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Volumn 2014, Issue 3, 2014, Pages

How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CLATHRIN; NEF PROTEIN;

EID: 84898733948     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.01754.001     Document Type: Article
Times cited : (93)

References (59)
  • 2
    • 0028180868 scopus 로고
    • Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
    • doi: 10.1016/0092-8674(94)90360-3
    • Aiken C, Konner J, Landau N, Lenburg M, Trono D. 1994. Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 76:853-864. doi: 10.1016/0092-8674(94)90360-3.
    • (1994) Cell , vol.76 , pp. 853-864
    • Aiken, C.1    Konner, J.2    Landau, N.3    Lenburg, M.4    Trono, D.5
  • 3
    • 0029924038 scopus 로고    scopus 로고
    • Mutational analysis of HIV-1 Nef: Identification of two mutants that are temperature-sensitive for CD4 downregulation
    • doi: 10.1006/viro.1996.0116
    • Aiken C, Krause L, Chen Y, Trono D. 1996. Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation. Virology 217:293-300. doi: 10.1006/viro.1996.0116.
    • (1996) Virology , vol.217 , pp. 293-300
    • Aiken, C.1    Krause, L.2    Chen, Y.3    Trono, D.4
  • 4
    • 0031572847 scopus 로고    scopus 로고
    • The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling
    • doi: 10.1016/S0969-2126(97)00286-4
    • Arold S, Franken P, Strub M, Hoh F, Benichou S, Benarous R, Dumas C. 1997. The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling. Structure 5:1361-1372. doi: 10.1016/S0969-2126(97)00286-4.
    • (1997) Structure , vol.5 , pp. 1361-1372
    • Arold, S.1    Franken, P.2    Strub, M.3    Hoh, F.4    Benichou, S.5    Benarous, R.6    Dumas, C.7
  • 5
    • 0027158904 scopus 로고
    • Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection
    • doi: 10.1084/jem.177.6.1561
    • Benson R, Sanfridson A, Ottinger J, Doyle C, Cullen B. 1993. Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection. The Journal of Experimental Medicine 177:1561-1566. doi: 10.1084/jem.177.6.1561.
    • (1993) The Journal of Experimental Medicine , vol.177 , pp. 1561-1566
    • Benson, R.1    Sanfridson, A.2    Ottinger, J.3    Doyle, C.4    Cullen, B.5
  • 6
    • 0038795645 scopus 로고    scopus 로고
    • Signals for sorting of transmembrane proteins to endosomes and lysosomes
    • doi: 10.1146/annurev.biochem.72.121801.161800
    • Bonifacino J, Traub L. 2003. Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annual Review of Biochemistry 72:395-447. doi: 10.1146/annurev.biochem.72.121801.161800.
    • (2003) Annual Review of Biochemistry , vol.72 , pp. 395-447
    • Bonifacino, J.1    Traub, L.2
  • 7
    • 0030858324 scopus 로고    scopus 로고
    • CD4: A co-receptor in the immune response and HIV infection
    • doi: 10.1016/S1357-2725(96)00154-9
    • Bowers K, Pitcher C, Marsh M. 1997. CD4: a co-receptor in the immune response and HIV infection. International Journal of Biochemistry & Cell Biology 29:871-875. doi: 10.1016/S1357-2725(96)00154-9.
    • (1997) International Journal of Biochemistry & Cell Biology , vol.29 , pp. 871-875
    • Bowers, K.1    Pitcher, C.2    Marsh, M.3
  • 8
    • 0032488027 scopus 로고    scopus 로고
    • A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor
    • doi: 10.1016/S0960-9822(07)00517-9
    • Bresnahan P, Yonemoto W, Ferrell S, Williams-Herman D, Geleziunas R, Greene W. 1998. A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor. Current Biology 8:1235-1238. doi: 10.1016/S0960-9822(07)00517-9.
