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Volumn 30, Issue 7, 2016, Pages 751-771

Genetic insights into the mechanisms of Fgf signaling

Author keywords

Erk1 2; Fgfr; Fibroblast growth factor; Receptor tyrosine kinase; Signaling

Indexed keywords

ADAPTOR PROTEIN; ADAPTOR PROTEIN GRB14; CRK LIKE PROTEIN; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTOR 8; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 3; FIBROBLAST GROWTH FACTOR RECEPTOR 4; GONADORELIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C GAMMA; PROTEIN KINASE C DELTA; PROTEIN TYROSINE PHOSPHATASE SHP 2; STAT1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; PROTEIN BINDING;

EID: 84962448787     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.277137.11     Document Type: Review
Times cited : (163)

References (251)
  • 1
    • 69249124251 scopus 로고    scopus 로고
    • Male-biased effects of gonadotropin-releasing hormone neuron- specific deletion of the phosphoinositide 3-kinase regulatory subunit p85α on the reproductive axis
    • Acosta-Martinez M, Luo J, Elias C, Wolfe A, Levine JE. 2009 Male-biased effects of gonadotropin-releasing hormone neuron- specific deletion of the phosphoinositide 3-kinase regulatory subunit p85α on the reproductive axis. Endocrinology 150: 4203–4212
    • (2009) Endocrinology , vol.150 , pp. 4203-4212
    • Acosta-Martinez, M.1    Luo, J.2    Elias, C.3    Wolfe, A.4    Levine, J.E.5
  • 4
    • 84874368710 scopus 로고    scopus 로고
    • Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity
    • Ahmed Z, Lin CC, Suen KM, Melo FA, Levitt JA, Suhling K, Ladbury JE. 2013 Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity. J Cell Biol 200: 493–504
    • (2013) J Cell Biol , vol.200 , pp. 493-504
    • Ahmed, Z.1    Lin, C.C.2    Suen, K.M.3    Melo, F.A.4    Levitt, J.A.5    Suhling, K.6    Ladbury, J.E.7
  • 6
    • 0242677706 scopus 로고    scopus 로고
    • Spatial and temporal expression of heparan sulfate in mouse development regulates FGF and FGF receptor assembly
    • Allen BL, Rapraeger AC. 2003 Spatial and temporal expression of heparan sulfate in mouse development regulates FGF and FGF receptor assembly. J Cell Biol 163: 637–648
    • (2003) J Cell Biol , vol.163 , pp. 637-648
    • Allen, B.L.1    Rapraeger, A.C.2
  • 7
    • 0032574824 scopus 로고    scopus 로고
    • Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development
    • Arman E, Haffner-Krausz R, Chen Y, Heath JK, Lonai P. 1998 Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development. Proc Natl Acad Sci 95: 5082–5087
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 5082-5087
    • Arman, E.1    Haffner-Krausz, R.2    Chen, Y.3    Heath, J.K.4    Lonai, P.5
  • 9
    • 80052289843 scopus 로고    scopus 로고
    • Role of fibroblast growth factor receptor signaling in kidney development
    • Bates CM. 2011 Role of fibroblast growth factor receptor signaling in kidney development. Pediatr Nephrol 26: 1373–1379
    • (2011) Pediatr Nephrol , vol.26 , pp. 1373-1379
    • Bates, C.M.1
  • 10
    • 0014499309 scopus 로고
    • Cutis gyratum, acanthosis nigricans and other congenital anomalies. A new syndrome
    • Beare JM, Dodge JA, Nevin NC. 1969 Cutis gyratum, acanthosis nigricans and other congenital anomalies. A new syndrome. Br J Dermatol 81: 241–247
    • (1969) Br J Dermatol , vol.81 , pp. 241-247
    • Beare, J.M.1    Dodge, J.A.2    Nevin, N.C.3
  • 13
    • 0031457616 scopus 로고    scopus 로고
    • Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung
    • Bellusci S, Grindley J, Emoto H, Itoh N, Hogan BL. 1997 Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development 124: 4867–4878
    • (1997) Development , vol.124 , pp. 4867-4878
    • Bellusci, S.1    Grindley, J.2    Emoto, H.3    Itoh, N.4    Hogan, B.L.5
  • 14
    • 77954516397 scopus 로고    scopus 로고
    • A random cell motility gradient downstream of FGF controls elongation of an amniote embryo
    • Benazeraf B, Francois P, Baker RE, Denans N, Little CD, Pourquie O. 2010 A random cell motility gradient downstream of FGF controls elongation of an amniote embryo. Nature 466: 248–252
    • (2010) Nature , vol.466 , pp. 248-252
    • Benazeraf, B.1    Francois, P.2    Baker, R.E.3    Denans, N.4    Little, C.D.5    Pourquie, O.6
  • 15
    • 0029134104 scopus 로고
    • Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
    • Bladt F, Riethmacher D, Isenmann S, Aguzzi A, Birchmeier C. 1995 Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 376: 768–771
    • (1995) Nature , vol.376 , pp. 768-771
    • Bladt, F.1    Riethmacher, D.2    Isenmann, S.3    Aguzzi, A.4    Birchmeier, C.5
  • 18
    • 84965089687 scopus 로고    scopus 로고
    • Fgfr1 regulates development through the combinatorial use of signaling proteins
    • Brewer JR, Molotkov A, Mazot P, Hoch RV, Soriano P. 2015 Fgfr1 regulates development through the combinatorial use of signaling proteins. Genes Dev 29: 1863–1874
    • (2015) Genes Dev , vol.29 , pp. 1863-1874
    • Brewer, J.R.1    Molotkov, A.2    Mazot, P.3    Hoch, R.V.4    Soriano, P.5
  • 22
    • 84925456768 scopus 로고    scopus 로고
    • Careless talk costs lives: Fibroblast growth factor receptor signalling and the consequences of pathway malfunction
    • Carter EP, Fearon AE, Grose RP. 2015 Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction. Trends Cell Biol 25: 221–233
    • (2015) Trends Cell Biol , vol.25 , pp. 221-233
    • Carter, E.P.1    Fearon, A.E.2    Grose, R.P.3
  • 23
    • 11144271353 scopus 로고    scopus 로고
    • Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis
    • Ceridono M, Belleudi F, Ceccarelli S, Torrisi MR. 2005 Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis. Biochem Biophys Res Commun 327: 523–532
    • (2005) Biochem Biophys Res Commun , vol.327 , pp. 523-532
    • Ceridono, M.1    Belleudi, F.2    Ceccarelli, S.3    Torrisi, M.R.4
  • 25
    • 33646527782 scopus 로고    scopus 로고
    • Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2–MAPK pathway
    • Chazaud C, Yamanaka Y, Pawson T, Rossant J. 2006 Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2–MAPK pathway. Dev Cell 10: 615–624
    • (2006) Dev Cell , vol.10 , pp. 615-624
    • Chazaud, C.1    Yamanaka, Y.2    Pawson, T.3    Rossant, J.4
  • 26
    • 0028239789 scopus 로고
    • Fibroblast growth factor receptor (FGFR) 3 Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1
    • Chellaiah AT, McEwen DG, Werner S, Xu J, Ornitz DM. 1994 Fibroblast growth factor receptor (FGFR) 3 Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1. J Biol Chem 269: 11620–11627
    • (1994) J Biol Chem , vol.269 , pp. 11620-11627
    • Chellaiah, A.T.1    McEwen, D.G.2    Werner, S.3    Xu, J.4    Ornitz, D.M.5
  • 27
    • 0033456159 scopus 로고    scopus 로고
    • Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis
    • Chen L, Adar R, Yang X, Monsonego EO, Li C, Hauschka PV, Yayon A, Deng CX. 1999 Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis. J Clin Invest 104: 1517–1525
    • (1999) J Clin Invest , vol.104 , pp. 1517-1525
    • Chen, L.1    Adar, R.2    Yang, X.3    Monsonego, E.O.4    Li, C.5    Hauschka, P.V.6    Yayon, A.7    Deng, C.X.8
  • 28
    • 84900305191 scopus 로고    scopus 로고
    • A Ser252Trp mutation in fibroblast growth factor receptor 2 (FGFR2) mimicking human Apert syndrome reveals an essential role for FGF signaling in the regulation of endochondral bone formation
    • Chen P, Zhang L, Weng T, Zhang S, Sun S, Chang M, Li Y, Zhang B, Zhang L. 2014a. A Ser252Trp mutation in fibroblast growth factor receptor 2 (FGFR2) mimicking human Apert syndrome reveals an essential role for FGF signaling in the regulation of endochondral bone formation. PLoS One 9: e87311
    • (2014) Plos One , vol.9
    • Chen, P.1    Zhang, L.2    Weng, T.3    Zhang, S.4    Sun, S.5    Chang, M.6    Li, Y.7    Zhang, B.8    Zhang, L.9
  • 30
    • 0032948651 scopus 로고    scopus 로고
    • Expression of the T-box gene Eomesodermin during early mouse development
    • Ciruna BG, Rossant J. 1999 Expression of the T-box gene Eomesodermin during early mouse development. Mech Dev 81: 199–203
    • (1999) Mech Dev , vol.81 , pp. 199-203
    • Ciruna, B.G.1    Rossant, J.2
  • 31
    • 0035408007 scopus 로고    scopus 로고
    • FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak
    • Ciruna B, Rossant J. 2001 FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev Cell 1: 37–49
    • (2001) Dev Cell , vol.1 , pp. 37-49
    • Ciruna, B.1    Rossant, J.2
  • 32
    • 0030743776 scopus 로고    scopus 로고
    • Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: A role for FGFR1 in morphogenetic movement through the primitive streak
    • Ciruna BG, Schwartz L, Harpal K, Yamaguchi TP, Rossant J. 1997 Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak. Development 124: 2829–2841
