-
1
-
-
19944433322
-
The extracellular signalregulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis
-
Bost, F., Aouadi, M., Caron, L., Even, P., Belmonte, N., Prot, M., Dani, C., Hofman, P., Pagés, G., Pouysségur, J., et al. (2005). The extracellular signalregulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis. Diabetes 54, 402-411.
-
(2005)
Diabetes
, vol.54
, pp. 402-411
-
-
Bost, F.1
Aouadi, M.2
Caron, L.3
Even, P.4
Belmonte, N.5
Prot, M.6
Dani, C.7
Hofman, P.8
Pagés, G.9
Pouysségur, J.10
-
2
-
-
0025290163
-
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control
-
Boulton, T.G., Yancopoulos, G.D., Gregory, J.S., Slaughter, C., Moomaw, C., Hsu, J., and Cobb, M.H. (1990). An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control. Science 249, 64-67.
-
(1990)
Science
, vol.249
, pp. 64-67
-
-
Boulton, T.G.1
Yancopoulos, G.D.2
Gregory, J.S.3
Slaughter, C.4
Moomaw, C.5
Hsu, J.6
Cobb, M.H.7
-
3
-
-
0025823448
-
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
-
Boulton, T.G., Nye, S.H., Robbins, D.J., Ip, N.Y., Radziejewska, E., Morgenbesser, S.D., DePinho, R.A., Panayotatos, N., Cobb, M.H., and Yancopoulos, G.D. (1991). ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 65, 663-675.
-
(1991)
Cell
, vol.65
, pp. 663-675
-
-
Boulton, T.G.1
Nye, S.H.2
Robbins, D.J.3
Ip, N.Y.4
Radziejewska, E.5
Morgenbesser, S.D.6
DePinho, R.A.7
Panayotatos, N.8
Cobb, M.H.9
Yancopoulos, G.D.10
-
4
-
-
33645072441
-
p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis
-
Bourcier, C., Jacquel, A., Hess, J., Peyrottes, I., Angel, P., Hofman, P., Auberger, P., Pouysségur, J., and Pagès, G. (2006). p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis. Cancer Res. 66, 2700-2707.
-
(2006)
Cancer Res.
, vol.66
, pp. 2700-2707
-
-
Bourcier, C.1
Jacquel, A.2
Hess, J.3
Peyrottes, I.4
Angel, P.5
Hofman, P.6
Auberger, P.7
Pouysségur, J.8
Pagès, G.9
-
5
-
-
0035282334
-
Mammalian MAP kinase signalling cascades
-
Chang, L., and Karin, M. (2001). Mammalian MAP kinase signalling cascades. Nature 410, 37-40.
-
(2001)
Nature
, vol.410
, pp. 37-40
-
-
Chang, L.1
Karin, M.2
-
6
-
-
0142074405
-
Spatial and temporal patterns of ERK signaling during mouse embryogenesis
-
Corson, L.B., Yamanaka, Y., Lai, K.M., and Rossant, J. (2003). Spatial and temporal patterns of ERK signaling during mouse embryogenesis. Development 130, 4527-4537.
-
(2003)
Development
, vol.130
, pp. 4527-4537
-
-
Corson, L.B.1
Yamanaka, Y.2
Lai, K.M.3
Rossant, J.4
-
7
-
-
77949464718
-
From basic research to clinical development of MEK1/2 inhibitors for cancer therapy
-
Frémin, C., and Meloche, S. (2010). From basic research to clinical development of MEK1/2 inhibitors for cancer therapy. J. Hematol. Oncol. 3, 8.
-
(2010)
J. Hematol. Oncol.
, vol.3
, pp. 8
-
-
Frémin, C.1
Meloche, S.2
-
8
-
-
34247358156
-
ERK2 but not ERK1 plays a key role in hepatocyte replication: an RNAi-mediated ERK2 knockdown approach in wild-type and ERK1 null hepatocytes
-
Frémin, C., Ezan, F., Boisselier, P., Bessard, A., Pagès, G., Pouysségur, J., and Baffet, G. (2007). ERK2 but not ERK1 plays a key role in hepatocyte replication: an RNAi-mediated ERK2 knockdown approach in wild-type and ERK1 null hepatocytes. Hepatology 45, 1035-1045.
