A Ser252Trp mutation in fibroblast growth factor receptor 2 (FGFR2) mimicking human apert syndrome reveals an essential role for FGF signaling in the regulation of endochondral bone formation

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Chen, Peng ^a,b   Zhang, Li ^a   Weng, Tujun ^a   Zhang, Shichang ^a   Sun, Shijin ^a   Chang, Mingtao ^a   Li, Yang ^a   Zhang, Bo ^a   Zhang, Lianyang ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b 324 Hospital of PLA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; FIBROBLAST GROWTH FACTOR RECEPTOR 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38;

ACROCEPHALOSYNDACTYLY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MASS; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DEMINERALIZATION; ENCHONDRAL OSSIFICATION; GAIN OF FUNCTION MUTATION; GROWTH PLATE; IN VITRO STUDY; LONG BONE; MESENCHYMAL STEM CELL; METAPHYSIS; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRABECULAR BONE; UPREGULATION;

ACROCEPHALOSYNDACTYLIA; ANIMALS; CELL DIFFERENTIATION; EMBRYONIC DEVELOPMENT; FLAVONOIDS; GENE KNOCK-IN TECHNIQUES; HUMANS; IMIDAZOLES; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; MUTATION; OSTEOGENESIS; PHOSPHORYLATION; PYRIDINES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84900305191     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0087311     Document Type: Article

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