Structural basis of human γ-secretase assembly

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 19, 2015, Pages 6003-6008

  Sun, Linfeng ^a   Zhao, Lingyun ^a   Yang, Guanghui ^a   Yan, Chuangye ^a   Zhou, Rui ^a   Zhou, Xiaoyuan ^a   Xie, Tian ^a   Zhao, Yanyu ^a   Wu, Shenjie ^a   Li, Xueming ^a   Shi, Yigong ^a  

^a TSINGHUA UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Cryo EM structure; Intramembrane protease; Presenilin; secretase

Indexed keywords

DIGITONIN; GAMMA SECRETASE; LYSOZYME; NICASTRIN; PRESENILIN 1; APH1A PROTEIN, HUMAN; DETERGENT; MEMBRANE PROTEIN; NICASTRIN PROTEIN; PEPTIDE HYDROLASE; PROTEIN BINDING; PSEN1 PROTEIN, HUMAN; PSENEN PROTEIN, HUMAN; SECRETASE;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYST; CRYOELECTRON MICROSCOPY; CRYSTAL STRUCTURE; ENZYME STRUCTURE; GLYCOSYLATION; HUMAN; PRIORITY JOURNAL; WILD TYPE; CATALYSIS; CELL MEMBRANE; CHEMISTRY; HEK293 CELL LINE; IMAGE PROCESSING; METABOLISM; PROTEIN SECONDARY STRUCTURE;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; CATALYSIS; CELL MEMBRANE; CRYOELECTRON MICROSCOPY; DETERGENTS; DIGITONIN; HEK293 CELLS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; PEPTIDE HYDROLASES; PRESENILIN-1; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY;

EID: 84929206964     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1506242112     Document Type: Article

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