    • (1997) Development , vol.124 , pp. 2829-2841
    • Ciruna, B.G.1    Schwartz, L.2    Harpal, K.3    Yamaguchi, T.P.4    Rossant, J.5
  • 33
    • 0029928791 scopus 로고    scopus 로고
    • Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3
    • Colvin JS, Bohne BA, Harding GW, McEwen DG, Ornitz DM. 1996 Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nat Genet 12: 390–397
    • (1996) Nat Genet , vol.12 , pp. 390-397
    • Colvin, J.S.1    Bohne, B.A.2    Harding, G.W.3    McEwen, D.G.4    Ornitz, D.M.5
  • 35
    • 0142074405 scopus 로고    scopus 로고
    • Spatial and temporal patterns of ERK signaling during mouse embryogenesis
    • Corson LB, Yamanaka Y, Lai KM, Rossant J. 2003 Spatial and temporal patterns of ERK signaling during mouse embryogenesis. Development 130: 4527–4537
    • (2003) Development , vol.130 , pp. 4527-4537
    • Corson, L.B.1    Yamanaka, Y.2    Lai, K.M.3    Rossant, J.4
  • 36
    • 0036679107 scopus 로고    scopus 로고
    • The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells
    • Cross MJ, Lu L, Magnusson P, Nyqvist D, Holmqvist K, Welsh M, Claesson-Welsh L. 2002 The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells. Mol Biol Cell 13: 2881–2893
    • (2002) Mol Biol Cell , vol.13 , pp. 2881-2893
    • Cross, M.J.1    Lu, L.2    Magnusson, P.3    Nyqvist, D.4    Holmqvist, K.5    Welsh, M.6    Claesson-Welsh, L.7
  • 37
    • 0028959288 scopus 로고
    • The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo
    • Crossley PH, Martin GR. 1995 The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development 121: 439–451
    • (1995) Development , vol.121 , pp. 439-451
    • Crossley, P.H.1    Martin, G.R.2
  • 38
    • 77952037166 scopus 로고    scopus 로고
    • Differential phosphoproteomics of fibroblast growth factor signaling: Identification of Src family kinase-mediated phosphorylation events
    • Cunningham DL, Sweet SM, Cooper HJ, Heath JK. 2010 Differential phosphoproteomics of fibroblast growth factor signaling: identification of Src family kinase-mediated phosphorylation events. J Proteome Res 9: 2317–2328
    • (2010) J Proteome Res , vol.9 , pp. 2317-2328
    • Cunningham, D.L.1    Sweet, S.M.2    Cooper, H.J.3    Heath, J.K.4
  • 39
    • 84929208109 scopus 로고    scopus 로고
    • Distinct sets of FGF receptors sculpt excitatory and inhibitory synaptogenesis
    • Dabrowski A, Terauchi A, Strong C, Umemori H. 2015 Distinct sets of FGF receptors sculpt excitatory and inhibitory synaptogenesis. Development 142: 1818–1830
    • (2015) Development , vol.142 , pp. 1818-1830
    • Dabrowski, A.1    Terauchi, A.2    Strong, C.3    Umemori, H.4
  • 40
    • 84955209323 scopus 로고    scopus 로고
    • Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
    • Degirolamo C, Sabba C, Moschetta A. 2016 Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23. Nat Rev Drug Discov 15: 51–69
    • (2016) Nat Rev Drug Discov , vol.15 , pp. 51-69
    • Degirolamo, C.1    Sabba, C.2    Moschetta, A.3
  • 41
    • 33846867972 scopus 로고    scopus 로고
    • ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation
    • Degoutin J, Vigny M, Gouzi JY. 2007 ALK activation induces Shc and FRS2 recruitment: signaling and phenotypic outcomes in PC12 cells differentiation. FEBS Lett 581: 727–734
    • (2007) FEBS Lett , vol.581 , pp. 727-734
    • Degoutin, J.1    Vigny, M.2    Gouzi, J.Y.3
  • 42
    • 23844468774 scopus 로고    scopus 로고
    • Control of the segmentation process by graded MAPK/ERK activation in the chick embryo
    • Delfini MC, Dubrulle J, Malapert P, Chal J, Pourquié O. 2005 Control of the segmentation process by graded MAPK/ERK activation in the chick embryo. Proc Natl Acad Sci 102: 11343–11348.
    • (2005) Proc Natl Acad Sci , vol.102 , pp. 11343-11348
    • Delfini, M.C.1    Dubrulle, J.2    Malapert, P.3    Chal, J.4    Pourquié, O.5
  • 44
    • 0033961133 scopus 로고    scopus 로고
    • An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal- epithelial signalling during mouse organogenesis
    • De Moerlooze L, Spencer-Dene B, Revest JM, Hajihosseini M, Rosewell I, Dickson C. 2000 An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal- epithelial signalling during mouse organogenesis. Development 127: 483–492
    • (2000) Development , vol.127 , pp. 483-492
    • De Moerlooze, L.1    Spencer-Dene, B.2    Revest, J.M.3    Hajihosseini, M.4    Rosewell, I.5    Dickson, C.6
  • 46
    • 0029917507 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 3 is a negative regulator of bone growth
    • Deng C, Wynshaw-Boris A, Zhou F, Kuo A, Leder P. 1996 Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 84: 911–921
    • (1996) Cell , vol.84 , pp. 911-921
    • Deng, C.1    Wynshaw-Boris, A.2    Zhou, F.3    Kuo, A.4    Leder, P.5
  • 47
    • 0037077235 scopus 로고    scopus 로고
    • Phosphorylation of STAT-3 in response to basic fibroblast growth factor occurs through a mechanism involving platelet-activating factor, JAK-2, and Src in human umbilical vein endothelial cells. Evidence for a dual kinase mechanism
    • Deo DD, Axelrad TW, Robert EG, Marcheselli V, Bazan NG, Hunt JD. 2002 Phosphorylation of STAT-3 in response to basic fibroblast growth factor occurs through a mechanism involving platelet-activating factor, JAK-2, and Src in human umbilical vein endothelial cells. Evidence for a dual kinase mechanism. J Biol Chem 277: 21237–21245
    • (2002) J Biol Chem , vol.277 , pp. 21237-21245
    • Deo, D.D.1    Axelrad, T.W.2    Robert, E.G.3    Marcheselli, V.4    Bazan, N.G.5    Hunt, J.D.6
  • 48
    • 33845444174 scopus 로고    scopus 로고
    • A complex oscillating network of signaling genes underlies the mouse segmentation clock
    • Dequeant ML, Glynn E, Gaudenz K, Wahl M, Chen J, Mushegian A, Pourquié O. 2006 A complex oscillating network of signaling genes underlies the mouse segmentation clock. Science 314: 1595–1598
    • (2006) Science , vol.314 , pp. 1595-1598
    • Dequeant, M.L.1    Glynn, E.2    Gaudenz, K.3    Wahl, M.4    Chen, J.5    Mushegian, A.6    Pourquié, O.7
  • 51
    • 78149263789 scopus 로고    scopus 로고
    • FGF signalling: Diverse roles during early vertebrate embryogenesis
    • Dorey K, Amaya E. 2010 FGF signalling: diverse roles during early vertebrate embryogenesis. Development 137: 3731–3742
    • (2010) Development , vol.137 , pp. 3731-3742
    • Dorey, K.1    Amaya, E.2
  • 52
    • 0842264188 scopus 로고    scopus 로고
    • Fgf8 mRNAdecay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo
    • Dubrulle J, Pourquié O. 2004. fgf8 mRNAdecay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo. Nature 427: 419–422
    • (2004) Nature , vol.427 , pp. 419-422
    • Dubrulle, J.1    Pourquié, O.2
  • 53
    • 0035958586 scopus 로고    scopus 로고
    • FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation
    • Dubrulle J, McGrew MJ, Pourquié O. 2001 FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation. Cell 106: 219–232
    • (2001) Cell , vol.106 , pp. 219-232
    • Dubrulle, J.1    McGrew, M.J.2    Pourquié, O.3
  • 54
    • 77951043677 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription-3 binding to the fibroblast growth factor receptor is activated by receptor amplification
    • Dudka AA, Sweet SM, Heath JK. 2010 Signal transducers and activators of transcription-3 binding to the fibroblast growth factor receptor is activated by receptor amplification. Cancer Res 70: 3391–3401
    • (2010) Cancer Res , vol.70 , pp. 3391-3401
    • Dudka, A.A.1    Sweet, S.M.2    Heath, J.K.3
  • 55
    • 34247261472 scopus 로고    scopus 로고
    • Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3
    • Eswarakumar VP, Schlessinger J. 2007 Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3. Proc Natl Acad Sci 104: 3937–3942
    • (2007) Proc Natl Acad Sci , vol.104 , pp. 3937-3942
    • Eswarakumar, V.P.1    Schlessinger, J.2
  • 63
    • 0035475308 scopus 로고    scopus 로고
    • Crk family adaptors-signalling complex formation and biological roles
    • Feller SM. 2001 Crk family adaptors-signalling complex formation and biological roles. Oncogene 20: 6348–6371
    • (2001) Oncogene , vol.20 , pp. 6348-6371
    • Feller, S.M.1
  • 66
    • 33144455197 scopus 로고    scopus 로고
    • Expression of a dominant negative FGF receptor in developing GNRH1 neurons disrupts axon outgrowth and targeting to the median eminence
    • Gill JC, Tsai PS. 2006 Expression of a dominant negative FGF receptor in developing GNRH1 neurons disrupts axon outgrowth and targeting to the median eminence. Biol Reprod 74: 463–472
    • (2006) Biol Reprod , vol.74 , pp. 463-472
    • Gill, J.C.1    Tsai, P.S.2
  • 67
    • 0037644786 scopus 로고    scopus 로고
