Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping

EMBO Journal

Volumn 35, Issue 15, 2016, Pages 1628-1643

  Fukumori, Akio ^a,b   Steiner, Harald ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

Author keywords

exosite; intramembrane proteolysis; photocrosslinking; substrate recognition; secretase

Indexed keywords

GAMMA SECRETASE; NICASTRIN; PRESENILIN 2;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN DEGRADATION;

EID: 84980325882     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201694151     Document Type: Article

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