Aph-1 associates directly with full-length and C-terminal fragments of γ-secretase substrates

Journal of Biological Chemistry

Volumn 285, Issue 15, 2010, Pages 11378-11391

  Chen, Allen C ^a   Guo, Lucie Y ^a   Ostaszewski, Beth L ^a   Selkoe, Dennis J ^a   LaVoie, Matthew J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; BI-DIRECTIONAL; C-TERMINAL FRAGMENTS; CO-IMMUNOPRECIPITATIONS; IN-SITU; INTRAMEMBRANE PROTEOLYSIS; ISOFORMS; LIVING CELL; MULTIPLE SYSTEMS; NICASTRIN; PRESENILINS; PROTEIN LEVEL; SECRETASE COMPLEX; SECRETASES; SIGNALING PATHWAYS;

COMPLEXATION; GLYCOPROTEINS; PROTEINS;

SUBSTRATES;

AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; GAMMA SECRETASE; HISTIDINE DERIVATIVE; ISOPROTEIN; JAGGED1;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; RAT;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HISTIDINE; HUMANS; LENTIVIRUS; MEMBRANE PROTEINS; MICE; PRESENILINS; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77951236521     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.088815     Document Type: Article

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