–11234.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 11229-11234
-
-
Craig, H.M.1
Pandori, M.W.2
Guatelli, J.C.3
-
66
-
-
0029924038
-
Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation
-
Aiken C, Krause L, Chen YL, Trono D. Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation. Virology 1996;217:293–300.
-
(1996)
Virology
, vol.217
, pp. 293-300
-
-
Aiken, C.1
Krause, L.2
Chen, Y.L.3
Trono, D.4
-
67
-
-
0031039979
-
Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling
-
Iafrate AJ, Bronson S, Skowronski J. Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling. EMBO J 1997;16:673–684.
-
(1997)
EMBO J
, vol.16
, pp. 673-684
-
-
Iafrate, A.J.1
Bronson, S.2
Skowronski, J.3
-
68
-
-
0033776709
-
HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes
-
Piguet V, Wan L, Borel C, Mangasarian A, Demaurex N, Thomas G, Trono D. HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. Nat Cell Biol 2000;2:163–167.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 163-167
-
-
Piguet, V.1
Wan, L.2
Borel, C.3
Mangasarian, A.4
Demaurex, N.5
Thomas, G.6
Trono, D.7
-
69
-
-
0035341464
-
PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic
-
Crump CM, Xiang Y, Thomas L, Gu F, Austin C, Tooze SA, Thomas G. PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic. EMBO J 2001;20:2191–2201.
-
(2001)
EMBO J
, vol.20
, pp. 2191-2201
-
-
Crump, C.M.1
Xiang, Y.2
Thomas, L.3
Gu, F.4
Austin, C.5
Tooze, S.A.6
Thomas, G.7
-
70
-
-
84861708657
-
An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I
-
Dikeakos JD, Thomas L, Kwon G, Elferich J, Shinde U, Thomas G. An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I. Mol Biol Cell 2012;23:2184–2197.
-
(2012)
Mol Biol Cell
, vol.23
, pp. 2184-2197
-
-
Dikeakos, J.D.1
Thomas, L.2
Kwon, G.3
Elferich, J.4
Shinde, U.5
Thomas, G.6
-
71
-
-
50849129910
-
HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells
-
Schaefer MR, Wonderlich ER, Roeth JF, Leonard JA, Collins KL. HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells. PLoS Pathog 2008;4:e1000131.
-
(2008)
PLoS Pathog
, vol.4
-
-
Schaefer, M.R.1
Wonderlich, E.R.2
Roeth, J.F.3
Leonard, J.A.4
Collins, K.L.5
-
72
-
-
0033515427
-
Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes
-
Piguet V, Gu F, Foti M, Demaurex N, Gruenberg J, Carpentier JL, Trono D. Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes. Cell 1999;97:63–73.
-
(1999)
Cell
, vol.97
, pp. 63-73
-
-
Piguet, V.1
Gu, F.2
Foti, M.3
Demaurex, N.4
Gruenberg, J.5
Carpentier, J.L.6
Trono, D.7
-
73
-
-
0028062729
-
Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic
-
Benichou S, Bomsel M, Bodeus M, Durand H, Doute M, Letourneur F, Camonis J, Benarous R. Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic. J Biol Chem 1994;269:30073–30076.
-
(1994)
J Biol Chem
, vol.269
, pp. 30073-30076
-
-
Benichou, S.1
Bomsel, M.2
Bodeus, M.3
Durand, H.4
Doute, M.5
Letourneur, F.6
Camonis, J.7
Benarous, R.8
-
74
-
-
2942737377
-
ARF1 regulates Nef-induced CD4 degradation
-
Fauré J, Stalder R, Borel C, Sobo K, Piguet V, Demaurex N, Gruenberg J, Trono D. ARF1 regulates Nef-induced CD4 degradation. Curr Biol 2004;14:1056–1064.
-
(2004)
Curr Biol
, vol.14
, pp. 1056-1064
-
-
Fauré, J.1
Stalder, R.2
Borel, C.3
Sobo, K.4
Piguet, V.5
Demaurex, N.6
Gruenberg, J.7
Trono, D.8
-
75
-
-
84907494171
-
Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor
-
Amorim NA, da Silva EM, de Castro RO, da Silva-Januário ME, Mendonça LM, Bonifacino JS, da Costa LJ, daSilva LL. Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor. J Biol Chem 2014;289:27744–27756.
-
(2014)
J Biol Chem
, vol.289
, pp. 27744-27756
-
-
Amorim, N.A.1
da Silva, E.M.2
de Castro, R.O.3
da Silva-Januário, M.E.4
Mendonça, L.M.5
Bonifacino, J.S.6
da Costa, L.J.7
daSilva, L.L.8
-
76
-
-
33746907799
-
Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1
-
Costa LJ, Chen N, Lopes A, Aguiar RS, Tanuri A, Plemenitas A, Peterlin BM. Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1. Retrovirology 2006;3:33.
-
(2006)
Retrovirology
, vol.3
, pp. 33
-
-
Costa, L.J.1
Chen, N.2
Lopes, A.3
Aguiar, R.S.4
Tanuri, A.5
Plemenitas, A.6
Peterlin, B.M.7
-
77
-
-
0032076086
-
Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4
-
Lu X, Yu H, Liu SH, Brodsky FM, Peterlin BM. Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4. Immunity 1998;8:647–656.
-
(1998)
Immunity
, vol.8
, pp. 647-656
-
-
Lu, X.1
Yu, H.2
Liu, S.H.3
Brodsky, F.M.4
Peterlin, B.M.5
-
78
-
-
84928485439
-
Viral bimolecular fluorescence complementation: a novel tool to study intracellular vesicular trafficking pathways
-
Dirk BS, Jacob RA, Johnson AL, Pawlak EN, Cavanagh PC, Van Nynatten L, Haeryfar SM, Dikeakos JD. Viral bimolecular fluorescence complementation: a novel tool to study intracellular vesicular trafficking pathways. PLoS One 2015;10:e0125619.
-
(2015)
PLoS One
, vol.10
-
-
Dirk, B.S.1
Jacob, R.A.2
Johnson, A.L.3
Pawlak, E.N.4
Cavanagh, P.C.5
Van Nynatten, L.6
Haeryfar, S.M.7
Dikeakos, J.D.8
-
79
-
-
84862197035
-
Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation
-
Mukerji J, Olivieri KC, Misra V, Agopian KA, Gabuzda D. Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation. Retrovirology 2012;9:33.
-
(2012)
Retrovirology
, vol.9
, pp. 33
-
-
Mukerji, J.1
Olivieri, K.C.2
Misra, V.3
Agopian, K.A.4
Gabuzda, D.5
-
80
-
-
84855916547
-
Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release
-
Shelton MN, Huang MB, Ali SA, Powell MD, Bond VC. Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release. J Virol 2012;86:406–419.
-
(2012)
J Virol
, vol.86
, pp. 406-419
-
-
Shelton, M.N.1
Huang, M.B.2
Ali, S.A.3
Powell, M.D.4
Bond, V.C.5
-
81
-
-
0032145709
-
The human immunodeficiency virus type 1 Nef protein binds the Src-related tyrosine kinase Lck SH2 domain through a novel phosphotyrosine independent mechanism
-
Dutartre H, Harris M, Olive D, Collette Y. The human immunodeficiency virus type 1 Nef protein binds the Src-related tyrosine kinase Lck SH2 domain through a novel phosphotyrosine independent mechanism. Virology 1998;247:200–211.
-
(1998)
Virology
, vol.247
, pp. 200-211
-
-
Dutartre, H.1
Harris, M.2
Olive, D.3
Collette, Y.4
-
82
-
-
0028878783
-
Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4
-
Saksela K, Cheng G, Baltimore D. Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4. EMBO J 1995;14:484–491.
-
(1995)
EMBO J
, vol.14
, pp. 484-491
-
-
Saksela, K.1
Cheng, G.2
Baltimore, D.3
-
83
-
-
0028805516
-
A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein
-
Lee CH, Leung B, Lemmon MA, Zheng J, Cowburn D, Kuriyan J, Saksela K. A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein. EMBO J 1995;14:5006–5015.
