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Volumn 89, Issue 24, 2015, Pages 12518-12524

AP-2 is the crucial clathrin adaptor protein for CD4 downmodulation by HIV-1 Nef in infected primary CD4+ T cells

Author keywords

[No Author keywords available]

Indexed keywords

ACOT8 PROTEIN; ADAPTOR PROTEIN; ADENOSINE TRIPHOSPHATASE; AP 1 PROTEIN; AP 2 PROTEIN; AP 3 PROTEIN; BETA COP PROTEIN; CD4 ANTIGEN; CLATHRIN; NEF PROTEIN; SHORT HAIRPIN RNA; THIOL ESTER HYDROLASE; UNCLASSIFIED DRUG; V1H PROTEIN; NEF PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84949802447     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01838-15     Document Type: Article
Times cited : (15)

References (32)
  • 1
    • 0346601814 scopus 로고    scopus 로고
    • The physiological relevance of CD4 receptor downmodulation during HIV infection
    • Lama J. 2003. The physiological relevance of CD4 receptor downmodulation during HIV infection. Curr HIV Res 1:167-184. http://dx.doi.org/10.2174/1570162033485276.
    • (2003) Curr HIV Res , vol.1 , pp. 167-184
    • Lama, J.1
  • 3
    • 0141780822 scopus 로고    scopus 로고
    • Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased env incorporation and viral replication
    • Arganaraz ER, Schindler M, Kirchhoff F, Cortes MJ, Lama J. 2003. Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased env incorporation and viral replication. J Biol Chem 278:33912-33919. http://dx.doi.org/10.1074/jbc.M303679200.
    • (2003) J Biol Chem , vol.278 , pp. 33912-33919
    • Arganaraz, E.R.1    Schindler, M.2    Kirchhoff, F.3    Cortes, M.J.4    Lama, J.5
  • 4
    • 0036231461 scopus 로고    scopus 로고
    • Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes
    • Lundquist CA, Tobiume M, Zhou J, Unutmaz D, Aiken C. 2002. Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes. J Virol 76:4625-4633.http://dx.doi.org/10.1128/JVI.76.9.4625-4633.2002.
    • (2002) J Virol , vol.76 , pp. 4625-4633
    • Lundquist, C.A.1    Tobiume, M.2    Zhou, J.3    Unutmaz, D.4    Aiken, C.5
  • 5
    • 0030684068 scopus 로고    scopus 로고
    • Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation
    • Greenberg ME, Bronson S, Lock M, Neumann M, Pavlakis GN, Skowronski J. 1997. Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation. EMBO J 16:6964-6976. http://dx.doi.org/10.1093/emboj/16.23.6964.
    • (1997) EMBO J , vol.16 , pp. 6964-6976
    • Greenberg, M.E.1    Bronson, S.2    Lock, M.3    Neumann, M.4    Pavlakis, G.N.5    Skowronski, J.6
  • 6
    • 23844509821 scopus 로고    scopus 로고
    • HIV nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent
    • Jin YJ, Cai CY, Zhang XP, Zhang HT, Hirst JA, Burakoff SJ. 2005. HIV nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent. J Immunol 175:3157-3164. http://dx.doi.org/10.4049/jimmunol.175.5.3157.
    • (2005) J Immunol , vol.175 , pp. 3157-3164
    • Jin, Y.J.1    Cai, C.Y.2    Zhang, X.P.3    Zhang, H.T.4    Hirst, J.A.5    Burakoff, S.J.6
  • 7
    • 0033515427 scopus 로고    scopus 로고
    • Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes
    • Piguet V, Gu F, Foti M, Demaurex N, Gruenberg J, Carpentier JL, Trono D. 1999. Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes. Cell 97:63-73. http://dx.doi.org/10.1016/S0092-8674(00)80715-1.
    • (1999) Cell , vol.97 , pp. 63-73
    • Piguet, V.1    Gu, F.2    Foti, M.3    Demaurex, N.4    Gruenberg, J.5    Carpentier, J.L.6    Trono, D.7
  • 8
    • 0032076086 scopus 로고    scopus 로고
    • Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4
    • Lu XB, Yu HF, Liu SH, Brodsky FM, Peterlin BM. 1998. Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4. Immunity 8:647-656. http://dx.doi.org/10.1016/S1074-7613(00)80569-5.
    • (1998) Immunity , vol.8 , pp. 647-656
    • Lu, X.B.1    Yu, H.F.2    Liu, S.H.3    Brodsky, F.M.4    Peterlin, B.M.5
  • 9
    • 0034713437 scopus 로고    scopus 로고
    • Interactions of HIV-1 Nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif
    • Craig HM, Reddy TR, Riggs NL, Dao PP, Guatelli JC. 2000. Interactions of HIV-1 Nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif. Virology 271:9-17. http://dx.doi.org/10.1006/viro.2000.0277.
    • (2000) Virology , vol.271 , pp. 9-17
    • Craig, H.M.1    Reddy, T.R.2    Riggs, N.L.3    Dao, P.P.4    Guatelli, J.C.5
  • 10
    • 0030920271 scopus 로고    scopus 로고
    • Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation
    • Liu LX, Margottin F, LeGall S, Schwartz O, Selig L, Benarous R, Benichou S. 1997. Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation. J Biol Chem 272: 13779-13785. http://dx.doi.org/10.1074/jbc.272.21.13779.
    • (1997) J Biol Chem , vol.272 , pp. 13779-13785
    • Liu, L.X.1    Margottin, F.2    LeGall, S.3    Schwartz, O.4    Selig, L.5    Benarous, R.6    Benichou, S.7
  • 12
    • 84924118537 scopus 로고    scopus 로고
    • Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation
    • Landi A, Vermeire J, Iannucci V, Vanderstraeten H, Naessens E, Bentahir M, Verhasselt B. 2014. Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation. Retrovirology 11:118. http://dx.doi.org/10.1186/s12977-014-0118-4.
    • (2014) Retrovirology , vol.11 , pp. 118
    • Landi, A.1    Vermeire, J.2    Iannucci, V.3    Vanderstraeten, H.4    Naessens, E.5    Bentahir, M.6    Verhasselt, B.7
  • 13
    • 0035080263 scopus 로고    scopus 로고
    • Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP
    • Janvier K, Craig H, Le Gall S, Benarous R, Guatelli J, Schwartz O, Benichou S. 2001. Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP. J Virol 75:3971-3976.http://dx.doi.org/10.1128/JVI.75.8.3971-3976.2001.
    • (2001) J Virol , vol.75 , pp. 3971-3976
    • Janvier, K.1    Craig, H.2    Le Gall, S.3    Benarous, R.4    Guatelli, J.5    Schwartz, O.6    Benichou, S.7
  • 14
    • 50849129910 scopus 로고    scopus 로고
    • HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells
    • Schaefer MR, Wonderlich ER, Roeth JF, Leonard JA, Collins KL. 2008. HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells. PLoS Pathog 4:e1000131. http://dx.doi.org/10.1371/journal.ppat.1000131.
    • (2008) PLoS Pathog , vol.4
    • Schaefer, M.R.1    Wonderlich, E.R.2    Roeth, J.F.3    Leonard, J.A.4    Collins, K.L.5
  • 15
    • 33745122662 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways
    • Roeth JF, Collins KL. 2006. Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways. Microbiol Mol Biol Rev 70:548-563. http://dx.doi.org/10.1128/MMBR.00042-05.
    • (2006) Microbiol Mol Biol Rev , vol.70 , pp. 548-563
    • Roeth, J.F.1    Collins, K.L.2
  • 17
    • 84904133963 scopus 로고    scopus 로고
    • The intraviral protein interaction network of hepatitis C virus
    • Hagen N, Bayer K, Rosch K, Schindler M. 2014. The intraviral protein interaction network of hepatitis C virus. Mol Cell Proteomics 13:1676-1689.http://dx.doi.org/10.1074/mcp.M113.036301.
    • (2014) Mol Cell Proteomics , vol.13 , pp. 1676-1689
    • Hagen, N.1    Bayer, K.2    Rosch, K.3    Schindler, M.4
  • 20
    • 0032530773 scopus 로고    scopus 로고
    • Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity
    • Craig HM, Pandori MW, Guatelli JC. 1998. Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity. Proc Natl Acad Sci U S A 95:11229-11234. http://dx.doi.org/10.1073/pnas.95.19.11229.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 11229-11234
    • Craig, H.M.1    Pandori, M.W.2    Guatelli, J.C.3
  • 21
    • 34247129671 scopus 로고    scopus 로고
    • Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor
    • Chaudhuri R, Lindwasser OW, Smith WJ, Hurley JH, Bonifacino JS. 2007. Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor. J Virol 81:3877-3890. http://dx.doi.org/10.1128/JVI.02725-06.
    • (2007) J Virol , vol.81 , pp. 3877-3890
    • Chaudhuri, R.1    Lindwasser, O.W.2    Smith, W.J.3    Hurley, J.H.4    Bonifacino, J.S.5
  • 22
    • 0141521574 scopus 로고    scopus 로고
    • Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles
    • Schindler M, Wurfl S, Benaroch P, Greenough TC, Daniels R, Easterbrook P, Brenner M, Munch J, Kirchhoff F. 2003. Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles. J Virol 77:10548-10556.http://dx.doi.org/10.1128/JVI.77.19.10548-10556.2003.
    • (2003) J Virol , vol.77 , pp. 10548-10556
    • Schindler, M.1    Wurfl, S.2    Benaroch, P.3    Greenough, T.C.4    Daniels, R.5    Easterbrook, P.6    Brenner, M.7    Munch, J.8    Kirchhoff, F.9
  • 23
    • 50949130687 scopus 로고    scopus 로고
    • Lysine 144, a ubiquitin attachment site in HIV-1 Nef, is required for Nef-mediated CD4 down-regulation
