Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma

Development (Cambridge)

Volumn 140, Issue 13, 2013, Pages 2711-2723

  Cai, Zhigang ^a   Tao, Chenqi ^a   Li, Hongge ^a   Ladher, Raj ^b   Gotoh, Noriko ^c   Feng, Gen Sheng ^d   Wang, Fen ^e   Zhang, Xin ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RIKEN KOBE INSTITUTE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

Coloboma; FGF; Frs2 ; Mitf; Mouse; Optic disc; Optic fissure; Optic nerve; Pax2; Ras; Shp2

Indexed keywords

BONE MORPHOGENETIC PROTEIN; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; PROTEIN TYROSINE PHOSPHATASE SHP 2; RAS PROTEIN; TRANSCRIPTION FACTOR PAX2; TRANSCRIPTION FACTOR SOX2;

ANIMAL CELL; ARTICLE; COLOBOMA; CONTROLLED STUDY; EMBRYO; EYE MALFORMATION; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; OPTIC DISK ANOMALY; OPTIC NERVE; OPTIC NERVE HYPOPLASIA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RETINA; SIGNAL TRANSDUCTION; UVEA DISEASE; WILD TYPE;

COLOBOMA; FGF; FRS2Α; MITF; MOUSE; OPTIC DISC; OPTIC FISSURE; OPTIC NERVE; PAX2; RAS; SHP2;

ANIMALS; COLOBOMA; FIBROBLAST GROWTH FACTORS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; OPTIC NERVE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; SIGNAL TRANSDUCTION;

DANIO RERIO; MAMMALIA;

EID: 84878869699     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.089987     Document Type: Article

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