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Volumn 53, Issue 7, 2014, Pages 1332-1343

Mitochondrial dysfunction promotes and aggravates the inflammatory response in normal human synoviocytes

Author keywords

Inflammation; Mitochondria; Oxidative stress; Resveratrol; Rheumatoid arthritis; Synoviocytes

Indexed keywords

3 (4 TERT BUTYLPHENYLSULFONYL) 2 PROPENENITRILE; ACETYLCYSTEINE; ANTIMYCIN A1; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; OLIGOMYCIN; PARAQUAT; PROSTAGLANDIN E2; REACTIVE OXYGEN METABOLITE; RESVERATROL;

EID: 84902963688     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/keu016     Document Type: Article
Times cited : (63)

References (50)
  • 1
    • 77951545407 scopus 로고    scopus 로고
    • Mr Outside and Mr Inside: classic and alternative views on the pathogenesis of rheumatoid arthritis
    • Schett G, Firestein G. Mr Outside and Mr Inside: classic and alternative views on the pathogenesis of rheumatoid arthritis. Ann Rheum Dis 2010; 69:787-9.
    • (2010) Ann Rheum Dis , vol.69 , pp. 787-789
    • Schett, G.1    Firestein, G.2
  • 3
  • 4
    • 33846212773 scopus 로고    scopus 로고
    • Increased DNA damage and oxidative stress in patients with rheumatoid arthritis
    • Altindag O, Karakoc M, Kocyigit A, Celik H, Soran N. Increased DNA damage and oxidative stress in patients with rheumatoid arthritis. Clin Biochem 2007; 40:167-71.
    • (2007) Clin Biochem , vol.40 , pp. 167-171
    • Altindag, O.1    Karakoc, M.2    Kocyigit, A.3    Celik, H.4    Soran, N.5
  • 5
    • 77952963790 scopus 로고    scopus 로고
    • Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint
    • Biniecka M, Kennedy A, Fearon U et al. Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint. Ann Rheum Dis 2010; 69:1172-8.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1172-1178
    • Biniecka, M.1    Kennedy, A.2    Fearon, U.3
  • 6
    • 0036192815 scopus 로고    scopus 로고
    • Lipid peroxidation, some extracellular antioxidants, and antioxidant enzymes in serum of patients with rheumatoid arthritis
    • Taysi S, Polat F, Gul M, Sari RA, Bakan E. Lipid peroxidation, some extracellular antioxidants, and antioxidant enzymes in serum of patients with rheumatoid arthritis. Rheumatol Int 2002; 21:200-4.
    • (2002) Rheumatol Int , vol.21 , pp. 200-204
    • Taysi, S.1    Polat, F.2    Gul, M.3    Sari, R.A.4    Bakan, E.5
  • 7
    • 79953313594 scopus 로고    scopus 로고
    • Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice
    • Wruck CJ, Fragoulis A, Gurzynski A et al. Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice. Ann Rheum Dis 2011; 70:844-50.
    • (2011) Ann Rheum Dis , vol.70 , pp. 844-850
    • Wruck, C.J.1    Fragoulis, A.2    Gurzynski, A.3
  • 8
    • 79960613859 scopus 로고    scopus 로고
    • Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis
    • Biniecka M, Kennedy A, Ng CT et al. Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis. Arthritis Res Ther 2011;13: R121.
    • (2011) Arthritis Res Ther , vol.13
    • Biniecka, M.1    Kennedy, A.2    Ng, C.T.3
  • 9
    • 0642342084 scopus 로고    scopus 로고
    • Evolutionary biology: essence of mitochondria
    • Henze K, Martin W. Evolutionary biology: essence of mitochondria. Nature 2003; 426:127-8.
    • (2003) Nature , vol.426 , pp. 127-128
    • Henze, K.1    Martin, W.2
  • 10
    • 79961123240 scopus 로고    scopus 로고
    • Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis
    • Biniecka M, Fox E, Gao W et al. Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis. Arthritis Rheum 2011; 63:2172-82.
