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Volumn 12, Issue 7, 2016, Pages 385-397

Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BEVACIZUMAB; CRYOPYRIN; CYCLOOXYGENASE 2; DAMAGE ASSOCIATED MOLECULAR PATTERN; FORMYLPEPTIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; JANUS KINASE; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; NOTCH RECEPTOR; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; STAT PROTEIN; STAT3 PROTEIN; TEMSIROLIMUS; TOFACITINIB; TUMOR NECROSIS FACTOR INHIBITOR; UNCLASSIFIED DRUG; HIF1A PROTEIN, HUMAN; NOTCH3 RECEPTOR;

EID: 84969981431     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2016.69     Document Type: Review
Times cited : (286)

References (152)
  • 1
    • 0034901463 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: Oxygen homeostasis and disease pathophysiology
    • Semenza, G. L. Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol. Med. 7, 345-350 (2001).
    • (2001) Trends Mol. Med. , vol.7 , pp. 345-350
    • Semenza, G.L.1
  • 2
    • 84877000835 scopus 로고    scopus 로고
    • Sensing hypoxia: Physiology, genetics and epigenetics
    • Prabhakar, N. R. Sensing hypoxia: physiology, genetics and epigenetics. J. Physiol. 591, 2245-2257 (2013).
    • (2013) J. Physiol. , vol.591 , pp. 2245-2257
    • Prabhakar, N.R.1
  • 3
    • 77955003794 scopus 로고    scopus 로고
    • Synovial tissue hypoxia and inflammation in vivo
    • Ng, C. T. et al. Synovial tissue hypoxia and inflammation in vivo. Ann. Rheum. Dis. 69, 1389-1395 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 1389-1395
    • Ng, C.T.1
  • 4
    • 77649132515 scopus 로고    scopus 로고
    • Angiogenesis and blood vessel stability in inflammatory arthritis
    • Kennedy, A. et al. Angiogenesis and blood vessel stability in inflammatory arthritis. Arthritis Rheum. 62, 711-721 (2010).
    • (2010) Arthritis Rheum. , vol.62 , pp. 711-721
    • Kennedy, A.1
  • 5
    • 79953729067 scopus 로고    scopus 로고
    • Tumor necrosis factor blocking therapy alters joint inflammation and hypoxia
    • Kennedy, A. et al. Tumor necrosis factor blocking therapy alters joint inflammation and hypoxia. Arthritis Rheum. 63, 923-932 (2011).
    • (2011) Arthritis Rheum. , vol.63 , pp. 923-932
    • Kennedy, A.1
  • 7
    • 0028199835 scopus 로고
    • Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis
    • Koch, A. E. et al. Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis. J. Immunol. 152, 4149-4156 (1994).
    • (1994) J. Immunol. , vol.152 , pp. 4149-4156
    • Koch, A.E.1
  • 8
    • 0032504752 scopus 로고    scopus 로고
    • Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization
    • Asahara, T. et al. Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization. Circ. Res. 83, 233-240 (1998).
    • (1998) Circ. Res. , vol.83 , pp. 233-240
    • Asahara, T.1
  • 9
    • 0033580889 scopus 로고    scopus 로고
    • Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
    • Holash, J. et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 284, 1994-1998 (1999).
    • (1999) Science , vol.284 , pp. 1994-1998
    • Holash, J.1
  • 10
    • 77955638772 scopus 로고    scopus 로고
    • Regulation of the angiopoietin-Tie ligand-receptor system with a novel splice variant of Tie1 reduces the severity of murine arthritis
    • Malik, N. M. et al. Regulation of the angiopoietin-Tie ligand-receptor system with a novel splice variant of Tie1 reduces the severity of murine arthritis. Rheumatology (Oxford) 49, 1828-1839 (2010).
    • (2010) Rheumatology (Oxford) , vol.49 , pp. 1828-1839
    • Malik, N.M.1
  • 11
    • 18644372654 scopus 로고    scopus 로고
    • Gene therapy targeting the Tie2 function ameliorates collagen-induced arthritis and protects against bone destruction
    • Chen, Y., Donnelly, E., Kobayashi, H., Debusk, L. M. & Lin, P. C. Gene therapy targeting the Tie2 function ameliorates collagen-induced arthritis and protects against bone destruction. Arthritis Rheum. 52, 1585-1594 (2005).
    • (2005) Arthritis Rheum. , vol.52 , pp. 1585-1594
    • Chen, Y.1    Donnelly, E.2    Kobayashi, H.3    Debusk, L.M.4    Lin, P.C.5
  • 12
    • 80051728761 scopus 로고    scopus 로고
    • Toll-like receptor 2 induced angiogenesis and invasion is mediated through the Tie2 signalling pathway in rheumatoid arthritis
    • Saber, T. et al. Toll-like receptor 2 induced angiogenesis and invasion is mediated through the Tie2 signalling pathway in rheumatoid arthritis. PLoS ONE 6, e23540 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e23540
    • Saber, T.1
  • 14
    • 0037309635 scopus 로고    scopus 로고
    • Angiopoietins, growth factors, and vascular morphology in early arthritis
    • Fearon, U. et al. Angiopoietins, growth factors, and vascular morphology in early arthritis. J. Rheumatol. 30, 260-268 (2003).
    • (2003) J. Rheumatol. , vol.30 , pp. 260-268
    • Fearon, U.1
  • 15
    • 84912052316 scopus 로고    scopus 로고
    • Redox-mediated angiogenesis in the hypoxic joint of inflammatory arthritis
    • Biniecka, M. et al. Redox-mediated angiogenesis in the hypoxic joint of inflammatory arthritis. Arthritis Rheumatol. 66, 3300-3310 (2014).
    • (2014) Arthritis Rheumatol. , vol.66 , pp. 3300-3310
    • Biniecka, M.1
  • 16
    • 0141504018 scopus 로고    scopus 로고
    • The role of reactive oxygen species in homeostasis and degradation of cartilage
    • Henrotin, Y. E., Bruckner, P. & Pujol, J. P. The role of reactive oxygen species in homeostasis and degradation of cartilage. Osteoarthritis Cartilage 11, 747-755 (2003).
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 747-755
    • Henrotin, Y.E.1    Bruckner, P.2    Pujol, J.P.3
  • 17
    • 0036954803 scopus 로고    scopus 로고
    • phox-containing NAD(P)H oxidase in vascular endothelial growth factor-induced signaling and angiogenesis
    • phox-containing NAD(P)H oxidase in vascular endothelial growth factor-induced signaling and angiogenesis. Circ. Res. 91, 1160-1167 (2002).
    • (2002) Circ. Res. , vol.91 , pp. 1160-1167
    • Ushio-Fukai, M.1
  • 18
    • 84942782007 scopus 로고    scopus 로고
    • Maintaining ancient organelles: Mitochondrial biogenesis and maturation
    • Vega, R. B., Horton, J. L. & Kelly, D. P. Maintaining ancient organelles: mitochondrial biogenesis and maturation. Circ. Res. 116, 1820-1834 (2015).
    • (2015) Circ. Res. , vol.116 , pp. 1820-1834
    • Vega, R.B.1    Horton, J.L.2    Kelly, D.P.3
  • 19
    • 33644992894 scopus 로고    scopus 로고
    • Mitochondrial DNA maintenance and bioenergetics
    • Stuart, J. A. & Brown, M. F. Mitochondrial DNA maintenance and bioenergetics. Biochim. Biophys. Acta 1757, 79-89 (2006).
    • (2006) Biochim. Biophys. Acta , vol.1757 , pp. 79-89
    • Stuart, J.A.1    Brown, M.F.2
  • 20
    • 84951182516 scopus 로고    scopus 로고
    • The roles of mitochondrial damage-associated molecular patterns in diseases
    • Nakahira, K., Hisata, S. & Choi, A. M. The roles of mitochondrial damage-associated molecular patterns in diseases. Antioxid. Redox Signal. 23, 1392-1350 (2015).