-
(1995)
EMBO J
, vol.14
, pp. 5006-5015
-
-
Lee, C.H.1
Leung, B.2
Lemmon, M.A.3
Zheng, J.4
Cowburn, D.5
Kuriyan, J.6
Saksela, K.7
-
84
-
-
84956906858
-
A conserved GPG-motif in the HIV-1 Nef core is required for principal Nef-activities
-
Martinez-Bonet M, Palladino C, Briz V, Rudolph JM, Fackler OT, Relloso M, Munoz-Fernandez MA, Madrid R. A conserved GPG-motif in the HIV-1 Nef core is required for principal Nef-activities. PLoS One 2015;10:e0145239.
-
(2015)
PLoS One
, vol.10
-
-
Martinez-Bonet, M.1
Palladino, C.2
Briz, V.3
Rudolph, J.M.4
Fackler, O.T.5
Relloso, M.6
Munoz-Fernandez, M.A.7
Madrid, R.8
-
85
-
-
84959504401
-
Molecular characterization of HIV-1 Nef and ACOT8 interaction: insights from in silico structural predictions and in vitro functional assays
-
Serena M, Giorgetti A, Busato M, Gasparini F, Diani E, Romanelli MG, Zipeto D. Molecular characterization of HIV-1 Nef and ACOT8 interaction: insights from in silico structural predictions and in vitro functional assays. Sci Rep 2016;6:22319.
-
(2016)
Sci Rep
, vol.6
, pp. 22319
-
-
Serena, M.1
Giorgetti, A.2
Busato, M.3
Gasparini, F.4
Diani, E.5
Romanelli, M.G.6
Zipeto, D.7
-
86
-
-
0030920271
-
Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation
-
Liu LX, Margottin F, Le Gall S, Schwartz O, Selig L, Benarous R, Benichou S. Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation. J Biol Chem 1997;272:13779–13785.
-
(1997)
J Biol Chem
, vol.272
, pp. 13779-13785
-
-
Liu, L.X.1
Margottin, F.2
Le Gall, S.3
Schwartz, O.4
Selig, L.5
Benarous, R.6
Benichou, S.7
-
87
-
-
0031559871
-
A novel acyl-CoA thioesterase enhances its enzymatic activity by direct binding with HIV Nef
-
Watanabe H, Shiratori T, Shoji H, Miyatake S, Okazaki Y, Ikuta K, Sato T, Saito T. A novel acyl-CoA thioesterase enhances its enzymatic activity by direct binding with HIV Nef. Biochem Biophys Res Commun 1997;238:234–239.
-
(1997)
Biochem Biophys Res Commun
, vol.238
, pp. 234-239
-
-
Watanabe, H.1
Shiratori, T.2
Shoji, H.3
Miyatake, S.4
Okazaki, Y.5
Ikuta, K.6
Sato, T.7
Saito, T.8
-
88
-
-
0034725614
-
The human thioesterase II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation
-
Cohen GB, Rangan VS, Chen BK, Smith S, Baltimore D. The human thioesterase II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation. J Biol Chem 2000;275:23097–23105.
-
(2000)
J Biol Chem
, vol.275
, pp. 23097-23105
-
-
Cohen, G.B.1
Rangan, V.S.2
Chen, B.K.3
Smith, S.4
Baltimore, D.5
-
89
-
-
19244382596
-
Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions
-
Liu LX, Heveker N, Fackler OT, Arold S, Le Gall S, Janvier K, Peterlin BM, Dumas C, Schwartz O, Benichou S, Benarous R. Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions. J Virol 2000;74:5310–5319.
-
(2000)
J Virol
, vol.74
, pp. 5310-5319
-
-
Liu, L.X.1
Heveker, N.2
Fackler, O.T.3
Arold, S.4
Le Gall, S.5
Janvier, K.6
Peterlin, B.M.7
Dumas, C.8
Schwartz, O.9
Benichou, S.10
Benarous, R.11
-
90
-
-
0028180868
-
Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
-
Aiken C, Konner J, Landau NR, Lenburg ME, Trono D. Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 1994;76:853–864.
-
(1994)
Cell
, vol.76
, pp. 853-864
-
-
Aiken, C.1
Konner, J.2
Landau, N.R.3
Lenburg, M.E.4
Trono, D.5
-
91
-
-
0031716336
-
Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: analysis of its role in enhancement of viral infectivity
-
Welker R, Harris M, Cardel B, Kräusslich HG. Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: analysis of its role in enhancement of viral infectivity. J Virol 1998;72:8833–8840.
-
(1998)
J Virol
, vol.72
, pp. 8833-8840
-
-
Welker, R.1
Harris, M.2
Cardel, B.3
Kräusslich, H.G.4
-
92
-
-
33644584737
-
Role of myristoylation and N-terminal basic residues in membrane association of the human immunodeficiency virus type 1 Nef protein
-
Bentham M, Mazaleyrat S, Harris M. Role of myristoylation and N-terminal basic residues in membrane association of the human immunodeficiency virus type 1 Nef protein. J Gen Virol 2006;87:563–571.
-
(2006)
J Gen Virol
, vol.87
, pp. 563-571
-
-
Bentham, M.1
Mazaleyrat, S.2
Harris, M.3
-
93
-
-
77950421393
-
HIV-1 Nef membrane association depends on charge, curvature, composition and sequence
-
Gerlach H, Laumann V, Martens S, Becker CF, Goody RS, Geyer M. HIV-1 Nef membrane association depends on charge, curvature, composition and sequence. Nat Chem Biol 2010;6:46–53.
-
(2010)
Nat Chem Biol
, vol.6
, pp. 46-53
-
-
Gerlach, H.1
Laumann, V.2
Martens, S.3
Becker, C.F.4
Goody, R.S.5
Geyer, M.6
-
94
-
-
0035478109
-
Deletion of N-terminal myristoylation site of HIV Nef abrogates both MHC-1 and CD4 down-regulation
-
Peng B, Robert-Guroff M. Deletion of N-terminal myristoylation site of HIV Nef abrogates both MHC-1 and CD4 down-regulation. Immunol Lett 2001;78:195–200.
-
(2001)
Immunol Lett
, vol.78
, pp. 195-200
-
-
Peng, B.1
Robert-Guroff, M.2
-
95
-
-
0033917035
-
Characterization and molecular basis of the oligomeric structure of HIV-1 nef protein
-
Arold S, Hoh F, Domergue S, Birck C, Delsuc MA, Jullien M, Dumas C. Characterization and molecular basis of the oligomeric structure of HIV-1 nef protein. Protein Sci 2000;9:1137–1148.
-
(2000)
Protein Sci
, vol.9
, pp. 1137-1148
-
-
Arold, S.1
Hoh, F.2
Domergue, S.3
Birck, C.4
Delsuc, M.A.5
Jullien, M.6
Dumas, C.7
-
96
-
-
77149168513
-
Genetic characterization of HIV type 1 Nef-induced vesicle secretion
-
Ali SA, Huang MB, Campbell PE, Roth WW, Campbell T, Khan M, Newman G, Villinger F, Powell MD, Bond VC. Genetic characterization of HIV type 1 Nef-induced vesicle secretion. AIDS Res Hum Retroviruses 2010;26:173–192.
-
(2010)
AIDS Res Hum Retroviruses
, vol.26
, pp. 173-192
-
-
Ali, S.A.1
Huang, M.B.2
Campbell, P.E.3
Roth, W.W.4
Campbell, T.5
Khan, M.6
Newman, G.7
Villinger, F.8
Powell, M.D.9
Bond, V.C.10
-
97
-
-
84955173009
-
Forty years of clathrin-coated vesicles
-
Robinson MS. Forty years of clathrin-coated vesicles. Traffic 2015; 16:1210–1238.
-
(2015)
Traffic
, vol.16
, pp. 1210-1238
-
-
Robinson, M.S.1
-
98
-
-
84891894909
-
Adaptor proteins involved in polarized sorting
-
Bonifacino JS. Adaptor proteins involved in polarized sorting. J Cell Biol 2014;204:7–17.
