Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

EMBO Journal

Volumn 16, Issue 4, 1997, Pages 673-684

  Iafrate, A John ^b   Bronson, Scott ^a   Skowronski, Jacek ^a  

^a Watson School of Biological Sciences   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

CD4; Nef; T cell activation; T cell receptor

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; NEF PROTEIN; T LYMPHOCYTE RECEPTOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CELLULAR IMMUNITY; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RECEPTOR BLOCKING; SIMIAN IMMUNODEFICIENCY VIRUS; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD; ANTIGENS, CD3; ANTIGENS, CD4; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; COS CELLS; DNA-BINDING PROTEINS; GENE EXPRESSION; GENE PRODUCTS, NEF; HIV-1; HUMANS; JURKAT CELLS; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHOPROTEINS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SIMIAN IMMUNODEFICIENCY VIRUS; TRANSCRIPTION FACTORS, TFII;

EID: 0031039979     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.4.673     Document Type: Article

References (51)

1. Aiken, C. and Trono, D. (1995) Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis. J. Virol., 69, 5048-5056.
2. Aiken, C., Konner, J., Landau, N.R., Lenburg, M.E. and Trono, D. (1994) Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell, 76, 853-864.
3. Aiken, C., Krause, L., Chen, Y.L. and Trono, D. (1996) Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation. Virology, 217, 293-300.
4. Anderson, S., Shugars, D.C., Swanstrom, R. and Garcia, J.V. (1993) Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells. J. Virol., 67, 4923-4931.
5. Anderson, S.J., Lenburg, M., Landau, N.R. and Garcia, J.V. (1994) The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef. J. Virol., 68, 3092-3101.
6. Baur, A.S., Sawai, E.T., Dazin, P., Fantl, W.J., Cheng-Mayer, C. and Peterlin, B.M. (1994) HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Immunity, 1, 373-384.
7. Benson, R.E., Sanfridson, A., Ottinger, J.S., Doyle, C. and Cullen, B.R. (1993) Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection. J. Exp. Med., 177, 1561-1566.
8. Brady, H.J., Pennington, D.J., Miles, C.G. and Dzierzak, E.A. (1993) CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration. EMBO J., 12, 4923-4932.
9. Brickell, P.M. (1992) The p60c-src family of protein-tyrosine kinases: structure, regulation and function. Crit. Rev. Oncogen., 3, 401-446.
10. Collette, Y., Chang, H.L., Cerdan, C., Chambot, H., Algarte, M., Mawas, C., Imbert, I., Burny, A. and Olive, D. (1995) Specific Th1 cytokine downregulation associated with primary clinically derived human immunodeficiency virus type 1 Nef gene-induced expression. J. Immunol., 156, 360-370.
11. De, S.K. and Marsh, J.W. (1994) HIV-1 Nef inhibits a common activation pathway in NIH3T3 cells. J. Biol. Chem., 269, 6656-6660.
12. de Ronde, A., Klaver, B., Keulen, W., Smit, L. and Goudsmit, J. (1992) Natural HIV-1 NEF accelerates virus replication in primary human lymphocytes. Virology, 188, 391-395.
13. Deacon, N.J. et al. (1995) Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science, 270, 988-991.
14. Du, Z., Lang, S.M., Sasseville, V.G., Lackner, A.A., Ilyinskii, P.O., Daniel, M.D., Jung, J.U. and Desrosiers, R.C. (1995) Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys. Cell, 82, 665-674.
15. Garcia, J.V. and Miller, A.D. (1991) Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature, 350, 508-511.
16. Gluzman, Y. (1981) SV40-transformed simian cells support the replication of early SV40 mutants. Cell, 23, 175-182.
17. Graziani, A., Galimi, F., Medico, E., Cottone, E., Gramaglia, D., Boccaccio, C. and Comoglio, P.M. (1996) The HIV-1 Nef protein interferes with phosphatidylinositol 3-kinase activation. J. Biol. Chem., 271, 6590-6593.
18. Grzesiek, S., Bax, A., Clore, G.M., Gronenborn, A.M., Hu, J.S., Kaufman, J., Palmer, I., Stahl, S.J. and Wingfield, P.T. (1996) The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase. Nature Struct. Biol., 3, 340-345.
19. Haughn, L., Gratton, S., Caron, L., Sekaly, R.P., Veillette, A. and Julius, M. (1992) Association of tyrosine kinase p561ck with CD4 inhibits the induction of growth through the alpha beta T-cell receptor. Nature, 358, 328-331.
20. Ho, W.Y., Cooke, M.P., Goodnow, C.C. and Davis, M.M. (1994) Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells. J. Exp. Med., 179, 1539-1549.
21. Janeway, C. (1992) The T cell receptor as a multicomponent signaling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Annu. Rev. Immunol., 10, 645-674.
22. Kestler, H.W., Ringler, D.J., Mori, K., Panicali, D.L., Sehgal, P.K., Daniel, M.D. and Desrosiers, R.C. (1991) Importance of the nef gene for maintenance of high virus load and development of AIDS. Cell, 65, 651-662.