    • Jin YJ, Cai CY, Zhang XP, Burakoff SJ. 2008. Lysine 144, a ubiquitin attachment site in HIV-1 Nef, is required for Nef-mediated CD4 down-regulation. J Immunol 180:7878-7886. http://dx.doi.org/10.4049/jimmunol.180.12.7878.
    • (2008) J Immunol , vol.180 , pp. 7878-7886
    • Jin, Y.J.1    Cai, C.Y.2    Zhang, X.P.3    Burakoff, S.J.4
  • 24
    • 0141730449 scopus 로고    scopus 로고
    • The di-leucine motif in the cytoplasmic tail of CD4 is not required for binding to human immunodeficiency virus type 1 Nef, but is critical for CD4 down-modulation
    • Bentham M, Mazaleyrat S, Harris M. 2003. The di-leucine motif in the cytoplasmic tail of CD4 is not required for binding to human immunodeficiency virus type 1 Nef, but is critical for CD4 down-modulation. J Gen Virol 84:2705-2713. http://dx.doi.org/10.1099/vir.0.19274-0.
    • (2003) J Gen Virol , vol.84 , pp. 2705-2713
    • Bentham, M.1    Mazaleyrat, S.2    Harris, M.3
  • 25
    • 33644584737 scopus 로고    scopus 로고
    • Role of myristoylation and N-terminal basic residues in membrane association of the human immunodeficiency virus type 1 Nef protein
    • Bentham M, Mazaleyrat S, Harris M. 2006. Role of myristoylation and N-terminal basic residues in membrane association of the human immunodeficiency virus type 1 Nef protein. J Gen Virol 87:563-571. http://dx.doi.org/10.1099/vir.0.81200-0.
    • (2006) J Gen Virol , vol.87 , pp. 563-571
    • Bentham, M.1    Mazaleyrat, S.2    Harris, M.3
  • 26
    • 0029795040 scopus 로고    scopus 로고
    • The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR
    • Grzesiek S, Stahl SJ, Wingfield PT, Bax A. 1996. The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR. Biochemistry 35:10256-10261.
    • (1996) Biochemistry , vol.35 , pp. 10256-10261
    • Grzesiek, S.1    Stahl, S.J.2    Wingfield, P.T.3    Bax, A.4
  • 27
    • 0028180868 scopus 로고
    • Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
    • Aiken C, Konner J, Landau NR, Lenburg ME, Trono D. 1994. Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 76:853-864. http://dx.doi.org/10.1016/0092-8674(94)90360-3.
    • (1994) Cell , vol.76 , pp. 853-864
    • Aiken, C.1    Konner, J.2    Landau, N.R.3    Lenburg, M.E.4    Trono, D.5
  • 28
    • 0032525137 scopus 로고    scopus 로고
    • The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes
    • Greenberg ME, Iafrate AJ, Skowronski J. 1998. The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes. EMBO J 17:2777-2789. http://dx.doi.org/10.1093/emboj/17.10.2777.
    • (1998) EMBO J , vol.17 , pp. 2777-2789
    • Greenberg, M.E.1    Iafrate, A.J.2    Skowronski, J.3
  • 29
    • 0242300205 scopus 로고    scopus 로고
    • Inhibition of human immunodeficiency virus type 1 replication in primary macrophages by using Tat-or CCR5-specific small interfering RNAs expressed from a lentivirus vector
    • Lee MTM, Coburn GA, McClure MO, Cullen BR. 2003. Inhibition of human immunodeficiency virus type 1 replication in primary macrophages by using Tat-or CCR5-specific small interfering RNAs expressed from a lentivirus vector. J Virol 77:11964-11972. http://dx.doi.org/10.1128/JVI.77.22.11964-11972.2003.
    • (2003) J Virol , vol.77 , pp. 11964-11972
    • Lee, M.T.M.1    Coburn, G.A.2    McClure, M.O.3    Cullen, B.R.4
  • 30
    • 82955188782 scopus 로고    scopus 로고
    • An enhanced monomeric blue fluorescent protein with the high chemical stability of the chromophore
    • Subach OM, Cranfill PJ, Davidson MW, Verkhusha VV. 2011. An enhanced monomeric blue fluorescent protein with the high chemical stability of the chromophore. PLoS One 6:e28674. http://dx.doi.org/10.1371/journal.pone.0028674.
    • (2011) PLoS One , vol.6
    • Subach, O.M.1    Cranfill, P.J.2    Davidson, M.W.3    Verkhusha, V.V.4
  • 32
    • 33746799703 scopus 로고    scopus 로고
    • Contribution of Vpu, Env, and Nef to CD4 down-modulation and resistance of human immunodeficiency virus type 1-infected T cells to superinfection
    • Wildum S, Schindler M, Munch J, Kirchhoff F. 2006. Contribution of Vpu, Env, and Nef to CD4 down-modulation and resistance of human immunodeficiency virus type 1-infected T cells to superinfection. J Virol 80:8047-8059. http://dx.doi.org/10.1128/JVI.00252-06.
    • (2006) J Virol , vol.80 , pp. 8047-8059
    • Wildum, S.1    Schindler, M.2    Munch, J.3    Kirchhoff, F.4


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