    • (1998) Current Biology , vol.8 , pp. 1235-1238
    • Bresnahan, P.1    Yonemoto, W.2    Ferrell, S.3    Williams-Herman, D.4    Geleziunas, R.5    Greene, W.6
  • 9
    • 79956336664 scopus 로고    scopus 로고
    • Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor nef
    • doi: 10.1371/journal.pone.0020033
    • Breuer S, Schievink SI, Schulte A, Blankenfeldt W, Fackler OT, Geyer M. 2011. Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor nef. PLOS ONE 6:e20033. doi: 10.1371/journal.pone.0020033.
    • (2011) PLOS ONE , vol.6
    • Breuer, S.1    Schievink, S.I.2    Schulte, A.3    Blankenfeldt, W.4    Fackler, O.T.5    Geyer, M.6
  • 10
    • 33845513921 scopus 로고    scopus 로고
    • Dynamic interaction of HIV-1 Nef with the clathrin-mediated endocytic pathway at the plasma membrane
    • doi: 10.1111/j.1600-0854.2006.00512.x
    • Burtey A, Rappoport J, Bouchet J, Basmaciogullari S, Guatelli J, Simon S, Benichou S, Benmerah A. 2007. Dynamic interaction of HIV-1 Nef with the clathrin-mediated endocytic pathway at the plasma membrane. Traffic 8:61-76. doi: 10.1111/j.1600-0854.2006.00512.x.
    • (2007) Traffic , vol.8 , pp. 61-76
    • Burtey, A.1    Rappoport, J.2    Bouchet, J.3    Basmaciogullari, S.4    Guatelli, J.5    Simon, S.6    Benichou, S.7    Benmerah, A.8
  • 11
    • 84878323594 scopus 로고    scopus 로고
    • The clathrin adaptor complexes as a paradigm for membrane-associated allostery
    • doi: 10.1002/pro.2235
    • Canagarajah B, Ren X, Bonifacino JS, Hurley JH. 2013. The clathrin adaptor complexes as a paradigm for membrane-associated allostery. Protein Science 22:517-529. doi: 10.1002/pro.2235.
    • (2013) Protein Science , vol.22 , pp. 517-529
    • Canagarajah, B.1    Ren, X.2    Bonifacino, J.S.3    Hurley, J.H.4
  • 13
    • 34247129671 scopus 로고    scopus 로고
    • Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor
    • doi: 10.1128/JVI.02725-06
    • Chaudhuri R, Lindwasser O, Smith W, Hurley J, Bonifacino J. 2007. Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor. Journal of Virology 81:3877-3890. doi: 10.1128/JVI.02725-06.
    • (2007) Journal of Virology , vol.81 , pp. 3877-3890
    • Chaudhuri, R.1    Lindwasser, O.2    Smith, W.3    Hurley, J.4    Bonifacino, J.5
  • 14
    • 62749181801 scopus 로고    scopus 로고
    • A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex
    • doi: 10.1128/JVI.02227-08
    • Chaudhuri R, Mattera R, Lindwasser O, Robinson M, Bonifacino J. 2009. A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex. Journal of Virology 83:2518-2530. doi: 10.1128/JVI.02227-08.
    • (2009) Journal of Virology , vol.83 , pp. 2518-2530
    • Chaudhuri, R.1    Mattera, R.2    Lindwasser, O.3    Robinson, M.4    Bonifacino, J.5
  • 15
    • 0011098260 scopus 로고    scopus 로고
    • The HIV-1 Nef protein as a target for antiretroviral therapy
    • doi: 10.1517/14728222.5.1.1
    • Coleman S, Day J, Guatelli J. 2001. The HIV-1 Nef protein as a target for antiretroviral therapy. Expert Opinion on Therapeutic Targets 5:1-22. doi: 10.1517/14728222.5.1.1.
    • (2001) Expert Opinion on Therapeutic Targets , vol.5 , pp. 1-22
    • Coleman, S.1    Day, J.2    Guatelli, J.3
  • 16
    • 0037123766 scopus 로고    scopus 로고
    • Molecular architecture and functional model of the endocytic AP2 complex
    • doi: 10.1016/S0092-8674(02)00735-3
    • Collins BM, Mccoy AJ, Kent HM, Evans PR, Owen DJ. 2002. Molecular architecture and functional model of the endocytic AP2 complex. Cell 109:523-535. doi: 10.1016/S0092-8674(02)00735-3.
