Bone loss caused by iron overload in a murine model: Importance of oxidative stress

Blood

Volumn 116, Issue 14, 2010, Pages 2582-2589

  Tsay, Jaime ^a   Yang, Zheiwei ^a   Ross, F Patrick ^b   Cunningham Rundles, Susanna ^a   Lin, Hong ^a   Coleman, Rhima ^b   Mayer Kuckuk, Philipp ^b   Doty, Stephen B ^b   Grady, Robert W ^a   Giardina, Patricia J ^a   Boskey, Adele L ^b   Vogiatzi, Maria G ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; INTERLEUKIN 6; IRON DEXTRAN; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; CORTICAL BONE; DISEASE SEVERITY; HEMOCHROMATOSIS; IRON OVERLOAD; MALE; MOUSE; NONHUMAN; OSTEOLYSIS; OSTEOPOROSIS; OXIDATIVE STRESS; PRIORITY JOURNAL; THALASSEMIA; TRABECULAR BONE;

EID: 77957747011     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-12-260083     Document Type: Article

References (50)

1. Beaumont C, Delaby C. Recycling iron in normal and pathological states. Semin Hematol. 2009;46(4):328-338.
2. Muñoz M, Villar I, Garcia-Erce JA. An update on iron physiology. World J Gastroenterol. 2009;15(37):4617-4626.
3. MacKenzie EL, Iwasaki K, Tsuji Y. Intracellular iron transport and storage: from molecular mechanisms to health implications. Antioxid Redox Signal. 2008;10(6):997-1030. (Pubitemid 351451707)
4. Vogiatzi MA, Macklin EA, Fung EB, et al. Prevalence of fractures among the thalassemia syndromes in North America. Bone. 2006;38(4):571-575.
5. Vogiatzi MA, Macklin EA, Fung EB, et al. Bone disease in thalassemia: a frequent and still unresolved problem. J Bone Miner Res. 2009;24(3):543-557.
6. Guggenbuhl P, Deugnier Y, Boisdet JF, et al. Bone mineral density in men with genetic hemochromatosis and HFE gene mutation. Osteoporos Int. 2005;16(12):1809-1814. (Pubitemid 41790893)
7. Mahachoklertwattana P, Sirikulchayanonta V, Chuansumrit A, et al. Bone histomorphometry in children and adolescents with β-thalassemia disease: iron-associated focal osteomalacia. J Clin Endocrinol Metab. 2003;88(8):3966-3972. (Pubitemid 37034553)
8. Weinberg ED. Role of iron in osteoporosis. Pediatr Endocrinol Rev. 2008;6(suppl 1):81-85.
9. Isomura H, Fujie K, Shibata K, et al. Bone metabolism and oxidative stress in postmenopausal rats with iron overload. Toxicology. 2004;197(2):93-100. (Pubitemid 38293418)
10. Kudo H, Suzuki S, Watanabe A, Kikuchi H, Sassa S, Sakamoto S. Effects of colloidal iron overload on renal and hepatic siderosis and the femur in male rats. Toxicology. 2008;246(2):143-147.
11. Zarjou A, Jeney V, Arosio P, et al. Ferritin-ferroxidase activity: a potent inhibitor of osteogenesis. J Bone Miner Res. 2010;25(1):164-172.
12. Ozment CP, Turi JL. Iron overload following red blood cell transfusion and its impact on disease severity. Biochim Biophys Acta. 2009;1790(7):694-701.
13. Faibish D, Gomes A, Boivin G, Binderman I, Boskey A. Infrared imaging of calcified tissue in bone biopsies from adults with osteomalacia. Bone. 2005;36(1):6-12. (Pubitemid 40128269)
14. Boskey AL, Mendelsohn R. Infrared spectroscopic characterization of mineralized tissues. Vib Spectrosc. 2005;38(1):107-114. (Pubitemid 40973201)
15. Huang RY, Miller LM, Carlson CS, Chance MR. Characterization of bone mineral composition in the proximal tibia of cynomolgus monkeys: effect of ovariectomy and nandrolone decanoate treatment. Bone. 2002;30(3):492-497.
16. Paschalis EP, Verdelis K, Mendelsohn R, Boskey A, Yamauchi M. Spectroscopic determination of collagen cross-links in bone. J Bone Miner Res. 2001;16(10):1821-1828. (Pubitemid 32911488)
17. Boskey AL, Pleshko N, Doty SB, Mendelsohn R. Applications of Fourier transform infrared (FT-IR) microscopy to the study of mineralization in bone and cartilage. Cells Materials. 1992;2:209-220.
18. Gruber HE. Modification of Goldner's Masson Trichrome stain. Biotech Histochem. 1992;67:30-34.
19. Chevion M, Berenshtein E, Stadtman ER. Human studies related to protein oxidation: protein carbonyl content as a marker of damage. Free Radic Res. 2000;33(suppl):S99-S108. (Pubitemid 32055069)
20. Jagger CJ, Lean JM, Davies JT, Chambers TJ. Tumor necrosis factor-alpha mediates osteopenia caused by depletion of antioxidants. Endocrinology. 2005;146(1):113-118.
21. Lean JM, Davies JT, Fuller K, et al. A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J Clin Invest. 2003;112(6):915-923. (Pubitemid 38063749)
22. Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA. N-acetylcystein: a safe antidote for cystein/glutathione deficiency. Curr Opin Pharmacol. 2007;7(4):355-359.
23. Rioja L, Girot R, Garabédian M, Cournot-Witmer G. Bone disease in children with homozygous beta-thalassemia. Bone Miner. 1990;8(1):69-86. (Pubitemid 20010636)
