The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells

Immunity

Volumn 10, Issue 6, 1999, Pages 661-671

  Cohen, George B ^a,b,d   Gandhi, Rajesh T ^a,e   Davis, Daniel M ^b   Mandelboim, Ofer ^b   Chen, Benjamin K ^a   Strominger, Jack L ^b   Baltimore, David ^a,c  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b HARVARD UNIVERSITY   (United States)

^c CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN;

ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CELL PROTECTION; CONSENSUS SEQUENCE; CYTOLYSIS; DOWN REGULATION; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE RESPONSE; LYMPHOBLASTOID CELL LINE; MAJOR HISTOCOMPATIBILITY COMPLEX; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NONHUMAN; PRIORITY JOURNAL;

EID: 0033151621     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80065-5     Document Type: Article

References (42)

1. Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A., and Struhl, K. (1996). Transient transfection methods for preparation of high-titer retroviral supernatants. In Current Protocols in Molecular Biology (New York: John Wiley and Sons), pp. 9.11.1-9.11.18.
2. Baker, B.W., Boettiger, D., Spooncer, E., and Norton, J.D. (1992). Efficient retroviral-mediated gene transfer into human B lymphoblastoid cells expressing mouse ecotropic viral receptor. Nucleic Acids Res. 20, 5234.
3. Barber, L.D., Percival, L., Valiante, N.M., Chen, L., Lee, C., Gumperz, J.E., Phillips, J.H., Lanier, L.L., Bigge, J.C., Parekh, R.B., et al. (1996). The inter-locus recombinant HLA-B*4601 has high selectivity in peptide binding and functions characteristic of HLA-C. J. Exp. Med. 184, 735-740.
4. Borrego, F., Ulbrecht, M., Weiss, E.H., Coligan, J.E., and Brooks, A.G. (1998). Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from NK cell-mediated lysis. J. Exp. Med. 187, 813-818.
5. Braud, V.M., Allan, D.S., Wilson, D., and McMichael, A.J. (1998a). TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide. Curr. Biol. 8, 1-10.
6. Braud, V., Allan, D.S., O'Callaghan, C.A., Soderstrom, K., D'Andrea, A., Ogg, G.S., Lazetic, S., Young, N.T., Bell, J.I., Phillips, J.H., et al. (1998b). HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature 391, 795-799.
7. Bruunsgaard, H., Pedersen, C., Skinhoj, P., and Pedersen, B.K. (1997). Clinical progression of HIV infection: Role of NK cells. Scand. J. Immunol. 46, 91-95.
8. Chen, B.K., Gandhi, R.T., and Baltimore, D. (1996). CD4 down-modulation during infection of human T cells with HIV-1 involves independent activities of vpu, env, and nef. J. Virol. 70, 6044-6053.
9. Collins, K.L., Chen, B.K., Kalams, S.A., Walker, B.D., and Baltimore, D. (1998). HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391, 397-401.
10. Davis, D.M., Reyburn, H.T., Pazmany, L., Chiu, I., Mandelboim, O., and Strominger, J.L. (1997). Impaired spontaneous endocytosis of HLA-G. Eur. J. Immunol. 27, 2714-2719.
11. Gandhi, R.T., Chen, B.K., Straus, S.E., Dale, J.K., Lenardo, M.J., and Baltimore, D. (1998). HIV-1 directly kills CD4+ T cells by a Fas-independent mechanism. J. Exp. Med. 187, 1113-1122.
12. Greenberg, M.E., Iafrate, A.J., and Skowronski, J. (1998). The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes. EMBO J. 17, 2777-2789.
13. Howcroft, T.K., Strebel, K., Martin, M.A., and Singer, D.S. (1993). Repression of MHC class I gene promoter activity by two-exon Tat of HIV. Science 260, 1320-1322.
14. Jackman, R.M., Stenger, S., Lee, A., Moody, D.B., Rogers, R.A., Niazi, K.R., Sugita, M., Modlin, R.L., Peters, P.J., and Porcelli, S.A. (1998). The tyrosine-containing cytoplasmic tail of CD1b is essential for its efficient presentation of bacterial lipid antigens. Immunity 8, 341-351.
15. Johnson, R.P., Trocha, A., Buchanan, T.M., and Walker, B.D. (1993). Recognition of a highly conserved region of HIV-1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone. J. Virol. 67, 438-445.
16. Kaslow, R.A., Carrington, M., Apple, R., Park, L., Munoz, A., Saah, A.J., Goedert, J.J., Winkler, C., O'Brien, S.J., Rinaldo, C., et al. (1996). Influence of combinations of human MHC genes on the course of HIV-1 infection. Nat. Med. 2, 405-411.
17. Kerkau, T., Bacik, I., Bennink, J.R., Yewdell, J.W., Hunig, T., Schimpl, A., and Schubert, U. (1997). The human immunodeficiency virus type 1 (HIV-1) Vpu protein interferes with an early step in the biosynthesis of MHC class I molecules. J. Exp. Med. 185, 1295-1305.
18. Lanier, L.L. (1998a). Follow the leader: NK cell receptors for classical and nonclassical MHC class I. Cell 92, 705-707.
