Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation

Journal of Virology

Volumn 74, Issue 19, 2000, Pages 9256-9266

  Le Gall, S ^a   Buseyne, F ^a   Trocha, A ^a   Walker, B D ^a   Heard, J M ^a   Schwartz, O ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CLATHRIN; DYNAMIN; HLA A2 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NEF PROTEIN; VIRUS PROTEIN;

ARTICLE; BIOGENESIS; CELL SURFACE; CELLULAR DISTRIBUTION; CYTOLYSIS; DOWN REGULATION; GOLGI COMPLEX; HELA CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CLATHRIN; DOWN-REGULATION; GENE PRODUCTS, NEF; GOLGI APPARATUS; HELA CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HIV-1; HUMAN; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; VIRUS REPLICATION;

EID: 0033798906     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.19.9256-9266.2000     Document Type: Article

References (50)

1. Major histocompatibility complex class I-binding peptides are recycled to the cell surface after internalization
2. HIV co-receptor down-regulation as anti-viral principle. SDF-1α dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication
3. The N-terminus of Nef from HIV/SIV associates with a protein complex containing Lck and a serine kinase
4. Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicle for membrane traffic
5. Molecular bases for the recognition of tyrosine-based sorting signals
6. A region from the medium chain adaptor subunit (μ) recognizes leucine- and tyrosine-based sorting signals
7. A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor
8. Trafficking of spontaneously endocytosed MHC proteins
9. The selective down-regulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
10. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
11. Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity
12. Induction of a mutant dynamin specifically blocks endocytic coated vesicle formation
13. Receptor-like nature of class I HLA: Endocytosis via coated pits
14. AP-4, a novel protein complex related to clathrin adaptors
15. Golgi-disturbing agents
16. Activation of Vav by Nef induces cytoskeletal rearrangements and down-stream effector functions
17. A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4
18. The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes
19. Recycling MHC class I molecules and endosomal peptide loading
20. MHC class I-restricted CTL responses to exogenous antigens
21. Nef interacts with μ subunits of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC-I molecules
22. Interactions between HIV-1 Nef and vacuolar ATPase facilitate the internalization of CD4
23. Major histocompatibility complex class I molecules internalized via coated pits in T lymphocytes
24. Nef-induced CD4 and major histocompatibility complex (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking
25. The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route
26. Interaction of tyrosine-based sorting signals with clathrin-associated proteins
27. Nef - An adaptor adaptor?
28. A structural explanation for the recognition of tyrosine-based endocytic signals
29. The origins of HLA-A,B,C polymorphism
30. The protein tyrosine kinase p56(lck) inhibits CD4 endocytosis by preventing entry of CD4 into coated pits
31. Oligomerization within virions and subcellular localization of human immunodeficiency virus type 1 integrase
32. Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the μ chain of adaptor complexes
33. Nef-induced CD4 degradation: A diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of β-COP in endosomes
34. The down-regulation of CD4 and MHC-I by primate lentiviruses: A paradigm for the modulation of cell surface receptors
35. HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complex
36. Viral strategies of immune evasion
37. Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site
38. Cycling of cell-surface MHC glycoproteins through primaquine-sensitive intracellular compartments
39. The dileucine-based sorting motif in HIV-1 Nef is not required for down-regulation of class I MHC
40. The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane
41. Dynamin and its partners: A progress report
42. Endocytosis of MHC-I molecules is induced by HIV-1 Nef
43. A novel adaptor-related protein complex
44. Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response
45. Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1
46. Constitutive endocytosis of HLA class I antigens requires a specific portion of the intracytoplasmic tail that shares structural features with other endocytosed molecules
47. PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization
48. Capture and processing of exogenous antigens for presentation on MHC molecules
49. Structural comparison of the two distinct sugar binding sites in wheat germ agglutinin
50. Antigen processing and presentation by the class I major histocompatibility complex