24. Dresner Pollak R, Rachmilewitz E, Blumenfeld A, Idelson M, Goldfarb AW. Bone mineral metabolism in adults with B-thalassemia major and intermedia. Br J Haematol. 2000;111:902-907. (Pubitemid 32098930)
25. Brittenham GM, Cohen AR, McLaren CE, et al. Hepatic iron stores and plasma ferritin concentrations in patients with sickle cell anemia and thalassemia major. Am J Hematol. 1993;42(1):81-85.
26. Porter JB, Davis BA. Monitoring chelation therapy to achieve optimal outcome in the treatment of thalassemia. Best Pract Res Clin Hematol. 2002;15(2):329-368.
27. Kalantar-Zadeh K, Rodriguez RA, Humphreys MH. Association between serum ferritin and measures of inflammation, nutrition and iron in haemodialysis patients. Nephrol Dial Transplant. 2004;19(1):141-149. (Pubitemid 38072625)
28. Prieto J, Barry M, Sherlock S. Serum ferritin in patients with iron overload and with acute and chronic liver diseases. Gastroenterology. 1975;68(3):525-533.
29. Angelucci E, Brittenham GM, McLaren CE, et al Hepatic iron concentration and total body iron stores in thalassemia major. N Engl J Med. 2000;343(5):327-331. (Pubitemid 30616698)
30. Chapman RWG, Hussain M, Gorman A, et al. Effect of ascorbic acid deficiency on serum ferritin concentrations in patients with β-thalassemia major and iron overload. J Clin Pathol. 1982;35:487-491. (Pubitemid 12116757)
31. Livrea MA, Tesoriere L, Pintaudi AM, et al. Oxidative stress and antioxidant status in β-thalassemia major: iron overload and depletion of lipid soluble antioxidants. Blood. 1996;88(9):3608-3614. (Pubitemid 26365599)
32. Fain O. Musculoskeletal manifestations of scurvy. Joint Bone Spine. 2005;72(2):124-128.
33. Munday K, Fulfold A, Bates CJ. Vitamin C status and collagen cross-link ratio in Gambian children. Br J Nutr. 2005;93(4):501-507.
34. De Sanctis V, Pinamonti A, Di Palma A, et al. Growth and development in thalassaemia major patients with severe bone lesions due to desferrioxamine. Eur J Pediatr. 1996;155(5):368-372. (Pubitemid 26117670)
35. Galaris D. Pantopoulos K. Oxidative stress and iron homeostasis: mechanistic and health aspects. Crit Rev Clin Lab Sci. 2008;45(1):1-23. (Pubitemid 351299652)
36. Walter PB, Knutson MD, Paler-Martinez A, et al. Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats. Proc Natl Acad Sci U S A. 2002;99(4):2264-2269. (Pubitemid 34169049)
37. Walter PB, Fung EB, Killilea DW, et al. Oxidative stress and inflammation in iron-overloaded patients with β-thalassaemia or sickle cell disease. Br J Haematol. 2006;135(2):254-263. (Pubitemid 44401624)
38. Morabito N, Russo GT, Gaudio A, et al. The "lively" cytokines network in β-thalassemia major-related osteoporosis. Bone. 2007;40(6):1588-1594. (Pubitemid 46766649)
39. Moshtaghi-Kashanian G-R, Gholamhoseinian A, Hoseinimoghadam A, Rajabalian S. Splenectomy changes the pattern of cytokine production in β-thalassemic patients. Cytokine. 2006;35(5):253-257. (Pubitemid 44827742)
40. Porto G, De Sousa M. Iron overload and immunity. World J Gastroenterol. 2007;13(35):4707-4715.
41. Maggio D, Barabani M, Pierandrei M, et al. Marked decrease in plasma anti-oxidants in aged osteoporotic women: results of a cross-sectional study. J Clin Endocrinol Metab. 2003;88(4):1523-1527. (Pubitemid 36623364)
42. Nakashima T, Takayanagi H. The dynamic interplay between osteoclasts and the immune system. Arch Biochem Biophys. 2008;473(2):166-171.
43. Voskaridou E, Kyrtsonis MC, Tempos E, et al. Bone resorption is increased in young adults with thalassemia major. Br J Haematol. 2001;112:36-41. (Pubitemid 32151146)
44. de Vernejoul MC, Pointillart A, Golenzer CC, et al. Effect of iron overload on bone remodeling in pigs. Am J Pathol. 1984;116(3):377-384. (Pubitemid 14034003)
45. Malluche HH. Aluminium and bone disease in chronic renal failure. Nephrol Dial Transplant. 2002;17(suppl 2):21-24. (Pubitemid 34413721)
46. Teitelbaum SL. Bone resorption by osteoclasts. Science. 2000;289:1504-1508.
47. Lam J, Takeshita S, Barker JE, et al. TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest. 2000;106(12):1481-1488. (Pubitemid 32038586)
48. Zhang YH, Heulsmann A, Tondravi MM, et al. Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways. J Biol Chem. 2001;276(1):563-568. (Pubitemid 32050352)
49. Sverremark E, Fernandez C. Immunogenicity of bacterial carbohydrates: cholera toxin modulates the immune response against dextran B512. Immunology. 1997;92(1):153-159. (Pubitemid 27380895)
50. Auerbach M, Rodgers GM. Intravenous iron. N Engl J Med. 2007;357(1):93-94.