    • (2015) Antioxid. Redox Signal. , vol.23 , pp. 1392-1450
    • Nakahira, K.1    Hisata, S.2    Choi, A.M.3
  • 21
    • 43349100442 scopus 로고    scopus 로고
    • Redox signalling and the inflammatory response in rheumatoid arthritis
    • Filippin, L. I., Vercelino, R., Marroni, N. P. & Xavier, R. M. Redox signalling and the inflammatory response in rheumatoid arthritis. Clin. Exp. Immunol. 152, 415-422 (2008).
    • (2008) Clin. Exp. Immunol. , vol.152 , pp. 415-422
    • Filippin, L.I.1    Vercelino, R.2    Marroni, N.P.3    Xavier, R.M.4
  • 22
    • 77957747011 scopus 로고    scopus 로고
    • Bone loss caused by iron overload in a murine model: Importance of oxidative stress
    • Tsay, J. et al. Bone loss caused by iron overload in a murine model: importance of oxidative stress. Blood 116, 2582-2589 (2010).
    • (2010) Blood , vol.116 , pp. 2582-2589
    • Tsay, J.1
  • 23
    • 0027198331 scopus 로고
    • Oxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseases
    • Bashir, S., Harris, G., Denman, M. A., Blake, D. R. & Winyard, P. G. Oxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseases. Ann. Rheum. Dis. 52, 659-666 (1993).
    • (1993) Ann. Rheum. Dis. , vol.52 , pp. 659-666
    • Bashir, S.1    Harris, G.2    Denman, M.A.3    Blake, D.R.4    Winyard, P.G.5
  • 24
    • 0028235917 scopus 로고
    • 8-Hydroxydeoxyguanosine. A marker of oxidative DNA damage in systemic lupus erythematosus
    • Lunec, J., Herbert, K., Blount, S., Griffiths, H. R. & Emery, P. 8-Hydroxydeoxyguanosine. A marker of oxidative DNA damage in systemic lupus erythematosus. FEBS Lett. 348, 131-138 (1994).
    • (1994) FEBS Lett. , vol.348 , pp. 131-138
    • Lunec, J.1    Herbert, K.2    Blount, S.3    Griffiths, H.R.4    Emery, P.5
  • 25
    • 1642549520 scopus 로고    scopus 로고
    • Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis
    • Hajizadeh, S., DeGroot, J., TeKoppele, J. M., Tarkowski, A. & Collins, L. V. Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis. Arthritis Res. Ther. 5, R234-R240 (2003).
    • (2003) Arthritis Res. Ther. , vol.5 , pp. R234-R240
    • Hajizadeh, S.1    DeGroot, J.2    TeKoppele, J.M.3    Tarkowski, A.4    Collins, L.V.5
  • 26
    • 77952963790 scopus 로고    scopus 로고
    • Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint
    • Biniecka, M. et al. Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint. Ann. Rheum. Dis. 69, 1172-1178 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 1172-1178
    • Biniecka, M.1
  • 27
    • 84865626752 scopus 로고    scopus 로고
    • Mitochondrial dysfunction increases inflammatory responsiveness to cytokines in normal human chondrocytes
    • Vaamonde-Garcia, C. et al. Mitochondrial dysfunction increases inflammatory responsiveness to cytokines in normal human chondrocytes. Arthritis Rheum. 64, 2927-2936 (2012).
    • (2012) Arthritis Rheum. , vol.64 , pp. 2927-2936
    • Vaamonde-Garcia, C.1
  • 28
    • 84902963688 scopus 로고    scopus 로고
    • Mitochondrial dysfunction promotes and aggravates the inflammatory response in normal human synoviocytes
    • Valcarcel-Ares, M. N. et al. Mitochondrial dysfunction promotes and aggravates the inflammatory response in normal human synoviocytes. Rheumatology (Oxford) 53, 1332-1343 (2014).
    • (2014) Rheumatology (Oxford) , vol.53 , pp. 1332-1343
    • Valcarcel-Ares, M.N.1
  • 29
    • 84931264535 scopus 로고    scopus 로고
    • Reactive oxygen species induce Cox-2 expression via TAK1 activation in synovial fibroblast cells
    • Onodera, Y., Teramura, T., Takehara, T., Shigi, K. & Fukuda, K. Reactive oxygen species induce Cox-2 expression via TAK1 activation in synovial fibroblast cells. FEBS Open Bio 5, 492-501 (2015).
    • (2015) FEBS Open Bio , vol.5 , pp. 492-501
    • Onodera, Y.1    Teramura, T.2    Takehara, T.3    Shigi, K.4    Fukuda, K.5
  • 30
    • 84864800622 scopus 로고    scopus 로고
    • H17 differentiation and aggravated arthritis in IEX-1-deficient mice by mitochondrial reactive oxygen species-mediated signaling
    • H17 differentiation and aggravated arthritis in IEX-1-deficient mice by mitochondrial reactive oxygen species-mediated signaling. J. Immunol. 189, 1639-1647 (2012).
    • (2012) J. Immunol. , vol.189 , pp. 1639-1647
    • Zhi, L.1    Ustyugova, I.V.2    Chen, X.3    Zhang, Q.4    Wu, M.X.5
  • 31
    • 34047116291 scopus 로고    scopus 로고
    • Mitochondrial point mutations do not limit the natural lifespan of mice
    • Vermulst, M. et al. Mitochondrial point mutations do not limit the natural lifespan of mice. Nat. Genet. 39, 540-543 (2007).
    • (2007) Nat. Genet. , vol.39 , pp. 540-543
    • Vermulst, M.1
  • 32
    • 79961123240 scopus 로고    scopus 로고
    • Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis
    • Biniecka, M. et al. Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis. Arthritis Rheum. 63, 2172-2182 (2011).
    • (2011) Arthritis Rheum. , vol.63 , pp. 2172-2182
    • Biniecka, M.1
  • 33
    • 55249088260 scopus 로고    scopus 로고
    • Mitochondrial depolarisation and oxidative stress in rheumatoid arthritis patients
    • Moodley, D., Mody, G., Patel, N. & Chuturgoon, A. A. Mitochondrial depolarisation and oxidative stress in rheumatoid arthritis patients. Clin. Biochem. 41, 1396-1401 (2008).
    • (2008) Clin. Biochem. , vol.41 , pp. 1396-1401
    • Moodley, D.1    Mody, G.2    Patel, N.3    Chuturgoon, A.A.4
  • 34
    • 25144461499 scopus 로고    scopus 로고
    • Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes
    • Da Sylva, T. R., Connor, A., Mburu, Y., Keystone, E. & Wu, G. E. Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes. Arthritis Res Ther. 7, R844-R851 (2005).
    • (2005) Arthritis Res Ther. , vol.7 , pp. R844-R851
    • Da Sylva, T.R.1    Connor, A.2    Mburu, Y.3    Keystone, E.4    Wu, G.E.5
  • 35
    • 79960613859 scopus 로고    scopus 로고
    • Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis
    • Biniecka, M. et al. Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis. Arthritis Res. Ther. 13, R121 (2011).
    • (2011) Arthritis Res. Ther. , vol.13 , pp. R121
    • Biniecka, M.1
  • 36
    • 79952184583 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)
    • Bulua, A. C. et al. Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J. Exp. Med. 208, 519-533 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 519-533
    • Bulua, A.C.1
  • 37
    • 84857918542 scopus 로고    scopus 로고
    • Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis
    • Harty, L. C. et al. Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis. Ann. Rheum. Dis. 71, 582-588 (2012).
