Genetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolates

Journal of Virology

Volumn 75, Issue 4, 2001, Pages 1672-1680

  Foster, J L ^a   Molina, R P ^a   Luo, T ^a   Arora, V K ^a   Huang, Y ^a   Ho, D D ^a   Garcia, J V ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NEF PROTEIN; P21 ACTIVATED KINASE 2; PROTEIN KINASE; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; GENE CONSTRUCT; GENE MUTATION; GENE STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; VIRAL GENETICS; VIRUS INFECTIVITY; VIRUS ISOLATION; VIRUS PARTICLE;

ACQUIRED IMMUNODEFICIENCY SYNDROME; AMINO ACID SEQUENCE; CELL LINE; GENE PRODUCTS, NEF; GENES, NEF; HIV INFECTIONS; HIV LONG-TERM SURVIVORS; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PLASMIDS; PROTEIN-SERINE-THREONINE KINASES; TRANSFECTION; VARIATION (GENETICS);

EID: 0035138509     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.4.1672-1680.2001     Document Type: Article

References (64)

1. Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
2. Mutational analysis of HIV-1 Nef: Identification of two mutants that are temperature-sensitive for CD4 downregulation
3. Lentivirus Nef specifically activates Pak2
4. The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase
5. Defective nef alleles in a cohort of hemophiliacs with progressing and nonprogressing HIV-1 infection
6. Polyomavirus T antigens: Molecular chaperones for multiprotein complexes
7. Activation of the PAK-related kinase by human immunodeficiency virus type 1 Nef in primary human peripheral blood lymphocytes and macrophages leads to phosphorylation of a PIX-p95 complex
8. High-efficiency transformation of mammalian cells by plasmid DNA
9. Differential effects of nef on HIV replication: Implications for viral pathogenesis in the host
10. HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy
11. Env sequences of simian immunodeficiency viruses from chimpanzees in Cameroon are strongly related to those of human immunodeficiency virus group N from the same geographic area
12. Analysis of the SH3-binding region of HIV-1 Nef: Partial functional defects introduced by mutations in the polyproline helix and the hydrophobic pocket
13. Evolution of human immunodeficiency virus type 1 nef and long terminal repeat sequences over 4 years in vivo and in vitro
14. Natural HIV-1 NEF accelerates virus replication in primary human lymphocytes
15. p21-activated kinase 1 plays a critical role in cellular activation by Nef
16. 2+ signaling in myelomonocytic cells through SH3-mediated protein-protein interactions
17. Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes
18. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef
19. The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes
20. HIV F/3′ orf encodes a phosphorylated GTP-binding protein resembling an oncogene product
21. In vivo derived HIV-1 nef gene products are heterogeneous and lack detectable nucleotide binding activity
22. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
23. Identification of regions in HIV-1 Nef required for efficient downregulation of cell surface CD4
24. Characterization of nef sequences in long-term survivors of human immunodeficiency virus type 1 infection
25. Biological characterization of nef in long-term survivors of human immunodeficiency virus type 1 infection
26. Genetic organization of a chimpanzee lentivirus related to HIV-1
27. Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling
28. Nef proteins of distinct HIV-1 or HIV-2 isolates differ in their binding properties for Hck: Isolation of a novel Nef binding factor with characteristics of an adaptor protein
29. Importance of the nef gene for maintenance of high virus loads and for development of AIDS
30. Role of the SH3-ligand domain of simian immunodeficiency virus Nef in interaction with Nef-associated kinase and simian AIDS in rhesus macaques
31. Sequence variations in human immunodeficiency virus type 1 Nef are associated with different stages of disease
32. The human immunodeficiency virus type 1 nef gene can to a large extent replace simian immunodeficiency virus nef in vivo
33. Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms
34. Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation
35. Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4
36. Infectivity enhancement by human immunodeficiency virus type 1 Nef is independent of its association with a cellular serine/threonine kinase
37. SIV/HIV nef recombinant virus (SHIVnef) produces simian AIDS in rhesus macaques
38. The HIV-1 Nef protein acts as a connector with sorting pathways in the golgi and at the plasma membrane
39. Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking
40. CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals
41. Anomalies in Nef expression within the central nervous system of HIV-1 positive individuals/AIDS patients with or without AIDS dementia complex
42. Functional characterization of human immunodeficiency virus type I nef genes in patients with divergent rates of disease progression
43. Molecular cloning and characterization of viruses isolated from chimpanzees with pathogenic human immunodeficiency virus type 1 infections
44. Nef-induced CD4 degradation: A diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of β-COP in endosomes
45. The downregulation of CD4 and MHC-I by primate lentiviruses: A paradigm for the modulation of cell surface receptors
46. HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes
47. The HIV-1 nef gene product is associated with phosphorylation of a 46 kD cellular protein
48. Sequence heterogeneity of Nef transcripts in HIV-1-infected subjects at different stages of disease
49. Identification of the Nef-associated kinase as p21-activated kinase 2
50. Interactions of HIV-1 Nef with cellular signal transducing proteins
51. Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4
52. Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes
53. Activation of PAK by HIV and SIV nef: Importance for AIDS in rhesus macaques
54. + long-term non-progressor
55. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
56. Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo
57. Identification of a new human immunodeficiency virus type 1 distinct from group M and group O
58. Effects of mutations within the 3′ orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity
59. Extensive diversification of human immunodeficiency virus type 1 subtype B strains during dual infection of a chimpanzee that progressed to AIDS
60. Viral dynamics in human immunodeficiency virus type 1 infection
61. HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis
62. Genealogical evidence for positive selection in the nef gene of HIV-1
63. Mutational analysis of the human immunodeficiency virus type 1 Eli Nef function
64. An African HIV-1 sequence from 1959 and implications for the origin of the epidemic