Nef-mediated resistance of human immunodeficiency virus type 1 to antiviral cytotoxic T lymphocytes

Journal of Virology

Volumn 76, Issue 4, 2002, Pages 1626-1631

  Yang, Otto O ^a   Nguyen, Phuong Thi ^a   Kalams, Spyros A ^a   Dorfman, Tanya ^a   Göttlinger, Heinrich G ^a   Stewart, Sheila ^a   Chen, Irvin S Y ^a   Threlkeld, Steven ^a   Walker, Bruce D ^a  

^a UCLA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NEF PROTEIN;

ANTIGEN PRESENTATION; ARTICLE; COCULTURE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DNA MODIFICATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR CLONING; PRIORITY JOURNAL; VIRUS GENE; VIRUS REPLICATION; VIRUS RESISTANCE;

CELLS, CULTURED; GENE PRODUCTS, NEF; HIV INFECTIONS; HIV-1; HUMANS; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC; VIRUS REPLICATION;

EID: 0036146227     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.4.1626-1631.2002     Document Type: Article

References (68)

1. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone
2. Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
3. HIV-1 Nef protein downregulation of CD4 surface expression: Relevance of the lck binding domain of CD4
4. HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization
5. Why can't cytotoxic T cells handle HIV?
6. In vitro binding and phosphorylation of human immunodeficiency virus type 1 Nef protein by serine/threonine protein kinase
7. + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection
8. The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation
9. The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
10. HIV-I Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
11. HIV-1 auxiliary proteins: Making connections in a dying cell
12. Regulation of HIV gene expression
13. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene
14. The human immunodeficiency virus type 1 capsid p2 domain confers sensitivity to the cyclophilin-binding drug SDZ NIM 811
15. Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys
16. Lymphoproliferative immune function in the Sydney Blood Bank Cohort, infected with natural nef/long terminal repeat mutants, and in other long-term survivors of transfusion-acquired HIV-1 infection
17. Strong human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte activity in Sydney Blood Bank Cohort patients infected with nef-defective HIV type 1
18. Antigen-specific T-cell receptors and their reactions with complexes formed by peptides with major histocompatibility complex proteins
19. HIV-1 regulatory/accessory genes: Keys to unraveling viral and host cell biology
20. Allele-specific peptide ligand motifs of HLA-C molecules
21. Construction and in vitro properties of HIV-1 mutants with deletions in "nonessential" genes
22. Vpu protein of human immunodeficiency virus type 1 enhances the release of capsids produced by gag gene constructs of widely divergent retroviruses
23. The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1
24. Strong cytotoxic T cell and weak neutralizing antibody responses in a subset of persons with stable nonprogressing HIV type 1 infection
25. 2 phase of the cell cycle by inhibiting p34cdc2 activity
26. The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells
27. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
28. Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone
29. HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes. Fine specificity of the gag-specific response defined by using unstimulated peripheral blood mononuclear cells and cloned effector cells
30. HIV-infected cell fusion assay
31. 2 + M phase of the cell cycle
32. Importance of the nef gene for maintenance of high virus loads and for development of AIDS
33. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
34. Human immunodeficiency virus (HIV) nef-specific cytotoxic T lymphocytes in noninfected heterosexual contact of HIV-infected patients
35. An HLA-C-restricted CD8+ cytotoxic T-lymphocyte clone recognizes a highly conserved epitope on human immunodeficiency virus type 1 gag
36. Mutational analysis of the human immunodeficiency virus: The orf-B region down-regulates virus replication
37. Cytotoxic T lymphocyte epitopes: Implications for HIV vaccines
38. The human immunodeficiency virus-1 nef gene product: A positive factor for viral infection and replication in primary lymphocytes and macrophages
39. Genomic sequence of HIV type 1 from four members of the Sydney Blood Bank Cohort of long-term nonprogressors
40. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
41. The HIV-1 Rev protein
42. Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS
43. MHC ligands and peptide motifs: First listing
44. Expression kinetics and subcellular localization of HIV-1 regulatory proteins Nef, Tat and Rev in acutely and chronically infected lymphoid cell lines
45. 2 by inhibiting the activation of p34cdc2-cyclin B
46. High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors
47. Targeting of human immunodeficiency virus-infected cells by CD8+ T lymphocytes armed with universal T-cell receptors
48. The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection
49. HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women
50. Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4
51. Impaired assembly and transport of HLA-A and -B antigens in a mutant TxB cell hybrid
52. Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids
53. Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes
54. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
55. The HIV nef protein associates with protein kinase C theta
56. The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes
57. Conservation and host specificity of Vpr-mediated cell cycle arrest suggest a fundamental role in primate lentivirus evolution and biology
58. Effects of mutations within the 3′ orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity
59. HIV accessory proteins: Leading roles for the supporting cast
60. Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type 1
61. Viral dynamics in human immunodeficiency virus type 1 infection
62. Adaptive evolution of human immunodeficiency virus-type 1 during the natural course of infection
63. Bi-specific monoclonal antibodies: Selective binding and complement fixation to cells that express two different surface antigens
64. Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes
65. Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: Evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms
66. Lysis of HIV-1-infected cells and inhibition of viral replication by universal receptor T cells
67. CD8+ cells in human immunodeficiency virus type I pathogenesis: Cytolytic and noncytolytic inhibition of viral replication