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 582-588
    • Harty, L.C.1
  • 38
    • 0033038486 scopus 로고    scopus 로고
    • Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis
    • Deng, G. M., Nilsson, I. M., Verdrengh, M., Collins, L. V. & Tarkowski, A. Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis. Nat. Med. 5, 702-705 (1999).
    • (1999) Nat. Med. , vol.5 , pp. 702-705
    • Deng, G.M.1    Nilsson, I.M.2    Verdrengh, M.3    Collins, L.V.4    Tarkowski, A.5
  • 39
    • 2642573579 scopus 로고    scopus 로고
    • Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses
    • Collins, L. V., Hajizadeh, S., Holme, E., Jonsson, I. M. & Tarkowski, A. Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses. J. Leukoc. Biol. 75, 995-1000 (2004).
    • (2004) J. Leukoc. Biol. , vol.75 , pp. 995-1000
    • Collins, L.V.1    Hajizadeh, S.2    Holme, E.3    Jonsson, I.M.4    Tarkowski, A.5
  • 40
    • 84899570365 scopus 로고    scopus 로고
    • Mitochondrial DNA induces inflammation and increases TLR9/NF-κB expression in lung tissue
    • Zhang, J. Z., Liu, Z., Liu, J., Ren, J. X. & Sun, T. S. Mitochondrial DNA induces inflammation and increases TLR9/NF-κB expression in lung tissue. Int. J. Mol. Med. 33, 817-824 (2014).
    • (2014) Int. J. Mol. Med. , vol.33 , pp. 817-824
    • Zhang, J.Z.1    Liu, Z.2    Liu, J.3    Ren, J.X.4    Sun, T.S.5
  • 41
    • 84938876306 scopus 로고    scopus 로고
    • Oxidative modification enhances the immunostimulatory effects of extracellular mitochondrial DNA on plasmacytoid dendritic cells
    • Pazmandi, K. et al. Oxidative modification enhances the immunostimulatory effects of extracellular mitochondrial DNA on plasmacytoid dendritic cells. Free Radic. Biol. Med. 77, 281-290 (2014).
    • (2014) Free Radic. Biol. Med. , vol.77 , pp. 281-290
    • Pazmandi, K.1
  • 42
    • 84879845082 scopus 로고    scopus 로고
    • Molecular biology for formyl peptide receptors in human diseases
    • Li, Y. & Ye, D. Molecular biology for formyl peptide receptors in human diseases. J. Mol. Med. (Berl.) 91, 781-789 (2013).
    • (2013) J. Mol. Med. (Berl.) , vol.91 , pp. 781-789
    • Li, Y.1    Ye, D.2
  • 43
    • 84905985090 scopus 로고    scopus 로고
    • A formyl peptide receptor agonist suppresses inflammation and bone damage in arthritis
    • Kao, W. et al. A formyl peptide receptor agonist suppresses inflammation and bone damage in arthritis. Br. J. Pharmacol. 171, 4087-4096 (2014).
    • (2014) Br. J. Pharmacol. , vol.171 , pp. 4087-4096
    • Kao, W.1
  • 44
    • 79951642032 scopus 로고    scopus 로고
    • Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
    • Nakahira, K. et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat. Immunol. 12, 222-230 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 222-230
    • Nakahira, K.1
  • 45
    • 33749261659 scopus 로고    scopus 로고
    • Adenosine 5?-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation
    • Bours, M. J., Swennen, E. L., Di Virgilio, F., Cronstein, B. N. & Dagnelie, P. C. Adenosine 5?-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol. Ther. 112, 358-404 (2006).
    • (2006) Pharmacol. Ther. , vol.112 , pp. 358-404
    • Bours, M.J.1    Swennen, E.L.2    Di Virgilio, F.3    Cronstein, B.N.4    Dagnelie, P.C.5
  • 46
    • 81755177800 scopus 로고    scopus 로고
    • 7 receptor in infectious diseases
    • 7 receptor in infectious diseases. PLoS Pathog. 7, e1002212 (2011).
    • (2011) PLoS Pathog. , vol.7 , pp. e1002212
    • Miller, C.M.1
  • 47
    • 84897018493 scopus 로고    scopus 로고
    • Dual role of autophagy in stress-induced cell death in rheumatoid arthritis synovial fibroblasts
    • Kato, M., Ospelt, C., Gay, R. E., Gay, S. & Klein, K. Dual role of autophagy in stress-induced cell death in rheumatoid arthritis synovial fibroblasts. Arthritis Rheumatol. 66, 40-48 (2014).
    • (2014) Arthritis Rheumatol. , vol.66 , pp. 40-48
    • Kato, M.1    Ospelt, C.2    Gay, R.E.3    Gay, S.4    Klein, K.5
  • 48
    • 84951807395 scopus 로고    scopus 로고
    • Autophagy induction contributes to the resistance to methotrexate treatment in rheumatoid arthritis fibroblast-like synovial cells through high mobility group box chromosomal protein 1
    • Xu, K. et al. Autophagy induction contributes to the resistance to methotrexate treatment in rheumatoid arthritis fibroblast-like synovial cells through high mobility group box chromosomal protein 1. Arthritis Res. Ther. 17, 374 (2015).
    • (2015) Arthritis Res. Ther. , vol.17 , pp. 374
    • Xu, K.1
  • 49
    • 78651393239 scopus 로고    scopus 로고
    • A role for mitochondria in NLRP3 inflammasome activation
    • Zhou, R., Yazdi, A. S., Menu, P. & Tschopp, J. A role for mitochondria in NLRP3 inflammasome activation. Nature 469, 221-225 (2011).
    • (2011) Nature , vol.469 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3    Tschopp, J.4
  • 50
    • 79961132978 scopus 로고    scopus 로고
    • Glycolysis and rheumatoid arthritis
    • Chang, X. & Wei, C. Glycolysis and rheumatoid arthritis. Int. J. Rheum. Dis. 14, 217-222 (2011).
    • (2011) Int. J. Rheum. Dis. , vol.14 , pp. 217-222
    • Chang, X.1    Wei, C.2
  • 51
    • 63349105399 scopus 로고    scopus 로고
    • Effects of hypoxia on glucose transport in primary equine chondrocytes in vitro and evidence of reduced GLUT1 gene expression in pathologic cartilage in vivo
    • Peansukmanee, S. et al. Effects of hypoxia on glucose transport in primary equine chondrocytes in vitro and evidence of reduced GLUT1 gene expression in pathologic cartilage in vivo. J. Orthop. Res. 27, 529-535 (2009).
    • (2009) J. Orthop. Res. , vol.27 , pp. 529-535
    • Peansukmanee, S.1
  • 52
    • 77953221111 scopus 로고    scopus 로고
    • Oxidant conditioning protects cartilage from mechanically induced damage
    • Ramakrishnan, P. et al. Oxidant conditioning protects cartilage from mechanically induced damage. J. Orthop. Res. 28, 914-920 (2010).
    • (2010) J. Orthop. Res. , vol.28 , pp. 914-920
    • Ramakrishnan, P.1
  • 53
    • 0018340481 scopus 로고
    • Glycolytic activity in human synovial lining cells in rheumatoid arthritis
    • Henderson, B., Bitensky, L. & Chayen, J. Glycolytic activity in human synovial lining cells in rheumatoid arthritis. Ann. Rheum. Dis. 38, 63-67 (1979).
    • (1979) Ann. Rheum. Dis. , vol.38 , pp. 63-67
    • Henderson, B.1    Bitensky, L.2    Chayen, J.3
  • 54
    • 0027405652 scopus 로고
    • An investigation of the abnormal metabolic status of synovial fluid from patients with rheumatoid arthritis by high field proton nuclear magnetic resonance spectroscopy
    • Naughton, D. et al. An investigation of the abnormal metabolic status of synovial fluid from patients with rheumatoid arthritis by high field proton nuclear magnetic resonance spectroscopy.FEBS Lett. 317, 135-138 (1993).
