HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: Analysis using short interfering RNA and knock-out mice

Journal of Biological Chemistry

Volumn 283, Issue 17, 2008, Pages 11772-11784

  Atkins, Katelyn M ^a   Thomas, Laurel ^a   Youker, Robert T ^a   Harriff, Melanie J ^a   Pissani, Franco ^a   You, Huihong ^a   Thomas, Gary ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELL MEMBRANES; RNA;

CLASS I; DO-MAINS; EMBRYONIC FIBROBLASTS; ENDOSOMAL COMPARTMENTS; ENDOSOMES; HUMAN IMMUNODEFICIENCY VIRUSES; KNOCK OUTS; MAJOR HISTOCOMPATIBILITY COMPLEX CLASSES; MAJOR HISTOCOMPATIBILITY COMPLEXES; PHOSPHOINOSITIDE; SHORT INTERFERING RNAS; SPLENOCYTES; SRC FAMILIES; SRC HOMOLOGY 2;

NUCLEIC ACIDS;

CARBOXY TERMINAL TELOPEPTIDE; DUAL SPECIFICITY PHOSPHATASE 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NEF PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE ZAP 70; PROTEIN P85; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA; SOMATOMEDIN B RECEPTOR; PACS 2 PROTEIN, MOUSE; PACS-2 PROTEIN, MOUSE; PACS2 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; VESICULAR TRANSPORT PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOSOME; ENZYME PHOSPHORYLATION; FIBROBLAST; GENE LOSS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; KNOCKOUT GENE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SPLEEN CELL; TRANS GOLGI NETWORK; ANIMAL; BIOLOGICAL MODEL; ENDOCYTOSIS; GENE; GENE EXPRESSION REGULATION; HELA CELL; METABOLISM; MOUSE MUTANT; PHOSPHORYLATION;

HUMAN IMMUNODEFICIENCY VIRUS 1; MUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ENDOCYTOSIS; ENDOSOMES; GENE EXPRESSION REGULATION, VIRAL; GENES, MHC CLASS I; HELA CELLS; HIV-1; HUMANS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; PHOSPHORYLATION; TRANS-GOLGI NETWORK; VESICULAR TRANSPORT PROTEINS;

EID: 44649173294     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707572200     Document Type: Article

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