-
(2014)
J Cell Biol
, vol.204
, pp. 7-17
-
-
Bonifacino, J.S.1
-
99
-
-
0038795645
-
Signals for sorting of transmembrane proteins to endosomes and lysosomes
-
Bonifacino JS, Traub LM. Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annu Rev Biochem 2003;72:395–447.
-
(2003)
Annu Rev Biochem
, vol.72
, pp. 395-447
-
-
Bonifacino, J.S.1
Traub, L.M.2
-
100
-
-
0032488055
-
A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4
-
Greenberg M, DeTulleo L, Rapoport I, Skowronski J, Kirchhausen T. A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4. Curr Biol 1998;8:1239–1242.
-
(1998)
Curr Biol
, vol.8
, pp. 1239-1242
-
-
Greenberg, M.1
DeTulleo, L.2
Rapoport, I.3
Skowronski, J.4
Kirchhausen, T.5
-
101
-
-
0034330458
-
Two independent regions of HIV-1 Nef are required for connection with the endocytic pathway through binding to the mu 1 chain of AP1 complex
-
Erdtmann L, Janvier K, Raposo G, Craig HM, Benaroch P, Berlioz-Torrent C, Guatelli JC, Benarous R, Benichou S. Two independent regions of HIV-1 Nef are required for connection with the endocytic pathway through binding to the mu 1 chain of AP1 complex. Traffic 2000;1:871–883.
-
(2000)
Traffic
, vol.1
, pp. 871-883
-
-
Erdtmann, L.1
Janvier, K.2
Raposo, G.3
Craig, H.M.4
Benaroch, P.5
Berlioz-Torrent, C.6
Guatelli, J.C.7
Benarous, R.8
Benichou, S.9
-
102
-
-
0034713437
-
Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif
-
Craig HM, Reddy TR, Riggs NL, Dao PP, Guatelli JC. Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif. Virology 2000;271:9–17.
-
(2000)
Virology
, vol.271
, pp. 9-17
-
-
Craig, H.M.1
Reddy, T.R.2
Riggs, N.L.3
Dao, P.P.4
Guatelli, J.C.5
-
103
-
-
0037424537
-
HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes
-
Janvier K, Craig H, Hitchin D, Madrid R, Sol-Foulon N, Renault L, Cherfils J, Cassel D, Benichou S, Guatelli J. HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes. J Biol Chem 2003;278:8725–8732.
-
(2003)
J Biol Chem
, vol.278
, pp. 8725-8732
-
-
Janvier, K.1
Craig, H.2
Hitchin, D.3
Madrid, R.4
Sol-Foulon, N.5
Renault, L.6
Cherfils, J.7
Cassel, D.8
Benichou, S.9
Guatelli, J.10
-
104
-
-
0032556872
-
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
-
Collins KL, Chen BK, Kalams SA, Walker BD, Baltimore D. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 1998;391:397–401.
-
(1998)
Nature
, vol.391
, pp. 397-401
-
-
Collins, K.L.1
Chen, B.K.2
Kalams, S.A.3
Walker, B.D.4
Baltimore, D.5
-
105
-
-
0036314505
-
Different effects of Nef-mediated HLA class I down-regulation on human immunodeficiency virus type 1-specific CD8(+) T-cell cytolytic activity and cytokine production
-
Tomiyama H, Akari H, Adachi A, Takiguchi M. Different effects of Nef-mediated HLA class I down-regulation on human immunodeficiency virus type 1-specific CD8(+) T-cell cytolytic activity and cytokine production. J Virol 2002;76:7535–7543.
-
(2002)
J Virol
, vol.76
, pp. 7535-7543
-
-
Tomiyama, H.1
Akari, H.2
Adachi, A.3
Takiguchi, M.4
-
106
-
-
0036066314
-
HIV-1 Vpr does not inhibit CTL-mediated apoptosis of HIV-1 infected cells
-
Lewinsohn DA, Lines R, Lewinsohn DM, Riddell SR, Greenberg PD, Emerman M, Bartz SR. HIV-1 Vpr does not inhibit CTL-mediated apoptosis of HIV-1 infected cells. Virology 2002;294:13–21.
-
(2002)
Virology
, vol.294
, pp. 13-21
-
-
Lewinsohn, D.A.1
Lines, R.2
Lewinsohn, D.M.3
Riddell, S.R.4
Greenberg, P.D.5
Emerman, M.6
Bartz, S.R.7
-
107
-
-
0036146227
-
Nef-mediated resistance of human immunodeficiency virus type 1 to antiviral cytotoxic T lymphocytes
-
Yang OO, Nguyen PT, Kalams SA, Dorfman T, Göttlinger HG, Stewart S, Chen IS, Threlkeld S, Walker BD. Nef-mediated resistance of human immunodeficiency virus type 1 to antiviral cytotoxic T lymphocytes. J Virol 2002;76:1626–1631.
-
(2002)
J Virol
, vol.76
, pp. 1626-1631
-
-
Yang, O.O.1
Nguyen, P.T.2
Kalams, S.A.3
Dorfman, T.4
Göttlinger, H.G.5
Stewart, S.6
Chen, I.S.7
Threlkeld, S.8
Walker, B.D.9
-
108
-
-
0033151621
-
The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
-
Cohen GB, Gandhi RT, Davis DM, Mandelboim O, Chen BK, Strominger JL, Baltimore D. The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. Immunity 1999;10:661–671.
-
(1999)
Immunity
, vol.10
, pp. 661-671
-
-
Cohen, G.B.1
Gandhi, R.T.2
Davis, D.M.3
Mandelboim, O.4
Chen, B.K.5
Strominger, J.L.6
Baltimore, D.7
-
109
-
-
0036889125
-
Direct binding of human immunodeficiency virus type 1 Nef to the major histocompatibility complex class I (MHC-I) cytoplasmic tail disrupts MHC-I trafficking
-
Williams M, Roeth JF, Kasper MR, Fleis RI, Przybycin CG, Collins KL. Direct binding of human immunodeficiency virus type 1 Nef to the major histocompatibility complex class I (MHC-I) cytoplasmic tail disrupts MHC-I trafficking. J Virol 2002;76:12173–12184.
-
(2002)
J Virol
, vol.76
, pp. 12173-12184
-
-
Williams, M.1
Roeth, J.F.2
Kasper, M.R.3
Fleis, R.I.4
Przybycin, C.G.5
Collins, K.L.6
-
110
-
-
40649109097
-
Selective downmodulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses
-
Specht A, DeGottardi MQ, Schindler M, Hahn B, Evans DT, Kirchhoff F. Selective downmodulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses. Virology 2008;373:229–237.
-
(2008)
Virology
, vol.373
, pp. 229-237
-
-
Specht, A.1
DeGottardi, M.Q.2
Schindler, M.3
Hahn, B.4
Evans, D.T.5
Kirchhoff, F.6
-
111
-
-
70649093102
-
Intracellular assembly and trafficking of MHC class I molecules
-
Donaldson JG, Williams DB. Intracellular assembly and trafficking of MHC class I molecules. Traffic 2009;10:1745–1752.
-
(2009)
Traffic
, vol.10
, pp. 1745-1752
-
-
Donaldson, J.G.1
Williams, D.B.2
-
112
-
-
0023187205
-
Major histocompatibility complex class I molecules internalized via coated pits in T lymphocytes
-
Machy P, Truneh A, Gennaro D, Hoffstein S. Major histocompatibility complex class I molecules internalized via coated pits in T lymphocytes. Nature 1987;328:724–726.
-
(1987)
Nature
, vol.328
, pp. 724-726
-
-
Machy, P.1
Truneh, A.2
Gennaro, D.3
Hoffstein, S.4
-
113
-
-
0021354721
-
Spontaneous internalization of Class I major histocompatibility complex molecules in T lymphoid cells
-
Tse DB, Pernis B. Spontaneous internalization of Class I major histocompatibility complex molecules in T lymphoid cells. J Exp Med 1984;159:193–207.