    • (1993) FEBS Lett. , vol.317 , pp. 135-138
    • Naughton, D.1
  • 55
    • 33847142327 scopus 로고    scopus 로고
    • Correlation between different components of synovial fluid and pathogenesis of rheumatic diseases
    • Ciurtin, C. et al. Correlation between different components of synovial fluid and pathogenesis of rheumatic diseases. Rom. J. Intern. Med. 44, 171-181 (2006).
    • (2006) Rom. J. Intern. Med. , vol.44 , pp. 171-181
    • Ciurtin, C.1
  • 56
    • 68149171810 scopus 로고    scopus 로고
    • Characterization of synovial tissue from arthritis patients: A proton magnetic resonance spectroscopic investigation
    • Hitchon, C. A., El-Gabalawy, H. S. & Bezabeh, T. Characterization of synovial tissue from arthritis patients: a proton magnetic resonance spectroscopic investigation. Rheumatol. Int. 29, 1205-1211 (2009).
    • (2009) Rheumatol. Int. , vol.29 , pp. 1205-1211
    • Hitchon, C.A.1    El-Gabalawy, H.S.2    Bezabeh, T.3
  • 57
    • 0030886724 scopus 로고    scopus 로고
    • Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium
    • Firestein, G. S., Echeverri, F., Yeo, M., Zvaifler, N. J. & Green, D. R. Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium. Proc. Natl Acad. Sci. USA 94, 10895-10900 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 10895-10900
    • Firestein, G.S.1    Echeverri, F.2    Yeo, M.3    Zvaifler, N.J.4    Green, D.R.5
  • 58
    • 0034142176 scopus 로고    scopus 로고
    • Rheumatoid arthritis and p53: How oxidative stress might alter the course of inflammatory diseases
    • Tak, P. P., Zvaifler, N. J., Green, D. R. & Firestein, G. S. Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases. Immunol. Today 21, 78-82 (2000).
    • (2000) Immunol. Today , vol.21 , pp. 78-82
    • Tak, P.P.1    Zvaifler, N.J.2    Green, D.R.3    Firestein, G.S.4
  • 59
    • 84933039838 scopus 로고    scopus 로고
    • HIF-1α and PFKFB3 mediate a tight relationship between proinflammatory activation and anerobic metabolism in atherosclerotic macrophages
    • Tawakol, A. et al. HIF-1α and PFKFB3 mediate a tight relationship between proinflammatory activation and anerobic metabolism in atherosclerotic macrophages. Arterioscler. Thromb. Vasc. Biol. 35, 1463-1471 (2015).
    • (2015) Arterioscler. Thromb. Vasc. Biol. , vol.35 , pp. 1463-1471
    • Tawakol, A.1
  • 60
    • 84941260856 scopus 로고    scopus 로고
    • Monocytes from patients with rheumatoid arthritis and type 2 diabetes mellitus display an increased production of interleukin (IL)-1b via the nucleotide-binding domain and leucine-rich repeat containing family pyrin 3 (NLRP3)-inflammasome activation: A possible implication for therapeutic decision in these patients
    • Ruscitti, P. et al. Monocytes from patients with rheumatoid arthritis and type 2 diabetes mellitus display an increased production of interleukin (IL)-1b via the nucleotide-binding domain and leucine-rich repeat containing family pyrin 3 (NLRP3)-inflammasome activation: a possible implication for therapeutic decision in these patients. Clin. Exp. Immunol. 182, 35-44 (2015).
    • (2015) Clin. Exp. Immunol. , vol.182 , pp. 35-44
    • Ruscitti, P.1
  • 61
    • 10744233368 scopus 로고    scopus 로고
    • Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells
    • Makino, Y. et al. Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells. J. Immunol. 171, 6534-6540 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 6534-6540
    • Makino, Y.1
  • 62
    • 72449133970 scopus 로고    scopus 로고
    • + T cells to pathophysiological hypoxia: A transcriptome analysis
    • + T cells to pathophysiological hypoxia: a transcriptome analysis. J. Rheumatol. 36, 2655-2669 (2009).
    • (2009) J. Rheumatol. , vol.36 , pp. 2655-2669
    • Gaber, T.1
  • 63
    • 20444429440 scopus 로고    scopus 로고
    • TCR engagement increases hypoxia-inducible factor-1α protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells
    • Nakamura, H. et al. TCR engagement increases hypoxia-inducible factor-1α protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells. J. Immunol. 174, 7592-7599 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 7592-7599
    • Nakamura, H.1
  • 64
    • 27544490377 scopus 로고    scopus 로고
    • + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6, 1123-1132 (2005).
    • (2005) Nat. Immunol. , vol.6 , pp. 1123-1132
    • Harrington, L.E.1
  • 66
    • 56349093347 scopus 로고    scopus 로고
    • - effector T cells
    • - effector T cells. Nat. Immunol. 9, 1347-1355 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 1347-1355
    • Dardalhon, V.1
  • 67
    • 0034606348 scopus 로고    scopus 로고
    • CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    • Schaerli, P. et al. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J. Exp. Med. 192, 1553-1562 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 1553-1562
    • Schaerli, P.1
  • 68
    • 84891838421 scopus 로고    scopus 로고
    • H17 cells in autoimmune arthritis
    • H17 cells in autoimmune arthritis. Nat. Med. 20, 62-68 (2014).
    • (2014) Nat. Med. , vol.20 , pp. 62-68
    • Komatsu, N.1
  • 69
    • 80052015098 scopus 로고    scopus 로고
    • IL-17A expression is localised to both mononuclear and polymorphonuclear synovial cell infiltrates
    • Moran, E. M. et al. IL-17A expression is localised to both mononuclear and polymorphonuclear synovial cell infiltrates. PLoS ONE 6, e24048 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e24048
    • Moran, E.M.1
  • 70
    • 80052277906 scopus 로고    scopus 로고
    • REG balance by hypoxia-inducible factor 1
    • REG balance by hypoxia-inducible factor 1. Cell 146, 772-784 (2011).
    • (2011) Cell , vol.146 , pp. 772-784
    • Dang, E.V.1
  • 71
    • 79960369458 scopus 로고    scopus 로고
    • REG cells
    • REG cells. J. Exp. Med. 208, 1367-1376 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 1367-1376
    • Shi, L.Z.1
  • 72
    • 84936818691 scopus 로고    scopus 로고
    • H17 lineage cells are resistant to regulatory T cell-mediated suppression in the context of autoimmunity
    • H17 lineage cells are resistant to regulatory T cell-mediated suppression in the context of autoimmunity. J. Immunol. 195, 528-540 (2015).
    • (2015) J. Immunol. , vol.195 , pp. 528-540
    • Basdeo, S.A.1
  • 73
    • 84867381718 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1α-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
    • Clambey, E. T. et al. Hypoxia-inducible factor-1α-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc. Natl Acad. Sci. USA 109, E2784-E2793 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. E2784-E2793
    • Clambey, E.T.1
  • 74
    • 47249118348 scopus 로고    scopus 로고
    • Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway
    • Shime, H. et al. Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway. J. Immunol. 180, 7175-7183 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 7175-7183
    • Shime, H.1
  • 75
    • 84938702403 scopus 로고    scopus 로고
    • Lactate regulates metabolic and pro-inflammatory circuits in control of T cell migration and effector functions
    • Haas, R. et al. Lactate regulates metabolic and pro-inflammatory circuits in control of T cell migration and effector functions. PLoS Biol. 13, e1002202 (2015).
