Enhanced Th17 differentiation and aggravated arthritis in IEX-1-deficient mice by mitochondrial reactive oxygen species-mediated signaling

Journal of Immunology

Volumn 189, Issue 4, 2012, Pages 1639-1647

  Zhi, Liang ^a   Ustyugova, Irina V ^a,c   Chen, Xinyuan ^a   Zhang, Qi ^a   Wu, Mei X ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^c SANOFI PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; B CELL ACTIVATING FACTOR; CELL PROTEIN; COLLAGEN; INTERLEUKIN 17; MITOQUINONE; PROTEIN IEX 1; REACTIVE OXYGEN METABOLITE; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; IMMUNOPATHOGENESIS; KNOCKOUT MOUSE; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH17 CELL; WILD TYPE;

ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; CELL DIFFERENTIATION; CELL SURVIVAL; IMMEDIATE-EARLY PROTEINS; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; MITOCHONDRIA; PHENOTYPE; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; TH17 CELLS; TRANSFECTION;

EID: 84864800622     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1200528     Document Type: Article

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