Inhibition of hypoxia-inducible factor-targeting Prolyl Hydroxylase Domain-containing Protein 2 (PHD2) enhances matrix synthesis by human chondrocytes

Journal of Biological Chemistry

Volumn 285, Issue 27, 2010, Pages 20472-20480

  Thoms, Brendan L ^a   Murphy, Christopher L ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2-OXOGLUTARATE; CARTILAGE REPAIR; CHONDROCYTES; CO-SUBSTRATE; EXTRACELLULAR MATRICES; EXTRACELLULAR MATRIX PROTEIN; HUMAN ARTICULAR CARTILAGE; HUMAN CHONDROCYTES; HYDROXYLASES; HYPOXIA-INDUCIBLE FACTORS; HYPOXIC ENVIRONMENTS; IN-VIVO; ISOFORMS; MASTER REGULATORS; MATRIX; MATRIX COMPONENTS; MATRIX SYNTHESIS; PROLYL HYDROXYLASE DOMAINS; PROTEOSOMAL DEGRADATION; TYPE II COLLAGENS; UP-REGULATION;

BODY FLUIDS; CARTILAGE; COLLAGEN; DRIVES; LIGAMENTS; MOLECULAR OXYGEN; RNA; TRANSCRIPTION; TRANSCRIPTION FACTORS;

GENE EXPRESSION REGULATION;

COLLAGEN TYPE 2; HYPOXIA INDUCIBLE FACTOR 2ALPHA; OXYGENASE; PROLYL HYDROXYLASE DOMAIN CONTAINING PROTEIN 2; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CARTILAGE CELL; CARTILAGE MATRIX; CHILD; CLINICAL ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; ENZYME INHIBITION; EXTRACELLULAR MATRIX; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MALE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN STABILITY; SCHOOL CHILD; TISSUE REPAIR; UPREGULATION;

ADOLESCENT; ADULT; BASE SEQUENCE; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHILD; CHONDROCYTES; COLLAGEN; EXTRACELLULAR MATRIX; FEMALE; GENE DELETION; HUMANS; ISOENZYMES; MALE; MIDDLE AGED; PROCOLLAGEN-PROLINE DIOXYGENASE; RNA, SMALL INTERFERING; SOX9 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 77954222576     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.115238     Document Type: Article

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