    • (2015) PLoS Biol. , vol.13 , pp. e1002202
    • Haas, R.1
  • 76
    • 29144513474 scopus 로고    scopus 로고
    • Standardisation of synovial tissue infiltrate analysis: How far have we come? How much further do we need to go?
    • Smith, M. D. et al. Standardisation of synovial tissue infiltrate analysis: how far have we come? How much further do we need to go? Ann. Rheum. Dis. 65, 93-100 (2006).
    • (2006) Ann. Rheum. Dis. , vol.65 , pp. 93-100
    • Smith, M.D.1
  • 77
    • 0037423948 scopus 로고    scopus 로고
    • HIF-1α is essential for myeloid cell-mediated inflammation
    • Cramer, T. et al. HIF-1α is essential for myeloid cell-mediated inflammation. Cell 11 2, 645-657 (2003).
    • (2003) Cell , vol.112 , pp. 645-657
    • Cramer, T.1
  • 78
    • 84864740633 scopus 로고    scopus 로고
    • Human monocytes and macrophages differ in their mechanisms of adaptation to hypoxia
    • Fangradt, M. et al. Human monocytes and macrophages differ in their mechanisms of adaptation to hypoxia. Arthritis Res. Ther. 14, R181 (2012).
    • (2012) Arthritis Res. Ther. , vol.14 , pp. R181
    • Fangradt, M.1
  • 79
    • 0141425768 scopus 로고    scopus 로고
    • Hypoxia-induced gene expression in human macrophages: Implications for ischemic tissues and hypoxia-regulated gene therapy
    • Burke, B. et al. Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy. Am. J. Pathol. 163, 1233-1243 (2003).
    • (2003) Am. J. Pathol. , vol.163 , pp. 1233-1243
    • Burke, B.1
  • 81
    • 84866542725 scopus 로고    scopus 로고
    • Hypoxia enhances the proliferative response of macrophages to CSF-1 and their pro-survival response to TNF
    • Hamilton, J. A. et al. Hypoxia enhances the proliferative response of macrophages to CSF-1 and their pro-survival response to TNF. PLoS ONE 7, e45853 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e45853
    • Hamilton, J.A.1
  • 82
    • 84862000246 scopus 로고    scopus 로고
    • Polarizing macrophages through reprogramming of glucose metabolism
    • Blagih, J. & Jones, R. G. Polarizing macrophages through reprogramming of glucose metabolism. Cell Metab. 15, 793-795 (2012).
    • (2012) Cell Metab. , vol.15 , pp. 793-795
    • Blagih, J.1    Jones, R.G.2
  • 83
    • 40349093192 scopus 로고    scopus 로고
    • Transcriptome of hypoxic immature dendritic cells: Modulation of chemokine/receptor expression
    • Ricciardi, A. et al. Transcriptome of hypoxic immature dendritic cells: modulation of chemokine/receptor expression. Mol. Cancer Res. 6, 175-185 (2008).
    • (2008) Mol. Cancer Res. , vol.6 , pp. 175-185
    • Ricciardi, A.1
  • 84
    • 55749095015 scopus 로고    scopus 로고
    • Divergent effects of hypoxia on dendritic cell functions
    • Mancino, A. et al. Divergent effects of hypoxia on dendritic cell functions. Blood 112, 3723-3734 (2008).
    • (2008) Blood , vol.112 , pp. 3723-3734
    • Mancino, A.1
  • 85
    • 79953109937 scopus 로고    scopus 로고
    • Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: Identification of TREM-1 as a novel hypoxic marker in vitro and in vivo
    • Bosco, M. C. et al. Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo. Blood 117, 2625-2639 (2011).
    • (2011) Blood , vol.117 , pp. 2625-2639
    • Bosco, M.C.1
  • 86
    • 84870300113 scopus 로고    scopus 로고
    • The hypoxic environment reprograms the cytokine/chemokine expression profile of human mature dendritic cells
    • Blengio, F. et al. The hypoxic environment reprograms the cytokine/chemokine expression profile of human mature dendritic cells. Immunobiology 218, 76-89 (2013).
    • (2013) Immunobiology , vol.218 , pp. 76-89
    • Blengio, F.1
  • 87
    • 57149114568 scopus 로고    scopus 로고
    • Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile
    • Elia, A. R. et al. Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile. J. Leukoc. Biol. 84, 1472-1482 (2008).
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 1472-1482
    • Elia, A.R.1
  • 88
    • 68249153389 scopus 로고    scopus 로고
    • Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cell-derived osteopontin
    • Yang, M. et al. Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cell-derived osteopontin. Immunology 128, e237-e249 (2009).
    • (2009) Immunology , vol.128 , pp. e237-e249
    • Yang, M.1
  • 89
    • 84876442403 scopus 로고    scopus 로고
    • Chronic hypoxia reprograms human immature dendritic cells by inducing a proinflammatory phenotype and TREM-1 expression
    • Pierobon, D. et al. Chronic hypoxia reprograms human immature dendritic cells by inducing a proinflammatory phenotype and TREM-1 expression. Eur. J. Immunol. 43, 949-966 (2013).
    • (2013) Eur. J. Immunol. , vol.43 , pp. 949-966
    • Pierobon, D.1
  • 90
    • 35148888161 scopus 로고    scopus 로고
    • Life with oxygen
    • Semenza, G. L. Life with oxygen. Science 318, 62-64 (2007).
    • (2007) Science , vol.318 , pp. 62-64
    • Semenza, G.L.1
  • 91
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
    • Kaelin, W. G. Jr & Ratcliffe, P. J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 30, 393-402 (2008).
    • (2008) Mol. Cell , vol.30 , pp. 393-402
    • Kaelin, W.G.1    Ratcliffe, P.J.2
  • 92
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell, P. H. et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399, 271-275 (1999).
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1
  • 93
    • 76649107352 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1-alpha (HIF-1a) is related to both angiogenesis and inflammation in rheumatoid arthritis
    • Brouwer, E. et al. Hypoxia inducible factor-1-alpha (HIF-1a) is related to both angiogenesis and inflammation in rheumatoid arthritis. Clin. Exp. Rheumatol. 27, 945-951 (2009).
    • (2009) Clin. Exp. Rheumatol. , vol.27 , pp. 945-951
    • Brouwer, E.1
  • 94
    • 0242335590 scopus 로고    scopus 로고
    • Upregulated hypoxia inducible factor-1 a and-2a pathway in rheumatoid arthritis and osteoarthritis
    • Giatromanolaki, A. et al. Upregulated hypoxia inducible factor-1 a and-2a pathway in rheumatoid arthritis and osteoarthritis. Arthritis Res. Ther. 5, R193-R201 (2003).
    • (2003) Arthritis Res. Ther. , vol.5 , pp. R193-R201
    • Giatromanolaki, A.1
  • 95
    • 84897980594 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factor-1 a provoke Toll-like receptor signalling-induced inflammation in rheumatoid arthritis
    • Hu, F et al. Hypoxia and hypoxia-inducible factor-1 a provoke Toll-like receptor signalling-induced inflammation in rheumatoid arthritis. Ann. Rheum. Dis. 73, 928-936 (2014).
    • (2014) Ann. Rheum. Dis. , vol.73 , pp. 928-936
    • Hu, F.1
  • 97
    • 84863821856 scopus 로고    scopus 로고
    • IL-17 and tumour necrosis factor a combination induces a HIF-1 a-dependent invasive phenotype in synoviocytes
    • Hot, A., Zrioual, S., Lenief, V. & Miossec, P. IL-17 and tumour necrosis factor a combination induces a HIF-1 a-dependent invasive phenotype in synoviocytes. Ann. Rheum. Dis. 71, 1393-1401 (2012).
