Hypoxia differentially affects IL-1β-stimulated MMP-1 and MMP-13 expression of fibroblast-like synoviocytes in an HIF-1α-dependent manner

Rheumatology

Volumn 51, Issue 3, 2012, Pages 443-450

  Lee, Yeon Ah ^a   Choi, Hyun M ^b   Lee, Sang Hoon ^a   Hong, Seung Jae ^a   Yang, Hyung In ^a   Yoo, Myung C ^b   Kim, Kyoung S ^b  

^a Kyung Hee University   (South Korea)

^b East West Bone and Joint Research Institute   (South Korea)

Author keywords

Fibroblast like synoviocytes; Hypoxia inducible factor 1 ; Matrix metalloproteinase; Small interfering RNA; Vascular endothelial growth factor

Indexed keywords

COLLAGENASE 3; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; SMALL INTERFERING RNA; VASCULOTROPIN;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOXIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; WESTERN BLOTTING;

ANOXIA; ARTHRITIS, RHEUMATOID; BLOTTING, WESTERN; CELLS, CULTURED; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTERLEUKIN-1BETA; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SYNOVIAL MEMBRANE; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84863258259     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/ker327     Document Type: Article

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