19. Lanier, L.L. (1998b). NK cell receptors. Annu. Rev. Immunol. 16, 359-393.
20. Lawlor, D.A., Zemmour, J., Ennis, P.D., and Parham, P. (1990). Evolution of class-I MHC genes and proteins: From natural selection to thymic selection. Annu. Rev. Immunol. 8, 23-63.
21. Lee, N., Llano, M., Carretero, M., Ishitani, A., Navarro, F., Lopez-Botet, M., and Geraghty, D.E. (1998). HLA-E is a major ligand for natural killer inhibitory receptor CD94/NKG2A. Proc. Natl. Acad. Sci. USA 95, 5199-5204.
22. Le Gall, S., Erdtmann, L., Benichou, S., Berlioz-Torrent, C., Liu, L., Benarous, R., Heard, J.M., and Schwartz, O. (1998). Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules. Immunity 8, 483-495.
23. Leibson, P.J. (1998). Cytotoxic lymphocyte recognition of HLA-E: Utilizing a nonclassical window to peer into classical MHC. Immunity 9, 289-294.
24. Littaua, R.A., Oldstone, M.B., Takeda, A., Debouck, C., Wong, J.T., Tuazon, C.U., Moss, B., Kievits, F., and Ennis, F.A. (1991). An HLA-C-restricted CD8+ cytotoxic T-lymphocyte clone recognizes a highly conserved epitope on HIV-1 gag. J. Virol. 65, 4051-4056.
25. Mandelboim, O., Reyburn, H.T., Vales-Gomez, M., Pazmany, L., Colonna, M., Borsellino, G., and Strominger, J.L. (1996). Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty MHC molecules. J. Exp. Med. 184, 913-922.
26. Nehete, P.N., Lewis, D.E., Tang, D.N., Pollack, M.S., and Sastry, K.J. (1998). Presence of HLA-C-restricted cytotoxic T-lymphocyte responses in long-term nonprogressors infected with HIV. Viral Immunol. 11, 119-129.
27. Pazmany, L., Mandelboim, O., Vales-Gomez, M., Davis, D.M., Reyburn, H.T., and Strominger, J.L. (1996). Protection from natural killer cell-mediated lysis by HLA-G expression on target cells. Science 274, 792-795.
28. Pear, W.S., Nolan, G.P., Scott, M.L., and Baltimore, D. (1993). Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA 90, 8392-8396.
29. Perez-Villar, J.J., Melero, I., Navarro, F., Carretero, M., Bellon, T., Llano, M., Colonna, M., Geraghty, D.E., and Lopez-Botet, M. (1997). The CD94/NKG2-A inhibitory receptor complex is involved in NK cell-mediated recognition of cells expressing HLA-G1. J. Immunol. 158, 5736-5743.
30. Ploegh, H.L. (1998). Viral strategies of immune evasion. Science 280, 248-253.
31. Sasazuki, T., Juji, T., Morishima, Y., Kinukawa, N., Kashiwabara, H., Inoko, H., Yoshida, T., Kimura, A., Akaza, T., Kamikawaji, N., et al. (1998). Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor. N. Engl. J. Med. 339, 1177-1185.
32. Schmid, I., Uittenbogaart, C.H., Keld, B., and Giorgi, J.V. (1994). A rapid method for measuring apoptosis and dual-color immunofluorescence by single laser flow cytometry. J. Immunol. Methods 170, 145-157.
33. Schwartz, O., Marechal, V., Le Gall, S., Lemonnier, F., and Heard, J.M. (1996). Endocytosis of MHC class I molecules is induced by the HIV-1 Nef protein. Nat. Med. 2, 338-342.
34. Shimizu, Y., and DeMars, R. (1989). Production of human cells expressing individual transferred HLA-A,-B,-C genes using an HLA-A, -B,-C null human cell line. J. Immunol. 142, 3320-3328.
35. Slezak, S.E., and Horan, P.K. (1989). Cell-mediated cytotoxicity. J. Immunol. Methods 117, 205-214.
36. Tay, C.H., Szomolanyi-Tsuda, E., and Welsh, R.M. (1998). Control of infections by NK cells. Curr. Top. Microbiol. Immunol. 230,193-220.
37. Valiante, N.M., Uhrberg, M., Shilling, H.G., Lienert-Weidenbach, K., Arnett, K.L., D'Andrea, A., Phillips, J.H., Lanier, L.L., and Parham, P. (1997). Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. Immunity 7, 739-751.
38. Wagtmann, N., Rajagopalan, S., Winter, C.C., Peruzzi, M., and Long, E.O. (1995). Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer. Immunity 3, 801-809.
39. Yokoyama, W.M. (1998). Natural killer cell receptors. Curr. Opin. Immunol. 10, 298-305.
40. Yoneda, N., Tatsumi, E., Kawano, S., Teshigawara, K., Oka, T., FuKuda, M., and Yamaguchi, N. (1992). Detection of Epstein-Barr virus genome in natural-killer-like cell line, YT. Leukemia 6, 136-141.
41. Zemmour, J., Gumperz, J.E., Hildebrand, W.H., Ward, F.E., Marsh, S.G., Williams, R.C., and Parham, P. (1992a). The molecular basis for reactivity of anti-Cw1 and anti-Cw3 alloantisera with HLA-B46 haplotypes. Tissue Antigens 39, 249-257.
42. Zemmour, J., Little, A.M., Schendel, D.J., and Parham, P. (1992b). The HLA-A,B "negative" mutant cell line C1R expresses a novel HLA-B35 allele, which also has a point mutation in the translation initiation codon. J. Immunol. 148, 1941-1948.