    • (2011) Arthritis Rheum , vol.63 , pp. 2172-2182
    • Biniecka, M.1    Fox, E.2    Gao, W.3
  • 11
    • 0037334593 scopus 로고    scopus 로고
    • Mitochondrial respiratory activity is altered in osteoarthritic human articular chondrocytes
    • Maneiro E, Martín M, de Andres M et al. Mitochondrial respiratory activity is altered in osteoarthritic human articular chondrocytes. Arthritis Rheum 2003; 48:700-8.
    • (2003) Arthritis Rheum , vol.48 , pp. 700-708
    • Maneiro, E.1    Martín, M.2    de Andres, M.3
  • 12
    • 77952236126 scopus 로고    scopus 로고
    • Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury
    • Ong S, Subrayan S, Lim S et al. Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury. Circulation 2010; 121:2012-22.
    • (2010) Circulation , vol.121 , pp. 2012-2022
    • Ong, S.1    Subrayan, S.2    Lim, S.3
  • 13
    • 84856415487 scopus 로고    scopus 로고
    • The role of mitochondria in insulin resistance and type 2 diabetes mellitus
    • Szendroedi J, Phielix E, Roden M. The role of mitochondria in insulin resistance and type 2 diabetes mellitus. Nat Rev Endocrinol 2011; 8:92-103.
    • (2011) Nat Rev Endocrinol , vol.8 , pp. 92-103
    • Szendroedi, J.1    Phielix, E.2    Roden, M.3
  • 14
    • 84865626752 scopus 로고    scopus 로고
    • Mitochondrial dysfunction increases inflammatory responsiveness to cytokines in normal human chondrocytes
    • Vaamonde-García C, Riveiro-Naveira RR, Valcárcel-Ares MN et al. Mitochondrial dysfunction increases inflammatory responsiveness to cytokines in normal human chondrocytes. Arthritis Rheum 2012; 64:2927-36.
    • (2012) Arthritis Rheum , vol.64 , pp. 2927-2936
    • Vaamonde-García, C.1    Riveiro-Naveira, R.R.2    Valcárcel-Ares, M.N.3
  • 15
    • 58849166887 scopus 로고    scopus 로고
    • Abnormal expression of the genes involved in cytokine networks and mitochondrial function in systemic juvenile idiopathic arthritis identified by DNA microarray analysis
    • Ishikawa S, Mima T, Aoki C et al. Abnormal expression of the genes involved in cytokine networks and mitochondrial function in systemic juvenile idiopathic arthritis identified by DNA microarray analysis. Ann Rheum Dis 2009;68: 264-72.
    • (2009) Ann Rheum Dis , vol.68 , pp. 264-272
    • Ishikawa, S.1    Mima, T.2    Aoki, C.3
  • 17
    • 4644219756 scopus 로고    scopus 로고
    • EP2/ EP4 signalling inhibits monocyte chemoattractant protein-1 production induced by interleukin 1beta in synovial fibroblasts
    • Largo R, Díez-Ortego I, Sanchez-Pernaute O et al. EP2/ EP4 signalling inhibits monocyte chemoattractant protein-1 production induced by interleukin 1beta in synovial fibroblasts. Ann Rheum Dis 2004; 63:1197-204.
    • (2004) Ann Rheum Dis , vol.63 , pp. 1197-1204
    • Largo, R.1    Díez-Ortego, I.2    Sanchez-Pernaute, O.3
  • 18
    • 49449087136 scopus 로고    scopus 로고
    • Mitochondrial dysfunction activates cyclooxygenase 2 expression in cultured normal human chondrocytes
    • Cillero-Pastor B, Caramés B, Lires-Deán M et al. Mitochondrial dysfunction activates cyclooxygenase 2 expression in cultured normal human chondrocytes. Arthritis Rheum 2008; 58:2409-19.
    • (2008) Arthritis Rheum , vol.58 , pp. 2409-2419
    • Cillero-Pastor, B.1    Caramés, B.2    Lires-Deán, M.3
  • 19
    • 77951250700 scopus 로고    scopus 로고
    • Oligomycin-induced bioenergetic adaptation in cancer cells with heterogeneous bioenergetic organization
    • Hao W, Chang CP, Tsao CC, Xu J. Oligomycin-induced bioenergetic adaptation in cancer cells with heterogeneous bioenergetic organization. J Biol Chem 2010;285: 12647-54.