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 1393-1401
    • Hot, A.1    Zrioual, S.2    Lenief, V.3    Miossec, P.4
  • 98
    • 84865657365 scopus 로고    scopus 로고
    • Interleukin-17A promotes rheumatoid arthritis synoviocytes migration and invasion under hypoxia by increasing MMP2 and MMP9 expression through NF-KB/HIF-1 a pathway
    • Li, G. et al. Interleukin-17A promotes rheumatoid arthritis synoviocytes migration and invasion under hypoxia by increasing MMP2 and MMP9 expression through NF-KB/HIF-1 a pathway. Mol. Immunol. 53, 227-236 (2013).
    • (2013) Mol. Immunol. , vol.53 , pp. 227-236
    • Li, G.1
  • 99
    • 84863258259 scopus 로고    scopus 로고
    • Hypoxia differentially affects IL-1 p-stimulated MMP-1 and MMP-13 expression of fibroblast-like synoviocytes in an HIF-1a-dependent manner
    • Lee, Y. A. et al. Hypoxia differentially affects IL-1 p-stimulated MMP-1 and MMP-13 expression of fibroblast-like synoviocytes in an HIF-1a-dependent manner. Rheumatology (Oxford) 51, 443-450 (2012).
    • (2012) Rheumatology (Oxford) , vol.51 , pp. 443-450
    • Lee, Y.A.1
  • 100
    • 52649153089 scopus 로고    scopus 로고
    • Hypoxia appears at pre-arthritic stage and shows co-localization with early synovial inflammation in collagen induced arthritis
    • Jeon, C. H. et al. Hypoxia appears at pre-arthritic stage and shows co-localization with early synovial inflammation in collagen induced arthritis. Clin. Exp. Rheumatol. 26, 646-648 (2008).
    • (2008) Clin. Exp. Rheumatol. , vol.26 , pp. 646-648
    • Jeon, C.H.1
  • 101
    • 70349774436 scopus 로고    scopus 로고
    • Human inflammatory synovial fibroblasts induce enhanced myeloid cell recruitment and angiogenesis through a hypoxia-inducible transcription factor 1a/vascular endothelial growth factor-mediated pathway in immunodeficient mice
    • del Rey, M. J. et al. Human inflammatory synovial fibroblasts induce enhanced myeloid cell recruitment and angiogenesis through a hypoxia-inducible transcription factor 1a/vascular endothelial growth factor-mediated pathway in immunodeficient mice. Arthritis Rheum. 60, 2926-2934 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 2926-2934
    • Del Rey, M.J.1
  • 102
    • 84926643950 scopus 로고    scopus 로고
    • The protective effects of chronic intermittent hypobaric hypoxia pretreatment against collagen-induced arthritis in rats
    • Shi, M. et al. The protective effects of chronic intermittent hypobaric hypoxia pretreatment against collagen-induced arthritis in rats. J. Inflamm. (Lond.) 12, 23 (2015).
    • (2015) J. Inflamm. (Lond.) , vol.12 , pp. 23
    • Shi, M.1
  • 103
    • 84861424521 scopus 로고    scopus 로고
    • An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes
    • Darce, J. et al. An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes. Immunity 36, 731-741 (2012).
    • (2012) Immunity , vol.36 , pp. 731-741
    • Darce, J.1
  • 104
    • 45749145804 scopus 로고    scopus 로고
    • Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene
    • Wu, S. et al. Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene. Mol. Ther. 16, 1227-1234 (2008).
    • (2008) Mol. Ther. , vol.16 , pp. 1227-1234
    • Wu, S.1
  • 105
    • 84865660860 scopus 로고    scopus 로고
    • Prolyl hydroxylase domain enzyme 2 is the major player in regulating hypoxic responses in rheumatoid arthritis
    • Muz, B., Larsen, H., Madden, L, Kiriakidis, S. & Paleolog, E. M. Prolyl hydroxylase domain enzyme 2 is the major player in regulating hypoxic responses in rheumatoid arthritis. Arthritis Rheum. 64, 2856-2867 (2012).
    • (2012) Arthritis Rheum. , vol.64 , pp. 2856-2867
    • Muz, B.1    Larsen, H.2    Madden, L.3    Kiriakidis, S.4    Paleolog, E.M.5
  • 106
    • 84922029176 scopus 로고    scopus 로고
    • CTGF increases vascular endothelial growth factor-dependent angiogenesis in human synovial fibroblasts by increasing miR-210 expression
    • Liu, S. C. et al. CTGF increases vascular endothelial growth factor-dependent angiogenesis in human synovial fibroblasts by increasing miR-210 expression. Cell Death Dis. 5, e1485 (2014).
    • (2014) Cell Death Dis. , vol.5 , pp. e1485
    • Liu, S.C.1
  • 107
    • 84863195085 scopus 로고    scopus 로고
    • Notch-1 mediates hypoxia-induced angiogenesis in rheumatoid arthritis
    • Gao, W. et al. Notch-1 mediates hypoxia-induced angiogenesis in rheumatoid arthritis. Arthritis Rheum. 64, 2104-2113 (2012).
    • (2012) Arthritis Rheum. , vol.64 , pp. 2104-2113
    • Gao, W.1
  • 108
    • 78650416408 scopus 로고    scopus 로고
    • From vessel sprouting to normalization: Role of the prolyl hydroxylase domain protein/hypoxia-inducible factor oxygen-sensing machinery
    • Coulon, C. et al. From vessel sprouting to normalization: role of the prolyl hydroxylase domain protein/hypoxia-inducible factor oxygen-sensing machinery. Arterioscler. Thromb. Vasc. Biol. 30, 2331-2336 (2010).
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , pp. 2331-2336
    • Coulon, C.1
  • 109
    • 77954222576 scopus 로고    scopus 로고
    • Inhibition of hypoxia-inducible factor-targeting prolyl hydroxylase domain-containing protein 2 (PHD2) enhances matrix synthesis by human chondrocytes
    • Thoms, B. L. & Murphy, C. L. Inhibition of hypoxia-inducible factor-targeting prolyl hydroxylase domain-containing protein 2 (PHD2) enhances matrix synthesis by human chondrocytes. J. Biol. Chem. 285, 20472-20480 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 20472-20480
    • Thoms, B.L.1    Murphy, C.L.2
  • 110
    • 84941950636 scopus 로고    scopus 로고
    • Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis
    • Tambuwala, M. M. et al. Targeted delivery of the hydroxylase inhibitor DMOG provides enhanced efficacy with reduced systemic exposure in a murine model of colitis. J. Control. Release 217, 221-227 (2015).
    • (2015) J. Control. Release , vol.217 , pp. 221-227
    • Tambuwala, M.M.1
  • 111
    • 0038308573 scopus 로고    scopus 로고
    • Tumor necrosis factor - A causes accumulation of a ubiquitinated form of hypoxia inducible factor-1 a through a nuclear factor-KB-dependent pathway
    • Zhou, J., Schmid, T. & Brune, B. Tumor necrosis factor - A causes accumulation of a ubiquitinated form of hypoxia inducible factor-1 a through a nuclear factor-KB-dependent pathway. Mol. Biol. Cell 14, 2216-2225 (2003).
    • (2003) Mol. Biol. Cell , vol.14 , pp. 2216-2225
    • Zhou, J.1    Schmid, T.2    Brune, B.3
  • 112
    • 0347334750 scopus 로고    scopus 로고
    • IL-1 p-mediated up-regulation of HIF-1 a via an NFKB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis
    • Jung, Y J., Isaacs, J. S., Lee, S., Trepel, J. & Neckers, L. IL-1 p-mediated up-regulation of HIF-1 a via an NFKB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J. 17, 2115-2117 (2003).
