Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease

EMBO Molecular Medicine

Volumn 8, Issue 5, 2016, Pages 458-465

  Kretner, Benedikt ^a,b   Trambauer, Johannes ^a   Fukumori, Akio ^b   Mielke, Janina ^a   Kuhn, Peer Hendrik ^b,c   Kremmer, Elisabeth ^d,e   Giese, Armin ^a   Lichtenthaler, Stefan F ^b,c,d   Haass, Christian ^a,b,d   Arzberger, Thomas ^a,b,f   Steiner, Harald ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d Technische Universität München Munich Cluster for Systems Neurology   (Germany)

^e INSTITUTE OF EPIDEMIOLOGY   (Germany)

^f LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Alzheimer's disease; Amyloid peptide 43; Neurodegeneration; Presenilin; secretase

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN 43; LEUCINE; MUTANT PROTEIN; PHENYLALANINE; PRESENILIN 1; UNCLASSIFIED DRUG; AMYLOID BETA-PROTEIN (1-43); PEPTIDE FRAGMENT; PSEN1 PROTEIN, HUMAN;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; MOLECULAR PATHOLOGY; MUTATION; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; WILD TYPE; FRONTAL LOBE; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MICROSCOPY; PATHOLOGY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; FRONTAL LOBE; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSCOPY; MUTANT PROTEINS; PEPTIDE FRAGMENTS; PRESENILIN-1;

EID: 84961266479     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201505952     Document Type: Article

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