    • (2010) J Biol Chem , vol.285 , pp. 12647-12654
    • Hao, W.1    Chang, C.P.2    Tsao, C.C.3    Xu, J.4
  • 20
    • 84857612440 scopus 로고    scopus 로고
    • Analysis of SF and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy
    • Wright HL, Bucknall RC, Moots RJ, Edwards SW. Analysis of SF and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy. Rheumatology 2012; 51:451-9.
    • (2012) Rheumatology , vol.51 , pp. 451-459
    • Wright, H.L.1    Bucknall, R.C.2    Moots, R.J.3    Edwards, S.W.4
  • 21
    • 1842683010 scopus 로고    scopus 로고
    • Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs
    • Johnson K, Svensson C, Etten D et al. Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs. Arthritis Rheum 2004; 50:1216-25.
    • (2004) Arthritis Rheum , vol.50 , pp. 1216-1225
    • Johnson, K.1    Svensson, C.2    Etten, D.3
  • 22
    • 77951588621 scopus 로고    scopus 로고
    • Mitochondrial DNA haplogroups modulate the serum levels of biomarkers in patients with osteoarthritis
    • Rego-Pérez I, Fernández-Moreno M, Deberg M et al. Mitochondrial DNA haplogroups modulate the serum levels of biomarkers in patients with osteoarthritis. Ann Rheum Dis 2010; 69:910-7.
    • (2010) Ann Rheum Dis , vol.69 , pp. 910-917
    • Rego-Pérez, I.1    Fernández-Moreno, M.2    Deberg, M.3
  • 23
    • 55249088260 scopus 로고    scopus 로고
    • Mitochondrial depolarisation and oxidative stress in rheumatoid arthritis patients
    • Moodley D, Mody G, Patel N, Chuturgoon AA. Mitochondrial depolarisation and oxidative stress in rheumatoid arthritis patients. Clin Biochem 2008;41: 1396-401.
    • (2008) Clin Biochem , vol.41 , pp. 1396-1401
    • Moodley, D.1    Mody, G.2    Patel, N.3    Chuturgoon, A.A.4
  • 24
    • 33646863322 scopus 로고    scopus 로고
    • Mitochondrial proteomic characterization of human normal articular chondrocytes
    • Ruiz-Romero C, López-Armada MJ, Blanco FJ. Mitochondrial proteomic characterization of human normal articular chondrocytes. Osteoarthritis Cartilage 2006; 14:507-18.
    • (2006) Osteoarthritis Cartilage , vol.14 , pp. 507-518
    • Ruiz-Romero, C.1    López-Armada, M.J.2    Blanco, F.J.3
  • 25
    • 25144436460 scopus 로고    scopus 로고
    • Somatic mutations in mitochondria: the chicken or the egg?
    • Ospelt C, Gay S. Somatic mutations in mitochondria: the chicken or the egg? Arthritis Res Ther 2005;7:179-80.
    • (2005) Arthritis Res Ther , vol.7 , pp. 179-180
    • Ospelt, C.1    Gay, S.2
  • 26
  • 27
    • 84857918542 scopus 로고    scopus 로고
    • Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis
    • Harty LC, Biniecka M, O'Sullivan J et al. Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis. Ann Rheum Dis 2012; 71:582-8.
    • (2012) Ann Rheum Dis , vol.71 , pp. 582-588
    • Harty, L.C.1    Biniecka, M.2    O'Sullivan, J.3
  • 28
    • 2642573579 scopus 로고    scopus 로고
    • Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses
    • Collins L, Hajizadeh S, Holme E, Jonsson I, Tarkowski A. Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses. J Leukoc Biol 2004; 75:995-1000.
    • (2004) J Leukoc Biol , vol.75 , pp. 995-1000
    • Collins, L.1    Hajizadeh, S.2    Holme, E.3    Jonsson, I.4    Tarkowski, A.5
  • 29
    • 50949098933 scopus 로고    scopus 로고
    • Autoimmunity and oxidatively modified autoantigens
    • Kurien BT, Scofield RH. Autoimmunity and oxidatively modified autoantigens. Autoimmun Rev 2008; 7:567-73.
