Nef-induced CD4 downregulation: A diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to β-COP

Journal of Virology

Volumn 75, Issue 8, 2001, Pages 3971-3976

  Janvier, K ^a   Craig, H ^a   Le Gall, S ^a   Benarous, R ^a   Guatelli, J ^a   Schwartz, O ^a   Benichou, S ^a  

^a INSTITUT COCHIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA COAT PROTEIN; CD4 ANTIGEN; COAT PROTEIN COMPLEX I; MEMBRANE PROTEIN; NEF PROTEIN; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; CELL SURFACE; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN TARGETING;

ADAPTOR PROTEIN COMPLEX GAMMA SUBUNITS; AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; ANTIGENS, CD4; ANTIGENS, CD8; BIOLOGICAL TRANSPORT; COATOMER PROTEIN; DOWN-REGULATION; ENDOCYTOSIS; GENE PRODUCTS, NEF; GLUTAMIC ACID; HELA CELLS; HIV-1; HUMANS; MACROMOLECULAR SUBSTANCES; MEMBRANE PROTEINS; MUTATION; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; REPRODUCIBILITY OF RESULTS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 0035080263     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.8.3971-3976.2001     Document Type: Article

References (23)

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3. A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor
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