-
(2007)
Hepatology
, vol.45
, pp. 1035-1045
-
-
Frémin, C.1
Ezan, F.2
Boisselier, P.3
Bessard, A.4
Pagès, G.5
Pouysségur, J.6
Baffet, G.7
-
9
-
-
79957573284
-
Strong negative feedback from Erk to Raf confers robustness to MAPK signalling
-
Fritsche-Guenther, R., Witzel, F., Sieber, A., Herr, R., Schmidt, N., Braun, S., Brummer, T., Sers, C., and Blüthgen, N. (2011). Strong negative feedback from Erk to Raf confers robustness to MAPK signalling. Mol. Syst. Biol. 7, 489.
-
(2011)
Mol. Syst. Biol.
, vol.7
, pp. 489
-
-
Fritsche-Guenther, R.1
Witzel, F.2
Sieber, A.3
Herr, R.4
Schmidt, N.5
Braun, S.6
Brummer, T.7
Sers, C.8
Blüthgen, N.9
-
10
-
-
0033535584
-
Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta
-
Giroux, S., Tremblay, M., Bernard, D., Cardin-Girard, J.F., Aubry, S., Larouche, L., Rousseau, S., Huot, J., Landry, J., Jeannotte, L., and Charron, J. (1999). Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta. Curr. Biol. 9, 369-372.
-
(1999)
Curr. Biol.
, vol.9
, pp. 369-372
-
-
Giroux, S.1
Tremblay, M.2
Bernard, D.3
Cardin-Girard, J.F.4
Aubry, S.5
Larouche, L.6
Rousseau, S.7
Huot, J.8
Landry, J.9
Jeannotte, L.10
Charron, J.11
-
11
-
-
77952574986
-
The MAPK ERK1 is a negative regulator of the adult steady-state splenic erythropoiesis
-
Guihard, S., Clay, D., Cocault, L., Saulnier, N., Opolon, P., Souyri, M., Pagès, G., Pouysségur, J., Porteu, F., and Gaudry, M. (2010). The MAPK ERK1 is a negative regulator of the adult steady-state splenic erythropoiesis. Blood 115, 3686-3694.
-
(2010)
Blood
, vol.115
, pp. 3686-3694
-
-
Guihard, S.1
Clay, D.2
Cocault, L.3
Saulnier, N.4
Opolon, P.5
Souyri, M.6
Pagès, G.7
Pouysségur, J.8
Porteu, F.9
Gaudry, M.10
-
12
-
-
10744228332
-
Essential role for ERK2 mitogen-activated protein kinase in placental development
-
Hatano, N., Mori, Y., Oh-hora, M., Kosugi, A., Fujikawa, T., Nakai, N., Niwa, H., Miyazaki, J., Hamaoka, T., and Ogata, M. (2003). Essential role for ERK2 mitogen-activated protein kinase in placental development. Genes Cells 8, 847-856.
-
(2003)
Genes Cells
, vol.8
, pp. 847-856
-
-
Hatano, N.1
Mori, Y.2
Oh-hora, M.3
Kosugi, A.4
Fujikawa, T.5
Nakai, N.6
Niwa, H.7
Miyazaki, J.8
Hamaoka, T.9
Ogata, M.10
-
13
-
-
0036872791
-
Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain
-
Hayashi, S., Lewis, P., Pevny, L., and McMahon, A.P. (2002). Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Gene Expr. Patterns 2, 93-97.
-
(2002)
Gene Expr. Patterns
, vol.2
, pp. 93-97
-
-
Hayashi, S.1
Lewis, P.2
Pevny, L.3
McMahon, A.P.4
-
14
-
-
41849088475
-
The roles of MAPKs in disease
-
Lawrence, M.C., Jivan, A., Shao, C., Duan, L., Goad, D., Zaganjor, E., Osborne, J., McGlynn, K., Stippec, S., Earnest, S., et al. (2008). The roles of MAPKs in disease. Cell Res. 18, 436-442.
-
(2008)
Cell Res.