    • (2003) FASEB J. , vol.17 , pp. 2115-2117
    • Jung, Y.J.1    Isaacs, J.S.2    Lee, S.3    Trepel, J.4    Neckers, L.5
  • 113
    • 84860855375 scopus 로고    scopus 로고
    • NFKB and HIF display synergistic behaviour during hypoxic inflammation
    • Bruning, U. et al. NFKB and HIF display synergistic behaviour during hypoxic inflammation. Cell. Mol. Life Sci. 69, 1319-1329 (2012).
    • (2012) Cell. Mol. Life Sci. , vol.69 , pp. 1319-1329
    • Bruning, U.1
  • 114
    • 68949207361 scopus 로고    scopus 로고
    • Hypoxia activates NF-KB-dependent gene expression through the canonical signaling pathway
    • Oliver, K. M. et al. Hypoxia activates NF-KB-dependent gene expression through the canonical signaling pathway. Antioxid. Redox Signal. 11, 2057-2064 (2009).
    • (2009) Antioxid. Redox Signal. , vol.11 , pp. 2057-2064
    • Oliver, K.M.1
  • 115
    • 77952037969 scopus 로고    scopus 로고
    • F VEGF-A expression in osteoclasts is regulated by NF-KB induction of HIF-1 a
    • Trebec-Reynolds, D. P., Voronov, I., Heersche, J. N. & Manolson, M. F VEGF-A expression in osteoclasts is regulated by NF-KB induction of HIF-1 a. J. Cell. Biochem. 110, 343-351 (2010).
    • (2010) J. Cell. Biochem. , vol.110 , pp. 343-351
    • Trebec-Reynolds, D.P.1    Voronov, I.2    Heersche, J.N.3    Manolson, M.4
  • 116
    • 84926952228 scopus 로고    scopus 로고
    • HMGB1 induces angiogenesis in rheumatoid arthritis via HIF-1 a activation
    • Park, S. Y et al. HMGB1 induces angiogenesis in rheumatoid arthritis via HIF-1 a activation. Eur. J. Immunol. 45, 1216-1227 (2015).
    • (2015) Eur. J. Immunol. , vol.45 , pp. 1216-1227
    • Park, S.Y.1
  • 117
    • 33845321931 scopus 로고    scopus 로고
    • Prolyl hydroxylase-1 negatively regulates IKB kinase-p, giving insight into hypoxia-induced NFKB activity
    • Cummins, E. P. et al. Prolyl hydroxylase-1 negatively regulates IKB kinase-p, giving insight into hypoxia-induced NFKB activity. Proc. Natl Acad. Sci. USA 103, 18154-18159 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 18154-18159
    • Cummins, E.P.1
  • 118
    • 33749518516 scopus 로고    scopus 로고
    • Posttranslational hydroxylation of ankyrin repeats in IKB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
    • Cockman, M. E. et al. Posttranslational hydroxylation of ankyrin repeats in IKB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc. Natl Acad. Sci. USA 103, 14767-14772 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 14767-14772
    • Cockman, M.E.1
  • 120
    • 33847046849 scopus 로고    scopus 로고
    • Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
    • Hellstrom, M. et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445, 776-780 (2007).
    • (2007) Nature , vol.445 , pp. 776-780
    • Hellstrom, M.1
  • 121
    • 33845642740 scopus 로고    scopus 로고
    • Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate
    • Diez, H. et al. Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. Exp. Cell Res. 313, 1-9 (2007).
    • (2007) Exp. Cell Res. , vol.313 , pp. 1-9
    • Diez, H.1
  • 122
    • 27644561755 scopus 로고    scopus 로고
    • Hypoxia requires notch signaling to maintain the undifferentiated cell state
    • Gustafsson, M. V. et al. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell 9, 617-628 (2005).
    • (2005) Dev Cell , vol.9 , pp. 617-628
    • Gustafsson, M.V.1
  • 123
    • 42149117769 scopus 로고    scopus 로고
    • Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways
    • Zheng, X. et al. Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proc. Natl Acad. Sci. USA 105, 3368-3373 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 3368-3373
    • Zheng, X.1
  • 124
    • 0030765924 scopus 로고    scopus 로고
    • STATs, cytokine signal transduction, and immunoregulation: Are we there yet?
    • O'Shea, J. J. Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet? Immunity 7, 1-11 (1997).
    • (1997) Immunity , vol.7 , pp. 1-11
    • O'Shea, J.1    Jaks, J.2
  • 125
    • 0036884944 scopus 로고    scopus 로고
    • Rheumatoid arthritis synoviocyte survival is dependent on Stat3
    • Krause, A., Scaletta, N., Ji, J. D. & Ivashkiv, L. B. Rheumatoid arthritis synoviocyte survival is dependent on Stat3. J. Immunol. 169, 6610-6616 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 6610-6616
    • Krause, A.1    Scaletta, N.2    Ji, J.D.3    Ivashkiv, L.B.4
  • 126
    • 80055117937 scopus 로고    scopus 로고
    • IL-1 p and TNFa-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis
    • Mori, T. et al. IL-1 p and TNFa-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis. Int. Immunol. 23, 701-712 (2011).
    • (2011) Int. Immunol. , vol.23 , pp. 701-712
    • Mori, T.1
  • 127
    • 79954620949 scopus 로고    scopus 로고
    • A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis
    • Stump, K. L. et al. A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis. Arthritis Res. Ther. 13, R68 (2011).
    • (2011) Arthritis Res. Ther. , vol.13 , pp. R68
    • Stump, K.L.1
  • 128
    • 84934985384 scopus 로고    scopus 로고
    • Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis
    • Gao, W. et al. Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis. Ann. Rheum. Dis. 74, 1275-1283 (2015).
    • (2015) Ann. Rheum. Dis. , vol.74 , pp. 1275-1283
    • Gao, W.1
  • 129
    • 79953171126 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1a enhances haptoglobin gene expression by improving binding of STAT3 to the promoter
    • Oh, M. K. et al. Hypoxia-inducible factor-1a enhances haptoglobin gene expression by improving binding of STAT3 to the promoter. J. Biol. Chem. 286, 8857-8865 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 8857-8865
    • Oh, M.K.1
  • 130
    • 23444449093 scopus 로고    scopus 로고
    • STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells
    • Jung, J. E. et al. STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells. FASEB J. 19, 1296-1298 (2005).
    • (2005) FASEB J. , vol.19 , pp. 1296-1298
    • Jung, J.E.1
  • 131
    • 57349168511 scopus 로고    scopus 로고
    • STAT3 inhibits the degradation of HIF-1 a by pVHL-mediated ubiquitination
    • Jung, J. E. et al. STAT3 inhibits the degradation of HIF-1 a by pVHL-mediated ubiquitination. Exp. Mol. Med. 40, 479-485 (2008).
    • (2008) Exp. Mol. Med. , vol.40 , pp. 479-485
    • Jung, J.E.1
  • 132
    • 77958553885 scopus 로고    scopus 로고
    • Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification
    • Cai, Q., Verma, S. C, Kumar, P., Ma, M. & Robertson, E. S. Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification. PLoS ONE 5, e9720 (2010).
    • (2010) PLoS ONE , vol.5 , pp. e9720
    • Cai, Q.1    Verma, S.C.2    Kumar, P.3    Ma, M.4    Robertson, E.S.5
  • 133
    • 72449173021 scopus 로고    scopus 로고
    • Notch signal activates hypoxia pathway through HES1-dependent SRC/signal transducers and activators of transcription 3 pathway Mol
    • Lee, J. H. et al. Notch signal activates hypoxia pathway through HES1-dependent SRC/signal transducers and activators of transcription 3 pathway Mol. Cancer Res. 7, 1663-1671 (2009).
