Functions of FGF signalling from the apical ectodermal ridge in limb development

Nature

Volumn 418, Issue 6897, 2002, Pages 501-508

  Sun, Xin ^a   Mariani, Francesca V ^a   Martin, Gail R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; SIGNALING; TISSUE;

FIBROBLAST GROWTH FACTOR (FGF);

NATURAL SCIENCES;

FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTOR 8;

DEVELOPMENTAL BIOLOGY; LIMB;

APICAL ECTODERMAL RIDGE; ARTICLE; CELL SURVIVAL; FORELIMB; GENE INACTIVATION; HINDLIMB; IMMUNOFLUORESCENCE; KNOCKOUT MOUSE; LIMB BUD; LIMB DEVELOPMENT; MESENCHYME; MOUSE; NICK END LABELING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKELETON; STEM CELL;

ANIMALS; APOPTOSIS; BODY PATTERNING; CELL COUNT; CELL DIVISION; ECTODERM; FEMALE; FIBROBLAST GROWTH FACTOR 8; FIBROBLAST GROWTH FACTORS; FORELIMB; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HINDLIMB; LIMB BUD; MALE; MESODERM; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MUSCLE, SKELETAL; PHENOTYPE; SIGNAL TRANSDUCTION; STEM CELLS; TIME FACTORS;

EID: 0036682468     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature00902     Document Type: Article

References (48)

1. Molecular models for vertebrate limb development
2. The proximo-distal sequence of the origin of the parts of the chick wing and the role of the ectoderm
3. A quantitative analysis of the effect of excision of the AER from the chick limb bud
4. The proximodistal determination of skeletal parts in the developing chick leg
5. Ectodermal-mesodermal interactions in the growth of limb buds in the chick embryo: Constancy and temporal limits of the ectodermal induction
6. FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb
7. FGF-2: Apical ectodermal ridge growth signal for chick limb development
8. Fibroblast growth factors
9. The roles of FGFs in the early development of vertebrate limbs
10. Conditional inactivation of Fgf 4 reveals complexity of signalling during limb bud development
11. Requirement of FGF-4 for postimplantation mouse development
12. Targeted disruption of Fgf 8 causes failure of cell migration in the gastrulating mouse embryo
13. Male-to-female sex reversal in mice lacking fibroblast growth factor 9
14. Temporal and spatial gradients of Fgf 8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures
15. Normal limb development in conditional mutants of Fgf 4
16. Fgt 8 signalling from the AER is essential for normal limb development
17. Fgf8 is required for outgrowth and patterning of the limbs
18. An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination
19. The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos
20. Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless
21. Fgf10 is essential for limb and lung formation
22. Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx 1, or Bmp4
23. Limbless: A new genetic mutant in the chick
24. The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development
25. Spatial and temporal patterns of cell death in limb bud mesoderm after apical ectodermal ridge removal
26. A re-examination of proximodistal patterning during vertebrate limb development
27. Pax-3 is required for the development of limb muscles: A possible role for the migration of dermomyotomal muscle progenitor cells
28. Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): Alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development
29. Histone phosphorylation and chromatin structure during mitosis in Chinese hamster cells
30. Cell division in the early growth and morphogenesis of the chick limb
31. Manifestation of the limb prepattern: Limb development in the absence of Sonic hedgehog function
32. Some distal limb structures develop in mice lacking Sonic hedgehog signalling
33. Size dependence during the development of the amphibian foot. Colchicine-induced digital loss and reduction
34. The effect of cell killing by X-irradiation on pattern formation in the chick limb
35. Cell migration and chick limb development: Chemotactic action of FGF-4 and the AER
36. The SH2 tyrosine phosphatase Shp2 is required for mammalian limb development
37. The establishment of the cartilage pattern in the embryonic chick wing, and evidence for a role of the dorsal and ventral ectoderm in normal wing development
38. Positional information in chick limb morphogenesis
39. Control of vertebrate limb outgrowth by the proximal factor Meis 2 and distal antagonism of BMPs by Gremlin
40. Conserved regulation of proximodistal limb axis development by Meis1/Hth
41. Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes
42. Cellular mechanisms of pattern formation in the developing limb
43. Interdigital regulation of digit identity and homeotic transformation by modulated BMP signalling
44. Genetic control of bone and joint formation
45. Mammalian limb bud development: In situ fate maps of early hindlimb buds
46. The genetics ofluxate mice. IV. Embryology
47. Cell fate in the chick limb bud and relationship to gene expression