-
(1984)
J Exp Med
, vol.159
, pp. 193-207
-
-
Tse, D.B.1
Pernis, B.2
-
114
-
-
77957258688
-
HIV-1 Nef binds a subpopulation of MHC-I throughout its trafficking itinerary and down-regulates MHC-I by perturbing both anterograde and retrograde trafficking
-
Yi L, Rosales T, Rose JJ, Chowdhury B, Chaudhury B, Knutson JR, Venkatesan S. HIV-1 Nef binds a subpopulation of MHC-I throughout its trafficking itinerary and down-regulates MHC-I by perturbing both anterograde and retrograde trafficking. J Biol Chem 2010;285:30884–30905.
-
(2010)
J Biol Chem
, vol.285
, pp. 30884-30905
-
-
Yi, L.1
Rosales, T.2
Rose, J.J.3
Chowdhury, B.4
Chaudhury, B.5
Knutson, J.R.6
Venkatesan, S.7
-
115
-
-
10344258588
-
HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail
-
Roeth JF, Williams M, Kasper MR, Filzen TM, Collins KL. HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail. J Cell Biol 2004;167:903–913.
-
(2004)
J Cell Biol
, vol.167
, pp. 903-913
-
-
Roeth, J.F.1
Williams, M.2
Kasper, M.R.3
Filzen, T.M.4
Collins, K.L.5
-
116
-
-
34548510349
-
HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2
-
Lubben NB, Sahlender DA, Motley AM, Lehner PJ, Benaroch P, Robinson MS. HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2. Mol Biol Cell 2007;18:3351–3365.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 3351-3365
-
-
Lubben, N.B.1
Sahlender, D.A.2
Motley, A.M.3
Lehner, P.J.4
Benaroch, P.5
Robinson, M.S.6
-
118
-
-
84878323594
-
The clathrin adaptor complexes as a paradigm for membrane-associated allostery
-
Canagarajah BJ, Ren X, Bonifacino JS, Hurley JH. The clathrin adaptor complexes as a paradigm for membrane-associated allostery. Protein Sci 2013;22:517–529.
-
(2013)
Protein Sci
, vol.22
, pp. 517-529
-
-
Canagarajah, B.J.1
Ren, X.2
Bonifacino, J.S.3
Hurley, J.H.4
-
119
-
-
84874033425
-
Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1
-
Ren X, Farías GG, Canagarajah BJ, Bonifacino JS, Hurley JH. Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1. Cell 2013;152:755–767.
-
(2013)
Cell
, vol.152
, pp. 755-767
-
-
Ren, X.1
Farías, G.G.2
Canagarajah, B.J.3
Bonifacino, J.S.4
Hurley, J.H.5
-
120
-
-
30844435721
-
HIV-1 Nef stabilizes AP-1 on membranes without inducing ARF1-independent de novo attachment
-
Coleman SH, Hitchin D, Noviello CM, Guatelli JC. HIV-1 Nef stabilizes AP-1 on membranes without inducing ARF1-independent de novo attachment. Virology 2006;345:148–155.
-
(2006)
Virology
, vol.345
, pp. 148-155
-
-
Coleman, S.H.1
Hitchin, D.2
Noviello, C.M.3
Guatelli, J.C.4
-
121
-
-
81255200501
-
ADP ribosylation factor 1 activity is required to recruit AP-1 to the major histocompatibility complex class I (MHC-I) cytoplasmic tail and disrupt MHC-I trafficking in HIV-1-infected primary T cells
-
Wonderlich ER, Leonard JA, Kulpa DA, Leopold KE, Norman JM, Collins KL. ADP ribosylation factor 1 activity is required to recruit AP-1 to the major histocompatibility complex class I (MHC-I) cytoplasmic tail and disrupt MHC-I trafficking in HIV-1-infected primary T cells. J Virol 2011;85:12216–12226.
-
(2011)
J Virol
, vol.85
, pp. 12216-12226
-
-
Wonderlich, E.R.1
Leonard, J.A.2
Kulpa, D.A.3
Leopold, K.E.4
Norman, J.M.5
Collins, K.L.6
-
122
-
-
79960391235
-
HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements
-
Leonard JA, Filzen T, Carter CC, Schaefer M, Collins KL. HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements. J Virol 2011;85:6867–6881.
-
(2011)
J Virol
, vol.85
, pp. 6867-6881
-
-
Leonard, J.A.1
Filzen, T.2
Carter, C.C.3
Schaefer, M.4
Collins, K.L.5
-
123
-
-
0037074008
-
HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway
-
Blagoveshchenskaya AD, Thomas L, Feliciangeli SF, Hung CH, Thomas G. HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway. Cell 2002;111:853–866.
-
(2002)
Cell
, vol.111
, pp. 853-866
-
-
Blagoveshchenskaya, A.D.1
Thomas, L.2
Feliciangeli, S.F.3
Hung, C.H.4
Thomas, G.5
-
124
-
-
44649173294
-
HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice
-
Atkins KM, Thomas L, Youker RT, Harriff MJ, Pissani F, You H, Thomas G. HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice. J Biol Chem 2008;283:11772–11784.
-
(2008)
J Biol Chem
, vol.283
, pp. 11772-11784
-
-
Atkins, K.M.1
Thomas, L.2
Youker, R.T.3
Harriff, M.J.4
Pissani, F.5
You, H.6
Thomas, G.7
-
125
-
-
0032563306
-
PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization
-
Wan L, Molloy SS, Thomas L, Liu G, Xiang Y, Rybak SL, Thomas G. PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization. Cell 1998;94:205–216.
-
(1998)
Cell
, vol.94
, pp. 205-216
-
-
Wan, L.1
Molloy, S.S.2
Thomas, L.3
Liu, G.4
Xiang, Y.5
Rybak, S.L.6
Thomas, G.7
-
126
-
-
10644261241
-
Human immunodeficiency virus type 1 Nef domains required for disruption of major histocompatibility complex class I trafficking are also necessary for coprecipitation of Nef with HLA-A2
-
Williams M, Roeth JF, Kasper MR, Filzen TM, Collins KL. Human immunodeficiency virus type 1 Nef domains required for disruption of major histocompatibility complex class I trafficking are also necessary for coprecipitation of Nef with HLA-A2. J Virol 2005;79:632–636.
-
(2005)
J Virol
, vol.79
, pp. 632-636
-
-
Williams, M.1
Roeth, J.F.2
Kasper, M.R.3
Filzen, T.M.4
Collins, K.L.5
-
127
-
-
0347504853
-
The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic
-
Scott GK, Gu F, Crump CM, Thomas L, Wan L, Xiang Y, Thomas G. The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic. EMBO J 2003;22:6234–6244.
-
(2003)
EMBO J
, vol.22
, pp. 6234-6244
-
-
Scott, G.K.1
Gu, F.2
Crump, C.M.3
Thomas, L.4
Wan, L.5
Xiang, Y.6
Thomas, G.7
-
128
-
-
0034312298
-
The plasma membrane as a combat zone in the HIV battlefield
-
Doms RW, Trono D. The plasma membrane as a combat zone in the HIV battlefield. Genes Dev 2000;14:2677–2688.
-
(2000)
Genes Dev
, vol.14
, pp. 2677-2688
-
-
Doms, R.W.1
Trono, D.2
-
129
-
-
34147169409
-
HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I
-
Hung CH, Thomas L, Ruby CE, Atkins KM, Morris NP, Knight ZA, Scholz I, Barklis E, Weinberg AD, Shokat KM, Thomas G. HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I. Cell Host Microbe 2007;1:121–133.
-
(2007)
Cell Host Microbe
, vol.1
, pp. 121-133
-
-
Hung, C.H.1
Thomas, L.2
Ruby, C.E.3
Atkins, K.M.4
Morris, N.P.5
Knight, Z.A.6
Scholz, I.7
Barklis, E.8
Weinberg, A.D.9
Shokat, K.M.10
Thomas, G.11
-
130
-
-
0035836367
-
HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway
-
Swann SA, Williams M, Story CM, Bobbitt KR, Fleis R, Collins KL. HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway. Virology 2001;282:267–277.
