Ex vivo isolation and characterization of CD4+CD25+ T cells with regulatory properties from human blood

Journal of Experimental Medicine

Volumn 193, Issue 11, 2001, Pages 1303-1310

  Dieckmann, Detlef ^a   Plottner, Heidi ^a   Berchtold, Susanne ^a   Berger, Thomas ^a   Schuler, Gerald ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Anergy; CD4+CD25+ T cells; Dendritic cells; Immune tolerance; Regulatory T cells

Indexed keywords

ANTIGEN SPECIFICITY; ARTICLE; CELL ISOLATION; CELL PROLIFERATION; CLONAL ANERGY; DENDRITIC CELL; EFFECTOR CELL; GENE DELETION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; PRIORITY JOURNAL; RECEPTOR UPREGULATION; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD; ANTIGENS, CD4; ANTIGENS, DIFFERENTIATION; CELL SEPARATION; HUMANS; IMMUNE TOLERANCE; IMMUNOCONJUGATES; IMMUNOPHENOTYPING; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTES, REGULATORY;

EID: 0035806244     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.193.11.1303     Document Type: Article

References (29)

1. Peripheral selection of the T cell repertoire
2. + thymocytes
3. A cell culture model for T lymphocyte clonal anergy
4. Self-ignorance in the peripheral T-cell pool
5. Immunologic self-tolerance by activated T cells expressing IL-2 receptor α chains (CD25): Breakdown of a single mechanism of self-tolerance causes various autoimmune disease
6. + naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
7. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
8. + T cells: A common basis between tumor immunity and autoimmunity
9. + immunoregulatory T cells is antigen nonspecific
10. Regulatory T cells in autoimmunity
11. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
12. + regulatory cells that control intestinal inflammation
13. + immunoregulatory T cells that control autoimmune diabetes
14. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
15. + T cells expressing IL-2 receptor α-chain (CD25) and having a functionally transitional nature into memory cells
16. + T cells
17. Restricted expression of p55 interleukin 2 receptor (CD25) on normal T cells
18. Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability
19. Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application
20. Dendritic cells and the control of immunity
21. + T-cell subset inhibits antigen-specific T-cell responses and prevent colitis
22. Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-β1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients
23. The emerging role of CTLA-4 as an immune attenuator
24. The role of CTLA-4 in the regulation and initiation of T-cell responses
25. + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
26. Regulatory CD4 T cells: Expression of IL-2R α chain, resistance to clonal deletion and IL-2 dependency
27. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity
28. The induction of tolerance by dendritic cells that have captured apoptotic cells
29. Differentiation of T regulatory cells by immature dendritic cells