    • Paracrine action of FGF4 during periimplantation development maintains trophectoderm and primitive endoderm
    • Goldin SN, Papaioannou VE. 2003 Paracrine action of FGF4 during periimplantation development maintains trophectoderm and primitive endoderm. Genesis 36: 40–47
    • (2003) Genesis , vol.36 , pp. 40-47
    • Goldin, S.N.1    Papaioannou, V.E.2
  • 69
    • 1842850649 scopus 로고    scopus 로고
    • FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts
    • Gotoh N, Laks S, Nakashima M, Lax I, Schlessinger J. 2004b. FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts. FEBS Lett 564: 14–18
    • (2004) FEBS Lett , vol.564 , pp. 14-18
    • Gotoh, N.1    Laks, S.2    Nakashima, M.3    Lax, I.4    Schlessinger, J.5
  • 70
    • 20144372283 scopus 로고    scopus 로고
    • The docking protein FRS2α is an essential component of multiplefibroblast growth factor responses during early mouse development
    • Gotoh N, Manova K, Tanaka S, Murohashi M, Hadari Y, Lee A, Hamada Y, Hiroe T, Ito M, Kurihara T, et al. 2005 The docking protein FRS2α is an essential component of multiplefibroblast growth factor responses during early mouse development. Mol Cell Biol 25: 4105–4116
    • (2005) Mol Cell Biol , vol.25 , pp. 4105-4116
    • Gotoh, N.1    Manova, K.2    Tanaka, S.3    Murohashi, M.4    Hadari, Y.5    Lee, A.6    Hamada, Y.7    Hiroe, T.8    Ito, M.9    Kurihara, T.10
  • 72
    • 84872367040 scopus 로고    scopus 로고
    • Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules
    • Griffin JN, Compagnucci C, Hu D, Fish J, Klein O, Marcucio R, Depew MJ. 2013 Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules. Dev Biol 374: 185–197
    • (2013) Dev Biol , vol.374 , pp. 185-197
    • Griffin, J.N.1    Compagnucci, C.2    Hu, D.3    Fish, J.4    Klein, O.5    Marcucio, R.6    Depew, M.J.7
  • 73
    • 0027428744 scopus 로고
    • Activating and inhibitory heparin sequences for FGF-2 (Basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4
    • Guimond S, Maccarana M, Olwin BB, Lindahl U, Rapraeger AC. 1993 Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4. J Biol Chem 268: 23906–23914
    • (1993) J Biol Chem , vol.268 , pp. 23906-23914
    • Guimond, S.1    Maccarana, M.2    Olwin, B.B.3    Lindahl, U.4    Rapraeger, A.C.5
  • 74
    • 0031835659 scopus 로고    scopus 로고
    • Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
    • Hadari YR, Kouhara H, Lax I, Schlessinger J. 1998 Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation. Mol Cell Biol 18: 3966–3973
    • (1998) Mol Cell Biol , vol.18 , pp. 3966-3973
    • Hadari, Y.R.1    Kouhara, H.2    Lax, I.3    Schlessinger, J.4
  • 76
    • 0035957343 scopus 로고    scopus 로고
    • A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert/Pfeiffer-syndrome-like phenotypes
    • Hajihosseini MK, Wilson S, De Moerlooze L, Dickson C. 2001 A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert/Pfeiffer-syndrome-like phenotypes. Proc Natl Acad Sci 98: 3855–3860
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 3855-3860
    • Hajihosseini, M.K.1    Wilson, S.2    De Moerlooze, L.3    Dickson, C.4
  • 80
    • 0035168141 scopus 로고    scopus 로고
    • Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation
    • Hart KC, Robertson SC, Donoghue DJ. 2001 Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation. Mol Biol Cell 12: 931–942
    • (2001) Mol Biol Cell , vol.12 , pp. 931-942
    • Hart, K.C.1    Robertson, S.C.2    Donoghue, D.J.3
  • 83
    • 0027931643 scopus 로고
    • FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations
    • Hebert JM, Rosenquist T, Gotz J, Martin GR. 1994 FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. Cell 78: 1017–1025
    • (1994) Cell , vol.78 , pp. 1017-1025
    • Hebert, J.M.1    Rosenquist, T.2    Gotz, J.3    Martin, G.R.4
  • 85
    • 84922896900 scopus 로고    scopus 로고
    • Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin
    • Hiratsuka T, Fujita Y, Naoki H, Aoki K, Kamioka Y, Matsuda M. 2015 Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin. Elife 4: e05178
    • (2015) Elife , vol.4
    • Hiratsuka, T.1    Fujita, Y.2    Naoki, H.3    Aoki, K.4    Kamioka, Y.5    Matsuda, M.6
  • 86
    • 33645068866 scopus 로고    scopus 로고
    • Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development
    • Hoch RV, Soriano P. 2006 Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development. Development 133: 663–673
    • (2006) Development , vol.133 , pp. 663-673
    • Hoch, R.V.1    Soriano, P.2
  • 88
    • 84871678213 scopus 로고    scopus 로고
    • GnRH neuronal migration and olfactory bulb neurite outgrowth are dependent on FGF receptor 1 signaling, specifically via the PI3K p110α isoform in chick embryo
    • Hu Y, Poopalasundaram S, Graham A, Bouloux PM. 2013 GnRH neuronal migration and olfactory bulb neurite outgrowth are dependent on FGF receptor 1 signaling, specifically via the PI3K p110α isoform in chick embryo. Endocrinology 154: 388–399
    • (2013) Endocrinology , vol.154 , pp. 388-399
    • Hu, Y.1    Poopalasundaram, S.2    Graham, A.3    Bouloux, P.M.4
  • 89
    • 18144421574 scopus 로고    scopus 로고
    • FGF signaling in flies and worms: More and more relevant to vertebrate biology
    • Huang P, Stern MJ. 2005 FGF signaling in flies and worms: more and more relevant to vertebrate biology. Cytokine Growth Factor Rev 16: 151–158
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 151-158
    • Huang, P.1    Stern, M.J.2
  • 90
    • 0028986599 scopus 로고
    • Reduced activation of RAF-1 and MAP kinase by a fibroblast growth factor receptor mutant deficient in stimulation of phosphatidylinositol hydrolysis
    • Huang J, Mohammadi M, Rodrigues GA, Schlessinger J. 1995 Reduced activation of RAF-1 and MAP kinase by a fibroblast growth factor receptor mutant deficient in stimulation of phosphatidylinositol hydrolysis. J Biol Chem 270: 5065–5072
    • (1995) J Biol Chem , vol.270 , pp. 5065-5072
    • Huang, J.1    Mohammadi, M.2    Rodrigues, G.A.3    Schlessinger, J.4
  • 91
    • 84908222357 scopus 로고    scopus 로고
    • Signalling dynamics in vertebrate segmentation
    • Hubaud A, Pourquié O. 2014 Signalling dynamics in vertebrate segmentation. Nat Rev Mol Cell Biol 15: 709–721
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 709-721
    • Hubaud, A.1    Pourquié, O.2
  • 92
    • 84856448427 scopus 로고    scopus 로고
    • Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal
    • Huh SH, Jones J, Warchol ME, Ornitz DM. 2012 Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal. PLoS Biol 10: e1001231
    • (2012) Plos Biol , vol.10
    • Huh, S.H.1    Jones, J.2    Warchol, M.E.3    Ornitz, D.M.4
  • 93
    • 0032557548 scopus 로고    scopus 로고
    • Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7)
    • Igarashi M, Finch PW, Aaronson SA. 1998 Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7). J Biol Chem 273: 13230–13235
    • (1998) J Biol Chem , vol.273 , pp. 13230-13235
    • Igarashi, M.1    Finch, P.W.2    Aaronson, S.A.3
  • 95
    • 35349007958 scopus 로고    scopus 로고
    • The Fgf families in humans, mice, and zebrafish: Their evolutional processes and roles in development, metabolism, and disease
    • Itoh N. 2007 The Fgf families in humans, mice, and zebrafish: their evolutional processes and roles in development, metabolism, and disease. Biol Pharm Bulletin 30: 1819–1825
    • (2007) Biol Pharm Bulletin , vol.30 , pp. 1819-1825
    • Itoh, N.1
  • 96
    • 84962366018 scopus 로고    scopus 로고
    • Endocrine FGFs: Evolution, physiology, pathophysiology, and pharmacotherapy
    • Itoh N, Ohta H, Konishi M. 2015 Endocrine FGFs: evolution, physiology, pathophysiology, and pharmacotherapy. Front Endocrinol 6: 154
    • (2015) Front Endocrinol , vol.6 , pp. 154
    • Itoh, N.1    Ohta, H.2    Konishi, M.3
  • 98
    • 0025912340 scopus 로고
    • The human fibroblast growth factor receptor genes: A common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain
    • Johnson DE, Lu J, Chen H, Werner S, Williams LT. 1991 The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain. Mol Cell Biol 11: 4627–4634
    • (1991) Mol Cell Biol , vol.11 , pp. 4627-4634
    • Johnson, D.E.1    Lu, J.2    Chen, H.3    Werner, S.4    Williams, L.T.5
  • 100
    • 84871561933 scopus 로고    scopus 로고
    • FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse
    • Kang M, Piliszek A, Artus J, Hadjantonakis AK. 2013 FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse. Development 140: 267–279
    • (2013) Development , vol.140 , pp. 267-279
    • Kang, M.1    Piliszek, A.2    Artus, J.3    Hadjantonakis, A.K.4
  • 102
    • 0037414760 scopus 로고    scopus 로고
    • The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2