    • (2009) Cancer Res. , vol.7 , pp. 1663-1671
    • Lee, J.H.1
  • 134
    • 84855708762 scopus 로고    scopus 로고
    • HIF-1a is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway
    • Qiang, L. et al. HIF-1a is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway. Cell Death Differ. 19, 284-294 (2012).
    • (2012) Cell Death Differ. , vol.19 , pp. 284-294
    • Qiang, L.1
  • 135
    • 71249105739 scopus 로고    scopus 로고
    • Jagged1 regulates the activation of astrocytes via modulation of NFKB and JAK/STAT/SOCS pathways
    • Morga, E. et al. Jagged1 regulates the activation of astrocytes via modulation of NFKB and JAK/STAT/SOCS pathways. Glia 57, 1741-1753 (2009).
    • (2009) Glia , vol.57 , pp. 1741-1753
    • Morga, E.1
  • 136
    • 0034814370 scopus 로고    scopus 로고
    • Neutralization of vascular endothelial growth factor prevents collagen-induced arthritis and ameliorates established disease in mice
    • Sone, H. et al. Neutralization of vascular endothelial growth factor prevents collagen-induced arthritis and ameliorates established disease in mice. Biochem. Biophys. Res. Commun. 281, 562-568 (2001).
    • (2001) Biochem. Biophys. Res. Commun. , vol.281 , pp. 562-568
    • Sone, H.1
  • 137
    • 10744228170 scopus 로고    scopus 로고
    • Blockade of vascular endothelial growth factor receptor i (VEGF-RI), but not VEGF-RII, suppresses joint destruction in the K/BxN model of rheumatoid arthritis
    • De Bandt, M. et al. Blockade of vascular endothelial growth factor receptor I (VEGF-RI), but not VEGF-RII, suppresses joint destruction in the K/BxN model of rheumatoid arthritis. J. Immunol. 171, 4853-4859 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 4853-4859
    • De Bandt, M.1
  • 138
    • 84888200948 scopus 로고    scopus 로고
    • Avastin exhibits therapeutic effects on collagen-induced arthritis in rat model
    • Wang, Y., Da, G., Li, H. & Zheng, Y Avastin exhibits therapeutic effects on collagen-induced arthritis in rat model. Inflammation 36, 1460-1467 (2013).
    • (2013) Inflammation , vol.36 , pp. 1460-1467
    • Wang, Y.1    Da, G.2    Li, H.3    Zheng, Y.4
  • 139
    • 37349048502 scopus 로고    scopus 로고
    • Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition
    • Robinson, A. et al. Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology 134, 145-155 (2008).
    • (2008) Gastroenterology , vol.134 , pp. 145-155
    • Robinson, A.1
  • 140
    • 3342955379 scopus 로고    scopus 로고
    • Novel mechanism of action for hydralazine: Induction of hypoxia-inducible factor-1 a, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases
    • Knowles, H. J., Tian, Y. M., Mole, D. R. & Harris, A. L. Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1 a, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases. Circ. Res. 95, 162-169 (2004).
    • (2004) Circ. Res. , vol.95 , pp. 162-169
    • Knowles, H.J.1    Tian, Y.M.2    Mole, D.R.3    Harris, A.L.4
  • 141
    • 84859445000 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: Mediators of cancer progression and targets for cancer therapy
    • Semenza, G. L. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy Trends Pharmacol. Sci. 33, 207-214 (2012).
    • (2012) Trends Pharmacol. Sci. , vol.33 , pp. 207-214
    • Semenza, G.L.1
  • 142
    • 2942724235 scopus 로고    scopus 로고
    • MTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
    • Majumder, P. K. et al. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat. Med. 10, 594-601 (2004).
    • (2004) Nat. Med. , vol.10 , pp. 594-601
    • Majumder, P.K.1
  • 143
    • 84896490241 scopus 로고    scopus 로고
    • PKM2, STAT3 and HIF-1a: The Warburg's vicious circle
    • Demaria, M. & Poli, V. PKM2, STAT3 and HIF-1a: the Warburg's vicious circle. JAKSTAT 1, 194-196 (2012).
    • (2012) JAKSTAT , vol.1 , pp. 194-196
    • Demaria, M.1    Poli, V.2
  • 144
    • 84866842363 scopus 로고    scopus 로고
    • Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
    • Anastasiou, D. et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat. Chem. Biol. 8, 839-847 (2012).
    • (2012) Nat. Chem. Biol. , vol.8 , pp. 839-847
    • Anastasiou, D.1
  • 145
    • 67650553603 scopus 로고    scopus 로고
    • MTOR: Taking cues from the immune microenvironment
    • Delgoffe, G. M. & Powell, J. D. mTOR: taking cues from the immune microenvironment. Immunology 127, 459-465 (2009).
    • (2009) Immunology , vol.127 , pp. 459-465
    • Delgoffe, G.M.1    Powell, J.D.2
  • 146
    • 84857910484 scopus 로고    scopus 로고
    • Autophagy activation by rapamycin reduces severity of experimental osteoarthritis
    • Carames, B. et al. Autophagy activation by rapamycin reduces severity of experimental osteoarthritis. Ann. Rheum. Dis. 71, 575-581 (2012).
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 575-581
    • Carames, B.1
  • 147
    • 84935036182 scopus 로고    scopus 로고
    • Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis
    • Zhang, Y. et al. Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis. Ann. Rheum. Dis. 74, 1432-1440 (2015).
    • (2015) Ann. Rheum. Dis. , vol.74 , pp. 1432-1440
    • Zhang, Y.1
  • 148
    • 84907228811 scopus 로고    scopus 로고
    • Metformin attenuates experimental autoimmune arthritis through reciprocal regulation of Th17/Treg balance and osteoclastogenesis
    • Son, H. J. et al. Metformin attenuates experimental autoimmune arthritis through reciprocal regulation of Th17/Treg balance and osteoclastogenesis. Mediators Inflamm. 2014, 973986 (2014).
    • (2014) Mediators Inflamm. , vol.2014 , pp. 973986
    • Son, H.J.1
  • 149
    • 84983410554 scopus 로고    scopus 로고
    • Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation
    • Yan, H., Zhou, H. F, Hu, Y & Pham, C. T. Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation. J. Rheum. Dis. Treat. 1, 5 (2015).
    • (2015) J. Rheum. Dis. Treat. , vol.1 , pp. 5
    • Yan, H.1    Zhou, H.F.2    Hu, Y.3    Pham, C.T.4
  • 150
    • 0015089140 scopus 로고
    • Synovial fluid pH, lactate, oxygen and carbon dioxide partial pressure in various joint diseases
    • Treuhaft, P. S. & D. J., M. C. Synovial fluid pH, lactate, oxygen and carbon dioxide partial pressure in various joint diseases. Arthritis Rheum. 14, 475-484 (1971).
    • (1971) Arthritis Rheum. , vol.14 , pp. 475-484
    • Treuhaft, P.S.1
  • 151
    • 0014878083 scopus 로고
    • Oxygen tension in synovial fluids
    • Lund-Olesen, K. Oxygen tension in synovial fluids. Arthritis Rheum. 13, 769-776 (1970).
    • (1970) Arthritis Rheum. , vol.13 , pp. 769-776
    • Lund-Olesen, K.1
  • 152
    • 38849135497 scopus 로고    scopus 로고
    • Synovial hypoxia as a cause of tendon rupture in rheumatoid arthritis
    • Sivakumar, B. et al. Synovial hypoxia as a cause of tendon rupture in rheumatoid arthritis. J. Hand Surg. Am. 33, 49-58 (2008).
    • (2008) J. Hand Surg. Am. , vol.33 , pp. 49-58
    • Sivakumar, B.1


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