    • (2002) Cell , vol.109 , pp. 523-535
    • Collins, B.M.1    McCoy, A.J.2    Kent, H.M.3    Evans, P.R.4    Owen, D.J.5
  • 17
    • 0032530773 scopus 로고    scopus 로고
    • Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity
    • doi: 10.1073/pnas.95.19.11229
    • Craig HM, Pandori MW, Guatelli JC. 1998. Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity. Proceedings of the National Academy of Sciences of the United States of America 95:11229-11234. doi: 10.1073/pnas.95.19.11229.
    • (1998) Proceedings of the National Academy of Sciences of the United States of America , vol.95 , pp. 11229-11234
    • Craig, H.M.1    Pandori, M.W.2    Guatelli, J.C.3
  • 18
    • 67449092266 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Nef protein targets CD4 to the multivesicular body pathway
    • doi: 10.1128/JVI.00548-09
    • daSilva L, Sougrat R, Burgos P, Janvier K, Mattera R, Bonifacino J. 2009. Human immunodeficiency virus type 1 Nef protein targets CD4 to the multivesicular body pathway. Journal of Virology 83:6578-6590. doi: 10.1128/JVI.00548-09.
    • (2009) Journal of Virology , vol.83 , pp. 6578-6590
    • daSilva, L.1    Sougrat, R.2    Burgos, P.3    Janvier, K.4    Mattera, R.5    Bonifacino, J.6
  • 21
    • 34248198351 scopus 로고    scopus 로고
    • The gamma/sigma1 and alpha/sigma2 hemicomplexes of clathrin adaptors AP-1 and AP-2 harbor the dileucine recognition site
    • doi: 10.1091/mbc.E07-01-0012
    • Doray B, Lee I, Knisely J, Bu G, Kornfeld S. 2007. The gamma/sigma1 and alpha/sigma2 hemicomplexes of clathrin adaptors AP-1 and AP-2 harbor the dileucine recognition site. Molecular Biology of the Cell 18:1887-1896. doi: 10.1091/mbc.E07-01-0012.
    • (2007) Molecular Biology of the Cell , vol.18 , pp. 1887-1896
    • Doray, B.1    Lee, I.2    Knisely, J.3    Bu, G.4    Kornfeld, S.5
  • 23
    • 53549119688 scopus 로고    scopus 로고
    • HIV-1 Nef: At the crossroads
    • doi: 10.1186/1742-4690-5-84
    • Foster J, Garcia J. 2008. HIV-1 Nef: at the crossroads. Retrovirology 5:84. doi: 10.1186/1742-4690-5-84.
    • (2008) Retrovirology , vol.5 , pp. 84
    • Foster, J.1    Garcia, J.2
  • 25
    • 0031711593 scopus 로고    scopus 로고
    • HIV-1: Fifteen proteins and an RNA
    • doi: 10.1146/annurev.biochem.67.1.1
    • Frankel A, Young J. 1998. HIV-1: fifteen proteins and an RNA. Annual Review of Biochemistry 67:1-25. doi: 10.1146/annurev.biochem.67.1.1.
    • (1998) Annual Review of Biochemistry , vol.67 , pp. 1-25
    • Frankel, A.1    Young, J.2
  • 26
    • 0025733252 scopus 로고
    • Serine phosphorylation-independent downregulation of cell-surface CD4 by nef
    • doi: 10.1038/350508a0
    • Garcia J, Miller A. 1991. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature 350:508-511. doi: 10.1038/350508a0.
