Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: Identification of TREM-1 as a novel hypoxic marker in vitro and in vivo

Blood

Volumn 117, Issue 9, 2011, Pages 2625-2639

  Bosco, Maria Carla ^a   Pierobon, Daniele ^b,c   Blengio, Fabiola ^a   Raggi, Federica ^a   Vanni, Cristina ^a   Gattorno, Marco ^a   Eva, Alessandra ^a   Novelli, Francesco ^b,c   Cappello, Paola ^b,c   Giovarelli, Mirella ^b,c   Varesio, Luigi ^a  

^a G GASLINI INSTITUTE   (Italy)

^b MOLINETTE HOSPITAL   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; HYPOXIA INDUCIBLE FACTOR; OXYGEN; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1;

ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CELL SURFACE; CHILD; CONTROLLED STUDY; DENDRITIC CELL; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOCOMPETENT CELL; IN VITRO STUDY; IN VIVO STUDY; JOINT; JUVENILE RHEUMATOID ARTHRITIS; MONOCYTE; NORMAL HUMAN; PHENOTYPE; PRIORITY JOURNAL; UPREGULATION;

EID: 79953109937     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-06-292136     Document Type: Article

References (50)

1. Banchereau J, Briere F, Caux C, et al. Immunobiology of dendritic cells. Annu Rev Immunol. 2000;18(4):767-811. (Pubitemid 30365397)
2. Cavanagh LL, Von Andrian UH. Travellers in many guises: the origins and destinations of dendritic cells. Immunol Cell Biol. 2002;80(5):448-462.
3. Mellman I, Steinman RM. Dendritic cells: specialized and regulated antigen processing machines. Cell. 2001;106(3):255-258. (Pubitemid 32772607)
4. Allavena P, Sica A, Vecchi A, et al. The chemokine receptor switch paradigm and dendritic cell migration: its significance in tumor tissues. Immunol Rev. 2000;177(1):141-149.
5. Rama I, Brune B, Torras J, et al. Hypoxia stimulus: an adaptive immune response during dendritic cell maturation. Kidney Int. 2008;73(7):816-825. (Pubitemid 351398285)
6. Bosco MC, Puppo M, Blengio F, et al. Monocytes and dendritic cells in a hypoxic environment: spotlights on chemotaxis and migration. Immunobiology. 2008;213(9):733-749.
7. Semenza GL. Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol Med. 2001;7(8):345-350. (Pubitemid 32735019)
8. Muz B, Khan MN, Kiriakidis S, Paleolog EM. Hypoxia: the role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis. Arthritis Res Ther. 2009;11(1):201-209.
9. Finger EC, Giaccia AJ. Hypoxia, inflammation, and the tumor microenvironment in metastatic disease. Cancer Metastasis Rev. 2010;29(2):285-293.
10. Cummins EP, Taylor CT. Hypoxia-responsive transcription factors. Pflugers Arch. 2005;450(6):363-371. (Pubitemid 41380694)
11. Rius J, Guma M, Schachtrup C, et al. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008;453(7196):807-811. (Pubitemid 351793778)
12. Ricciardi A, Elia AR, Cappello P, et al. Transcriptome of hypoxic immature dendritic cells: modulation of chemokine/receptor expression. Mol Cancer Res. 2008;6(2):175-185. (Pubitemid 351342405)
13. Elia AR, Cappello P, Puppo M, et al. Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile. J Leukoc Biol. 2008;84(6):1472-1482. (Pubitemid 352774482)
14. Mancino A, Schioppa T, Larghi P, et al. Divergent effects of hypoxia on dendritic cell functions. Blood. 2008;112(9):3723-3734.
15. Jantsch J, Chakravortty D, Turza N, et al. Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function. J Immunol. 2008;180(7):4697-4705.
16. Klesney-Tait J, Turnbull IR, Colonna M. The TREM receptor family and signal integration. Nat Immunol. 2006;7(12):1266-1273. (Pubitemid 46111244)
17. Bouchon A, Dietrich J, Colonna M. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol. 2000;164(10):4991-4995. (Pubitemid 30305166)
18. Ravelli A, Martini A. Juvenile idiopathic arthritis. Lancet. 2007;369(9563):767-778.
19. Bosco MC, Delfino S, Ferlito F, et al. Hypoxic synovial environment and expression of macrophage inflammatory protein MIP-3 alpha/CCL20 in juvenile idiopathic arthritis. Arthritis Rheum. 2008;58(6):1833-1838. (Pubitemid 351847538)
20. Bosco MC, Delfino S, Ferlito F, et al. The hypoxic synovial environment regulates expression of vascular endothelial growth factor and osteopontin in juvenile idiopathic arthritis. J Rheumatol. 2009;36(6):1318-1329.
21. Bosco MC, Puppo M, Santangelo C, et al. Hypoxia modifies the transcriptome of primary human monocytes: modulation of novel immunerelated genes and identification of CC-chemokine ligand 20 as a new hypoxia-inducible gene. J Immunol. 2006;177(3):1941-1955. (Pubitemid 44092535)
22. Ivanov S, Liao SY, Ivanova A, et al. Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. Am J Pathol. 2001;158(3):905-919. (Pubitemid 32221783)