    • Kim HJ, Kim JH, Bae SC, Choi JY, Kim HJ, Ryoo HM. 2003 The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2. J Biol Chem 278: 319–326
    • (2003) J Biol Chem , vol.278 , pp. 319-326
    • Kim, H.J.1    Kim, J.H.2    Bae, S.C.3    Choi, J.Y.4    Kim, H.J.5    Ryoo, H.M.6
  • 103
    • 0036007120 scopus 로고    scopus 로고
    • An allelic series at the PDGFαR locus indicates unequalcontributions of distinct signaling pathways during development
    • Klinghoffer RA, Hamilton TG, Hoch R, Soriano P. 2002 An allelic series at the PDGFαR locus indicates unequalcontributions of distinct signaling pathways during development. Dev Cell 2: 103–113
    • (2002) Dev Cell , vol.2 , pp. 103-113
    • Klinghoffer, R.A.1    Hamilton, T.G.2    Hoch, R.3    Soriano, P.4
  • 104
    • 0040627311 scopus 로고    scopus 로고
    • Contribution of Src and Ras pathways in FGF-2 induced endothelial cell differentiation
    • Klint P, Kanda S, Kloog Y, Claesson-Welsh L. 1999 Contribution of Src and Ras pathways in FGF-2 induced endothelial cell differentiation. Oncogene 18: 3354–3364
    • (1999) Oncogene , vol.18 , pp. 3354-3364
    • Klint, P.1    Kanda, S.2    Kloog, Y.3    Claesson-Welsh, L.4
  • 105
    • 0037013284 scopus 로고    scopus 로고
    • Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation
    • Kong M, Wang CS, Donoghue DJ. 2002 Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation. J Biol Chem 277: 15962–15970
    • (2002) J Biol Chem , vol.277 , pp. 15962-15970
    • Kong, M.1    Wang, C.S.2    Donoghue, D.J.3
  • 106
    • 0030706168 scopus 로고    scopus 로고
    • A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
    • Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I, Schlessinger J. 1997 A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell 89: 693–702
    • (1997) Cell , vol.89 , pp. 693-702
    • Kouhara, H.1    Hadari, Y.R.2    Spivak-Kroizman, T.3    Schilling, J.4    Bar-Sagi, D.5    Lax, I.6    Schlessinger, J.7
  • 108
    • 0035848684 scopus 로고    scopus 로고
    • Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction
    • Kurokawa K, Iwashita T, Murakami H, Hayashi H, Kawai K, Takahashi M. 2001 Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction. Oncogene 20: 1929–1938
    • (2001) Oncogene , vol.20 , pp. 1929-1938
    • Kurokawa, K.1    Iwashita, T.2    Murakami, H.3    Hayashi, H.4    Kawai, K.5    Takahashi, M.6
  • 110
    • 0033520278 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk
    • Larsson H, Klint P, Landgren E, Claesson-Welsh L. 1999 Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk. J Biol Chem 274: 25726–25734
    • (1999) J Biol Chem , vol.274 , pp. 25726-25734
    • Larsson, H.1    Klint, P.2    Landgren, E.3    Claesson-Welsh, L.4
  • 111
    • 0024375271 scopus 로고
    • Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor
    • Lee PL, Johnson DE, Cousens LS, Fried VA, Williams LT. 1989 Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor. Science 245: 57–60
    • (1989) Science , vol.245 , pp. 57-60
    • Lee, P.L.1    Johnson, D.E.2    Cousens, L.S.3    Fried, V.A.4    Williams, L.T.5
  • 112
    • 0030933498 scopus 로고    scopus 로고
    • Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain
    • Lee SM, Danielian PS, Fritzsch B, McMahon AP. 1997 Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain. Development 124: 959–969
    • (1997) Development , vol.124 , pp. 959-969
    • Lee, S.M.1    Danielian, P.S.2    Fritzsch, B.3    McMahon, A.P.4
  • 113
    • 0033673531 scopus 로고    scopus 로고
    • Fgf8 signalling fromthe AER is essential for normal limb development
    • Lewandoski M, Sun X, Martin GR. 2000 Fgf8 signalling fromthe AER is essential for normal limb development. Nat Genet 26: 460–463
    • (2000) Nat Genet , vol.26 , pp. 460-463
    • Lewandoski, M.1    Sun, X.2    Martin, G.R.3
  • 114
    • 0032938128 scopus 로고    scopus 로고
    • A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors
    • Li C, Chen L, Iwata T, Kitagawa M, Fu XY, Deng CX. 1999 A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors. Hum Mol Genet 8: 35–44
    • (1999) Hum Mol Genet , vol.8 , pp. 35-44
    • Li, C.1    Chen, L.2    Iwata, T.3    Kitagawa, M.4    Fu, X.Y.5    Deng, C.X.6
  • 115
    • 12344278405 scopus 로고    scopus 로고
    • FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity
    • Li X, Brunton VG, Burgar HR, Wheldon LM, Heath JK. 2004 FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity. J Cell Sci 117: 6007–6017
    • (2004) J Cell Sci , vol.117 , pp. 6007-6017
    • Li, X.1    Brunton, V.G.2    Burgar, H.R.3    Wheldon, L.M.4    Heath, J.K.5
  • 117
    • 0027496895 scopus 로고
    • Mice carrying null mutations of the genes encoding insulinlike growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
    • Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A. 1993 Mice carrying null mutations of the genes encoding insulinlike growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75: 59–72
    • (1993) Cell , vol.75 , pp. 59-72
    • Liu, J.P.1    Baker, J.2    Perkins, A.S.3    Robertson, E.J.4    Efstratiadis, A.5
  • 118
    • 0032708854 scopus 로고    scopus 로고
    • FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate
    • Liu A, Losos K, Joyner AL. 1999a. FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate. Development 126: 4827–4838
    • (1999) Development , vol.126 , pp. 4827-4838
    • Liu, A.1    Losos, K.2    Joyner, A.L.3
  • 119
    • 0033581955 scopus 로고    scopus 로고
    • Src is required for cell migration and shape changes induced by fibroblast growth factor 1
    • Liu J, Huang C, Zhan X. 1999b. Src is required for cell migration and shape changes induced by fibroblast growth factor 1. Oncogene 18: 6700–6706
    • (1999) Oncogene , vol.18 , pp. 6700-6706
    • Liu, J.1    Huang, C.2    Zhan, X.3
  • 120
    • 0036203355 scopus 로고    scopus 로고
    • Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18
    • Liu Z, Xu J, Colvin JS, Ornitz DM. 2002 Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18. Genes Dev 16: 859–869
    • (2002) Genes Dev , vol.16 , pp. 859-869
    • Liu, Z.1    Xu, J.2    Colvin, J.S.3    Ornitz, D.M.4
  • 124
    • 43749110077 scopus 로고    scopus 로고
    • Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning
    • Mariani FV, Ahn CP, Martin GR. 2008 Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning. Nature 453: 401–405
    • (2008) Nature , vol.453 , pp. 401-405
    • Mariani, F.V.1    Ahn, C.P.2    Martin, G.R.3
  • 125
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
    • Marshall CJ. 1995 Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80: 179–185
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 126
    • 34447634477 scopus 로고    scopus 로고
    • Initiation to end point: The multiple roles of fibroblast growth factors in neural development
    • Mason I. 2007 Initiation to end point: the multiple roles of fibroblast growth factors in neural development. Nat Rev Neurosci 8: 583–596
    • (2007) Nat Rev Neurosci , vol.8 , pp. 583-596
    • Mason, I.1
  • 127
    • 0034967978 scopus 로고    scopus 로고
    • Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade
    • Melillo RM, Santoro M, Ong SH, Billaud M, Fusco A, Hadari YR, Schlessinger J, Lax I. 2001 Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade. Mol Cell Biol 21: 4177–4187
    • (2001) Mol Cell Biol , vol.21 , pp. 4177-4187
    • Melillo, R.M.1    Santoro, M.2    Ong, S.H.3    Billaud, M.4    Fusco, A.5    Hadari, Y.R.6    Schlessinger, J.7    Lax, I.8
  • 128
    • 0026570847 scopus 로고
    • Determination of ligand-binding specificity by alternative splicing: Two distinct growth factor receptors encoded by a single gene
    • Miki T, Bottaro DP, Fleming TP, Smith CL, Burgess WH, Chan AM, Aaronson SA. 1992 Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc Natl Acad Sci 89: 246–250
    • (1992) Proc Natl Acad Sci , vol.89 , pp. 246-250
    • Miki, T.1    Bottaro, D.P.2    Fleming, T.P.3    Smith, C.L.4    Burgess, W.H.5    Chan, A.M.6    Aaronson, S.A.7
  • 129
    • 0032532479 scopus 로고    scopus 로고
    • Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless
    • Min H, Danilenko DM, Scully SA, Bolon B, Ring BD, Tarpley JE, DeRose M, Simonet WS. 1998 Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev 12: 3156–3161
    • (1998) Genes Dev , vol.12 , pp. 3156-3161
    • Min, H.1    Danilenko, D.M.2    Scully, S.A.3    Bolon, B.4    Ring, B.D.5    Tarpley, J.E.6    Derose, M.7    Simonet, W.S.8
  • 130
    • 0025941527 scopus 로고
    • A tyrosine- phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-γ1
    • Mohammadi M, Honegger AM, Rotin D, Fischer R, Bellot F, Li W, Dionne CA, Jaye M, Rubinstein M, Schlessinger J. 1991 A tyrosine- phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-γ1. Mol Cell Biol 11: 5068–5078
