Multilayered mechanism of CD4 downregulation by HIV-1 vpu involving distinct ER retention and ERAD targeting steps

PLoS Pathogens

Volumn 6, Issue 4, 2010, Pages 1-18

  Magadán, Javier G ^a   Pérez Victoria, F Javier ^a   Sougrat, Rachid ^a   Ye, Yihong ^b   Strebel, Klaus ^c   Bonifacino, Juan S ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; LYSINE; NEF PROTEIN; PROTEIN P97; SERINE; SMALL INTERFERING RNA; THREONINE; UBIQUITIN; VPU PROTEIN; CD4 ANTIGEN; CDC48 PROTEIN; CELL CYCLE PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; MULTIPROTEIN COMPLEX; NPLOC4 PROTEIN, HUMAN; NUCLEAR PROTEIN; PROTEIN; UFD1L PROTEIN, HUMAN; VIRUS PROTEIN; VPU PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME BINDING; HELA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROLYSIS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LIFE CYCLE; MEMBRANE POTENTIAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UBIQUITINATION; VIRUS PARTICLE; CELL SEPARATION; FLOW CYTOMETRY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; PATHOGENICITY;

HUMAN IMMUNODEFICIENCY VIRUS 1; VESICULAR STOMATITIS VIRUS;

ADENOSINE TRIPHOSPHATASES; ANTIGENS, CD4; CELL CYCLE PROTEINS; CELL SEPARATION; DOWN-REGULATION; ENDOPLASMIC RETICULUM; FLOW CYTOMETRY; HELA CELLS; HIV INFECTIONS; HIV-1; HUMAN IMMUNODEFICIENCY VIRUS PROTEINS; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MULTIPROTEIN COMPLEXES; NUCLEAR PROTEINS; PROTEINS; UBIQUITINATION; VIRAL REGULATORY AND ACCESSORY PROTEINS;

EID: 77954047969     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000869     Document Type: Article

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