23. Kirchhoff, F., Greenough, T.C., Brettler, D.B., Sullivan, J.L. and Desrosiers, R.C. (1995) Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. New Engl. J. Med., 332, 228-232.
24. Lee, C.-H., Saksela, K., Mirza, U.A., Chait, B.T. and Kuryan, J. (1996) Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain. Cell, 85, 931-942.
25. Lindemann, D., Wilhelm, R., Renard, P., Althage, A., Zinkernagel, R. and Mous, J. (1994) Severe immunodeficiency associated with a human immunodeficiency virus 1 NEF/3′-long terminal repeat transgene. J. Exp. Med., 179, 979-807.
26. Lowell, C.A., Soriano, P. and Varmus, H.E. (1994) Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes Dev., 8, 387-398.
27. Luo, T. and Garcia, J.V. (1996) The association of Nef with cellular serine/ threonine kinase and its enhancement of infectivity are viral isolate dependent. J. Virol., 70, 6493-6496.
28. Luria, S., Chambers, I. and Berg, P. (1991) Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA. Proc. Natl Acad. Sci. USA, 88, 5326-5330.
29. Mariani, R. and Skowronski, J. (1993) CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type I-infected individuals. Proc. Natl Acad. Sci. USA, 90, 5549-5553.
30. Mariani, R., Kirchhoff, F., Greenough, T.C., Sullivan, J.L., Desrosiers, R.C. and Skowronski, J. (1996) High frequency of defective nef alleles in a long-term survivor with nonproeressive HIV-1 infection. J. Virol., 70, 7752-7764.
31. Miller, M.D., Warmerdam, M.T., Gaston, I., Greene, W.C. and Feinberg, M.B. (1994) The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages. J. Exp. Med., 179, 101-113.
32. Myers, G., Berzofsky, J.A., Rabson, A.B. and Smith, T.E. (1993) Human Retroviruses and AIDS. Los Alamos National Laboratory, Los Alamos, NM.
33. Nishizumi, H., Taniuchi, I., Yamanashi, Y., Kitamura, D., Ilic, D., Mori, S., Watanabe, T. and Yamamoto, T. (1995) Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyndeficient mice. Immunity, 3, 549-560.
34. Nunn, M.F. and Marsh, J.W. (1996) Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family. J. Virol., 70, 6157-6161.
35. Regier, D.A. and Desrosiers, R.C. (1990) The complete nucleotide sequence of a pathogenic molecular clone of simian immunodeficiency virus. AIDS Res. Hum. Retroviruses, 6, 1221-1231.
36. Rhee, S.S. and Marsh, J.V. (1994) Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4. J. Virol., 68, 5156-5163.
37. Saksela, K., Cheng, G. and Baltimore, D. (1995) Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4. EMBO J., 14, 484-491.
38. lck protein tyrosine kinase interact with a common element in CD4 cytoplasmic tail. Proc. Natl Acad. Sci. USA, 92, 349-353.
39. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
40. Sawai, E.T., Baur, A., Struble, H., Peterlin, B.M., Levy, J.A., Cheng-Mayer, C. (1994) Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes. Proc. Natl Acad. Sci. USA, 91, 1539-1543.
41. Sawai, E.T., Baur, A.S., Peterlin, B.M., Levy, J.A. and Cheng-Mayer, C. (1995) A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity J. Biol. Chem., 270, 15307-15314.
42. Shugars, D.C., Smith, M.S., Glueck, D.H., Nantermet, P.V., Seillier-Moiseiwitsch, F. and Swanstrom, R. (1993) Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo. J. Virol., 67, 4639-4650.
43. Skowronski, J. and Mariani, R. (1995) Transient assay for Nef-induced down-regulation of CD4 antigen expression on the cell surface. In Karn, J. (ed.), HIV-1: A Practical Approach. IRL Press, Oxford, UK, pp. 231-242.
44. Skowronski, J., Parks, D. and Mariani, R. (1993) Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene. EMBO J., 12, 703-713.
45. Spina, C.A., Kwoh, T.J., Chowers, M.Y., Guatelli, J.C. and Richman, D.D. (1994) The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes. J. Exp. Med., 179, 115-123.
46. Tanaka, M. and Herr, W. (1990) Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation. Cell, 60, 375-386.
47. Weiss, A. and Littman, D.R. (1994) Signal transduction by lymphocyte antigen receptors. Cell, 76, 263-274.
48. Wilson, A.C., Peterson, M.G. and Herr, W. (1995) The HCF repeat is an unusual proteolytic cleavage signal. Genes Dev., 9, 2445-2458.
49. Yokoyama, W.M., Koning, F., Kehn, P.J., Pereira, G.M.B., Stingl, G., Coligan, J.E. and Shevach, E.M. (1988) Characterization of a cell surface-expressed disulfide-linker dimer involved in murine T cell activation. J. Immunol., 141, 369-376.
50. Zenner, G., Dirk zur Hausen, J., Burn, P. and Mustelin, T. (1995) Towards unraveling the complexity of T cell signal transduction. BioEssays, 17, 967-975.
51. Zhu, L., van den Heuvel, S., Helin, K., Fattaey, A., Ewen, M., Livingstone, D., Dyson, N. and Harlow, E. (1993) Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev., 262, 2050-2054.