    • (1991) Mol Cell Biol , vol.11 , pp. 5068-5078
    • Mohammadi, M.1    Honegger, A.M.2    Rotin, D.3    Fischer, R.4    Bellot, F.5    Li, W.6    Dionne, C.A.7    Jaye, M.8    Rubinstein, M.9    Schlessinger, J.10
  • 131
    • 0026641249 scopus 로고
    • Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis
    • Mohammadi M, Dionne CA, Li W, Li N, Spivak T, Honegger AM, Jaye M, Schlessinger J. 1992 Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis. Nature 358: 681–684
    • (1992) Nature , vol.358 , pp. 681-684
    • Mohammadi, M.1    Dionne, C.A.2    Li, W.3    Li, N.4    Spivak, T.5    Honegger, A.M.6    Jaye, M.7    Schlessinger, J.8
  • 133
    • 29744440528 scopus 로고    scopus 로고
    • Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes
    • Moon AM, Guris DL, Seo JH, Li L, Hammond J, Talbot A, Imamoto A. 2006 Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes. Dev Cell 10: 71–80
    • (2006) Dev Cell , vol.10 , pp. 71-80
    • Moon, A.M.1    Guris, D.L.2    Seo, J.H.3    Li, L.4    Hammond, J.5    Talbot, A.6    Imamoto, A.7
  • 135
    • 1042289662 scopus 로고    scopus 로고
    • Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype
    • Murakami S, Balmes G, McKinney S, Zhang Z, Givol D, de Crombrugghe B. 2004 Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype. Genes Dev 18: 290–305
    • (2004) Genes Dev , vol.18 , pp. 290-305
    • Murakami, S.1    Balmes, G.2    McKinney, S.3    Zhang, Z.4    Givol, D.5    De Crombrugghe, B.6
  • 136
    • 79951680614 scopus 로고    scopus 로고
    • FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis
    • Naiche LA, Holder N, Lewandoski M. 2011 FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis. Proc Natl Acad Sci 108: 4018–4023
    • (2011) Proc Natl Acad Sci , vol.108 , pp. 4018-4023
    • Naiche, L.A.1    Holder, N.2    Lewandoski, M.3
  • 137
    • 67650495042 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase activity in the neural crest is essential fornormal heart and skull development
    • Nakamura T, Gulick J, Colbert MC, Robbins J. 2009 Protein tyrosine phosphatase activity in the neural crest is essential fornormal heart and skull development. Proc Natl Acad Sci 106: 11270–11275
    • (2009) Proc Natl Acad Sci , vol.106 , pp. 11270-11275
    • Nakamura, T.1    Gulick, J.2    Colbert, M.C.3    Robbins, J.4
  • 138
    • 0032413011 scopus 로고    scopus 로고
    • Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3
    • Naski MC, Colvin JS, Coffin JD, Ornitz DM. 1998 Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. Development 125: 4977–4988
    • (1998) Development , vol.125 , pp. 4977-4988
    • Naski, M.C.1    Colvin, J.S.2    Coffin, J.D.3    Ornitz, D.M.4
  • 141
    • 70349934958 scopus 로고    scopus 로고
    • Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo
    • Nichols J, Silva J, Roode M, Smith A. 2009 Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo. Development 136: 3215–3222
    • (2009) Development , vol.136 , pp. 3215-3222
    • Nichols, J.1    Silva, J.2    Roode, M.3    Smith, A.4
  • 142
    • 84878230511 scopus 로고    scopus 로고
    • The regulation of runt-related transcription factor 2 by fibroblast growth factor-2 and connexin43 requires the inositol polyphosphate/ protein kinase Cδ cascade
    • Niger C, Luciotti MA, Buo AM, Hebert C, Ma V, Stains JP. 2013 The regulation of runt-related transcription factor 2 by fibroblast growth factor-2 and connexin43 requires the inositol polyphosphate/ protein kinase Cδ cascade. J Bone Miner Res 28: 1468–1477
    • (2013) J Bone Miner Res , vol.28 , pp. 1468-1477
    • Niger, C.1    Luciotti, M.A.2    Buo, A.M.3    Hebert, C.4    Ma, V.5    Stains, J.P.6
  • 143
    • 34547418278 scopus 로고    scopus 로고
    • The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock
    • Niwa Y, Masamizu Y, Liu T, Nakayama R, Deng CX, Kageyama R. 2007 The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock. Dev Cell 13: 298–304
    • (2007) Dev Cell , vol.13 , pp. 298-304
    • Niwa, Y.1    Masamizu, Y.2    Liu, T.3    Nakayama, R.4    Deng, C.X.5    Kageyama, R.6
  • 144
    • 79958056964 scopus 로고    scopus 로고
    • Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis
    • Niwa Y, Shimojo H, Isomura A, Gonzalez A, Miyachi H, Kageyama R. 2011 Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis. Genes Dev 25: 1115–1120
    • (2011) Genes Dev , vol.25 , pp. 1115-1120
    • Niwa, Y.1    Shimojo, H.2    Isomura, A.3    Gonzalez, A.4    Miyachi, H.5    Kageyama, R.6
  • 146
    • 0036205735 scopus 로고    scopus 로고
    • FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis
    • Ohbayashi N, Shibayama M, Kurotaki Y, Imanishi M, Fujimori T, Itoh N, Takada S. 2002 FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. Genes Dev 16: 870–879
    • (2002) Genes Dev , vol.16 , pp. 870-879
    • Ohbayashi, N.1    Shibayama, M.2    Kurotaki, Y.3    Imanishi, M.4    Fujimori, T.5    Itoh, N.6    Takada, S.7
  • 149
    • 0001056526 scopus 로고    scopus 로고
    • Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2
    • Ong SH, Goh KC, Lim YP, Low BC, Klint P, Claesson-Welsh L, Cao X, Tan YH, Guy GR. 1996 Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2. Biochem Biophys Res Commun 225: 1021–1026
    • (1996) Biochem Biophys Res Commun , vol.225 , pp. 1021-1026
    • Ong, S.H.1    Goh, K.C.2    Lim, Y.P.3    Low, B.C.4    Klint, P.5    Claesson-Welsh, L.6    Cao, X.7    Tan, Y.H.8    Guy, G.R.9
  • 150
    • 0033974109 scopus 로고    scopus 로고
    • FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors
    • Ong SH, Guy GR, Hadari YR, Laks S, Gotoh N, Schlessinger J, Lax I. 2000 FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors. Mol Cell Biol 20: 979–989
    • (2000) Mol Cell Biol , vol.20 , pp. 979-989
    • Ong, S.H.1    Guy, G.R.2    Hadari, Y.R.3    Laks, S.4    Gotoh, N.5    Schlessinger, J.6    Lax, I.7
  • 151
    • 0035933094 scopus 로고    scopus 로고
    • Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins
    • Ong SH, Hadari YR, Gotoh N, Guy GR, Schlessinger J, Lax I. 2001 Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins. Proc Natl Acad Sci 98: 6074–6079
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 6074-6079
    • Ong, S.H.1    Hadari, Y.R.2    Gotoh, N.3    Guy, G.R.4    Schlessinger, J.5    Lax, I.6
  • 153
    • 0033951768 scopus 로고    scopus 로고
    • FGFs, heparan sulfate and FGFRs: Complex interactions essential for development
    • Ornitz DM. 2000 FGFs, heparan sulfate and FGFRs: complex interactions essential for development. Bioessays 22: 108–112
    • (2000) Bioessays , vol.22 , pp. 108-112
    • Ornitz, D.M.1
  • 154
    • 84926520018 scopus 로고    scopus 로고
    • The Fibroblast Growth Factor signaling pathway
    • Ornitz DM, Itoh N. 2015 The Fibroblast Growth Factor signaling pathway. Wiley Interdiscip Rev Dev Biol 4: 215–266
    • (2015) Wiley Interdiscip Rev Dev Biol , vol.4 , pp. 215-266
    • Ornitz, D.M.1    Itoh, N.2
  • 155
    • 0026665252 scopus 로고
    • Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3
    • Ornitz DM, Leder P. 1992 Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3. J Biol Chem 267: 16305–16311
    • (1992) J Biol Chem , vol.267 , pp. 16305-16311
    • Ornitz, D.M.1    Leder, P.2
  • 156
    • 84938151232 scopus 로고    scopus 로고
    • Fibroblast growth factor signaling in skeletal development and disease
    • Ornitz DM, Marie PJ. 2015 Fibroblast growth factor signaling in skeletal development and disease. Genes Development 29: 1463–1486
    • (2015) Genes Development , vol.29 , pp. 1463-1486
    • Ornitz, D.M.1    Marie, P.J.2
  • 158
    • 0026344226 scopus 로고
    • Developmental expression of two murine fibroblast growth factor receptors, flg and bek
    • Orr-Urtreger A, Givol D, Yayon A, Yarden Y, Lonai P. 1991 Developmental expression of two murine fibroblast growth factor receptors, flg and bek. Development 113: 1419–1434
    • (1991) Development , vol.113 , pp. 1419-1434
    • Orr-Urtreger, A.1    Givol, D.2    Yayon, A.3    Yarden, Y.4    Lonai, P.5
  • 161
    • 0032146074 scopus 로고    scopus 로고
    • Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos
    • Partanen J, Schwartz L, Rossant J. 1998 Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos. Genes Dev 12: 2332–2344
    • (1998) Genes Dev , vol.12 , pp. 2332-2344
    • Partanen, J.1    Schwartz, L.2    Rossant, J.3
  • 163
    • 11844262678 scopus 로고    scopus 로고
    • Hush puppy: A new mouse mutant with pinna, ossicle, and inner ear defects
    • Pau H, Fuchs H, de Angelis MH, Steel KP. 2005 Hush puppy: a new mouse mutant with pinna, ossicle, and inner ear defects. Laryngoscope 115: 116–124
    • (2005) Laryngoscope , vol.115 , pp. 116-124