    • (2008) Autoimmun Rev , vol.7 , pp. 567-573
    • Kurien, B.T.1    Scofield, R.H.2
  • 30
    • 79951594767 scopus 로고    scopus 로고
    • Mitochondrial control of the NLRP3 inflammasome
    • Kepp O, Galluzzi L, Kroemer G. Mitochondrial control of the NLRP3 inflammasome. Nat Immunol 2011;12: 199-200.
    • (2011) Nat Immunol , vol.12 , pp. 199-200
    • Kepp, O.1    Galluzzi, L.2    Kroemer, G.3
  • 31
    • 77950275298 scopus 로고    scopus 로고
    • Circulating mitochondrial DAMPs cause inflammatory responses to injury
    • Zhang Q, Raoof M, Chen Y et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 2010; 464:104-7.
    • (2010) Nature , vol.464 , pp. 104-107
    • Zhang, Q.1    Raoof, M.2    Chen, Y.3
  • 32
    • 0036838532 scopus 로고    scopus 로고
    • Modulation of cell recruitment by anti-inflammatory agents in antigen-induced arthritis
    • López-Armada MJ, Sánchez-Pernaute O, Largo R et al. Modulation of cell recruitment by anti-inflammatory agents in antigen-induced arthritis. Ann Rheum Dis 2002;61: 1027-30.
    • (2002) Ann Rheum Dis , vol.61 , pp. 1027-1030
    • López-Armada, M.J.1    Sánchez-Pernaute, O.2    Largo, R.3
  • 34
    • 0031042274 scopus 로고    scopus 로고
    • Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes
    • Crofford L, Tan B, McCarthy C, Hla T. Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes. Arthritis Rheum 1997; 40:226-36.
    • (1997) Arthritis Rheum , vol.40 , pp. 226-236
    • Crofford, L.1    Tan, B.2    McCarthy, C.3    Hla, T.4
  • 35
    • 33745044261 scopus 로고    scopus 로고
    • Cytokines, tumor necrosis factor-alpha and interleukin-1beta, differentially regulate apoptosis in osteoarthritis cultured human chondrocytes
    • López-Armada MJ, Caramés B, Lires-Deán M et al. Cytokines, tumor necrosis factor-alpha and interleukin-1beta, differentially regulate apoptosis in osteoarthritis cultured human chondrocytes. Osteoarthritis Cartilage 2006; 14:660-9.
    • (2006) Osteoarthritis Cartilage , vol.14 , pp. 660-669
    • López-Armada, M.J.1    Caramés, B.2    Lires-Deán, M.3
  • 36
    • 33745266737 scopus 로고    scopus 로고
    • Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases
    • Park J, Pillinger M, Abramson S. Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases. Clin Immunol 2006; 119:229-40.
    • (2006) Clin Immunol , vol.119 , pp. 229-240
    • Park, J.1    Pillinger, M.2    Abramson, S.3
  • 37
    • 0035943611 scopus 로고    scopus 로고
    • Prostaglandin E regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1 beta-treated human synovial fibroblasts
    • Faour WH, He Y, He QW et al. Prostaglandin E regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1 beta-treated human synovial fibroblasts. J Biol Chem 2001; 276:31720-31.
    • (2001) J Biol Chem , vol.276 , pp. 31720-31731
    • Faour, W.H.1    He, Y.2    He, Q.W.3
  • 38
    • 40049104518 scopus 로고    scopus 로고
    • 4-Hydroxynonenal-protein adducts: a reliable biomarker of lipid oxidation in liver diseases
    • Poli G, Biasi F, Leonarduzzi G. 4-Hydroxynonenal-protein adducts: a reliable biomarker of lipid oxidation in liver diseases. Mol Aspects Med 2008; 29:67-71.
    • (2008) Mol Aspects Med , vol.29 , pp. 67-71
    • Poli, G.1    Biasi, F.2    Leonarduzzi, G.3
  • 39
    • 59649098933 scopus 로고    scopus 로고
    • Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis
    • Li X, Ellman M, Muddasani P et al. Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis. Arthritis Rheum 2009; 60:513-23.