-
(2001)
Virology
, vol.282
, pp. 267-277
-
-
Swann, S.A.1
Williams, M.2
Story, C.M.3
Bobbitt, K.R.4
Fleis, R.5
Collins, K.L.6
-
131
-
-
0033798906
-
Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation
-
Le Gall S, Buseyne F, Trocha A, Walker BD, Heard JM, Schwartz O. Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation. J Virol 2000;74:9256–9266.
-
(2000)
J Virol
, vol.74
, pp. 9256-9266
-
-
Le Gall, S.1
Buseyne, F.2
Trocha, A.3
Walker, B.D.4
Heard, J.M.5
Schwartz, O.6
-
132
-
-
77958041295
-
Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action
-
Dikeakos JD, Atkins KM, Thomas L, Emert-Sedlak L, Byeon IJ, Jung J, Ahn J, Wortman MD, Kukull B, Saito M, Koizumi H, Williamson DM, Hiyoshi M, Barklis E, Takiguchi M, et al. Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action. Mol Biol Cell 2010;21:3279–3292.
-
(2010)
Mol Biol Cell
, vol.21
, pp. 3279-3292
-
-
Dikeakos, J.D.1
Atkins, K.M.2
Thomas, L.3
Emert-Sedlak, L.4
Byeon, I.J.5
Jung, J.6
Ahn, J.7
Wortman, M.D.8
Kukull, B.9
Saito, M.10
Koizumi, H.11
Williamson, D.M.12
Hiyoshi, M.13
Barklis, E.14
Takiguchi, M.15
-
134
-
-
0344286482
-
Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation
-
Pitcher C, Höning S, Fingerhut A, Bowers K, Marsh M. Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation. Mol Biol Cell 1999;10:677–691.
-
(1999)
Mol Biol Cell
, vol.10
, pp. 677-691
-
-
Pitcher, C.1
Höning, S.2
Fingerhut, A.3
Bowers, K.4
Marsh, M.5
-
135
-
-
0026506657
-
The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits
-
Pelchen-Matthews A, Boulet I, Littman DR, Fagard R, Marsh M. The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits. J Cell Biol 1992;117:279–290.
-
(1992)
J Cell Biol
, vol.117
, pp. 279-290
-
-
Pelchen-Matthews, A.1
Boulet, I.2
Littman, D.R.3
Fagard, R.4
Marsh, M.5
-
136
-
-
0023659754
-
HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product
-
Guy B, Kieny MP, Riviere Y, Le Peuch C, Dott K, Girard M, Montagnier L, Lecocq JP. HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product. Nature 1987;330:266–269.
-
(1987)
Nature
, vol.330
, pp. 266-269
-
-
Guy, B.1
Kieny, M.P.2
Riviere, Y.3
Le Peuch, C.4
Dott, K.5
Girard, M.6
Montagnier, L.7
Lecocq, J.P.8
-
137
-
-
0027315870
-
CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals
-
Mariani R, Skowronski J. CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals. Proc Natl Acad Sci USA 1993;90:5549–5553.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 5549-5553
-
-
Mariani, R.1
Skowronski, J.2
-
138
-
-
0028200761
-
Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4
-
Rhee SS, Marsh JW. Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4. J Virol 1994;68:5156–5163.
-
(1994)
J Virol
, vol.68
, pp. 5156-5163
-
-
Rhee, S.S.1
Marsh, J.W.2
-
139
-
-
0036231461
-
Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes
-
Lundquist CA, Tobiume M, Zhou J, Unutmaz D, Aiken C. Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes. J Virol 2002;76:4625–4633.
-
(2002)
J Virol
, vol.76
, pp. 4625-4633
-
-
Lundquist, C.A.1
Tobiume, M.2
Zhou, J.3
Unutmaz, D.4
Aiken, C.5
-
140
-
-
33845513921
-
Dynamic interaction of HIV-1 Nef with the clathrin-mediated endocytic pathway at the plasma membrane
-
Burtey A, Rappoport JZ, Bouchet J, Basmaciogullari S, Guatelli J, Simon SM, Benichou S, Benmerah A. Dynamic interaction of HIV-1 Nef with the clathrin-mediated endocytic pathway at the plasma membrane. Traffic 2007;8:61–76.
-
(2007)
Traffic
, vol.8
, pp. 61-76
-
-
Burtey, A.1
Rappoport, J.Z.2
Bouchet, J.3
Basmaciogullari, S.4
Guatelli, J.5
Simon, S.M.6
Benichou, S.7
Benmerah, A.8
-
141
-
-
0030684068
-
Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation
-
Greenberg ME, Bronson S, Lock M, Neumann M, Pavlakis GN, Skowronski J. Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation. EMBO J 1997;16:6964–6976.
-
(1997)
EMBO J
, vol.16
, pp. 6964-6976
-
-
Greenberg, M.E.1
Bronson, S.2
Lock, M.3
Neumann, M.4
Pavlakis, G.N.5
Skowronski, J.6
-
142
-
-
23844509821
-
HIV Nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent
-
Jin YJ, Cai CY, Zhang X, Zhang HT, Hirst JA, Burakoff SJ. HIV Nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent. J Immunol 2005;175:3157–3164.
-
(2005)
J Immunol
, vol.175
, pp. 3157-3164
-
-
Jin, Y.J.1
Cai, C.Y.2
Zhang, X.3
Zhang, H.T.4
Hirst, J.A.5
Burakoff, S.J.6
-
143
-
-
0029989195
-
Nef-CD4 physical interaction sensed with the yeast two-hybrid system
-
Rossi F, Gallina A, Milanesi G. Nef-CD4 physical interaction sensed with the yeast two-hybrid system. Virology 1996;217:397–403.
-
(1996)
Virology
, vol.217
, pp. 397-403
-
-
Rossi, F.1
Gallina, A.2
Milanesi, G.3
-
144
-
-
0035088131
-
Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain
-
Preusser A, Briese L, Baur AS, Willbold D. Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain. J Virol 2001;75:3960–3964.
-
(2001)
J Virol
, vol.75
, pp. 3960-3964
-
-
Preusser, A.1
Briese, L.2
Baur, A.S.3
Willbold, D.4
-
145
-
-
0028843339
-
Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail
-
Salghetti S, Mariani R, Skowronski J. Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail. Proc Natl Acad Sci USA 1995;92:349–353.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 349-353
-
-
Salghetti, S.1
Mariani, R.2
Skowronski, J.3
-
146
-
-
57749196168
-
A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex
-
Kelly BT, McCoy AJ, Späte K, Miller SE, Evans PR, Höning S, Owen DJ. A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex. Nature 2008;456:976–979.
-
(2008)
Nature
, vol.456
, pp. 976-979
-
-
Kelly, B.T.1
McCoy, A.J.2
Späte, K.3
Miller, S.E.4
Evans, P.R.5
Höning, S.6
Owen, D.J.7
-
147
-
-
84949802447
-
AP-2 is the crucial clathrin adaptor protein for CD4 downmodulation by HIV-1 Nef in infected primary CD4+ T cells
-
Gondim MV, Wiltzer-Bach L, Maurer B, Banning C, Arganaraz E, Schindler M. AP-2 is the crucial clathrin adaptor protein for CD4 downmodulation by HIV-1 Nef in infected primary CD4+ T cells. J Virol 2015;89:12518–12524.
-
(2015)
J Virol
, vol.89
, pp. 12518-12524
-
-
Gondim, M.V.1
Wiltzer-Bach, L.2
Maurer, B.3
Banning, C.4
Arganaraz, E.5
Schindler, M.6
-
148
-
-
84924118537
-
Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation
-
Landi A, Vermeire J, Iannucci V, Vanderstraeten H, Naessens E, Bentahir M, Verhasselt B. Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation. Retrovirology 2014;11:118.