    • Pau, H.1    Fuchs, H.2    De Angelis, M.H.3    Steel, K.P.4
  • 166
    • 58149118293 scopus 로고    scopus 로고
    • Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst
    • Plusa B, Piliszek A, Frankenberg S, Artus J, Hadjantonakis AK. 2008 Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst. Development 135: 3081–3091
    • (2008) Development , vol.135 , pp. 3081-3091
    • Plusa, B.1    Piliszek, A.2    Frankenberg, S.3    Artus, J.4    Hadjantonakis, A.K.5
  • 167
    • 0032483520 scopus 로고    scopus 로고
    • Heparan sulfate oligosaccharides require 6-O-sulfation for promotion of basic fibroblast growth factor mitogenic activity
    • Pye DA, Vives RR, Turnbull JE, Hyde P, Gallagher JT. 1998 Heparan sulfate oligosaccharides require 6-O-sulfation for promotion of basic fibroblast growth factor mitogenic activity. J Biol Chem 273: 22936–22942
    • (1998) J Biol Chem , vol.273 , pp. 22936-22942
    • Pye, D.A.1    Vives, R.R.2    Turnbull, J.E.3    Hyde, P.4    Gallagher, J.T.5
  • 169
    • 84866792640 scopus 로고    scopus 로고
    • Glycosaminoglycan- dependent restriction of FGF diffusion is necessary for lacrimal gland development
    • Qu X, Pan Y, Carbe C, Powers A, Grobe K, Zhang X. 2012 Glycosaminoglycan- dependent restriction of FGF diffusion is necessary for lacrimal gland development. Development 139: 2730–2739
    • (2012) Development , vol.139 , pp. 2730-2739
    • Qu, X.1    Pan, Y.2    Carbe, C.3    Powers, A.4    Grobe, K.5    Zhang, X.6
  • 170
    • 0027395119 scopus 로고
    • SNT, a differentiationspecific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells
    • Rabin SJ, Cleghon V, Kaplan DR. 1993 SNT, a differentiationspecific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells. Mol Cell Biol 13: 2203–2213
    • (1993) Mol Cell Biol , vol.13 , pp. 2203-2213
    • Rabin, S.J.1    Cleghon, V.2    Kaplan, D.R.3
  • 171
    • 0033594971 scopus 로고    scopus 로고
    • Comparison of the intracellular signaling responses by three chimeric fibroblast growth factor receptors in PC12 cells
    • Raffioni S, Thomas D, Foehr ED, Thompson LM, Bradshaw RA. 1999 Comparison of the intracellular signaling responses by three chimeric fibroblast growth factor receptors in PC12 cells. Proc Natl Acad Sci 96: 7178–7183
    • (1999) Proc Natl Acad Sci , vol.96 , pp. 7178-7183
    • Raffioni, S.1    Thomas, D.2    Foehr, E.D.3    Thompson, L.M.4    Bradshaw, R.A.5
  • 172
    • 0347717892 scopus 로고    scopus 로고
    • Activation of the ERK1/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytes
    • Raucci A, Laplantine E, Mansukhani A, Basilico C. 2004 Activation of the ERK1/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytes. J Biol Chem 279: 1747–1756
    • (2004) J Biol Chem , vol.279 , pp. 1747-1756
    • Raucci, A.1    Laplantine, E.2    Mansukhani, A.3    Basilico, C.4
  • 173
    • 0034677773 scopus 로고    scopus 로고
    • Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner
    • Reilly JF, Mickey G, Maher PA. 2000 Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner. J Biol Chem 275: 7771–7778
    • (2000) J Biol Chem , vol.275 , pp. 7771-7778
    • Reilly, J.F.1    Mickey, G.2    Maher, P.A.3
  • 175
    • 33646823663 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase activity is critical for glucose metabolismand embryo survival in murine blastocysts
    • Riley JK, Carayannopoulos MO, Wyman AH, Chi M, Moley KH. 2006 Phosphatidylinositol 3-kinase activity is critical for glucose metabolismand embryo survival in murine blastocysts. J Biol Chem 281: 6010–6019
    • (2006) J Biol Chem , vol.281 , pp. 6010-6019
    • Riley, J.K.1    Carayannopoulos, M.O.2    Wyman, A.H.3    Chi, M.4    Moley, K.H.5
  • 179
    • 0033151612 scopus 로고    scopus 로고
    • FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway
    • Sahni M, Ambrosetti DC, Mansukhani A, Gertner R, Levy D, Basilico C. 1999 FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway. Genes Dev 13: 1361–1366
    • (1999) Genes Dev , vol.13 , pp. 1361-1366
    • Sahni, M.1    Ambrosetti, D.C.2    Mansukhani, A.3    Gertner, R.4    Levy, D.5    Basilico, C.6
  • 180
    • 0034960254 scopus 로고    scopus 로고
    • STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2
    • Sahni M, Raz R, Coffin JD, Levy D, Basilico C. 2001 STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2. Development 128: 2119–2129
    • (2001) Development , vol.128 , pp. 2119-2129
    • Sahni, M.1    Raz, R.2    Coffin, J.D.3    Levy, D.4    Basilico, C.5
  • 181
    • 65549164714 scopus 로고    scopus 로고
    • A novel interaction between fibroblast growth factor receptor 3 and the p85 subunit of phosphoinositide 3-kinase: Activation-dependent regulation of ERK by p85 in multiple myeloma cells
    • Salazar L, Kashiwada T, Krejci P, Muchowski P, Donoghue D, Wilcox WR, Thompson LM. 2009 A novel interaction between fibroblast growth factor receptor 3 and the p85 subunit of phosphoinositide 3-kinase: activation-dependent regulation of ERK by p85 in multiple myeloma cells. Hum Mol Genet 18: 1951–1961
    • (2009) Hum Mol Genet , vol.18 , pp. 1951-1961
    • Salazar, L.1    Kashiwada, T.2    Krejci, P.3    Muchowski, P.4    Donoghue, D.5    Wilcox, W.R.6    Thompson, L.M.7
  • 182
    • 0034919848 scopus 로고    scopus 로고
    • Inductive signal and tissue responsiveness defining the tectum and the cerebellum
    • Sato T, Araki I, Nakamura H. 2001 Inductive signal and tissue responsiveness defining the tectum and the cerebellum. Development 128: 2461–2469
    • (2001) Development , vol.128 , pp. 2461-2469
    • Sato, T.1    Araki, I.2    Nakamura, H.3
  • 183
    • 0035214904 scopus 로고    scopus 로고
    • Fgf/MAPK signalling is a crucial positional cue in somite boundary formation
    • Sawada A, Shinya M, Jiang YJ, Kawakami A, Kuroiwa A, Takeda H. 2001 Fgf/MAPK signalling is a crucial positional cue in somite boundary formation. Development 128: 4873–4880
    • (2001) Development , vol.128 , pp. 4873-4880
    • Sawada, A.1    Shinya, M.2    Jiang, Y.J.3    Kawakami, A.4    Kuroiwa, A.5    Takeda, H.6
  • 186
    • 0028174023 scopus 로고
    • Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
    • Schuchardt A, D’Agati V, Larsson-Blomberg L, Costantini F, Pachnis V. 1994 Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature 367: 380–383
    • (1994) Nature , vol.367 , pp. 380-383
    • Schuchardt, A.1    D’Agati, V.2    Larsson-Blomberg, L.3    Costantini, F.4    Pachnis, V.5
  • 187
    • 58149289662 scopus 로고    scopus 로고
    • Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2)
    • Schuller AC, Ahmed Z, Levitt JA, Suen KM, Suhling K, Ladbury JE. 2008 Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2). Biochem J 416: 189–199
    • (2008) Biochem J , vol.416 , pp. 189-199
    • Schuller, A.C.1    Ahmed, Z.2    Levitt, J.A.3    Suen, K.M.4    Suhling, K.5    Ladbury, J.E.6
  • 188
    • 79251537178 scopus 로고    scopus 로고
    • Genetic inactivation of ERK1 and ERK2 in chondrocytes promotes bone growth and enlarges the spinal canal
    • Sebastian A, Matsushita T, Kawanami A, Mackem S, Landreth GE, Murakami S. 2011 Genetic inactivation of ERK1 and ERK2 in chondrocytes promotes bone growth and enlarges the spinal canal. J Orthop Res 29: 375–379
    • (2011) J Orthop Res , vol.29 , pp. 375-379
    • Sebastian, A.1    Matsushita, T.2    Kawanami, A.3    Mackem, S.4    Landreth, G.E.5    Murakami, S.6
  • 189
    • 66349106792 scopus 로고    scopus 로고
    • Structural and functional basis of a role for CRKL in a fibroblast growth factor 8-induced feed-forward loop
    • Seo JH, Suenaga A, Hatakeyama M, Taiji M, Imamoto A. 2009 Structural and functional basis of a role for CRKL in a fibroblast growth factor 8-induced feed-forward loop. Mol Cell Biol 29: 3076–3087
    • (2009) Mol Cell Biol , vol.29 , pp. 3076-3087
    • Seo, J.H.1    Suenaga, A.2    Hatakeyama, M.3    Taiji, M.4    Imamoto, A.5
  • 190
    • 0029062582 scopus 로고
    • Fibroblast growth factor receptors display both common and distinct signaling pathways
    • Shaoul E, Reich-Slotky R, Berman B, Ron D. 1995 Fibroblast growth factor receptors display both common and distinct signaling pathways. Oncogene 10: 1553–1561
    • (1995) Oncogene , vol.10 , pp. 1553-1561
    • Shaoul, E.1    Reich-Slotky, R.2    Berman, B.3    Ron, D.4
  • 193
    • 0036510743 scopus 로고    scopus 로고
    • Regulation of osteoblast, chondrocyte, and osteoclast functions by fibroblast growth factor (FGF)-18 in comparison with FGF-2 and FGF- 10
    • Shimoaka T, Ogasawara T, Yonamine A, Chikazu D, Kawano H, Nakamura K, Itoh N, Kawaguchi H. 2002 Regulation of osteoblast, chondrocyte, and osteoclast functions by fibroblast growth factor (FGF)-18 in comparison with FGF-2 and FGF- 10. J Biol Chem 277: 7493–7500