    • (1991) Nature , vol.350 , pp. 508-511
    • Garcia, J.1    Miller, A.2
  • 27
    • 0034795885 scopus 로고    scopus 로고
    • CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivo
    • doi: 10.1128/JVI.75.21.10113-10117.2001
    • Glushakova S, Munch J, Carl S, Greenough T, Sullivan J, Margolis L, Kirchhoff F. 2001. CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivo. Journal of Virology 75:10113-10117. doi: 10.1128/JVI.75.21.10113-10117.2001.
    • (2001) Journal of Virology , vol.75 , pp. 10113-10117
    • Glushakova, S.1    Munch, J.2    Carl, S.3    Greenough, T.4    Sullivan, J.5    Margolis, L.6    Kirchhoff, F.7
  • 29
    • 0032488055 scopus 로고    scopus 로고
    • A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4
    • doi: 10.1016/S0960-9822(07)00518-0
    • Greenberg M, Detulleo L, Rapoport I, Skowronski J, Kirchhausen T. 1998. A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4. Current Biology 8:1239-1242. doi: 10.1016/S0960-9822(07)00518-0.
    • (1998) Current Biology , vol.8 , pp. 1239-1242
    • Greenberg, M.1    Detulleo, L.2    Rapoport, I.3    Skowronski, J.4    Kirchhausen, T.5
  • 30
    • 0030684068 scopus 로고    scopus 로고
    • Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation
    • doi: 10.1093/emboj/16.23.6964
    • Greenberg ME, Bronson S, Lock M, Neumann M, Pavlakis GN, Skowronski J. 1997. Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation. The EMBO Journal 16:6964-6976. doi: 10.1093/emboj/16.23.6964.
    • (1997) The EMBO Journal , vol.16 , pp. 6964-6976
    • Greenberg, M.E.1    Bronson, S.2    Lock, M.3    Neumann, M.4    Pavlakis, G.N.5    Skowronski, J.6
  • 31
    • 0029881450 scopus 로고    scopus 로고
    • The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase
    • doi: 10.1038/nsb0496-340
    • Grzesiek S, Bax A, Clore G, Gronenborn A, Hu J, Kaufman J, Palmer I, Stahl S, Wingfield P. 1996a. The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase. Nature Structural Biology 3:340-345. doi: 10.1038/nsb0496-340.
    • (1996) Nature Structural Biology , vol.3 , pp. 340-345
    • Grzesiek, S.1    Bax, A.2    Clore, G.3    Gronenborn, A.4    Hu, J.5    Kaufman, J.6    Palmer, I.7    Stahl, S.8    Wingfield, P.9
  • 33
    • 0029795040 scopus 로고    scopus 로고
    • The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. mapping of the Nef binding surface by NMR
    • doi: 10.1021/bi9611164
    • Grzesiek S, Stahl SJ, Wingfield PT, Bax A. 1996b. The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. mapping of the Nef binding surface by NMR. Biochemistry 35:10256-10261. doi: 10.1021/bi9611164.
    • (1996) Biochemistry , vol.35 , pp. 10256-10261
    • Grzesiek, S.1    Stahl, S.J.2    Wingfield, P.T.3    Bax, A.4
  • 34
    • 0023659754 scopus 로고
    • HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product
    • doi: 10.1038/330266a0
    • Guy B, Kieny M, Riviere Y, Le Peuch C, Dott K, Girard M, Montagnier L, Lecocq J. 1987. HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product. Nature 330:266-269. doi: 10.1038/330266a0.
    • (1987) Nature , vol.330 , pp. 266-269
    • Guy, B.1    Kieny, M.2    Riviere, Y.3    Le Peuch, C.4    Dott, K.5    Girard, M.6    Montagnier, L.7    Lecocq, J.8
  • 35
    • 79958770579 scopus 로고    scopus 로고
    • Conformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assembly
    • doi: 10.1111/j.1600-0854.2011.01205.x
    • Horenkamp F, Breuer S, Schulte A, Lulf S, Weyand M, Saksela K, Geyer M. 2011. Conformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assembly. Traffic 12:867-877. doi: 10.1111/j.1600-0854.2011.01205.x.