-
(2014)
Retrovirology
, vol.11
, pp. 118
-
-
Landi, A.1
Vermeire, J.2
Iannucci, V.3
Vanderstraeten, H.4
Naessens, E.5
Bentahir, M.6
Verhasselt, B.7
-
149
-
-
34249847836
-
Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef
-
Pizzato M, Helander A, Popova E, Calistri A, Zamborlini A, Palù G, Göttlinger HG. Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef. Proc Natl Acad Sci USA 2007;104:6812–6817.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 6812-6817
-
-
Pizzato, M.1
Helander, A.2
Popova, E.3
Calistri, A.4
Zamborlini, A.5
Palù, G.6
Göttlinger, H.G.7
-
150
-
-
84894595646
-
The Nef-like effect of murine leukemia virus glycosylated gag on HIV-1 infectivity is mediated by its cytoplasmic domain and depends on the AP-2 adaptor complex
-
Usami Y, Popov S, Gottlinger HG. The Nef-like effect of murine leukemia virus glycosylated gag on HIV-1 infectivity is mediated by its cytoplasmic domain and depends on the AP-2 adaptor complex. J Virol 2014;88:3443–3454.
-
(2014)
J Virol
, vol.88
, pp. 3443-3454
-
-
Usami, Y.1
Popov, S.2
Gottlinger, H.G.3
-
151
-
-
84912535422
-
Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection
-
de Carvalho JV, de Castro RO, da Silva EZ, Silveira PP, da Silva-Januário ME, Arruda E, Jamur MC, Oliver C, Aguiar RS, daSilva LL. Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection. PLoS One 2014;9:e113691.
-
(2014)
PLoS One
, vol.9
-
-
de Carvalho, J.V.1
de Castro, R.O.2
da Silva, E.Z.3
Silveira, P.P.4
da Silva-Januário, M.E.5
Arruda, E.6
Jamur, M.C.7
Oliver, C.8
Aguiar, R.S.9
daSilva, L.L.10
-
152
-
-
67449092266
-
Human immunodeficiency virus type 1 Nef protein targets CD4 to the multivesicular body pathway
-
daSilva LL, Sougrat R, Burgos PV, Janvier K, Mattera R, Bonifacino JS. Human immunodeficiency virus type 1 Nef protein targets CD4 to the multivesicular body pathway. J Virol 2009;83:6578–6590.
-
(2009)
J Virol
, vol.83
, pp. 6578-6590
-
-
daSilva, L.L.1
Sougrat, R.2
Burgos, P.V.3
Janvier, K.4
Mattera, R.5
Bonifacino, J.S.6
-
153
-
-
0038632363
-
Effects of HIV-1 Nef on retrograde transport from the plasma membrane to the endoplasmic reticulum
-
Johannes L, Pezo V, Mallard F, Tenza D, Wiltz A, Saint-Pol A, Helft J, Antony C, Benaroch P. Effects of HIV-1 Nef on retrograde transport from the plasma membrane to the endoplasmic reticulum. Traffic 2003;4:323–332.
-
(2003)
Traffic
, vol.4
, pp. 323-332
-
-
Johannes, L.1
Pezo, V.2
Mallard, F.3
Tenza, D.4
Wiltz, A.5
Saint-Pol, A.6
Helft, J.7
Antony, C.8
Benaroch, P.9
-
154
-
-
84866355290
-
AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway
-
Dores MR, Paing MM, Lin H, Montagne WA, Marchese A, Trejo J. AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway. Mol Biol Cell 2012;23:3612–3623.
-
(2012)
Mol Biol Cell
, vol.23
, pp. 3612-3623
-
-
Dores, M.R.1
Paing, M.M.2
Lin, H.3
Montagne, W.A.4
Marchese, A.5
Trejo, J.6
-
155
-
-
1842509099
-
Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins
-
Peden AA, Oorschot V, Hesser BA, Austin CD, Scheller RH, Klumperman J. Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins. J Cell Biol 2004;164:1065–1076.
-
(2004)
J Cell Biol
, vol.164
, pp. 1065-1076
-
-
Peden, A.A.1
Oorschot, V.2
Hesser, B.A.3
Austin, C.D.4
Scheller, R.H.5
Klumperman, J.6
-
156
-
-
13444291133
-
Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes
-
Coleman SH, Van Damme N, Day JR, Noviello CM, Hitchin D, Madrid R, Benichou S, Guatelli JC. Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes. J Virol 2005;79:2066–2078.
-
(2005)
J Virol
, vol.79
, pp. 2066-2078
-
-
Coleman, S.H.1
Van Damme, N.2
Day, J.R.3
Noviello, C.M.4
Hitchin, D.5
Madrid, R.6
Benichou, S.7
Guatelli, J.C.8
-
157
-
-
70350230237
-
Membrane traffic within the Golgi apparatus
-
Glick BS, Nakano A. Membrane traffic within the Golgi apparatus. Annu Rev Cell Dev Biol 2009;25:113–132.
-
(2009)
Annu Rev Cell Dev Biol
, vol.25
, pp. 113-132
-
-
Glick, B.S.1
Nakano, A.2
-
158
-
-
0031425955
-
Inhibition of endosome function in CHO cells bearing a temperature-sensitive defect in the coatomer (COPI) component epsilon-COP
-
Daro E, Sheff D, Gomez M, Kreis T, Mellman I. Inhibition of endosome function in CHO cells bearing a temperature-sensitive defect in the coatomer (COPI) component epsilon-COP. J Cell Biol 1997;139:1747–1759.
-
(1997)
J Cell Biol
, vol.139
, pp. 1747-1759
-
-
Daro, E.1
Sheff, D.2
Gomez, M.3
Kreis, T.4
Mellman, I.5
-
159
-
-
0030812588
-
Functional dissection of COP-I subunits in the biogenesis of multivesicular endosomes
-
Gu F, Aniento F, Parton RG, Gruenberg J. Functional dissection of COP-I subunits in the biogenesis of multivesicular endosomes. J Cell Biol 1997;139:1183–1195.
-
(1997)
J Cell Biol
, vol.139
, pp. 1183-1195
-
-
Gu, F.1
Aniento, F.2
Parton, R.G.3
Gruenberg, J.4
-
160
-
-
0029869843
-
An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes
-
Aniento F, Gu F, Parton RG, Gruenberg J. An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes. J Cell Biol 1996;133:29–41.
-
(1996)
J Cell Biol
, vol.133
, pp. 29-41
-
-
Aniento, F.1
Gu, F.2
Parton, R.G.3
Gruenberg, J.4
-
161
-
-
0035138509
-
Genetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolates
-
Foster JL, Molina RP, Luo T, Arora VK, Huang Y, Ho DD, Garcia JV. Genetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolates. J Virol 2001;75:1672–1680.
-
(2001)
J Virol
, vol.75
, pp. 1672-1680
-
-
Foster, J.L.1
Molina, R.P.2
Luo, T.3
Arora, V.K.4
Huang, Y.5
Ho, D.D.6
Garcia, J.V.7
-
162
-
-
0035080263
-
Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP
-
Janvier K, Craig H, Le Gall S, Benarous R, Guatelli J, Schwartz O, Benichou S. Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP. J Virol 2001;75:3971–3976.
-
(2001)
J Virol
, vol.75
, pp. 3971-3976
-
-
Janvier, K.1
Craig, H.2
Le Gall, S.3
Benarous, R.4
Guatelli, J.5
Schwartz, O.6
Benichou, S.7
-
163
-
-
84874377202
-
Extracellular vesicles: exosomes, microvesicles, and friends
-
Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol 2013;200:373–383.
-
(2013)
J Cell Biol
, vol.200
, pp. 373-383
-
-
Raposo, G.1
Stoorvogel, W.2
-
164
-
-
20044362379
-
Nef-induced alteration of the early/recycling endosomal compartment correlates with enhancement of HIV-1 infectivity
-
Madrid R, Janvier K, Hitchin D, Day J, Coleman S, Noviello C, Bouchet J, Benmerah A, Guatelli J, Benichou S. Nef-induced alteration of the early/recycling endosomal compartment correlates with enhancement of HIV-1 infectivity. J Biol Chem 2005;280:5032–5044.