23. Smolewska E, Stanczyk J, Brozik H, et al. Distribution and clinical significance of blood dendritic cells in children with juvenile idiopathic arthritis. Ann Rheum Dis. 2008;67(6):762-768. (Pubitemid 351829375)
24. Sharif O, Knapp S. From expression to signaling: roles of TREM-1 and TREM-2 in innate immunity and bacterial infection. Immunobiology. 2008;213(9):701-713.
25. Tessarz AS, Cerwenka A. The TREM-1/DAP12 pathway. Immunol Lett. 2008;116(2):111-116.
26. Collins CE, La DT, Yang HT, et al. Elevated synovial expression of triggering receptor expressed on myeloid cells 1 in patients with septic arthritis or rheumatoid arthritis. Ann Rheum Dis. 2009;68(11):1768-1774.
27. Kuai J, Gregory B, Hill A, et al. TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines. Rheumatology (Oxford). 2009;48(11):1352-1358.
28. Bosco MC, Varesio L. Monocytic cell gene regulation by the hypoxic synovial environment in juvenile idiopathic arthritis: implications for disease pathogenesis. J Clin Rheumatol Musculoskel Med. 2010;1(1):47-55.
29. Lutzky V, Hannawi S, Thomas R. Cells of the synovium in rheumatoid arthritis: dendritic cells. Arthritis Res Ther. 2007;9(4):219-231.
30. Yang M, Ma C, Liu S, et al. Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cell-derived osteopontin. Immunology. 2009;128(1):e237-e249.
31. Wang Q, Liu C, Zhu F, et al. Reoxygenation of hypoxia-differentiated dendritic cells induces Th1 and Th17 cell differentiation. Mol Immunol. 2010;47(4):922-931.
32. Zhao W, Darmanin S, Fu Q, et al. Hypoxia suppresses the production of matrix metalloproteinases and the migration of human monocyte-derived dendritic cells. Eur J Immunol. 2005;35(12):3468-3477. (Pubitemid 43025528)
33. Fang HY, Hughes R, Murdoch C, et al. Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood. 2009;114(4):844-859.
34. Schakel K. Dendritic cells: why can they help and hurt us. Exp Dermatol. 2009;18(3):264-273.
35. Colonna M, Nakajima H, Cella M. A family of inhibitory and activating Ig-like receptors that modulate function of lymphoid and myeloid cells. Semin Immunol. 2000;12(2):121-127. (Pubitemid 30199276)
36. Kanazawa N. Dendritic cell immunoreceptors: C-type lectin receptors for pattern-recognition and signaling on antigen-presenting cells. J Dermatol Sci. 2007;45(2):77-86. (Pubitemid 46108481)
37. Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010;11(5):373-384.
38. Bowdish DM, Gordon S. Conserved domains of the class A scavenger receptors: evolution and function. Immunol Rev. 2009;227(1):19-31.
39. Chabowski A, Gorski J, Calles-Escandon J, Tandon NN, Bonen A. Hypoxia-induced fatty acid transporter translocation increases fatty acid transport and contributes to lipid accumulation in the heart. FEBS Lett. 2006;580(15):3617-3623. (Pubitemid 43902797)
40. Brown ML, Ramprasad MP, Umeda PK, et al. A macrophage receptor for apolipoprotein B48: cloning, expression, and atherosclerosis. Proc Natl Acad Sci U S A. 2000;97(13):7488-7493. (Pubitemid 30431490)
41. Maddaluno L, Verbrugge SE, Martinoli C, et al. The adhesion molecule L1 regulates transendothelial migration and trafficking of dendritic cells. J Exp Med. 2009;206(3):623-635.
42. Hegde VL, Singh NP, Nagarkatti PS, Nagarkatti M. CD44 mobilization in allogeneic dendritic cell-T cell immunological synapse plays a key role in T cell activation. J Leukoc Biol. 2008;84(1):134-142. (Pubitemid 351960288)
43. Gerber JS, Mosser DM. Stimulatory and inhibitory signals originating from the macrophage Fcgamma receptors. Microbes Infect. 2001;3(2):131-139. (Pubitemid 32209330)
44. Mamegano K, Kuroki K, Miyashita R, et al. Association of LILRA2 (ILT1, LIR7) splice site polymorphism with systemic lupus erythematosus and microscopic polyangiitis. Genes Immun. 2008;9(3):214-223. (Pubitemid 351584187)
45. Takamatsu H, Okuno T, Kumanogoh A. Regulation of immune cell responses by semaphorins and their receptors. Cell Mol Immunol. 2010;7(2):83-88.
46. Yerkovich ST, Roponen M, Smith ME, et al. Allergen-enhanced thrombomodulin (blood dendritic cell antigen 3, CD141) expression on dendritic cells is associated with a TH2-skewed immune response. J Allergy Clin Immunol. 2009;123(1):209-216.
47. Ghosh S, Karin M. Missing pieces in the NFkappaB puzzle. Cell. 2002;109(2 suppl):S81-S96.
48. Cavaillon JM. Monocyte TREM-1 membrane expression in non-infectious inflammation. Crit Care. 2009;13(3):152-153.
49. El Mezayen R, El Gazzar M, Seeds MC, et al. Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin. Immunol Lett. 2007;111(1):36-44. (Pubitemid 47017473)
50. Foell D, Wittkowski H, Roth J. Mechanisms of disease: a 'DAMP' view of inflammatory arthritis. Nat Clin Pract Rheumatol. 2007;3(7):382-390.