, vol.18
, pp. 436-442
-
-
Lawrence, M.C.1
Jivan, A.2
Shao, C.3
Duan, L.4
Goad, D.5
Zaganjor, E.6
Osborne, J.7
McGlynn, K.8
Stippec, S.9
Earnest, S.10
-
15
-
-
37549016809
-
Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels
-
Lefloch, R., Pouysségur, J., and Lenormand, P. (2008). Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels. Mol. Cell. Biol. 28, 511-527.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 511-527
-
-
Lefloch, R.1
Pouysségur, J.2
Lenormand, P.3
-
16
-
-
55949088852
-
Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development
-
Newbern, J., Zhong, J., Wickramasinghe, R.S., Li, X., Wu, Y., Samuels, I., Cherosky, N., Karlo, J.C., O'Loughlin, B., Wikenheiser, J., et al. (2008). Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development. Proc. Natl. Acad. Sci. USA 105, 17115-17120.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 17115-17120
-
-
Newbern, J.1
Zhong, J.2
Wickramasinghe, R.S.3
Li, X.4
Wu, Y.5
Samuels, I.6
Cherosky, N.7
Karlo, J.C.8
O'Loughlin, B.9
Wikenheiser, J.10
-
17
-
-
0030904130
-
'Green mice' as a source of ubiquitous green cells
-
Okabe, M., Ikawa, M., Kominami, K., Nakanishi, T., and Nishimune, Y. (1997). 'Green mice' as a source of ubiquitous green cells. FEBS Lett. 407, 313-319.
-
(1997)
FEBS Lett.
, vol.407
, pp. 313-319
-
-
Okabe, M.1
Ikawa, M.2
Kominami, K.3
Nakanishi, T.4
Nishimune, Y.5
-
18
-
-
17144458301
-
Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice
-
Pagès, G., Guérin, S., Grall, D., Bonino, F., Smith, A., Anjuere, F., Auberger, P., and Pouysségur, J. (1999). Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science 286, 1374-1377.
-
(1999)
Science
, vol.286
, pp. 1374-1377
-
-
Pagès, G.1
Guérin, S.2
Grall, D.3
Bonino, F.4
Smith, A.5
Anjuere, F.6
Auberger, P.7
Pouysségur, J.8
-
19
-
-
0034997845
-
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions
-
Pearson, G., Robinson, F., Beers Gibson, T., Xu, B.E., Karandikar, M., Berman, K., and Cobb, M.H. (2001). Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22, 153-183.
-
(2001)
Endocr. Rev.
, vol.22
, pp. 153-183
-
-
Pearson, G.1
Robinson, F.2
Beers Gibson, T.3
Xu, B.E.4
Karandikar, M.5
Berman, K.6
Cobb, M.H.7
-
20
-
-
84879856767
-
ERK2 but not ERK1 mediates HGF-induced motility in non-small cell lung carcinoma cell lines
-
Radtke, S., Milanovic, M., Rossé, C., De Rycker, M., Lachmann, S., Hibbert, A., Kermorgant, S., and Parker, P.J. (2013). ERK2 but not ERK1 mediates HGF-induced motility in non-small cell lung carcinoma cell lines. J. Cell Sci. 126, 2381-2391.
-
(2013)
J. Cell Sci.
, vol.126
, pp. 2381-2391
-
-
Radtke, S.1
Milanovic, M.2
Rossé, C.3
De Rycker, M.4
Lachmann, S.5
Hibbert, A.6
Kermorgant, S.7
Parker, P.J.8
-
22
-
-
0242607637
-
An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development
-
Saba-El-Leil, M.K., Vella, F.D., Vernay, B., Voisin, L., Chen, L., Labrecque, N., Ang, S.L., and Meloche, S. (2003). An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. EMBO Rep. 4, 964-968.
-
(2003)
EMBO Rep.
, vol.4
, pp. 964-968
-
-
Saba-El-Leil, M.K.1
Vella, F.D.2
Vernay, B.3
Voisin, L.4
Chen, L.5
Labrecque, N.6
Ang, S.L.7
Meloche, S.8
-
23
-
-
58549105755
-
MAP'ing CNS development and cognition: an ERKsome process
-
Samuels, I.S., Saitta, S.C., and Landreth, G.E. (2009). MAP'ing CNS development and cognition: an ERKsome process. Neuron 61, 160-167.