-
(2005)
J Biol Chem
, vol.280
, pp. 5032-5044
-
-
Madrid, R.1
Janvier, K.2
Hitchin, D.3
Day, J.4
Coleman, S.5
Noviello, C.6
Bouchet, J.7
Benmerah, A.8
Guatelli, J.9
Benichou, S.10
-
165
-
-
0031034161
-
Nef proteins encoded by human and simian immunodeficiency viruses induce the accumulation of endosomes and lysosomes in human T cells
-
Sanfridson A, Hester S, Doyle C. Nef proteins encoded by human and simian immunodeficiency viruses induce the accumulation of endosomes and lysosomes in human T cells. Proc Natl Acad Sci USA 1997;94:873–878.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 873-878
-
-
Sanfridson, A.1
Hester, S.2
Doyle, C.3
-
166
-
-
71849085384
-
HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells
-
Lenassi M, Cagney G, Liao M, Vaupotic T, Bartholomeeusen K, Cheng Y, Krogan NJ, Plemenitas A, Peterlin BM. HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells. Traffic 2010;11:110–122.
-
(2010)
Traffic
, vol.11
, pp. 110-122
-
-
Lenassi, M.1
Cagney, G.2
Liao, M.3
Vaupotic, T.4
Bartholomeeusen, K.5
Cheng, Y.6
Krogan, N.J.7
Plemenitas, A.8
Peterlin, B.M.9
-
167
-
-
52149109150
-
HIV-1 Nef protein is secreted into vesicles that can fuse with target cells and virions
-
Campbell TD, Khan M, Huang MB, Bond VC, Powell MD. HIV-1 Nef protein is secreted into vesicles that can fuse with target cells and virions. Ethn Dis 2008;18(2 Suppl 2):S2-14–19.
-
(2008)
Ethn Dis
, vol.18
, Issue.2
, pp. S2-14-19
-
-
Campbell, T.D.1
Khan, M.2
Huang, M.B.3
Bond, V.C.4
Powell, M.D.5
-
169
-
-
84942838662
-
ESCRTs are everywhere
-
Hurley JH. ESCRTs are everywhere. EMBO J 2015;34:2398–2407.
-
(2015)
EMBO J
, vol.34
, pp. 2398-2407
-
-
Hurley, J.H.1
-
170
-
-
80052621127
-
How ubiquitin functions with ESCRTs
-
Shields SB, Piper RC. How ubiquitin functions with ESCRTs. Traffic 2011;12:1306–1317.
-
(2011)
Traffic
, vol.12
, pp. 1306-1317
-
-
Shields, S.B.1
Piper, R.C.2
-
171
-
-
37749032764
-
Requirements for the selective degradation of CD4 receptor molecules by the human immunodeficiency virus type 1 Vpu protein in the endoplasmic reticulum
-
Binette J, Dube M, Mercier J, Halawani D, Latterich M, Cohen EA. Requirements for the selective degradation of CD4 receptor molecules by the human immunodeficiency virus type 1 Vpu protein in the endoplasmic reticulum. Retrovirology 2007;4:75.
-
(2007)
Retrovirology
, vol.4
, pp. 75
-
-
Binette, J.1
Dube, M.2
Mercier, J.3
Halawani, D.4
Latterich, M.5
Cohen, E.A.6
-
172
-
-
0032012456
-
A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif
-
Margottin F, Bour SP, Durand H, Selig L, Benichou S, Richard V, Thomas D, Strebel K, Benarous R. A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. Mol Cell 1998;1:565–574.
-
(1998)
Mol Cell
, vol.1
, pp. 565-574
-
-
Margottin, F.1
Bour, S.P.2
Durand, H.3
Selig, L.4
Benichou, S.5
Richard, V.6
Thomas, D.7
Strebel, K.8
Benarous, R.9
-
173
-
-
77954047969
-
Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps
-
Magadán JG, Pérez-Victoria FJ, Sougrat R, Ye Y, Strebel K, Bonifacino JS. Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps. PLoS Pathog 2010;6:e1000869.
-
(2010)
PLoS Pathog
, vol.6
-
-
Magadán, J.G.1
Pérez-Victoria, F.J.2
Sougrat, R.3
Ye, Y.4
Strebel, K.5
Bonifacino, J.S.6
-
174
-
-
50949130687
-
Lysine 144, a ubiquitin attachment site in HIV-1 Nef, is required for Nef-mediated CD4 down-regulation
-
Jin YJ, Cai CY, Zhang X, Burakoff SJ. Lysine 144, a ubiquitin attachment site in HIV-1 Nef, is required for Nef-mediated CD4 down-regulation. J Immunol 2008;180:7878–7886.
-
(2008)
J Immunol
, vol.180
, pp. 7878-7886
-
-
Jin, Y.J.1
Cai, C.Y.2
Zhang, X.3
Burakoff, S.J.4
-
175
-
-
2542448950
-
Role of mammalian vacuolar protein-sorting proteins in endocytic trafficking of a non-ubiquitinated G protein-coupled receptor to lysosomes
-
Hislop JN, Marley A, Von Zastrow M. Role of mammalian vacuolar protein-sorting proteins in endocytic trafficking of a non-ubiquitinated G protein-coupled receptor to lysosomes. J Biol Chem 2004;279:22522–22531.
-
(2004)
J Biol Chem
, vol.279
, pp. 22522-22531
-
-
Hislop, J.N.1
Marley, A.2
Von Zastrow, M.3
-
176
-
-
78651097807
-
The role of ubiquitination in lysosomal trafficking of δ-opioid receptors
-
Henry AG, White IJ, Marsh M, von Zastrow M, Hislop JN. The role of ubiquitination in lysosomal trafficking of δ-opioid receptors. Traffic 2011;12:170–184.
-
(2011)
Traffic
, vol.12
, pp. 170-184
-
-
Henry, A.G.1
White, I.J.2
Marsh, M.3
von Zastrow, M.4
Hislop, J.N.5
-
177
-
-
46249107273
-
Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain
-
Yamashita Y, Kojima K, Tsukahara T, Agawa H, Yamada K, Amano Y, Kurotori N, Tanaka N, Sugamura K, Takeshita T. Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain. J Cell Sci 2008;121:1727–1738.
-
(2008)
J Cell Sci
, vol.121
, pp. 1727-1738
-
-
Yamashita, Y.1
Kojima, K.2
Tsukahara, T.3
Agawa, H.4
Yamada, K.5
Amano, Y.6
Kurotori, N.7
Tanaka, N.8
Sugamura, K.9
Takeshita, T.10
-
178
-
-
34249905192
-
Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1
-
Wolfe BL, Marchese A, Trejo J. Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1. J Cell Biol 2007;177:905–916.
-
(2007)
J Cell Biol
, vol.177
, pp. 905-916
-
-
Wolfe, B.L.1
Marchese, A.2
Trejo, J.3
-
179
-
-
84862591663
-
ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting
-
Dores MR, Chen B, Lin H, Soh UJ, Paing MM, Montagne WA, Meerloo T, Trejo J. ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting. J Cell Biol 2012;197:407–419.
-
(2012)
J Cell Biol
, vol.197
, pp. 407-419
-
-
Dores, M.R.1
Chen, B.2
Lin, H.3
Soh, U.J.4
Paing, M.M.5
Montagne, W.A.6
Meerloo, T.7
Trejo, J.8
-
180
-
-
84890875112
-
ALIX and the multivesicular endosome: ALIX in Wonderland
-
Bissig C, Gruenberg J. ALIX and the multivesicular endosome: ALIX in Wonderland. Trends Cell Biol 2014;24:19–25.
-
(2014)
Trends Cell Biol
, vol.24
, pp. 19-25
-
-
Bissig, C.1
Gruenberg, J.2
-
181
-
-
70350125373
-
Interactions between SIVNef, SIVGagPol and Alix correlate with viral replication and progression to AIDS in rhesus macaques
-
Jesus da Costa L, Lopes Dos Santos A, Mandic R, Shaw K, Santana de Aguiar R, Tanuri A, Luciw PA, Peterlin BM. Interactions between SIVNef, SIVGagPol and Alix correlate with viral replication and progression to AIDS in rhesus macaques. Virology 2009;394:47–56.