    • (2009) Arthritis Rheum , vol.60 , pp. 513-523
    • Li, X.1    Ellman, M.2    Muddasani, P.3
  • 40
    • 4043148692 scopus 로고    scopus 로고
    • Effects of hypoxia on the expression and activity of cyclooxygenase 2 in fibroblast-like synoviocytes: interactions with monocyte-derived soluble mediators
    • Demasi M, Cleland LG, Cook-Johnson RJ, James MJ. Effects of hypoxia on the expression and activity of cyclooxygenase 2 in fibroblast-like synoviocytes: interactions with monocyte-derived soluble mediators. Arthritis Rheum 2004; 50:2441-9.
    • (2004) Arthritis Rheum , vol.50 , pp. 2441-2449
    • Demasi, M.1    Cleland, L.G.2    Cook-Johnson, R.J.3    James, M.J.4
  • 41
    • 0027328056 scopus 로고
    • Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF
    • Schulze-Osthoff K, Beyaert R, Vandevoorde V, Haegeman G, Fiers W. Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF. EMBO J 1993; 12:3095-104.
    • (1993) EMBO J , vol.12 , pp. 3095-3104
    • Schulze-Osthoff, K.1    Beyaert, R.2    Vandevoorde, V.3    Haegeman, G.4    Fiers, W.5
  • 42
    • 77954105455 scopus 로고    scopus 로고
    • Mitochondrial dysfunction increases allergic airway inflammation
    • Aguilera-Aguirre L, Bacsi A, Saavedra-Molina A et al. Mitochondrial dysfunction increases allergic airway inflammation. J Immunol 2009; 183:5379-87.
    • (2009) J Immunol , vol.183 , pp. 5379-5387
    • Aguilera-Aguirre, L.1    Bacsi, A.2    Saavedra-Molina, A.3
  • 43
    • 62349092245 scopus 로고    scopus 로고
    • Atypical pathways of NF-kappaB activation and aging
    • Kriete A, Mayo KL. Atypical pathways of NF-kappaB activation and aging. Exp Gerontol 2009; 44:250-5.
    • (2009) Exp Gerontol , vol.44 , pp. 250-255
    • Kriete, A.1    Mayo, K.L.2
  • 44
    • 21244441080 scopus 로고    scopus 로고
    • Involvement of reactive oxygen species in cyclic stretch-induced NFkappaB activation in human fibroblast cells
    • Amma H, Naruse K, Ishiguro N, Sokabe M. Involvement of reactive oxygen species in cyclic stretch-induced NFkappaB activation in human fibroblast cells. Br J Pharmacol 2005; 145:364-73.
    • (2005) Br J Pharmacol , vol.145 , pp. 364-373
    • Amma, H.1    Naruse, K.2    Ishiguro, N.3    Sokabe, M.4
  • 46
  • 47
    • 82955235595 scopus 로고    scopus 로고
    • Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function
    • Xuzhu G, Komai-Koma M, Leung BP et al. Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function. Ann Rheum Dis 2012; 71:129-35.
    • (2012) Ann Rheum Dis , vol.71 , pp. 129-135
    • Xuzhu, G.1    Komai-Koma, M.2    Leung, B.P.3
  • 48
    • 51849141393 scopus 로고    scopus 로고
    • The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP production
    • Dave M, Attur M, Palmer G et al. The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP production. Arthritis Rheum 2008; 58:2786-97.
    • (2008) Arthritis Rheum , vol.58 , pp. 2786-2797
    • Dave, M.1    Attur, M.2    Palmer, G.3
  • 49
    • 84863011114 scopus 로고    scopus 로고
    • Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
    • Park SJ, Ahmad F, Philp A et al. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 2012; 148:421-33.
    • (2012) Cell , vol.148 , pp. 421-433
    • Park, S.J.1    Ahmad, F.2    Philp, A.3
  • 50
    • 77649272110 scopus 로고    scopus 로고
    • A systems biology perspective on Nrf2-mediated antioxidant response
    • Zhang Q, Pi J, Woods CG, Andersen ME. A systems biology perspective on Nrf2-mediated antioxidant response. Toxicol Appl Pharmacol 2010; 244:84-97.
    • (2010) Toxicol Appl Pharmacol , vol.244 , pp. 84-97
    • Zhang, Q.1    Pi, J.2    Woods, C.G.3    Andersen, M.E.4


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