-
(2009)
Neuron
, vol.61
, pp. 160-167
-
-
Samuels, I.S.1
Saitta, S.C.2
Landreth, G.E.3
-
24
-
-
35148894535
-
Extracellular signalregulated kinase 2 (ERK2) knockdown mice show deficits in long-term memory; ERK2 has a specific function in learning and memory
-
Satoh, Y., Endo, S., Ikeda, T., Yamada, K., Ito, M., Kuroki, M., Hiramoto, T., Imamura, O., Kobayashi, Y., Watanabe, Y., et al. (2007). Extracellular signalregulated kinase 2 (ERK2) knockdown mice show deficits in long-term memory; ERK2 has a specific function in learning and memory. J. Neurosci. 27, 10765-10776.
-
(2007)
J. Neurosci.
, vol.27
, pp. 10765-10776
-
-
Satoh, Y.1
Endo, S.2
Ikeda, T.3
Yamada, K.4
Ito, M.5
Kuroki, M.6
Hiramoto, T.7
Imamura, O.8
Kobayashi, Y.9
Watanabe, Y.10
-
25
-
-
78751493171
-
Deletion of ERK1 and ERK2 in the CNS causes cortical abnormalities and neonatal lethality: Erk1 deficiency enhances the impairment of neurogenesis in Erk2-deficient mice
-
Satoh, Y., Kobayashi, Y., Takeuchi, A., Pagès, G., Pouysségur, J., and Kazama, T. (2011). Deletion of ERK1 and ERK2 in the CNS causes cortical abnormalities and neonatal lethality: Erk1 deficiency enhances the impairment of neurogenesis in Erk2-deficient mice. J. Neurosci. 31, 1149-1155.
-
(2011)
J. Neurosci.
, vol.31
, pp. 1149-1155
-
-
Satoh, Y.1
Kobayashi, Y.2
Takeuchi, A.3
Pagès, G.4
Pouysségur, J.5
Kazama, T.6
-
26
-
-
77950353276
-
ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motifdependent signaling events
-
Shin, S., Dimitri, C.A., Yoon, S.O., Dowdle, W., and Blenis, J. (2010). ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motifdependent signaling events. Mol. Cell 38, 114-127.
-
(2010)
Mol. Cell
, vol.38
, pp. 114-127
-
-
Shin, S.1
Dimitri, C.A.2
Yoon, S.O.3
Dowdle, W.4
Blenis, J.5
-
27
-
-
33845904217
-
ERK1 and ERK2 mitogen-activated protein kinases affect Rasdependent cell signaling differentially
-
Vantaggiato, C., Formentini, I., Bondanza, A., Bonini, C., Naldini, L., and Brambilla, R. (2006). ERK1 and ERK2 mitogen-activated protein kinases affect Rasdependent cell signaling differentially. J. Biol. 5, 14.
-
(2006)
J. Biol.
, vol.5
, pp. 14
-
-
Vantaggiato, C.1
Formentini, I.2
Bondanza, A.3
Bonini, C.4
Naldini, L.5
Brambilla, R.6
-
28
-
-
77953387301
-
Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation
-
Voisin, L., Saba-El-Leil, M.K., Julien, C., Frémin, C., and Meloche, S. (2010). Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation. Mol. Cell. Biol. 30, 2918-2932.
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 2918-2932
-
-
Voisin, L.1
Saba-El-Leil, M.K.2
Julien, C.3
Frémin, C.4
Meloche, S.5
-
29
-
-
0242300107
-
Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation
-
Yao, Y., Li, W., Wu, J., Germann, U.A., Su, M.S., Kuida, K., and Boucher, D.M. (2003). Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation. Proc. Natl. Acad. Sci. USA 100, 12759-12764.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 12759-12764
-
-
Yao, Y.1
Li, W.2
Wu, J.3
Germann, U.A.4
Su, M.S.5
Kuida, K.6
Boucher, D.M.7
|