    • (2011) Traffic , vol.12 , pp. 867-877
    • Horenkamp, F.1    Breuer, S.2    Schulte, A.3    Lulf, S.4    Weyand, M.5    Saksela, K.6    Geyer, M.7
  • 36
    • 0030958508 scopus 로고    scopus 로고
    • Identification of regions in HIV-1 Nef required for efficient downregulation of cell surface CD4
    • doi: 10.1006/viro.1997.8517
    • Hua J, Blair W, Truant R, Cullen BR. 1997. Identification of regions in HIV-1 Nef required for efficient downregulation of cell surface CD4. Virology 231:231-238. doi: 10.1006/viro.1997.8517.
    • (1997) Virology , vol.231 , pp. 231-238
    • Hua, J.1    Blair, W.2    Truant, R.3    Cullen, B.R.4
  • 37
    • 77953884976 scopus 로고    scopus 로고
    • A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex
    • doi: 10.1016/j.cell.2010.05.006
    • Jackson L, Kelly B, Mccoy A, Gaffry T, James L, Collins B, Honing S, Evans P, Owen D. 2010. A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex. Cell 141:1220-1229. doi: 10.1016/j.cell.2010.05.006.
    • (2010) Cell , vol.141 , pp. 1220-1229
    • Jackson, L.1    Kelly, B.2    McCoy, A.3    Gaffry, T.4    James, L.5    Collins, B.6    Honing, S.7    Evans, P.8    Owen, D.9
  • 39
    • 0346102461 scopus 로고    scopus 로고
    • Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 gamma-sigma1 and AP-3 delta-sigma3 hemicomplexes
    • doi: 10.1083/jcb.200307157
    • Janvier K, Kato Y, Boehm M, Rose J, Martina J, Kim B, Venkatesan S, Bonifacino J. 2003. Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 gamma-sigma1 and AP-3 delta-sigma3 hemicomplexes. The Journal of Cell Biology 163:1281-1290. doi: 10.1083/jcb.200307157.
    • (2003) The Journal of Cell Biology , vol.163 , pp. 1281-1290
    • Janvier, K.1    Kato, Y.2    Boehm, M.3    Rose, J.4    Martina, J.5    Kim, B.6    Venkatesan, S.7    Bonifacino, J.8
  • 41
    • 23844509821 scopus 로고    scopus 로고
    • HIV Nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent
    • Jin Y, Cai C, Zhang X, Zhang H, Hirst J, Burakoff S. 2005. HIV Nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent. Journal of Immunology 175:3157-3164.
    • (2005) Journal of Immunology , vol.175 , pp. 3157-3164
    • Jin, Y.1    Cai, C.2    Zhang, X.3    Zhang, H.4    Hirst, J.5    Burakoff, S.6
  • 42
    • 84876220704 scopus 로고    scopus 로고
    • Identification of a novel binding site between HIV type 1 nef c-terminal flexible loop and AP2 required for nef-mediated CD4 downregulation
    • doi: 10.1089/AID.2012.0286
    • Jin YJ, Cai CY, Mezei M, Ohlmeyer M, Sanchez R, Burakoff SJ. 2013. Identification of a novel binding site between HIV type 1 nef c-terminal flexible loop and AP2 required for nef-mediated CD4 downregulation. AIDS Research and Human Retroviruses 29:725-731. doi: 10.1089/AID.2012.0286.
    • (2013) AIDS Research and Human Retroviruses , vol.29 , pp. 725-731
    • Jin, Y.J.1    Cai, C.Y.2    Mezei, M.3    Ohlmeyer, M.4    Sanchez, R.5    Burakoff, S.J.6
  • 43
    • 57749196168 scopus 로고    scopus 로고
    • A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex
    • doi: 10.1038/nature07422
    • Kelly BT, Mccoy AJ, Spate K, Miller SE, Evans PR, Honing S, Owen DJ. 2008. A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex. Nature 456:976-979. doi: 10.1038/nature07422.