-
(2009)
Virology
, vol.394
, pp. 47-56
-
-
Jesus da Costa, L.1
Lopes Dos Santos, A.2
Mandic, R.3
Shaw, K.4
Santana de Aguiar, R.5
Tanuri, A.6
Luciw, P.A.7
Peterlin, B.M.8
-
182
-
-
59749098450
-
ESCRT proteins and the regulation of endocytic delivery to lysosomes
-
Luzio JP, Piper SC, Bowers K, Parkinson MD, Lehner PJ, Bright NA. ESCRT proteins and the regulation of endocytic delivery to lysosomes. Biochem Soc Trans 2009;37:178–180.
-
(2009)
Biochem Soc Trans
, vol.37
, pp. 178-180
-
-
Luzio, J.P.1
Piper, S.C.2
Bowers, K.3
Parkinson, M.D.4
Lehner, P.J.5
Bright, N.A.6
-
183
-
-
26244468727
-
Downregulation of cell surface receptors by the K3 family of viral and cellular ubiquitin E3 ligases
-
Lehner PJ, Hoer S, Dodd R, Duncan LM. Downregulation of cell surface receptors by the K3 family of viral and cellular ubiquitin E3 ligases. Immunol Rev 2005;207:112–125.
-
(2005)
Immunol Rev
, vol.207
, pp. 112-125
-
-
Lehner, P.J.1
Hoer, S.2
Dodd, R.3
Duncan, L.M.4
-
184
-
-
0037093467
-
Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101-dependent degradation
-
Hewitt EW, Duncan L, Mufti D, Baker J, Stevenson PG, Lehner PJ. Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101-dependent degradation. EMBO J 2002;21:2418–2429.
-
(2002)
EMBO J
, vol.21
, pp. 2418-2429
-
-
Hewitt, E.W.1
Duncan, L.2
Mufti, D.3
Baker, J.4
Stevenson, P.G.5
Lehner, P.J.6
-
185
-
-
33644927263
-
Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane
-
Booth AM, Fang Y, Fallon JK, Yang JM, Hildreth JE, Gould SJ. Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane. J Cell Biol 2006;172:923–935.
-
(2006)
J Cell Biol
, vol.172
, pp. 923-935
-
-
Booth, A.M.1
Fang, Y.2
Fallon, J.K.3
Yang, J.M.4
Hildreth, J.E.5
Gould, S.J.6
-
186
-
-
84937436865
-
Exosomes: implications in HIV-1 pathogenesis
-
Madison MN, Okeoma CM. Exosomes: implications in HIV-1 pathogenesis. Viruses 2015;7:4093–4118.
-
(2015)
Viruses
, vol.7
, pp. 4093-4118
-
-
Madison, M.N.1
Okeoma, C.M.2
-
187
-
-
84941931064
-
Exosome biogenesis, regulation, and function in viral infection
-
Alenquer M, Amorim MJ. Exosome biogenesis, regulation, and function in viral infection. Viruses 2015;7:5066–5083.
-
(2015)
Viruses
, vol.7
, pp. 5066-5083
-
-
Alenquer, M.1
Amorim, M.J.2
-
188
-
-
84934928627
-
Human semen contains exosomes with potent anti-HIV-1 activity
-
Madison MN, Roller RJ, Okeoma CM. Human semen contains exosomes with potent anti-HIV-1 activity. Retrovirology 2014;11:102.
-
(2014)
Retrovirology
, vol.11
, pp. 102
-
-
Madison, M.N.1
Roller, R.J.2
Okeoma, C.M.3
-
189
-
-
79951687153
-
HIV Type 1 Nef is released from infected cells in CD45(+) microvesicles and is present in the plasma of HIV-infected individuals
-
Raymond AD, Campbell-Sims TC, Khan M, Lang M, Huang MB, Bond VC, Powell MD. HIV Type 1 Nef is released from infected cells in CD45(+) microvesicles and is present in the plasma of HIV-infected individuals. AIDS Res Hum Retroviruses 2011;27:167–178.
-
(2011)
AIDS Res Hum Retroviruses
, vol.27
, pp. 167-178
-
-
Raymond, A.D.1
Campbell-Sims, T.C.2
Khan, M.3
Lang, M.4
Huang, M.B.5
Bond, V.C.6
Powell, M.D.7
-
190
-
-
69949128211
-
Massive secretion by T cells is caused by HIV Nef in infected cells and by Nef transfer to bystander cells
-
Muratori C, Cavallin LE, Krätzel K, Tinari A, De Milito A, Fais S, D'Aloja P, Federico M, Vullo V, Fomina A, Mesri EA, Superti F, Baur AS. Massive secretion by T cells is caused by HIV Nef in infected cells and by Nef transfer to bystander cells. Cell Host Microbe 2009;6:218–230.
-
(2009)
Cell Host Microbe
, vol.6
, pp. 218-230
-
-
Muratori, C.1
Cavallin, L.E.2
Krätzel, K.3
Tinari, A.4
De Milito, A.5
Fais, S.6
D'Aloja, P.7
Federico, M.8
Vullo, V.9
Fomina, A.10
Mesri, E.A.11
Superti, F.12
Baur, A.S.13
-
191
-
-
84921435563
-
The HIV Nef protein modulates cellular and exosomal miRNA profiles in human monocytic cells
-
Aqil M, Naqvi AR, Mallik S, Bandyopadhyay S, Maulik U, Jameel S. The HIV Nef protein modulates cellular and exosomal miRNA profiles in human monocytic cells. J Extracell Vesicles 2014;3: 10.3402/jev.v3.23129.
-
(2014)
J Extracell Vesicles
, vol.3
-
-
Aqil, M.1
Naqvi, A.R.2
Mallik, S.3
Bandyopadhyay, S.4
Maulik, U.5
Jameel, S.6
-
192
-
-
84883414693
-
The HIV-1 Nef protein binds argonaute-2 and functions as a viral suppressor of RNA interference
-
Aqil M, Naqvi AR, Bano AS, Jameel S. The HIV-1 Nef protein binds argonaute-2 and functions as a viral suppressor of RNA interference. PLoS One 2013;8:e74472.
-
(2013)
PLoS One
, vol.8
-
-
Aqil, M.1
Naqvi, A.R.2
Bano, A.S.3
Jameel, S.4
-
193
-
-
84906968837
-
Exosomes from human immunodeficiency virus type 1 (HIV-1)-infected cells license quiescent CD4+ T lymphocytes to replicate HIV-1 through a Nef- and ADAM17-dependent mechanism
-
Arenaccio C, Chiozzini C, Columba-Cabezas S, Manfredi F, Affabris E, Baur A, Federico M. Exosomes from human immunodeficiency virus type 1 (HIV-1)-infected cells license quiescent CD4+ T lymphocytes to replicate HIV-1 through a Nef- and ADAM17-dependent mechanism. J Virol 2014;88:11529–11539.
-
(2014)
J Virol
, vol.88
, pp. 11529-11539
-
-
Arenaccio, C.1
Chiozzini, C.2
Columba-Cabezas, S.3
Manfredi, F.4
Affabris, E.5
Baur, A.6
Federico, M.7
-
194
-
-
77949558495
-
ADAM-17: the enzyme that does it all
-
Gooz M. ADAM-17: the enzyme that does it all. Crit Rev Biochem Mol Biol 2010;45:146–169.
-
(2010)
Crit Rev Biochem Mol Biol
, vol.45
, pp. 146-169
-
-
Gooz, M.1
-
195
-
-
84904704297
-
Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles
-
Colombo M, Raposo G, Thery C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol 2014;30:255–289.
-
(2014)
Annu Rev Cell Dev Biol
, vol.30
, pp. 255-289
-
-
Colombo, M.1
Raposo, G.2
Thery, C.3
-
196
-
-
84928810795
-
Exosomes are unlikely involved in intercellular Nef transfer
-
Luo X, Fan Y, Park IW, He JJ. Exosomes are unlikely involved in intercellular Nef transfer. PLoS One 2015;10:e0124436.
-
(2015)
PLoS One
, vol.10
-
-
Luo, X.1
Fan, Y.2
Park, I.W.3
He, J.J.4
|