    • (2002) J Biol Chem , vol.277 , pp. 7493-7500
    • Shimoaka, T.1    Ogasawara, T.2    Yonamine, A.3    Chikazu, D.4    Kawano, H.5    Nakamura, K.6    Itoh, N.7    Kawaguchi, H.8
  • 195
    • 34548371795 scopus 로고    scopus 로고
    • RNA interference and inhibition of MEK–ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis
    • Shukla V, Coumoul X, Wang RH, Kim HS, Deng CX. 2007 RNA interference and inhibition of MEK–ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis. Nat Genet 39: 1145–1150
    • (2007) Nat Genet , vol.39 , pp. 1145-1150
    • Shukla, V.1    Coumoul, X.2    Wang, R.H.3    Kim, H.S.4    Deng, C.X.5
  • 196
    • 0029045856 scopus 로고
    • Strain-dependent epithelial defects in mice lacking the EGF receptor
    • Sibilia M, Wagner EF. 1995 Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269: 234–238
    • (1995) Science , vol.269 , pp. 234-238
    • Sibilia, M.1    Wagner, E.F.2
  • 200
    • 0028356454 scopus 로고
    • Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766
    • Sorokin A, Mohammadi M, Huang J, Schlessinger J. 1994 Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766. J Biol Chem 269: 17056–17061
    • (1994) J Biol Chem , vol.269 , pp. 17056-17061
    • Sorokin, A.1    Mohammadi, M.2    Huang, J.3    Schlessinger, J.4
  • 201
    • 84866439571 scopus 로고    scopus 로고
    • Development of the lip and palate: FGF signalling
    • Stanier P, Pauws E. 2012 Development of the lip and palate: FGF signalling. Front Oral Biol 16: 71–80
    • (2012) Front Oral Biol , vol.16 , pp. 71-80
    • Stanier, P.1    Pauws, E.2
  • 203
    • 0017979060 scopus 로고
    • Cutis gyratum and acanthosis nigricans associated with other anomalies: A distinctive syndrome
    • Stevenson RE, Ferlauto GJ, Taylor HA. 1978 Cutis gyratum and acanthosis nigricans associated with other anomalies: a distinctive syndrome. J Pediatr 92: 950–952
    • (1978) J Pediatr , vol.92 , pp. 950-952
    • Stevenson, R.E.1    Ferlauto, G.J.2    Taylor, H.A.3
  • 204
    • 0034103657 scopus 로고    scopus 로고
    • Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development
    • Sun X, Lewandoski M, Meyers EN, Liu YH, Maxson RE Jr, Martin GR. 2000 Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development. Nat Genet 25: 83–86
    • (2000) Nat Genet , vol.25 , pp. 83-86
    • Sun, X.1    Lewandoski, M.2    Meyers, E.N.3    Liu, Y.H.4    Maxson, R.E.5    Martin, G.R.6
  • 205
    • 0036682468 scopus 로고    scopus 로고
    • Functions of FGF signalling fromthe apical ectodermal ridge in limb development
    • Sun X, Mariani FV, Martin GR. 2002 Functions of FGF signalling fromthe apical ectodermal ridge in limb development. Nature 418: 501–508
    • (2002) Nature , vol.418 , pp. 501-508
    • Sun, X.1    Mariani, F.V.2    Martin, G.R.3
  • 207
    • 2342419356 scopus 로고    scopus 로고
    • Additive effects of PDGF receptor β signaling pathways in vascular smooth muscle cell development
    • Tallquist MD, French WJ, Soriano P. 2003 Additive effects of PDGF receptor β signaling pathways in vascular smooth muscle cell development. PLoS Biol 1: E52
    • (2003) Plos Biol , vol.1
    • Tallquist, M.D.1    French, W.J.2    Soriano, P.3
  • 208
    • 0029790656 scopus 로고    scopus 로고
    • FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2
    • Tan Y, Rouse J, Zhang A, Cariati S, Cohen P, Comb MJ. 1996 FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2. EMBO J 15: 4629–4642
    • (1996) EMBO J , vol.15 , pp. 4629-4642
    • Tan, Y.1    Rouse, J.2    Zhang, A.3    Cariati, S.4    Cohen, P.5    Comb, M.J.6
  • 210
    • 84925545317 scopus 로고    scopus 로고
    • PI3K in cancer: Divergent roles of isoforms, modes of activation and therapeutic targeting
    • Thorpe LM, Yuzugullu H, Zhao JJ. 2015 PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting. Nat Rev Cancer 15: 7–24
    • (2015) Nat Rev Cancer , vol.15 , pp. 7-24
    • Thorpe, L.M.1    Yuzugullu, H.2    Zhao, J.J.3
  • 213
    • 0037227318 scopus 로고    scopus 로고
    • Fgfr1 regulates patterning of the pharyngeal region
    • Trokovic N, Trokovic R, Mai P, Partanen J. 2003 Fgfr1 regulates patterning of the pharyngeal region. Genes Dev 17: 141–153
    • (2003) Genes Dev , vol.17 , pp. 141-153
    • Trokovic, N.1    Trokovic, R.2    Mai, P.3    Partanen, J.4
  • 214
    • 84879604942 scopus 로고    scopus 로고
    • Role of FGFRL1 and other FGF signaling proteins in early kidney development
    • Trueb B, Amann R, Gerber SD. 2013 Role of FGFRL1 and other FGF signaling proteins in early kidney development. Cell Mol Life Sci 70: 2505–2518
    • (2013) Cell Mol Life Sci , vol.70 , pp. 2505-2518
    • Trueb, B.1    Amann, R.2    Gerber, S.D.3
  • 215
    • 0033397681 scopus 로고    scopus 로고
    • Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch
    • Trumpp A, Depew MJ, Rubenstein JL, Bishop JM, Martin GR. 1999 Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev 13: 3136–3148
    • (1999) Genes Dev , vol.13 , pp. 3136-3148
    • Trumpp, A.1    Depew, M.J.2    Rubenstein, J.L.3    Bishop, J.M.4    Martin, G.R.5
  • 216
    • 11244325104 scopus 로고    scopus 로고
    • Targeted expression of a dominant-negative fibroblast growth factor (FGF) receptor in gonadotropin-releasing hormone (GnRH) neurons reduces FGF responsiveness and the size of GnRH neuronal population
    • Tsai PS, Moenter SM, Postigo HR, El Majdoubi M, Pak TR, Gill JC, Paruthiyil S, Werner S, Weiner RI. 2005 Targeted expression of a dominant-negative fibroblast growth factor (FGF) receptor in gonadotropin-releasing hormone (GnRH) neurons reduces FGF responsiveness and the size of GnRH neuronal population. Mol Endocrinol (Baltimore, Md) 19: 225–236
    • (2005) Mol Endocrinol (Baltimore, Md , vol.19 , pp. 225-236
    • Tsai, P.S.1    Moenter, S.M.2    Postigo, H.R.3    El Majdoubi, M.4    Pak, T.R.5    Gill, J.C.6    Paruthiyil, S.7    Werner, S.8    Weiner, R.I.9
  • 218
    • 77956682916 scopus 로고    scopus 로고
    • Extending the family table: Insights from beyond vertebrates into the regulation of embryonic development by FGFs
    • Tulin S, Stathopoulos A. 2010 Extending the family table: insights from beyond vertebrates into the regulation of embryonic development by FGFs. Birth Defects Res C Embryo Today 90: 214–227
    • (2010) Birth Defects Res C Embryo Today , vol.90 , pp. 214-227
    • Tulin, S.1    Stathopoulos, A.2
  • 219
    • 0026541181 scopus 로고
    • Atruncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor
    • Ueno H, Gunn M, Dell K, Tseng A Jr, Williams L. 1992.Atruncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor. J Biol Chem 267: 1470–1476
    • (1992) J Biol Chem , vol.267 , pp. 1470-1476
    • Ueno, H.1    Gunn, M.2    Dell, K.3    Tseng, A.4    Williams, L.5
  • 220
    • 84951320585 scopus 로고    scopus 로고
    • Germline variant FGFR4 p.G388R exposes a membrane-proximal STAT3 binding site
    • Ulaganathan VK, Sperl B, Rapp UR, Ullrich A. 2015 Germline variant FGFR4 p.G388R exposes a membrane-proximal STAT3 binding site. Nature 528: 570–574
    • (2015) Nature , vol.528 , pp. 570-574
    • Ulaganathan, V.K.1    Sperl, B.2    Rapp, U.R.3    Ullrich, A.4
  • 222
    • 0028332812 scopus 로고
    • Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1
    • Vainikka S, Joukov V, Wennstrom S, Bergman M, Pelicci PG, Alitalo K. 1994 Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1. J Biol Chem 269: 18320–18326
    • (1994) J Biol Chem , vol.269 , pp. 18320-18326
    • Vainikka, S.1    Joukov, V.2    Wennstrom, S.3    Bergman, M.4    Pelicci, P.G.5    Alitalo, K.6
  • 223
    • 0030033411 scopus 로고    scopus 로고
    • Association of a 85- kDa serine kinase with activated fibroblast growth factor receptor-4
    • Vainikka S, Joukov V, Klint P, Alitalo K. 1996 Association of a 85- kDa serine kinase with activated fibroblast growth factor receptor-4. J Biol Chem 271: 1270–1273
    • (1996) J Biol Chem , vol.271 , pp. 1270-1273
    • Vainikka, S.1    Joukov, V.2    Klint, P.3    Alitalo, K.4
  • 224
    • 84930619544 scopus 로고    scopus 로고
    • Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways
    • Vasudevan HN, Mazot P, He F, Soriano P. 2015 Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways. Elife 4: e07186
    • (2015) Elife , vol.4
    • Vasudevan, H.N.1    Mazot, P.2    He, F.3    Soriano, P.4
  • 225
    • 37249044796 scopus 로고    scopus 로고
    • FGF signaling acts upstream of the NOTCH and WNT signaling pathways to control segmentation clock oscillations in mouse somitogenesis
    • Wahl MB, Deng C, Lewandoski M, Pourquie O. 2007 FGF signaling acts upstream of the NOTCH and WNT signaling pathways to control segmentation clock oscillations in mouse somitogenesis. Development 134: 4033–4041
    • (2007) Development , vol.134 , pp. 4033-4041