    • (2008) Nature , vol.456 , pp. 976-979
    • Kelly, B.T.1    McCoy, A.J.2    Spate, K.3    Miller, S.E.4    Evans, P.R.5    Honing, S.6    Owen, D.J.7
  • 44
    • 0028835788 scopus 로고
    • Brief report: Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection
    • doi: 10.1056/NEJM199501263320405
    • Kirchhoff F, Greenough T, Brettler D, Sullivan J, Desrosiers R. 1995. Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. The New England Journal of Medicine 332:228-232. doi: 10.1056/NEJM199501263320405.
    • (1995) The New England Journal of Medicine , vol.332 , pp. 228-232
    • Kirchhoff, F.1    Greenough, T.2    Brettler, D.3    Sullivan, J.4    Desrosiers, R.5
  • 45
    • 0033578072 scopus 로고    scopus 로고
    • Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef-and Vpu-inhibitable manner
    • doi: 10.1016/S0960-9822(99)80284-X
    • Lama J, Mangasarian A, Trono D. 1999. Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef-and Vpu-inhibitable manner. Current Biology 9:622-631. doi: 10.1016/S0960-9822(99)80284-X.
    • (1999) Current Biology , vol.9 , pp. 622-631
    • Lama, J.1    Mangasarian, A.2    Trono, D.3
  • 46
    • 0343494918 scopus 로고    scopus 로고
    • Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain
    • doi: 10.1016/S0092-8674(00)81276-3
    • Lee C, Saksela K, Mirza U, Chait B, Kuriyan J. 1996. Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain. Cell 85:931-942. doi: 10.1016/S0092-8674(00)81276-3.
    • (1996) Cell , vol.85 , pp. 931-942
    • Lee, C.1    Saksela, K.2    Mirza, U.3    Chait, B.4    Kuriyan, J.5
  • 47
    • 38349109364 scopus 로고    scopus 로고
    • A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2
    • doi: 10.1128/JVI.01874-07
    • Lindwasser O, Smith W, Chaudhuri R, Yang P, Hurley J, Bonifacino J. 2008. A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2. Journal of Virology 82:1166-1174. doi: 10.1128/JVI.01874-07.
    • (2008) Journal of Virology , vol.82 , pp. 1166-1174
    • Lindwasser, O.1    Smith, W.2    Chaudhuri, R.3    Yang, P.4    Hurley, J.5    Bonifacino, J.6
  • 48
    • 78751505790 scopus 로고    scopus 로고
    • Conservation and diversification of dileucine signal recognition by adaptor protein (AP) complex variants
    • doi: 10.1074/jbc.M110.197178
    • Mattera R, Boehm M, Chaudhuri R, Prabhu Y, Bonifacino JS. 2011. Conservation and diversification of dileucine signal recognition by adaptor protein (AP) complex variants. The Journal of Biological Chemistry 286:2022-2030. doi: 10.1074/jbc.M110.197178.
    • (2011) The Journal of Biological Chemistry , vol.286 , pp. 2022-2030
    • Mattera, R.1    Boehm, M.2    Chaudhuri, R.3    Prabhu, Y.4    Bonifacino, J.S.5
  • 50
    • 8444222772 scopus 로고    scopus 로고
    • Adaptors for clathrin coats: Structure and function
    • doi: 10.1146/annurev.cellbio.20.010403.104543
    • Owen D, Collins B, Evans P. 2004. Adaptors for clathrin coats: structure and function. Annual Review of Cell and Developmental Biology 20:153-191. doi: 10.1146/annurev.cellbio.20.010403.104543.
    • (2004) Annual Review of Cell and Developmental Biology , vol.20 , pp. 153-191
    • Owen, D.1    Collins, B.2    Evans, P.3
  • 51
    • 0035088131 scopus 로고    scopus 로고
    • Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain
    • doi: 10.1128/JVI.75.8.3960-3964.2001
    • Preusser A, Briese L, Baur AS, Willbold D. 2001. Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain. Journal of Virology 75:3960-3964. doi: 10.1128/JVI.75.8.3960-3964.2001.