    • Wahl, M.B.1    Deng, C.2    Lewandoski, M.3    Pourquie, O.4
  • 226
    • 0027955135 scopus 로고
    • Fibroblast growth factor receptors have different signaling and mitogenic potentials
    • Wang JK, Gao G, Goldfarb M. 1994 Fibroblast growth factor receptors have different signaling and mitogenic potentials. Mol Cell Biol 14: 181–188
    • (1994) Mol Cell Biol , vol.14 , pp. 181-188
    • Wang, J.K.1    Gao, G.2    Goldfarb, M.3
  • 230
    • 84881222338 scopus 로고    scopus 로고
    • Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis
    • Wang C, Chang JY, Yang C, Huang Y, Liu J, You P, McKeehan WL, Wang F, Li X. 2013 Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis. J Biol Chem 288: 22174–22183
    • (2013) J Biol Chem , vol.288 , pp. 22174-22183
    • Wang, C.1    Chang, J.Y.2    Yang, C.3    Huang, Y.4    Liu, J.5    You, P.6    McKeehan, W.L.7    Wang, F.8    Li, X.9
  • 231
    • 61649087689 scopus 로고    scopus 로고
    • ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing
    • Warzecha CC, Sato TK, Nabet B, Hogenesch JB, Carstens RP. 2009 ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. Mol Cell 33: 591–601
    • (2009) Mol Cell , vol.33 , pp. 591-601
    • Warzecha, C.C.1    Sato, T.K.2    Nabet, B.3    Hogenesch, J.B.4    Carstens, R.P.5
  • 232
    • 0031700905 scopus 로고    scopus 로고
    • FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung
    • Weinstein M, Xu X, Ohyama K, Deng CX. 1998 FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. Development 125: 3615–3623
    • (1998) Development , vol.125 , pp. 3615-3623
    • Weinstein, M.1    Xu, X.2    Ohyama, K.3    Deng, C.X.4
  • 233
    • 33646705916 scopus 로고    scopus 로고
    • FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains
    • White AC, Xu J, Yin Y, Smith C, Schmid G, Ornitz DM. 2006 FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains. Development 133: 1507–1517
    • (2006) Development , vol.133 , pp. 1507-1517
    • White, A.C.1    Xu, J.2    Yin, Y.3    Smith, C.4    Schmid, G.5    Ornitz, D.M.6
  • 234
    • 84862753735 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase 1 and 2 are not required for GnRH neuron development and normal female reproductive axis function in mice
    • Wierman ME, Xu M, Pierce A, Bliesner B, Bliss SP, Roberson MS. 2012 Extracellular signal-regulated kinase 1 and 2 are not required for GnRH neuron development and normal female reproductive axis function in mice. Neuroendocrinology 95: 289–296
    • (2012) Neuroendocrinology , vol.95 , pp. 289-296
    • Wierman, M.E.1    Xu, M.2    Pierce, A.3    Bliesner, B.4    Bliss, S.P.5    Roberson, M.S.6
  • 236
    • 0032540941 scopus 로고    scopus 로고
    • Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins
    • Xu H, Lee KW, Goldfarb M. 1998a. Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins. J Biol Chem 273: 17987–17990
    • (1998) J Biol Chem , vol.273 , pp. 17987-17990
    • Xu, H.1    Lee, K.W.2    Goldfarb, M.3
  • 237
    • 0031885801 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 2 (FGFR2)- mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction
    • Xu X, Weinstein M, Li C, Naski M, Cohen RI, Ornitz DM, Leder P, Deng C. 1998b. Fibroblast growth factor receptor 2 (FGFR2)- mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development 125: 753–765
    • (1998) Development , vol.125 , pp. 753-765
    • Xu, X.1    Weinstein, M.2    Li, C.3    Naski, M.4    Cohen, R.I.5    Ornitz, D.M.6    Leder, P.7    Deng, C.8
  • 238
    • 0028582035 scopus 로고
    • Fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation
    • Yamaguchi TP, Harpal K, Henkemeyer M, Rossant J. 1994. fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes Dev 8: 3032–3044
    • (1994) Genes Dev , vol.8 , pp. 3032-3044
    • Yamaguchi, T.P.1    Harpal, K.2    Henkemeyer, M.3    Rossant, J.4
  • 239
    • 76449083746 scopus 로고    scopus 로고
    • FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst
    • Yamanaka Y, Lanner F, Rossant J. 2010 FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst. Development 137: 715–724
    • (2010) Development , vol.137 , pp. 715-724
    • Yamanaka, Y.1    Lanner, F.2    Rossant, J.3
  • 241
    • 27944493875 scopus 로고    scopus 로고
    • Dosage-dependent effects of Akt1/protein kinase Bα (PKBα) and Akt3/PKBγ on thymus, skin, and cardiovascular and nervous system development in mice
    • Yang ZZ, Tschopp O, Di-Poi N, Bruder E, Baudry A, Dummler B, Wahli W, Hemmings BA. 2005 Dosage-dependent effects of Akt1/protein kinase Bα (PKBα) and Akt3/PKBγ on thymus, skin, and cardiovascular and nervous system development in mice. Mol Cell Biol 25: 10407–10418
    • (2005) Mol Cell Biol , vol.25 , pp. 10407-10418
    • Yang, Z.Z.1    Tschopp, O.2    Di-Poi, N.3    Bruder, E.4    Baudry, A.5    Dummler, B.6    Wahli, W.7    Hemmings, B.A.8
  • 242
    • 60549091399 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription mediate fibroblast growth factor-induced vascular endothelial morphogenesis
    • Yang X, Qiao D, Meyer K, Friedl A. 2009 Signal transducers and activators of transcription mediate fibroblast growth factor-induced vascular endothelial morphogenesis. Cancer Res 69: 1668–1677
    • (2009) Cancer Res , vol.69 , pp. 1668-1677
    • Yang, X.1    Qiao, D.2    Meyer, K.3    Friedl, A.4
  • 243
    • 21244473773 scopus 로고    scopus 로고
    • Comprehensive expression atlas of fibroblast growth factors and their receptors generated by a novel robotic in situ hybridization platform
    • Yaylaoglu MB, Titmus A, Visel A, Alvarez-Bolado G, Thaller C, Eichele G. 2005 Comprehensive expression atlas of fibroblast growth factors and their receptors generated by a novel robotic in situ hybridization platform. Dev Dyn 234: 371–386
    • (2005) Dev Dyn , vol.234 , pp. 371-386
    • Yaylaoglu, M.B.1    Titmus, A.2    Visel, A.3    Alvarez-Bolado, G.4    Thaller, C.5    Eichele, G.6
  • 244
    • 40949140612 scopus 로고    scopus 로고
    • A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesis
    • Yin L, Du X, Li C, Xu X, Chen Z, Su N, Zhao L, Qi H, Li F, Xue J, et al. 2008 A Pro253Arg mutation in fibroblast growth factor receptor 2 (Fgfr2) causes skeleton malformation mimicking human Apert syndrome by affecting both chondrogenesis and osteogenesis. Bone 42: 631–643
    • (2008) Bone , vol.42 , pp. 631-643
    • Yin, L.1    Du, X.2    Li, C.3    Xu, X.4    Chen, Z.5    Su, N.6    Zhao, L.7    Qi, H.8    Li, F.9    Xue, J.10
  • 245
    • 41649095548 scopus 로고    scopus 로고
    • FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis
    • Yu K, Ornitz DM. 2008 FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis. Development 135: 483–491
    • (2008) Development , vol.135 , pp. 483-491
    • Yu, K.1    Ornitz, D.M.2
  • 246
    • 0034685916 scopus 로고    scopus 로고
    • Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4
    • Yu C, Wang F, Kan M, Jin C, Jones RB, Weinstein M, Deng CX, McKeehan WL. 2000 Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. J Biol Chem 275: 15482–15489
    • (2000) J Biol Chem , vol.275 , pp. 15482-15489
    • Yu, C.1    Wang, F.2    Kan, M.3    Jin, C.4    Jones, R.B.5    Weinstein, M.6    Deng, C.X.7    McKeehan, W.L.8
  • 247
    • 0038782306 scopus 로고    scopus 로고
    • Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth
    • Yu K, Xu J, Liu Z, Sosic D, Shao J, Olson EN, Towler DA, Ornitz DM. 2003 Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Development 130: 3063–3074
    • (2003) Development , vol.130 , pp. 3063-3074
    • Yu, K.1    Xu, J.2    Liu, Z.3    Sosic, D.4    Shao, J.5    Olson, E.N.6    Towler, D.A.7    Ornitz, D.M.8
  • 248
    • 23644451052 scopus 로고    scopus 로고
    • Independent repression of bile acid synthesis and activation of c-Jun N-terminal kinase (JNK) by activated hepatocyte fibroblast growth factor receptor 4 (FGFR4) and bile acids
    • Yu C, Wang F, Jin C, Huang X, McKeehan WL. 2005 Independent repression of bile acid synthesis and activation of c-Jun N-terminal kinase (JNK) by activated hepatocyte fibroblast growth factor receptor 4 (FGFR4) and bile acids. J Biol Chem 280: 17707–17714
    • (2005) J Biol Chem , vol.280 , pp. 17707-17714
    • Yu, C.1    Wang, F.2    Jin, C.3    Huang, X.4    McKeehan, W.L.5
  • 250
    • 33744937606 scopus 로고    scopus 로고
    • Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family
    • Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM. 2006 Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J Biol Chem 281: 15694–15700
    • (2006) J Biol Chem , vol.281 , pp. 15694-15700
    • Zhang, X.1    Ibrahimi, O.A.2    Olsen, S.K.3    Umemori, H.4    Mohammadi, M.5    Ornitz, D.M.6


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