    • (2001) Journal of Virology , vol.75 , pp. 3960-3964
    • Preusser, A.1    Briese, L.2    Baur, A.S.3    Willbold, D.4
  • 52
    • 84874033425 scopus 로고    scopus 로고
    • Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1
    • doi: 10.1016/j.cell.2012.12.042
    • Ren X, Farias GG, Canagarajah B, Bonifacino JS, Hurley JH. 2013. Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1. Cell 152:755-767. doi: 10.1016/j.cell.2012.12.042.
    • (2013) Cell , vol.152 , pp. 755-767
    • Ren, X.1    Farias, G.G.2    Canagarajah, B.3    Bonifacino, J.S.4    Hurley, J.H.5
  • 53
    • 0028200761 scopus 로고
    • Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4
    • Rhee S, Marsh J. 1994. Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4. Journal of Virology 68:5156-5163.
    • (1994) Journal of Virology , vol.68 , pp. 5156-5163
    • Rhee, S.1    Marsh, J.2
  • 54
    • 0033578016 scopus 로고    scopus 로고
    • Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein
    • doi: 10.1016/S0960-9822(99)80283-8
    • Ross T, Oran A, Cullen B. 1999. Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein. Current Biology 9:613-621. doi: 10.1016/S0960-9822(99)80283-8.
    • (1999) Current Biology , vol.9 , pp. 613-621
    • Ross, T.1    Oran, A.2    Cullen, B.3
  • 55
    • 0033082686 scopus 로고    scopus 로고
    • Overcoming expression and purification problems of RhoGDI using a family of "parallel" expression vectors
    • doi: 10.1006/prep.1998.1003
    • Sheffield P, Garrard S, Derewenda Z. 1999. Overcoming expression and purification problems of RhoGDI using a family of "parallel" expression vectors. Protein Expression and Purification 15:34-39. doi: 10.1006/prep.1998.1003.
    • (1999) Protein Expression and Purification , vol.15 , pp. 34-39
    • Sheffield, P.1    Garrard, S.2    Derewenda, Z.3
  • 56
    • 0027533215 scopus 로고
    • Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene
    • Skowronski J, Parks D, Mariani R. 1993. Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene. The EMBO Journal 12:703-713.
    • (1993) The EMBO Journal , vol.12 , pp. 703-713
    • Skowronski, J.1    Parks, D.2    Mariani, R.3
  • 57
    • 0034963119 scopus 로고    scopus 로고
    • A modular polycistronic expression system for overexpressing protein complexes in Escherichia coli
    • doi: 10.1006/prep.2000.1363
    • Tan S. 2001. A modular polycistronic expression system for overexpressing protein complexes in Escherichia coli. Protein Expression and Purification 21:224-234. doi: 10.1006/prep.2000.1363.
    • (2001) Protein Expression and Purification , vol.21 , pp. 224-234
    • Tan, S.1
  • 58
    • 0026610156 scopus 로고
    • Effect of myristoylation on p27 nef subcellular distribution and suppression of HIV-LTR transcription
    • doi: 10.1016/0042-6822(92)90293-X
    • Yu G, Felsted R. 1992. Effect of myristoylation on p27 nef subcellular distribution and suppression of HIV-LTR transcription. Virology 187:46-55. doi: 10.1016/0042-6822(92)90293-X.
    • (1992) Virology , vol.187 , pp. 46-55
    • Yu, G.1    Felsted, R.2
  • 59
    • 84856760126 scopus 로고    scopus 로고
    • A structure-based mechanism for Arf1-dependent recruitment of coatomer to membranes
    • doi: 10.1016/j.cell.2012.01.015
    • Yu XC, Breitman M, Goldberg J. 2012. A structure-based mechanism for Arf1-dependent recruitment of coatomer to membranes. Cell 148:530-542. doi: 10.1016/j.cell.2012.01.015.
    • (2012) Cell , vol.148 , pp. 530-542
    • Yu, X.C.1    Breitman, M.2    Goldberg, J.3


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